Tag: M.W:200-300

Application of 151-21-3, In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. The reactant in an enzyme-catalyzed reaction is called a substrate.151-21-3, Name is Sodium dodecyl sulfate, SMILES is O=S(OCCCCCCCCCCCC)([O-])=O.[Na+], belongs to thiazines compound. In a article, author is Morak-Mlodawska, Beata, introduce new discover of the category.

Synthesis and selected immunological properties of 10-substituted 1,8-diazaphenothiazines

A new type of tricyclic azaphenothiazines-1,8-diazaphenothiazines-was obtained in the reaction of 2,3- and 3,4-disubstituted pyridines. The reaction ran as the Smiles rearrangement. The 1,8-diazaphenothiazine system was determined using NOE experiment and 2D NMR spectra (COSY, HSQC, HMBC). 10H-1,8-diazaphenothiazine was transformed into 10-derivatives with alkyl, aminoalkyl, amidoalkyl, sulfonamidoalkyl, and nitrogen half-mustard groups. The compounds were tested for their effects on phytohemagglutinin A-induced proliferative response of human peripheral blood mononuclear cells (PBMC) and lipopolysaccharide-induced tumor necrosis factor alpha production by human whole blood cultures. The compounds exhibited differential, dose-dependent inhibitory activities in these tests. All the compounds were low toxic against PBMC. The compounds showing the highest antiproliferative activity strongly inhibited the growth of leukemia L-1210 and colon cancer SW-948 cell lines, similarly as cisplatin, a reference drug.

Application of 151-21-3, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 151-21-3 is helpful to your research.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Application of 92-30-8, In homogeneous catalysis, catalysts are in the same phase as the reactants. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, SMILES is FC(C(C=C1N2)=CC=C1SC3=C2C=CC=C3)(F)F, belongs to thiazines compound. In a article, author is Dar’in, Dmitrii, introduce new discover of the category.

Realizing the Trifunctional Potential of Alkyl 4-Chloro-2-diazo-3-oxobutanoates: Convenient Assembly of 6,7-Dihydro-4H-[1,2,3]triazolo[5,1-c][1,4]thiazine Core

The first example of exploiting the trifunctional character of alkyl 4-chloro-2-diazo-3-oxobutanoates in the reactions with vicinal N , S -bis-nucleophiles leading to the formation of bicyclic 6,7-dihydro-4 H -[1,2,3]triazolo[5,1- c ][1,4]thiazines is presented. The key to the successful realization of the atom-economical synthetic strategy is the initial S (N) 2 event, which facilitates the subsequent domino 1,2,3-triazole formation via the Wolff reaction. Equally important is the choice of sodium acetate as the base: acetic acid formed in the course of the initial nucleophilic substitution acts as an efficient catalyst for the Wolff reaction, which suppresses the competing, unwanted fragmentation path (observed when other bases are used).

Application of 92-30-8, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 92-30-8 is helpful to your research.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. , Product Details of 5872-08-2, 5872-08-2, Name is (7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid, molecular formula is C10H16O4S, belongs to thiazines compound. In a document, author is Hamed, Eman O., introduce the new discover.

Cyclization of N-benzyl cyanoacetamide: Novel synthesis and biological activity of pyrrole, pyrimidine, and pyran derivatives

Heteroannulation of N-Benzyl cyanoacetamide 1 to a new series of heterocycles has been developed. Thus, reaction of 1 with different polarized pi systems afforded pyrrolo 4, pyridone 6, pyridine 8, and diazapene 10 derivatives, respectively. N-Benzyl cyanoacetamide that undergo condensation reaction with salicylaldehyde yielded pyran derivative 11. Nitrosation of 11 furnished condensed pyran 13. Compound 11 reacted with benzaldehyde, carbon disulfide (cyclizing agent), and ammonium thiocyanate to provide pyrane 17, thiazine 18, and thiourea 20 derivatives, respectively. Cinnamoyl isothiocyanate was reacted with compound 11 to produce non-isolable thiourea derivative 21. The newly synthesized compounds have been characterized by infrared (IR), proton nuclear magnetic resonance (H-1 NMR), and carbon nuclear magnetic resonance (C-13 NMR) spectral data. The compounds were then evaluated for antibacterial and anticancer activities.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 5872-08-2 is helpful to your research. Product Details of 5872-08-2.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

The transformation of simple hydrocarbons into more complex and valuable products has revolutionised modern synthetic chemistry. This type of reactivity has quickly become one of the cornerstones of modern catalysis. 56-17-7, Name is 2,2′-Disulfanediyldiethanamine dihydrochloride, formurla is C4H14Cl2N2S2. In a document, author is Ogurok, Volodymyr M., introducing its new discovery. Recommanded Product: 56-17-7.

Synthesis of the symmetrical 3,5-bis(difluoromethyl)-1,4-thiazine 1,1-dioxides

A convenient synthesis of the symmetrical bis(difluoromethyl)-1,4-thiazine 1,1-dioxides was carried out via heterocyclization of bis(2,2,3,3-tetrafluoropropyl)sulfone with ammonia and primary amines. The reaction with excess of ammonia leads to the formation of 3,5-bis(difluoromethyl)-4H-1,4-thiazine 1,1-dioxide. The result of the reaction with primary amines is determined by spatial nature of substituent at the nitrogen atom. 3,5-Bis(difluoromethyl)-4-propyl-4H-1,4-thiazine 1,1-dioxide and 3,5-bis(difluoromethyl)-4-(p-tolyl)-4H-1,4-thiazine 1,1-dioxide were prepared by the reactions of bis(2,2,3,3-tetrafluoropropyl)sulfone with n-propylamine and p-toluidine accordingly. The reaction of bis(2,2,3,3-tetrafluoropropyl)sulfone with tert-butylamine gives the 1,1′-sulfonylbis(N-(tert-butyl)-3,3-difluoroprop-1-en-2-amine). (C) 2015 Elsevier B.V. All rights reserved.

If you are hungry for even more, make sure to check my other article about 56-17-7, Recommanded Product: 56-17-7.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 103-47-9, Name is N-Cyclohexyltaurine, molecular formula is , belongs to thiazines compound. In a document, author is Vandarkuzhali, S. Anbu Anjugam, HPLC of Formula: C8H17NO3S.

Arachis hypogaea derived activated carbon/Pt catalyst: Reduction of organic dyes

Activated carbon from agro waste groundnut (Arachis hypogaea) shell was prepared by chemical activation and used as support for dispersion of 5% platinum nanoparticles. The Pt nanoparticles were obtained by the reduction in hydrogen gas medium. The synthesized groundnut activated carbon/platinum catalyst was characterized by various techniques such as X-ray powder diffraction, electron microscopies and X-ray photoelectron spectroscopy. The catalytic behaviour of the synthesized catalyst was investigated by exploring it as catalyst for the reduction of various classes of dyes; namely, triphenylmethane dyes such as malachite green, phenol red and bromophenol blue, xanthene dyes: rose bengal, rhodamine 6 G, rhodamine B, thiazine dye: methyelene blue, azo dye: congo red and 4-nitrophenol by sodium borohydride in aqueous medium. Under suitable reaction conditions, for all tested dyes, cationic dyes were reduced at a faster rate than anionic dyes. The rate of reduction on the structure of dye and nature of catalyst was employed.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 103-47-9, HPLC of Formula: C8H17NO3S.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner.92-39-7, Name is 2-Chloro-10H-phenothiazine, SMILES is ClC(C=C1N2)=CC=C1SC3=C2C=CC=C3, belongs to thiazines compound. However, they have proven to be challenging because of the mutual inactivation of both catalysts. In a document, author is Ghoneim, Amira A., introduce the new discover, Formula: C12H8ClNS.

Design, synthesis and anticancer evaluation of novel thiazine, pyrimidine and pyridine derivatives

Acylisothiocyanate (1) was allowed to react with benzylidenemalononitrile producing oxazine derivative (2). Also, compound (1) was reacted with sodium azide followed by refluxing with sodium ethoxide affording thiazinotetrazole derivative (4). The reaction of acetylacetone with compound (1) gave pyridine derivative (5) by intramolecularcycloaddition while it was reacted with N-methyl aniline affording thiazine derivative (7). In addition, it was reacted with cyanoacetamide producing mercaptopyrimidine derivative (9). Finally, compound (1) was refluxed with phenylhydrazine, urea, guanidmum carbonate and anthranilic acid in the presence of dry acetone affording triazole derivative (11), N-substituted pyrimidine (15), compound (18) and thiopyrimidine derivative (19) respectively. The structures of the new compounds were confiimed on the basis of elemental and spectral data. Some of the synthesized compounds were screened as anticancer.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 92-39-7. Formula: C12H8ClNS.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner.2235-54-3, Name is Ammonium dodecyl sulfate, SMILES is O=S(OCCCCCCCCCCCC)([O-])=O.[NH4+], belongs to thiazines compound. However, they have proven to be challenging because of the mutual inactivation of both catalysts. In a document, author is Proshin, A. N., introduce the new discover, Formula: C12H29NO4S.

Biological activity of some sulfur- and selenium-containing spiro compounds

Cytotoxicity to K-562 leukemia cell line of two spiro compounds containing selenium or sulfur atom in their structure were compared. 4-Fluorophenyl-(1-thia-3-azaspiro[5.5] undec-2-en-2-yl] amine hydrobromide was synthesized and characterized for the first time. It was found that the introduction of a sulfur atom is more promising for this biological model, since it leads to a 3-fold increase in the therapeutic index in the case of the sulfur-containing compound.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 2235-54-3. Formula: C12H29NO4S.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 154445-78-0, Name is 2,2,4,6,7-Pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl chloride, belongs to thiazines compound, is a common compound. In a pantent, author is Goudou, Francesca, once mentioned the new application about 154445-78-0, Computed Properties of C13H17ClO3S.

Orbicularisine: A Spiro-Indolothiazine Isolated from Gills of the Tropical Bivalve Codakia orbicularis

A novel spiro-indolofuranone fused to a thiazine skeleton, orbicularisine (1), was isolated from gills of the mollusk Codakia orbicularis. The isolation and structure elucidation using spectroscopic evidence including mass and NMR spectroscopy are described. The final structure of 1 was supported by key HMBC correlation.

If you¡¯re interested in learning more about 154445-78-0. The above is the message from the blog manager. Computed Properties of C13H17ClO3S.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Related Products of 154445-78-0, In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. The reactant in an enzyme-catalyzed reaction is called a substrate.154445-78-0, Name is 2,2,4,6,7-Pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl chloride, SMILES is O=S(C1=C(C)C(C)=C(OC(C)(C)C2)C2=C1C)(Cl)=O, belongs to thiazines compound. In a article, author is Artym, Jolanta, introduce new discover of the category.

Selected azaphenothiazines inhibit delayed type hypersensitivity and carrageenan reaction in mice

Several, previously selected azaphenothiazines, as strongly antiproliferative agents in in vitro models, were subjected to evaluation for their potential immunosuppressive effects in the model of delayed type hypersensitivity (DTH) to ovalbumin (OVA) in BALB/c mice and in foot pad inflammation induced by carrageenan in CBA mice. In the DTH model the compounds were given to mice intraperitoneally (i.p.) in 50 mu g or 250 mu g doses, 1 h before the elicitation of the response. In the carrageenan-induced foot pad inflammation the compounds were given i.p. in 50 mu g or 250 mu g doses, 24 h and 2 h before administration of carrageenan. Among the compounds, the significantly suppressive activities in both models were exhibited only by compound 5 (6-chloroethylureidoethyldiquino[3,2-b;2′,3′-e][1,4]thiazine) and compound 4 (6-acetylaminobuty1-9-chloroquino[3,2-blbenzo[1,4]thiazine). Structure-activity relationship, plausible mechanism of action and potential application in therapy of the compounds are discussed. (C) 2016 Elsevier B.V. All rights reserved.

Related Products of 154445-78-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 154445-78-0.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Reference of 5872-08-2. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme preventing a reaction from occurring. Irreversible inhibitors are therefore the equivalent of poisons. 5872-08-2, Name is (7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid, belongs to thiazines compound. Introduce new discover of the category.

A SIMPLE SYNTHESIS OF 4-HYDROXY-3,4-DIHYDROPYRIDO[3,4-d]PYRIMIDINE-2(1H)-THIONE DERIVATIVES BY THE REACTION OF 3-ISOTHIOCYANATOPYRIDIN-4-YL KETONES WITH PRIMARY AMINES

The reaction of aryl(3-isothiocyanatopyridin-4-yl)methanones, prepared easily from commercially available 3-aminopyridine, with primary amines at room temperature afforded 3-substituted 4-aryl-4-hydroxy-3,4-dihydropyrido[3,4-d]pyrimidine-2(1H)-thiones in good yields. These ketones could be converted to new tricyclic heterocyclic systems, 2,3-dihydro-5H-pyrido[3,4-d]thiazolo [3,2-a]pyrimidine and 3,4-dihydro-2H,6H-pyrido [3′,4′:4,5]-pyrimido[2,1-b] [1,3]thiazine, upon treatment with 2-bromoethanamine hydrobromide and 3-bromopropaneamine hydrobromide, respectively, in the presence two equivalents of triethylamine.

Reference of 5872-08-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 5872-08-2 is helpful to your research.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem