Tag: M.W:200-300

Chemistry is a science major with cience and engineering. , HPLC of Formula: C4H14Cl2N2S2, The main research directions are chemical synthesis, preparation and modification of special coatings, and research on the structure and performance of functional materials.Introducing a new discovery about 56-17-7, Name is 2,2′-Disulfanediyldiethanamine dihydrochloride, molecular formula is C4H14Cl2N2S2, belongs to thiazines compound. In a document, author is Yennawar, Hemant P..

Crystal structure of rac-2,3-diphenyl-2,3,5,6-tetrahydro-4H-1,3-thiazin-4-one 1-oxide

In the title compound, C(16)Hi(5)NO(2)S [alternative name: rac-2,3-diphenyl-1,3-thiazinan-4-one 1-oxide], the thiazine ring exhibits an envelope conformation, with the S atom forming the flap. The sulfoxide 0 atom is in a pseudo-axial position on the thiazine ring and is trans to the phenyl group on C-2. The phenyl rings form a dihedral angle of 89.47 (19)degrees. In this racemate crystal, homochiral molecules form slabs parallel to (010) of thickness b/2 which then stack with alternating chirality in the b-axis direction. The stacking is aided by edge-to-face interactions between the phenyl rings of racemic molecules. Within each of the single-enantiomer slabs, the molecules are held by C-H center dot center dot center dot O-type interactions, with an H center dot center dot center dot O distance of 2.30 angstrom, forming infinite chains along the c-axis direction, as well by the edge-to-face interactions between phenyl rings of neighboring molecules in the a-axis direction.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 56-17-7. HPLC of Formula: C4H14Cl2N2S2.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Electric Literature of 154445-78-0, In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. The reactant in an enzyme-catalyzed reaction is called a substrate.154445-78-0, Name is 2,2,4,6,7-Pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl chloride, SMILES is O=S(C1=C(C)C(C)=C(OC(C)(C)C2)C2=C1C)(Cl)=O, belongs to thiazines compound. In a article, author is Grkovic, Tanja, introduce new discover of the category.

NMR Fingerprints of the Drug-like Natural-Product Space Identify Iotrochotazine A: A Chemical Probe to Study Parkinson’s Disease

The NMR spectrum of a mixture of small molecules is a fingerprint of all of its components. Herein, we present an NMR fingerprint method that takes advantage of the fact that fractions contain simplified NMR profiles, with minimal signal overlap, to allow the identification of unique spectral patterns. The approach is exemplified in the identification of a novel natural product, iotrochotazine A (1), sourced from an Australian marine sponge Iotrochota sp. Compound 1 was used as a chemical probe in a phenotypic assay panel based on human olfactory neurosphere-derived cells (hONS) from idiopathic Parkinson’s disease patients. Compound 1 at 1 mm was not cytotoxic but specifically affected the morphology and cellular distribution of lysosomes and early endosomes.

Electric Literature of 154445-78-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 154445-78-0.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemistry is a science major with cience and engineering. , Product Details of 151-21-3, The main research directions are chemical synthesis, preparation and modification of special coatings, and research on the structure and performance of functional materials.Introducing a new discovery about 151-21-3, Name is Sodium dodecyl sulfate, molecular formula is C12H25NaO4S, belongs to thiazines compound. In a document, author is Bosson-Vanga, Henriette.

Differential activity of methylene blue against erythrocytic and hepatic stages of Plasmodium

Background: In the context of malaria elimination/eradication, drugs that are effective against the different developmental stages of the parasite are highly desirable. The oldest synthetic anti-malarial drug, the thiazine dye methylene blue (MB), is known for its activity against Plasmodium blood stages, including gametocytes. The aim of the present study was to investigate a possible effect of MB against malaria parasite liver stages. Methods: MB activity was investigated using both in vitro and in vivo models. In vitro assays consisted of testing MB activity on Plasmodium falciparum, Plasmodium cynomolgi and Plasmodium yoelii parasites in human, simian or murine primary hepatocytes, respectively. MB in vivo activity was evaluated using intravital imaging in BALB/c mice infected with a transgenic bioluminescent P. yoelii parasite line. The transmission-blocking activity of MB was also addressed using mosquitoes fed on MB-treated mice. Results: MB shows no activity on Plasmodium liver stages, including hypnozoites, in vitro in primary hepatocytes. In BALB/c mice, MB has moderate effect on P. yoelii hepatic development but is highly effective against blood stage growth. MB is active against gametocytes and abrogates parasite transmission from mice to mosquitoes. Conclusion: While confirming activity of MB against both sexual and asexual blood stages, the results indicate that MB has only little activity on the development of the hepatic stages of malaria parasites.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 92-39-7, Name is 2-Chloro-10H-phenothiazine, belongs to thiazines compound, is a common compound. In a pantent, author is Behalo, Mohamed S., once mentioned the new application about 92-39-7, Quality Control of 2-Chloro-10H-phenothiazine.

Synthesis of Some Novel Thiazolo[3,2-a]pyrimidine and Pyrimido[2,1-b][1,3]thiazine Derivatives and their Antimicrobial Evaluation

A 2-(2-Mercapto-4-(4-phenoxyphenyl)-6-(thiophen-2-yl)-1,6-dihydropyrimidin-5-yl) acetic acid was used as a reactive key precursor to design various pyrimidine derivatives such as thiazolo[3,2-a]pyrimidines and pyrimido[2,1-b][1,3]thiazines. The chemical structures of the newly synthesized products were confirmed by their elemental analyses and spectral data (IR, H-1 NMR, C-13 NMR, and mass spectra). The antibacterial and antifungal activities of some of the synthesized products were also evaluated, and it was found that compounds 3, 5, 9, and 11 exhibited potent activity against tested microorganisms in comparison with standard drugs.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 92-39-7, you can contact me at any time and look forward to more communication. Quality Control of 2-Chloro-10H-phenothiazine.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Reference of 92-30-8, In homogeneous catalysis, catalysts are in the same phase as the reactants. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, SMILES is FC(C(C=C1N2)=CC=C1SC3=C2C=CC=C3)(F)F, belongs to thiazines compound. In a article, author is Niu Liping, introduce new discover of the category.

Synthesis of the Fused Tetracyclic Thiazinan-4-one Derivatives and Their Anti-tumor Activitiy

The benzothiazin-4-one intermediates were prepared by the one-pot three-components condensation from the N-Boc-L-prolinal 1, amino acid ethyl/methyl ester hydrochlorides 2a similar to 2d, and mercaptobenzoic acids 3a similar to 3b. After removal of Boc, the target novel fused tetracyclic thiazinan-4-one derivatives 6 similar to 11 were afforded by the intramolecular cyclo- amidation reaction. The absolute configurations of the newly generated chiral carbon (1-C) were determined by the coupling constants of H-1 and H-2 and the X-ray crystallographic structures. The tetracyclic alkaloids were examined for their anti-proliferative activity against Hela and A549 tumor cells. The results showed that some compounds could moderately inhibit the growth of Hela cells, and among them, (13aR, 13bR)-1,2,3,13b-tetrahydrobenzo[e]pyrrolo[2′, 1′: 3,4] pyrazino[2,1b][1,3] thiazine-5,8(6H, 13aH)-dione (6b) was the best one with the IC50 value of 9.50 mu mol/L. However, all the compounds showed no anti-tumor activity against A549.

Reference of 92-30-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 92-30-8.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 103-47-9, Name is N-Cyclohexyltaurine, belongs to thiazines compound, is a common compound. In a pantent, author is Yennawar, Hemant P., once mentioned the new application about 103-47-9, Quality Control of N-Cyclohexyltaurine.

Crystal structure of N-[(2S,5R)-4-oxo-2,3-diphenyl-1,3-thiazinan-5-yl]acetamide 0.375-hydrate

The asymmetric unit of the title compound, C18H18N2O2S.0.375H(2)O, has two independent organic molecules (A and B) and 3/4 of a water molecule distributed over three sites. In molecule A, the 1,3-thiazine ring is in a boat conformation, with the C atoms at the 2- and 5-positions out of the plane. The angle between the two phenyl rings is 51.70 (12)degrees. In molecule B, the thiazine ring is in a half-chair conformation, with the S atom forming the back of the half chair. The angle between the two phenyl rings is 84.44 (14)degrees. The A molecule features an intramolecular N-H center dot center dot center dot O hydrogen bond, which closes an S(5) ring motif. In the crystal, the corresponding N-H grouping of the B molecule participates in an intermolecular hydrogen bond to the A molecule. The A molecule participates in a C-H center dot center dot center dot O interaction back to the B molecule, whilst the B molecule features an intramolecular C-H center dot center dot center dot O link, which generates an S(10) loop.

If you are hungry for even more, make sure to check my other article about 103-47-9, Quality Control of N-Cyclohexyltaurine.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemistry is a science major with cience and engineering. , Recommanded Product: N-Cyclohexyltaurine, The main research directions are chemical synthesis, preparation and modification of special coatings, and research on the structure and performance of functional materials.Introducing a new discovery about 103-47-9, Name is N-Cyclohexyltaurine, molecular formula is C8H17NO3S, belongs to thiazines compound. In a document, author is Muthusamy, Sengodagounder.

BF3 . OEt2 Catalyzed Synthesis of 1,3-Thiazines/-Selenazines

An efficient strategy for the synthesis of 3,4-dihydro-2H-1,3-thiazines / 3,4-dihydro-2H-1,3-selenazines from propargylic alcohols and thioamides/thiosemicarbazones/selenamides is described. The reaction is accomplished in moderate to excellent yield under mild conditions that did not require the exclusion of air or moisture and offers an operationally simplistic and convenient route to the synthetically useful six-membered N,S/Se-heterocycles.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 103-47-9, Recommanded Product: N-Cyclohexyltaurine.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Synthetic Route of 92-39-7, In homogeneous catalysis, catalysts are in the same phase as the reactants. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 92-39-7, Name is 2-Chloro-10H-phenothiazine, SMILES is ClC(C=C1N2)=CC=C1SC3=C2C=CC=C3, belongs to thiazines compound. In a article, author is Ohashi, Seishi, introduce new discover of the category.

The first observation on polymerization of 1,3-benzothiazines: synthesis of mono- and bis-thiazine monomers and thermal properties of their polymers

A monofunctional 1,3-benzothiazine (PH-a-BZT) has been synthesized by a method different from the one reported in the literature. Additionally, a difunctional version of 1,3-benzothiazine (PH-ddm-BZT) monomer has been synthesized. Polymerization of mono- and bis-thiazine monomers has been studied and confirmed for the first time. The two monomers are characterized with proton and carbon nuclear magnetic resonance spectroscopy (H-1-NMR, C-13-NMR) along with Fourier transform infrared (FT-IR) spectroscopy. The cross-linked polybenzothiazine which is derived from the bis-thiazine monomer shows excellent thermal properties as examined by thermogravimetric analysis (TGA). Polybenzothiazine is developed in hopes that it could mimic many of benzoxazine’s popular attributes while containing sulfur in place of oxygen atoms. It can also possess unique advantages such as higher flame retardancy and adhesiveness to the metal substrate than polybenzoxazine due to the characteristic sulfur atom in its polymer.

Synthetic Route of 92-39-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 92-39-7.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

The transformation of simple hydrocarbons into more complex and valuable products has revolutionised modern synthetic chemistry. This type of reactivity has quickly become one of the cornerstones of modern catalysis. 5872-08-2, Name is (7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid, formurla is C10H16O4S. In a document, author is Gomha, Sobhi M., introducing its new discovery. Application In Synthesis of (7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid.

Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents

Background: Pyrazoles, thiazoles and 1,3,4-thiadiazoles have been reported to possess various pharmacological activities. Results: An efficient and a novel approach for the synthesis of some novel pyrazole based-azoles are described via multi-component reaction under controlled microwave heating conditions. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, H-1 NMR and mass spectral data. All the synthesized compounds were tested for in vitro activities against two antitumor cell lines, human lung cancer and human hepatocellular carcinoma compared with the employed standard antitumor drug (cisplatin). Conclusions: All the newly synthesized compounds were evaluated for their anticancer activity against human lung cancer and human hepatocellular carcinoma cell lines using MTT assay. The results obtained exploring the high potency of six of the tested compounds compared with cisplatin.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 5872-08-2. Application In Synthesis of (7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Electric Literature of 151-21-3, In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. The reactant in an enzyme-catalyzed reaction is called a substrate.151-21-3, Name is Sodium dodecyl sulfate, SMILES is O=S(OCCCCCCCCCCCC)([O-])=O.[Na+], belongs to thiazines compound. In a article, author is Sirakanyan, Samvel N., introduce new discover of the category.

Synthesis and antimicrobial activity of new derivatives of pyrano[4”,3”:4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine and new heterocyclic systems

Taking into account previously obtained biological results on some polyheterocyclic compounds (containing different heteroatoms) and in particular on several 8-amino-5-isopropyl-2,2-dimethyl-10-(methylthio)-1,4-dihydro-2H-pyrano[4”,3”:4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines Ia-v we have carried out the synthesis of twentyone 8-amino-5-isobutyl-2,2-dimethyl-10-(methylthio)-1,4-dihydro-2H-pyrano[4”,3”:4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines 6. Therefore we have slightly modified the structure of the previously studied I introducing at C-5 an isobutyl group instead of the previously examined isopropyl ones in order to see if this variation (changing a little the lipophilicity) will affect the biological activity. Furthermore thieno[3,2-d]pyrimidine-8-thione 7 and their S-alkylated 8 were synthesized. Finally by alkylation of 5-isobutyl-2,2-dimethyl-10-thioxo-1,4,10,11-tetrahydro-2H-pyrano[4”,3”:4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-8(9H)-one 3 with alkyl dichlorides (bifunctional reagents) we realized the cyclization of a thiazole or thiazine ring on the [b] side of the pyrimidine ring with formation of the new condensed pentaheterocyclic systems: pyrano[4”,3”:4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d][1,3]thiazolo[3,2-a]pyrimidin-8-one 11 and pyrano[4”’,3”’:4”,5”]pyrido[3”,2”:4′,5′]thieno[3′,2′:4,5]pyrimido[2,1-b][1,3]thiazin-8-one 12. It was found that some of the synthesized compounds showed interesting antimicrobial activity (by agar diffusion method) against some gram-positive and gram-negative bacilli strains. [GRAPHICS] .

Electric Literature of 151-21-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 151-21-3.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem