Tag: M.W:200-300

Chemical Research Letters, May 2021. Redox catalysis has been broadly utilized in electrochemical synthesis. The appropriate choice of redox mediator can avoid electrode passivation, which strongly inhibit the efficient activation of substrates. 5872-08-2, Name is (7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid, molecular formula is C10H16O4S. In an article, author is Reddy, B. V. Subba,once mentioned of 5872-08-2, HPLC of Formula: https://www.ambeed.com/products/5872-08-2.html.

Intramolecular C-O/C-S bond insertion of alpha-diazoesters for the synthesis of 2-aryl-4H-benzo[d][1,3]oxazine and 2-aryl-4H-benzo[d][1,3]thiazine derivatives

An intramolecular C-O insertion of 2-(2-arylamidophenyl)-2-diazoacetate has been achieved using a catalytic amount of copper triflate under mild conditions to produce 2-aryl-4H-benzo[d][1,3]oxazine-4-carboxylate in good yields. In addition, 2-diazo-2-(2-arylthioamidophenyl)acetate affords the corresponding 2-aryl-4H-benzo[d][1,3]thiazine derivatives under similar conditions. This is the first example of the synthesis of benzoxazines and benzothiazines from ortho-amidophenyl diazoacetate and ortho-thioamidophenyl diazoacetate, respectively.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

New Advances in Chemical Research, May 2021.Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, nano-ceramics, preparation and modification of special coatings. 139-65-1, Name is 4,4-Thiodianiline, belongs to thiazines compound, is a common compound. In a pantent, author is Pitre, Spencer P., once mentioned the new application about 139-65-1, Related Products of 139-65-1.

Understanding the Kinetics and Spectroscopy of Photoredox Catalysis and Transition-Metal-Free Alternatives

CONSPECTUS: Over the past decade, the field of photoredox catalysis has gained increasing attention in synthetic organic chemistry because of its wide applicability in sustainable free-radical-mediated processes. Numerous examples have shown that under carefully optimized conditions, efficient and highly selective processes can be developed through excitation of a photosensitizer using inexpensive, readily available light sources. However, despite all of these recent advancements, some generalizations and/or misconceptions have become part of the photoredox culture, and often many of these discoveries lack in-depth investigations into the excited-state kinetics and underlying mechanisms. In this Account, we begin with a tutorial for understanding both the redox properties of excited states and how to measure the kinetics of excited-state processes. We discuss the generalization of direct excitation of closed-shell species to generate more potent reductive or oxidative excited states, using the helium atom as a quantitative example. We also outline how to apply redox potentials to calculate whether the proposed electron transfer events are thermodynamically feasible. In the second half of our tutorial, we discuss how to measure the kinetics of excited-state processes using techniques such as steady-state and time-resolved fluorescence and transient spectroscopy and how to apply the data using Stem-Volmer and kinetic analysis. Then we shift gears to discuss our recent contributions to the field of photoredox catalysis. Our lab focuses on developing transition metal-free alternatives to ruthenium and iridium bipyridyl complexes for these transformations, with the goal of developing systems in which the reaction kinetics is more favorable. We have found that methylene blue, a member of the thiazine dye family, can be employed in photoredox processes such as oxidative hydroxylations of arylboronic acids to phenols. Interestingly, we were able to demonstrate that methylene blue is more efficient for this reaction than Ru(bpy)(3)Cl-2, which upon further examination using transient spectroscopic techniques we were able to relate to the reductive quenching ability of the aliphatic amine. Recently we were also successful in applying methylene blue for radical trifluoromethylation reactions, which is discussed in detail. Finally, we have also demonstrated that common organic electron donors, such as alpha-sexithiophene, can be used in photoredox processes, which we demonstrate using the dehalogenation of vic-dibromides as a model system. This is a particularly interesting system because well-defined, long-lived intermediates allowed us to fully characterize the catalytic cycle. Once again, through an in-depth kinetic analysis we were able to gain valuable insights into our reaction mechanism, which demonstrates how powerful a tool proper kinetic analysis can be in the design and optimization of photoredox processes.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemical Research Letters, May 2021. Redox catalysis has been broadly utilized in electrochemical synthesis. The appropriate choice of redox mediator can avoid electrode passivation, which strongly inhibit the efficient activation of substrates. 92-39-7, Name is 2-Chloro-10H-phenothiazine, molecular formula is C12H8ClNS. In an article, author is Patel, Chandani,once mentioned of 92-39-7, Application In Synthesis of 2-Chloro-10H-phenothiazine.

Synthesis and Antimicrobial Activity of 1,2-Benzothiazine Derivatives

A number of 1,2-benzothiazines have been synthesized in a three-step process. Nine chalcones 1-9 bearing methyl, fluoro, chloro and bromo substituents were chlorosulfonated with chlorosulfonic acid to generate the chalcone sulfonyl chlorides 10-18. These were converted to the dibromo compounds 19-27 through reaction with bromine in glacial acetic acid. Compounds 19-27 were reacted with ammonia, methylamine, ethylamine, aniline and benzylamine to generate a library of 45 1,2-benzothiazines 28-72. Compounds 28-72 were evaluated for their antimicrobial activity using broth microdilution techniques against two Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and two Gram-negative bacteria (Proteus vulgaris and Salmonella typhimurium). The results demonstrated that none of the compounds showed any activity against Gram-negative bacteria P. vulgaris and S. typhimurium; however, compounds 31, 33, 38, 43, 45, 50, 53, 55, 58, 60, 63 and 68 showed activity against Gram-positive bacteria Bacillus subtilis and Staphylococcous aureus. The range of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was 25-600 mu g/mL, though some of the MIC and MBC concentrations were high, indicating weak activity. Structure activity relationship studies revealed that the compounds with a hydrogen atom or an ethyl group on the nitrogen of the thiazine ring exerted antibacterial activity against Gram-positive bacteria. The results also showed that the compounds where the benzene ring of the benzoyl moiety contained a methyl group or a chlorine or bromine atom in the para position showed higher antimicrobial activity. Similar influences were identified where either a bromine or chlorine atom was in the meta position.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

New Advances in Chemical Research, May 2021.Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, nano-ceramics, preparation and modification of special coatings. 5872-08-2, Name is (7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid, belongs to thiazines compound, is a common compound. In a pantent, author is Gomha, Sobhi M., once mentioned the new application about 5872-08-2, Computed Properties of https://www.ambeed.com/products/5872-08-2.html.

Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents

Background: Pyrazoles, thiazoles and 1,3,4-thiadiazoles have been reported to possess various pharmacological activities. Results: An efficient and a novel approach for the synthesis of some novel pyrazole based-azoles are described via multi-component reaction under controlled microwave heating conditions. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, H-1 NMR and mass spectral data. All the synthesized compounds were tested for in vitro activities against two antitumor cell lines, human lung cancer and human hepatocellular carcinoma compared with the employed standard antitumor drug (cisplatin). Conclusions: All the newly synthesized compounds were evaluated for their anticancer activity against human lung cancer and human hepatocellular carcinoma cell lines using MTT assay. The results obtained exploring the high potency of six of the tested compounds compared with cisplatin.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 5872-08-2. Computed Properties of https://www.ambeed.com/products/5872-08-2.html.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

New Advances in Chemical Research, May 2021.Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, nano-ceramics, preparation and modification of special coatings. 139-65-1, Name is 4,4-Thiodianiline, belongs to thiazines compound, is a common compound. In a pantent, author is Belskaya, Nataliya P., once mentioned the new application about 139-65-1, Name: 4,4-Thiodianiline.

1,3-Dipolar cycloaddition of 3-alkylsulfanyl-2-arylazo-3-(tert-cycloalkylamino)acrylonitriles with N-methyl- and N-phenylmaleimides

A series of 1,2-diaza-1,3-butadienes with terminal S,N-acetal function were obtained and reacted with N-methyl- and N-phenylmaleimides. As a result of the 1,3-dipolar cycloaddition, a range of new functionalized nonaromatic heterocyclic compounds including: octahydro-1H-pyrrolo[3,4-a]indolizine, octahydropyrrolo[3′,4′:3,4]pyrrolo[1,2-a]azepine, hexahydropyrrolo[3′,41:3,4]pyrrolo[2,1-c][1,4]oxazine and -thiazine, were obtained with good yields in mild conditions. Experimental and theoretic results allowed establishment of a relationship between the structures of the tert-cycloallcylamine group and the activity of the azomethine ylides generated. (C) 2014 Elsevier Ltd. All rights reserved.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, belongs to thiazines compound, is a common compound. In a pantent, author is Pluta, Krystian, once mentioned the new application about 92-30-8, Safety of 2-(Trifluoromethyl)-10H-phenothiazine.

Azaphenothiazines – promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties

For the last two decades, classical phenothiazines have attracted attention of researchers, as the hitherto investigations have revealed many significant biological activities within this class of compounds, other than originally discovered neuroleptic ones. Important, new pharmaceutical results on phenothiazines, as 10-substituted dibenzothiazines, were recently highlighted in several reviews. Azaphenothiazines are structurally modified phenothiazines by substitution of one or both benzene rings in the phenothiazine ring system with the azine rings, such as: pyridine, pyridazine, pyrimidine, pyrazine, 1,2,4-triazine, quinoline, quinoxaline, benzoxazine and benzothiazine. They form over 50 different heterocyclic systems, of tri-, tetra-, penta- and hexacyclic structures, and contain from one to even four azine nitrogen atoms. This review summarizes the methodical knowledge on azaphenothiazines, referring to their nomenclature, synthesis, structure analysis and above all significant varied biological activities, examined in vitro and in vivo. It describes, in addition, current trends in the synthesis of azaphenothiazines. The influence of the azaphenothiazine ring system, the nature of the substituents, predominantly at the thiazine nitrogen atom, as well as at the azine nitrogen atom and carbon atom, on the biological activities, were also discussed. (C) 2017 Elsevier Masson SAS. All rights reserved.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 154445-78-0, Name is 2,2,4,6,7-Pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl chloride, belongs to thiazines compound, is a common compound. In a pantent, author is Olejniczak, Anna, once mentioned the new application about 154445-78-0, Synthetic Route of 154445-78-0.

Pressure-Stabilized Solvates of Xylazine Hydrochloride

High pressure strongly favors the highest-density polymorph Z of active pharmaceutical ingredient 2-(2,6-xylidino)-5,6-dihydro-4H-1,3-thiazine hydrochloride (xylazine hydrochloride, XylHCl) up to about 0.1 GPa only, but still higher pressure destabilizes this structure. Above 0.1 GPa, XylHCl preferentially crystallizes as solvates with CH2Cl2, CHCl3, or (CH3)(2)CHOH depending on the solvent used. However, when XylHCl center dot H2O is dissolved in any of these solvents, the high-pressure crystallizations yield the hydrate XylHCl center dot H2O only. The single crystals of the CH2C12, CHCl3, and (CH3)(2)CHOH solvates could be grown in situ in a diamond anvil cell, which allowed their structure determination from the single-crystal diffraction data. At 0.4 GPa the XylHCl center dot H2O hydrate undergoes a pressure-induced phase transition doubling the unit cell dimensions.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

New Advances in Chemical Research, May 2021.Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, nano-ceramics, preparation and modification of special coatings. 56-17-7, Name is 2,2′-Disulfanediyldiethanamine dihydrochloride, belongs to thiazines compound, is a common compound. In a pantent, author is Kalirajan, R., once mentioned the new application about 56-17-7, Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Novel Thiazine Substituted 9-Anilinoacridines: Synthesis, Antitumour Activity and Structure Activity Relationships

Background: 9-anilinoacridines are acting as DNA-intercalating agents which plays an important role as antitumor drugs, due to their anti-proliferative properties. Some anticancer agents contain 9-anilinoacridines such as amsacrine (m-AMSA), and nitracrine (Ledakrine) have been already developed. Methods: In this study, novel 9-anilinoacridines substituted with thiazines 4a-r were designed, synthesized, characterized by physical and spectral data and their cytotoxic activities against DLA cell lines were evaluated. Results: Among those compounds, 4b, c, e, g, i, j, k, m, o, p, q, r exhibited significant short term in vitro cytotoxic activity against Daltons lymphoma ascites (DLA) cells with CTC50 value of 0.18 to 0.31 mu M. The compounds 4b, c, e, g, y j, k, m, o, p, q, r are also exhibited significant long term in vitro anti-tumour activity against human tumor cell lines, HEp-2 (laryngeal epithelial carcinoma) by Sulforhodamine B assay with CTC50 value of 0.20 to 0.39 mu M. The compounds 4b, i, j exhibited significant in vivo antitumor activity with % Increase in Life Span (ILS) 48-82%. Conclusion: Results obtained in this study clearly demonstrated that many of the thiazine substituted 9-anilinoacridines exert interesting anti-tumour activity. The compounds 4b, i, j have significant anti-tumour activity and useful drugs after further refinement. The above derivatives will encourage to design future antitumor agents with high therapeutic potentials.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 5872-08-2, Name is (7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid, belongs to thiazines compound, is a common compound. In a pantent, author is Sadigh, M. Khadem, once mentioned the new application about 5872-08-2, HPLC of Formula: https://www.ambeed.com/products/5872-08-2.html.

A comparative study of media polarity effects on the linear and third-order nonlinear optical responses of thiazine dyes

In this paper, solvent effects on the linear and nonlinear optical responses of thiazine dyes were investigated. Spectroscopic and open aperture Z-scan techniques were used for studying linear and nonlinear responses of azure A and methylene blue dyes. The experimental results show that linear and nonlinear optical properties of used dyes depend highly on the molecular structure and their surrounding media characteristics. The calculated contribution of various media-induced interactions indicate that solvent hydrogen bond acceptor and solvent dipolarity and polarizability abilities have significant effects on the linear and nonlinear absorption characteristics of thiazine dyes. Moreover, by transition of the linear optics domain to nonlinear optics, similar resonance structures were obtained for thiazine dyes. So, the spectroscopic technique can be considered as a simple method for prediction of dominant resonance structures and effective solvent polarity parameters on the third-order nonlinear properties of azure A and methylene blue dyes.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemical Research Letters, May 2021. Redox catalysis has been broadly utilized in electrochemical synthesis. The appropriate choice of redox mediator can avoid electrode passivation, which strongly inhibit the efficient activation of substrates. 103-47-9, Name is N-Cyclohexyltaurine, molecular formula is C8H17NO3S. In an article, author is Muthusamy, Sengodagounder,once mentioned of 103-47-9, Recommanded Product: N-Cyclohexyltaurine.

BF3 . OEt2 Catalyzed Synthesis of 1,3-Thiazines/-Selenazines

An efficient strategy for the synthesis of 3,4-dihydro-2H-1,3-thiazines / 3,4-dihydro-2H-1,3-selenazines from propargylic alcohols and thioamides/thiosemicarbazones/selenamides is described. The reaction is accomplished in moderate to excellent yield under mild conditions that did not require the exclusion of air or moisture and offers an operationally simplistic and convenient route to the synthetically useful six-membered N,S/Se-heterocycles.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem