Tag: M.W:200-300

Related Products of 1910-85-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1910-85-6, Name is 1-Chloro-10H-phenothiazine, molecular formula is C12H8ClNS. In a Article£¬once mentioned of 1910-85-6

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors

The phenothiazine system was identified as a favorable cap group for potent and selective histone deacetylase 6 (HDAC6) inhibitors. Here, we report the preparation and systematic variation of phenothiazines and their analogues containing a benzhydroxamic acid moiety as the zinc-binding group. We evaluated their ability to selectively inhibit HDAC6 by a recombinant HDAC enzyme assay, by determining the protein acetylation levels in cells by western blotting (tubulin vs histone acetylation), and by assessing their effects on various cancer cell lines. Structure-activity relationship studies revealed that incorporation of a nitrogen atom into the phenothiazine framework results in increased potency and selectivity for HDAC6 (more than 500-fold selectivity relative to the inhibition of HDAC1, HDAC4, and HDAC8), as rationalized by molecular modeling and docking studies. The binding mode was confirmed by co-crystallization of the potent azaphenothiazine inhibitor with catalytic domain 2 from Danio rerio HDAC6.

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research.Keep reading other articles of 1-Chloro-10H-phenothiazine!Related Products of 1910-85-6

Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

1910-85-6, Name is 1-Chloro-10H-phenothiazine, belongs to thiazines compound, category: thiazines, is a common compound. In an article, once mentioned the new application about 1910-85-6.

Studies on Diamagnetic Susceptibility of Biologically Active Heterocycles. 1. Diamagnetic Susceptibility of Phenothiazines

Diamagnetic susceptibilities for a number of phenothiazines are reported.A theoretical method to estimate the diamagnetic susceptibility of these biologically active heterocycles is presented.Phenothiazines have been considered to be composed of two units: one consisting of a benzene nucleus containing amino and thio groups at ortho positions to the substituents and the other consisting of a benzene ring with substituents.The diamagnetic contributions of these two units have been obtained from the diamagnetic susceptibilities of substituted o-aminobenzenethiols and benzenes and have been used in estimating the diamagnetic susceptibilities of phenothiazines.It has provided excellent theoretical results.Such an excellent agreement between measured and estimated values is due to the fact that the interactions between substituents which affect the diamagnetism have been duly accounted for in such calculations.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. category: thiazines

Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

Synthetic Route of 3939-23-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 3939-23-9, molcular formula is C12H8BrNS, introducing its new discovery.

ANTI-INFECTIVE HETEROCYCLIC COMPOUNDS AND USES THEREOF

The present invention relates to heterocyclic compounds of Formula I useful as anti-infective agents. The present invention further relates to a method of treating an infection by administering such compounds, and to pharmaceutical compositions comprising such compounds.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Synthetic Route of 3939-23-9, you can also check out more blogs aboutSynthetic Route of 3939-23-9

Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

Application of 1910-85-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1910-85-6, Name is 1-Chloro-10H-phenothiazine, molecular formula is C12H8ClNS. In a Article£¬once mentioned of 1910-85-6

REACTION OF CHLORO DERIVATIVES OF 10-BENZYL- AND 10-(4′-FLUOROBENZYL)PHENOTHIAZINES WITH NITRILES AND AMINES UNDER ARYNE-FORMING CONDITIONS

2-Chloro-10-benzylphenothiazine (1) and 2-chloro-10-(4′-fluorobenzyl)phenothiazine (2) react with aliphatic nitriles (3 and 4) and LDA to yield typical 2-substituted aryne products (9a,b and 9g,h, respectively).However, treatment of 1 with aromatic nitriles (5-8) and LDA supplies 2-(arylmethyl)-1-cyano rearranged nitriles (10c-f), whereas 2, when treated similarly, affords both rearranged nitriles (10i-l) and typical 2-arylated nitrile products (9i-j).An explanation in terms of the effect of substituents on the competing aryne and tandem addition-rearrangement pathways is presented.The crystal structure of one of the rearranged 1-cyanophenothiazines (10c) was obtained and reveals that the molecule adopts the “extra” conformation in which the 10-benzyl group is in the pseudo axial position.The reaction of 1 and 2 with various lithium amides in the corresponding free amine solvents gives the corresponding 2-aminated products (11) and (12) in excellent yields.Both 1-chloro-10-benzylphenothiazine (18) and 1 supply the same product, 10-benzyl-2-N,N-diisopropylaminophenothiazine (11a), when made to react with LDA in diisopropylamine solvent, indicating that each of these reactions proceeds via the same aryne intermediate, and not through the SRN1 mechanism.

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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

Application of 38642-74-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 38642-74-9, molcular formula is C13H8N2S, introducing its new discovery.

Copper-Catalyzed Aerobic Oxidative Amination of Indole Derivatives via Single-Electron Transfer

An efficient and clean approach for the oxidative amination of indole derivatives with phenothiazines is developed under copper-catalyzed aerobic conditions. The reaction is carried out via the cross-coupling of indole radical cation and phenothiazine radical in air. This approach offers a new perspective in the application of phenothiazine as a nitrogen group source for C?N bond formation reactions.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Application of 38642-74-9

Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? , category: thiazines, The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 272437-84-0, Name is 3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid, molecular formula is C9H7NO3S. In a article£¬once mentioned of 272437-84-0

Bicyclic pyrazole compounds as antibacterial agents

Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 272437-84-0.

Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

Related Products of 23503-68-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 23503-68-6, Name is 2-(Methylsulfonyl)-10H-phenothiazine, molecular formula is C13H11NO2S2. In a Patent£¬once mentioned of 23503-68-6

A 2 – (methyl sulfonyl) – 10H-phenothiazine preparation method (by machine translation)

A 2 the […] (methyl sulfonyl) – 10H the method for preparing phenothiazine […], which belongs to the technical field of pharmaceutical intermediates. The method to the chlorobenzene sulfonyl chloride and 2 the sodium salt of thiophenols […] as the starting material, which has not been reported to the two novel intermediate product M1 and M3, each experimental step are different from the explore the ideal correlation reference the literature, in particular for synthesizing final product the 2 […] (methyl sulfonyl) – 10H the phenothiazine […] the cyclization process in the literature is completely breaks the restrictions of various conditions. The whole process of the method of the invention of simple steps, the operation is simple, and is easy to control the reaction mild condition, each step the advantages of the high product yield, is suitable for industrial production, the invention has the advantages of the use of the relatively large value and social and economic benefits. (by machine translation)

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Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

Synthetic Route of 3939-23-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 3939-23-9, molcular formula is C12H8BrNS, introducing its new discovery.

Bromination of 10-Phenylphenothiazine and 10-Phenylphenoxazine

The reaction of either 10-phenylphenothiazine (1) with bromine in acetic acid or the cation radical of 1 with bromide ion gives ring substitution only and in accord with customary stoichiometry for nucleophilic substitution of aromatic cation radicals.However, the reaction of 1 with pyridinium bromide perbromide (2) gives predominantly 10-phenyl ring substitution and a small amount of ring substitution products.Evidence is presented which indicates that ring substitution occurs via cation radical whereas 10-phenyl substitution proceeds via electrophilic attack on the neutral molecule 1.Substitution of 10-phenylphenoxazine (4) occurs predominantly but not exclusively on the phenoxazine ring; some bromination does occur on the 10-phenyl ring.In contrast, the reaction of 4 with bromine gives only ring mono- and disubstitution products.These results indicate that both 1 and 4 react similarly under the same conditions.

If you are interested in 3939-23-9, you can contact me at any time and look forward to more communication. Synthetic Route of 3939-23-9

Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

Reference of 23503-68-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 23503-68-6, Name is 2-(Methylsulfonyl)-10H-phenothiazine, molecular formula is C13H11NO2S2. In a Article£¬once mentioned of 23503-68-6

Synthesis and biological properties of aryl methyl sulfones

A novel group of aryl methyl sulfones based on nonsteroidal anti-inflammatory compounds exhibiting a methyl sulfone instead of the acetic or propionic acid group was designed, synthesized and evaluated in vitro for inhibition against the human cyclooxygenase of COX-1 and COX-2 isoenzymes and in vivo for anti-inflammatory activity using the carrageenan induced rat paw edema model in rats. Also, in vitro chemosensitivity and in vivo analgesic and intestinal side effects were determined for defining the therapeutic and safety profile. Molecular modeling assisted the design of compounds and the interpretation of the experimental results. Biological assay results showed that methyl sulfone compounds 2 and 7 were the most potent COX inhibitors of this series and best than the corresponding carboxylic acids (methyl sulfone 2: IC50 COX-1 = 0.04 and COX-2 = 0.10 muM, and naproxen: IC50 COX-1 = 11.3 and COX-2 = 3.36 muM). Interestingly, the inhibitory activity of compound 2 represents a significant improvement compared to that of the parent carboxylic compound, naproxen. Further support to the results were gained by the docking studies which suggested the ability of compound 2 and 7 to bind into COX enzyme with low binding free energies. The improvement of the activity of some sulfones compared to the carboxylic analogues would be performed through a change of the binding mode or mechanism compared to the standard binding mode displayed by ibuprofen, as disclosed by molecular modeling studies. So, this study paves the way for further attention in investigating the participation of these new compounds in the pain inhibitory mechanisms. The most promising compounds 2 and 7 possess a therapeutical profile that enables their chemical scaffolds to be utilized for development of new NSAIDs.

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 23503-68-6.

Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

1910-85-6, Name is 1-Chloro-10H-phenothiazine, belongs to thiazines compound, Recommanded Product: 1-Chloro-10H-phenothiazine, is a common compound. In an article, once mentioned the new application about 1910-85-6.

Antimicrobial efficacy of photodynamic therapy on dental implant surfaces: A systematic review of in vitro studies

Background: To systematically review the literature regarding the antimicrobial effects of photodynamic therapy (PDT) on multi-bacterial species and the possible surface alterations of dental implants as a result of PDT. Methods: The addressed focused question was: ?Does PDT show antimicrobial efficacy against multi-bacterial species colonization and result in surface alteration on dental implants?? Electronic databases including MEDLINE and EMBASE up to and including December 2018 were searched. Results: Seven studies were included. Two studies used a total of 110 titanium dental implants, while 1 study included a total of 72 zirconia dental implants. Three studies investigated the antimicrobial PDT effects on titanium discs, while 1 study used titanium plates with germanium prisms. All in-vitro studies used diode laser. Energy fluence was reported only in 2 studies. Power output and density were 100 mW (mW) and 150 mW cm?2, respectively. All in-vitro studies reported the multibacterial species outcomes after the application of antimicrobial PDT. All studies showed a significant reduction in the bacterial load. Only two studies reported the outcomes of microstructural changes on the titanium surface, in which both studies did not report any significant alterations on the titanium implants or discs with the application of PDT. Conclusion: This systematic review demonstrated significant reduction in the bacterial load but inconclusive findings regarding structural alterations on the titanium surface with the use of PDT. The results of this review should be considered preliminary and further in-vitro studies with standardized laser parameters are needed to obtain strong conclusions.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Recommanded Product: 1-Chloro-10H-phenothiazine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about Recommanded Product: 1-Chloro-10H-phenothiazine

Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem