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Bicyclic pyrazole compounds as antibacterial agents

Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.

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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

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The Extraction of Organic Bromo-compounds

The liquid extraction of organic bromo-compounds is discussed.The effect of the bromo-substituent on the partition coefficient depends on the activity of the extractant.The influence of the positions and numbers of bromine substituents on the partition coefficiemts is surveyed.

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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

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1910-85-6, Name is 1-Chloro-10H-phenothiazine, belongs to thiazines compound, SDS of cas: 1910-85-6, is a common compound. In an article, once mentioned the new application about 1910-85-6.

Bactericidal efficacy of photodynamic therapy against Enterococcus faecalis in infected root canals: A systematic literature review

Objective: The aim was to review the bactericidal efficacy of photodynamic therapy (PDT) against Enterococcus faecalis (E. faecalis) in infected root canals. Methods: To address the focused question “Does PDT exhibit bactericidal effects against E. faecalis in infected root canals?” PubMed/Medline and Google-Scholar databases were searched from 1985 up to August 2013 using various combinations of the following key words: “antibacterial; “bactericidal; “endodontic; “root canal” and “photodynamic therapy”. Original studies, experimental studies and articles published only in English language were included. Letters to the editor, historic reviews and unpublished data were excluded. The pattern of the present review was customized to primarily summarize the pertinent information. Results: Seventeen studies (16 ex vivo and one in vivo) were included. In these studies, numbers of teeth used ranged between 30 and 220 teeth. In these studies, wavelengths of diode laser used, diameter of fiber and power output ranged between 625 and 805. nm, 200. mum and 0.4. cm, and 40. mW and 5. W respectively. Twelve studies reported PDT to be effective in eliminating E. faecalis from infected root canals. Four studies reported conventional irrigation and instrumentation to be more efficient in killing E. faecalis than PDT. One study reported PDT and conventional endodontic regimes to be equally effective in eliminating E. faecalis from infected root canals. In most studies, toluidine blue and/or methylene blue were used as photosensitizers. Conclusion: Efficacy of PDT in eliminating E. faecalis from infected root canals remains questionable.

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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

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Learning from clinical phenotypes: Low-dose biophotonics therapies in oral diseases

This narrative review on the use of biophotonics therapies for management of oral diseases is written as a tribute to Prof. Crispian Scully. His seminal contributions to the field are highlighted by the detailed, comprehensive description of clinical presentations of oral diseases. This has enabled a more thorough, fundamental understanding of many of these pathologies by research from his group as well as inspired mechanistic investigations in many groups globally. In the same vein, a major emphasis of this narrative review is to focus on the evidence from human case reports rather than in vitro or in vivo animal studies that showcases the growing and broad impact of biophotonics therapies. The similarities and differences between two distinct forms of low-dose biophotonics treatments namely photodynamic therapy and photobiomodulation therapy are discussed. As evident in this review, a majority of these reports provide promising evidence for their clinical efficacy. However, a lack of adequate technical details, precise biological rationale, and limited outcome measures limits the current utility of these treatments. Future investigations should attempt to address these shortcomings and develop better designed, rigorous, controlled studies to fully harness the tremendous potential of low-dose biophotonics therapies.

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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

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Adjunctive use of antimicrobial photodynamic therapy in the treatment of medication-related osteonecrosis of the jaws: A case report

Medication-related osteonecrosis of the jaws is a delayed healing condition commonly recognized as a serious adverse effect of antiresorptive therapy and is particularly associated with aminobisphosphonate treatment. In the present report, a 62-year-old osteoporotic female patient treated with intramuscular injections of clodronate for 3 years exhibited clinical signs of exposed necrotic bone and inflamed mucosa 4 months after tooth extractions in the mandibular interforaminal region. The treatment consisted of sequestrectomy, open-flap debridement, and adjunctive use of antimicrobial photodynamic therapy to decontaminate the affected hard and soft tissues. Successful results were obtained and maintained from both clinical and radiological aspects. No recurrence was observed up to 6 months of follow-up.

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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

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Spin-orbit charge transfer intersystem crossing in perylenemonoimide-phenothiazine compact electron donor-acceptor dyads

The spin-orbit charge transfer intersystem crossing (SOCT-ISC) of perylenemonoimide-phenothiazine compact dyads was shown to depend on the molecular geometry and the vector dipole orientations of the two chromophores, and the dyads show high triplet state quantum yields (57%).

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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

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Ratiometric polymer probe for detection of peroxynitrite and the application for live-cell imaging

Peroxynitrite (ONOO?) is one of the sources of oxidation stress involved in many biological signaling pathways. The role of ONOO? being a double-edged sword in biological systems drives the development of effective detection tools. In this work, a boronate-based polymeric fluorescent probe PB-PVA was synthesized and the probe performance was evaluated. The probe exhibits ratiometric sensing of ONOO? in a range of 0?6 muM. There is good linear relationship between the probe fluorescence intensity ratio and ONOO? concentration. The probe also displays moderate selectivity towards ONOO? over other ROS. Moreover, it is water-soluble and possesses good biocompatibility which aids the imaging of ONOO? in living cells. These properties could make the probe a promising tool in in vitro study related to ONOO?

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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

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category: thiazines, Interested yet? Read on for other articles about category: thiazines!

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NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS

Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives hereof useful in methods of treatment of bacterial infections in mammals, particularly man.

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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

Extracurricular laboratory:new discovery of 272437-84-0

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Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? , COA of Formula: C9H7NO3S, The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 272437-84-0, Name is 3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid, molecular formula is C9H7NO3S. In a article£¬once mentioned of 272437-84-0

ANTIBACTERIAL COMPOUNDS

Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man

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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

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SUBSTITUTED 2-BENZYLIDENE-2H-BENZO[b][1,4]THIAZIN-3(4H)-ONES, DERIVATIVES THEREOF, AND THERAPEUTIC USES THEREOF

The present invention relates to compounds according to Formula I and salts thereof, wherein R 1 R2, R3, R4, Ar, and n are as defined herein. Methods for preparing compounds of Formula I are also provided. The present invention further includes methods of treating cellular proliferative disorders, such as cancer, with the compounds of Formula I.

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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem