Tag: M.W:100-200

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 20277-69-4, Name is Sodium methanesulfinate, SMILES is CS([O-])=O.[Na+], in an article , author is Yennawar, Hemant P., once mentioned of 20277-69-4, Name: Sodium methanesulfinate.

Crystal structure of the 1 : 1 adduct of 2,3-diphenyl-3,4,5,6-tetrahydro-2H-1,3-thiazin-4-one with triphenyltin chloride

The title adduct, chlorido(2,3-diphenyl-3,4,5,6-tetrahydro-2H-1,3-thiazin-4-one-kappa O) triphenyltin, [Sn(C6H5)(3)Cl(C16H15NOS)], resulted from reaction of 2,3-diphenyl- 3,4,5,6-tetrahydro-2H-1,3-thiazin-4-one with triphenyltin chloride. The thiazine ring has an envelope conformation with the S atom forming the flap. The molecule has five phenyl rings, two of them attached to the thiazine ring at positions 2 and 3, and three in coordination with the Sn-IV atom. The three rings of the triphenyltin group are involved in intramolecular interactions of different types, C-H center dot center dot center dot O, edge-to-face (or T-type) pi-pi interactions with the 3-phenyl ring of the thiazine, T-type interactions with both phenyl rings of the thiazine etc. On the other hand, all the phenyl rings participate in intermolecular pi-pi interactions. There is one instance of a ‘parallel-displaced’-type interaction extending continuously along the a-axis direction and seven instances of T-type interactions stabilizing the crystal lattice.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 26978-64-3, Name is 4-Hydroxybutane-1-sulfonic acid, molecular formula is C4H10O4S. In an article, author is Nasiri, Farough,once mentioned of 26978-64-3, Computed Properties of C4H10O4S.

Stereoselective Solvent-Free Synthesis of 4-Hydroxy-1,3-thiazinane-2-thiones

An efficient solvent-free one-pot stereoselective synthesis of 4-hydroxy-1,3-thiazinane-2-thione derivatives from the reaction of primary amines and carbon disulfide in the presence of alpha,beta-unsaturated aldehydes has been reported. The 4-hydroxy-1,3-thiazinane-2-thione derivatives were easily converted to the related dehydrated or acetylated products.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 7143-01-3, Name is Methanesulfonic anhydride, SMILES is CS(=O)(OS(C)(=O)=O)=O, in an article , author is Sirakanyan, Samvel N., once mentioned of 7143-01-3, Product Details of 7143-01-3.

Synthesis of New Derivatives of Heterocyclic Systems Containing Triazolopyrimidine, thiazolo[3,2-a]pyrimidine and pyrimido[2,1-b] thiazine Moiety Showing Promising Antimicrobial Activity

Background and Objective: Continuing our research in the field of heterocyclic compounds and exploiting our experience in the synthesis of pyridothieno(furo)[3,2-d]pyrimidine derivatives decorated by suitable reactive groups (in turn able to give rise to the formation of new heterocyclic rings), we now carried out a research with the aim of building in different position of the pyrimidine some new hetero-rings: the 1,3,4-triazole, thiazole and thiazine. Moreover their possible antimicrobial activity against some gram-positive and gram-negative bacilli strains has been evaluated. Methods: Starting from the hydrazino derivative of pyrido[3′,2′:4,5]thieno(furo)[3,2-d]pyrimidines 2 (7) by reflux with triethyl orthoformate or formic acid, some substituted isomeric pyrido[3′,2′:4,5]thieno(furo)[2,3-e][1,2,4]triazolopyrimidines 3 and 4 (10) have been synthesized. By alkylation of compounds 8 with alkyl dichlorides, the cyclization to a thiazoline or to a thiazine ring on the [a] side of the pyrimidine ring occurs, with the formation of the new pentacyclic systems: pyrido[3′,2′:4,5]thieno[3,2-d][1,3]thiazolo[3,2-a]pyrimidin-7(8)-one 15 and pyrido[3 ”,2 ”:4′,5′]furo(thieno)[3′,2′:4,5]pyrimido[2,1-b][1,3]thiazin-7(8)-ones 16. Results: 11-Alkyl(aryl)-8,8-dimethyl-7,10-dihydro-8H-pyrano[4 ”,3 ”:4′,]pyrido[3′,2′:4,5]thieno[2,3-e][1,2,4] triazolo[4,3-c]pyrimidines 3 gave a Dimroth rearrangement in acidic media. It was observed that the cyclization of compounds 7 and 8 occurred linearly with the expected formation of pyrido[3′,2′:4,5]thieno(furo)[3,2-d][1,2,4]triazolo[4,3-a]pyrimidin-7(8)-ones 10 and pyrido[3′,2′:4,5]thieno[3,2-d][1,3]thiazolo[3,2-a]pyrimidin-7(8)-one 15 and pyrido[3 ”,2 ”:4′,5′]furo(thieno)[3′,2′:4,5]pyrimido[2,1-b][1,3]thiazin-7(8)-ones 16: that is triazole, thiazole and thiazine ring condensation occurs at the [b] side of the pyrimidine ring. During the alkylation of compounds 7, the unusual cleavage of the hydrazino group took place with the formation of 8(9)-methylpyrido[3′,2′:4,5]thieno(furo)[3,2-d]pyrimidin-7(8)-ones 12. Conclusion: The synthesis of some new ‘complex’ pentaheterocyclic systems containing triazolopyrimidine, thiazolo[3,2-a]pyrimidine and pyrimido[2,1-b]thiazine moiety based on the pyrido[3′,2′:4,5]thieno(furo)[3,2-d]pyrimidines is described. During the alkylation of 9(10)-hydrazinopyrido[3′,2′:4,5]thieno(furo)[3,2-d]pyrimidin-7(8)-ones 7 an unexpected cleavage of the hydrazino group has been observed with the formation of 8(9)-methylpyrido[3′,2′:4,5]thieno(furo)[3,2-d]pyrimidin-7(8)-ones 12. Biological tests on the newly synthesized compounds evidenced that some of them showed promising antimicrobial activity.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, COA of Formula: C6H4ClNO25326-23-8, Name is 6-Chloronicotinic acid, SMILES is O=C(O)C1=CN=C(Cl)C=C1, belongs to thiazines compound. In a article, author is Paul, Mathias, introduce new discover of the category.

Breslow Intermediates from a Thiazolin-2-ylidene and Fluorinated Aldehydes: XRD and Solution-Phase NMR Spectroscopic Characterization

The first generation and X-ray diffraction (XRD) analysis of a crystalline Breslow intermediate (BI) derived from a thiazolin-2-ylidene, that is, the aromatic heterocycle present in vitamin B-1, is reported. Key to success was the combined use of pentafluorobenzaldehyde and a thiazolin-2-ylidene carrying an enol-stabilizing dispersion energy donor as N-substituent. A so-called primary intermediate (PI) could be isolated in protonated form (pPI) as well and analyzed by XRD. Furthermore, the first stable BI derived from an aromatic thiazolin-2-ylidene and an aliphatic aldehyde (trifluoroacetaldehyde) was prepared and characterized by NMR spectroscopy in solution. When switching to a saturated thiazolidin-2-ylidene, reaction with pentafluorobenzaldehyde afforded a new BI in solution (NMR spectroscopy). Attempts to crystallize the latter BI resulted in the isolation of a novel thiazolidin-2-ylidene dimer that had undergone rearrangement to a hexahydro[1,4]-thiazino[3,2-b]-1,4-thiazine.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 5326-23-8. COA of Formula: C6H4ClNO2.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 7143-01-3, Name is Methanesulfonic anhydride, molecular formula is , belongs to thiazines compound. In a document, author is Ershov, Yu A., HPLC of Formula: C2H6O5S2.

Kinetic Model of the Enzyme Catalysis of Redox Reactions

The characteristics of equilibrium between the monomeric and dimeric forms of the thiazine dye methylene blue in aqueous solutions containing potassium salts are determined via spectrophotometry. It is found that raising the salt concentration shifts equilibrium toward the formation of the dimer. Based on the results from studying the reduction of methylene blue by ascorbic acid in the presence of albumin in various ionic media, it is shown that the effect the protein has on the rate of hydrogen transfer depends on the ion composition of the solution. The effect albumin has on this reaction is similar to that of amino compounds. It is concluded that the stage of the reduction affected by amino compounds and proteins is the protonation of the neutral form of the dye.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

196597-78-1, Name is 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one, molecular formula is C11H10O2, belongs to thiazines compound, is a common compound. In a patnet, author is Velikorodov, A. V., once mentioned the new application about 196597-78-1, Quality Control of 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one.

Synthesis of New Derivatives of 5-Acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione

5-Acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione reacted with cyclohexyl and benzyl (4-aminophenyl)carbamates in boiling ethanol in the presence of a catalytic amount of glacial acetic acid to give the corresponding Schiff bases, cyclohexyl and benzyl (4-{[(E)-1-(4-hydroxy-2,6-dioxo-3,6-dihydro-2H-1,3-thiazin-5-yl)ethylidene]amino}phenyl)carbamates. Heating of the latter in dimethylformamide for 2 h was accompanied by evolution of COS with the formation of cyclohexyl and benzyl {4-[6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl]phenyl}carbamates. The condensation of the title compound with benzene-1,2-diamine in propan-2-ol, followed by addition of 5-arylfuran-2-carbaldehyde and trifluoroacetic acid afforded 5-(2-{5-[4-bromo(nitro)phenyl]furan-2-yl}-2,3-dihydro-1H-1,5-benzodiazepin-4-yl)-4-hydroxy-2H-1,3-thiazine-2,6(3H)-diones. 5-((E)-3-{5-[4-Bromo(nitro)phenyl]furan-2-yl}prop-2-enoyl)-4-hydroxy-2H-1,3-thiazine-2,6(3H)-diones were synthesized by condensation of 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione with 5-[4-bromo(nitro)phenyl]furan-2-carbaldehydes in chloroform in the presence of catalytic amounts of pyridine and piperidine.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 196597-78-1. The above is the message from the blog manager. Quality Control of 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 7143-01-3, Name is Methanesulfonic anhydride, molecular formula is , belongs to thiazines compound. In a document, author is Yavari, Issa, Computed Properties of C2H6O5S2.

A synthesis of functionalized arylthio-acrylates, benzo[b][1,4]thiazines and benzo[4,5]thiazolo[3,2-a]azepines from 2-methylbenzothiazole and acetylenic esters in aqueous media

Alkyl (Z)-3-((2-(N-((E)-3-methoxy-3-oxoprop-1-en-1-yl)acetamido)phenyl)thio)acrylates are obtained from the reaction between 2-methylbenzothiazole and alkyl propiolates in 70% aqueous alcohol, in moderate yields. When dialkyl acetylenedicarboxylates were used under similar conditions, tetra-alkyl 9,10-dihydrobenzo[4,5]thiazolo[3,2-a]azepine-7,8,9,10-tetracarboxylates, together with dialkyl 4-acetyl-3,4-dihydro-2H-benzo[b][1,4]thiazine-2,3-dicarboxylates were obtained in about 4:1 ratios. The stereochemistry of these products has been confirmed by X-ray diffraction.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 7143-01-3, in my other articles. Computed Properties of C2H6O5S2.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemistry is an experimental science, Product Details of 10297-73-1, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 10297-73-1, Name is 4′-(Methylsulfonyl)acetophenone, molecular formula is C9H10O3S, belongs to thiazines compound. In a document, author is Luo, Tao.

Visible light-driven oxidation of arsenite, sulfite and thiazine dyes: A new strategy for using waste to treat waste

Recently, the advanced oxidation processes (AOPs) based on sulfate radical (SO4 center dot-) using sulfite has received increasing concerns. Metal-free activation of sulfite is still in urgent demands from the perspective of cleaner production since the reported efficient systems containing sulfite has been relied on the transition metals. In this work, methylene blue (MB+), a well-known photosensitizer and thiazine dye contaminant, was utilized to activate sulfite for the efficient photooxidation of arsenite (As(III)) to arsenate (As(V)) under visible light (LED lamps with wavelength 640 nm) and sunlight, respectively. The initial oxidation rates of 5-40 mu M As(III) are 28-folde116-fold as that of the decolorization of 0.27 mu M MB+ with 50 mu M sulfite at pH 7.3. The maximum stoichiometric ratio MB+: As(III): sulfite was obtained to be 1 : 142: 247, suggesting an efficient utilization of both MB+ and sulfite as waste resources. The electrical energy per order (EE/O) index was calculated to be 1.83 x 10(-3) kWh L-1 for the visible light-MB+-sulfite system, which is much less than those reported systems. Oxysulfur radicals (mainly peroxymonosulfate radical, SO5 center dot-) produced in this photochemical system are responsible for As(III) oxidation. The other two common thiazine dyes (thionine and Azure B) are also capable of activating sulfite for As(III) oxidation due to the same chromophores. Thus the novel strategy of using waste sulfite and the thiazine dyes is promising for As(III) oxidation under sunlight, with which low-concentration wastes of thiazine dye and sulfite can be utilized to achieve the goal of cleaner production. (C) 2020 Elsevier Ltd. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 10297-73-1, in my other articles. Product Details of 10297-73-1.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

In an article, author is Matsuura, Koji, once mentioned the application of 6192-52-5, Name is 4-Methylbenzenesulfonic acid hydrate, molecular formula is C7H10O4S, molecular weight is 190.2169, MDL number is MFCD00142137, category is thiazines. Now introduce a scientific discovery about this category, Safety of 4-Methylbenzenesulfonic acid hydrate.

Paper-based diagnostic devices for evaluating the quality of human sperm

Male infertility, which amounts to half of all infertility cases, is a serious problem worldwide. The percentage of fertility-related patients in sub-Saharan African countries is higher than that for the developed countries. In low-resource countries, examination of sperm characteristics for male infertility cannot be undertaken because of poor clinical access. To evaluate male fertility in assisted reproductive medicine laboratories, the numbers of motile human sperm, the degree of sperm motility, and sperm morphology have been commonly analyzed using a microscope. It is challenging to monitor the health status of human sperm in resource-limited or remote settings for two primary reasons: (1) high capital cost (equipment for currently accepted procedural standard), and (2) complexity of the currently accepted procedural standard used to simultaneously measure human sperm concentration and motility by skillful embryologists. Determining the health status of human sperm in order to evaluate fertilization capacity using various types of low-cost, easy-to-use, and rapid devices (or systems) is a longstanding but interesting biotechnologically relevant issue in various scientific communities such as male reproduction. Furthering such efforts will inherently influence birth rate in both developed and developing nations. We have demonstrated an inexpensive but robust and easy-to-handle device for monitoring the health status of human sperm made by patterning a piece of paper and measuring the activity of a specific enzyme-a simple and elegant solution. After applying semen to the hydrophilic center circle of our patterned paper, a thiazine assay can be used to suggest sperm concentration in semen, and a tetrazolium-based colorimetric assay (MTT assay) data can be used to help estimate the percentage of motile human sperm (sperm motility) in semen based on the character that motile human sperm moved in and on the paper. Using this paper-based device, we can evaluate fertility levels without consulting doctors and use our assay to compare results with World Health Organization (WHO) reference values for sperm concentration (> 2×10(7)) and motility (> 50 %). The duration and cost of one entire test are 30 min and 0.1 USD, respectively. We believe that this paper-based assay system would be useful for fertility checks based on WHO references, without need of a microscope, at home. Using this assay method, males in developed or developing countries who are reluctant or unable to consult assisted reproductive technologies clinics can self-analyze their sperm characteristics. We further note that our approach adheres to WHO regulations, especially in regard to in vitro diagnostic device performance with an associated diagnostic algorithm to enhance diagnostic accuracy (compared with just one diagnostic output), and we wish to emphasize that our research could significantly advance a broad range of diagnostic developments including paper-based diagnostic devices, in vitro diagnostic devices, and diagnosis of other diseases in various divisions of translational medicine. These results, we believe, will be of interest to a wide scientific audience working in materials science (biomaterials), chemistry (analytical and clinical), lab-on-a-chip technologies (the development of diagnostic tools), reproductive medicine, bioengineering, and translational medicine.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Electric Literature of 6192-52-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 6192-52-5, Name is 4-Methylbenzenesulfonic acid hydrate, SMILES is O=S(C1=CC=C(C)C=C1)(O)=O.[H]O[H], belongs to thiazines compound. In a article, author is Czerwonka, Arkadiusz, introduce new discover of the category.

Evaluation of the effect of 2-(2,4-dihydroxyphenyl)-4H-benzofuro[3,2-d][1,3]thiazin-4-one on colon cells and its anticancer potential

In this paper, we present the biological effect of the newly synthesized 2-(2,4-dihydroxyphenyl)-4H-benzofuro[3,2-d][1,3]thiazin-4-one (DPBT) on human colon adenocarcinoma cell lines (HT-29 and LS180). Additionally, DPBT cytotoxicity was examined in human colon epithelial cells (CCD 841 CoTr) and human skin fibroblasts (HSF). The studies revealed a significant decrease in the proliferation of cancer cells after exposure to DPBT at concentrations in the range of 10-100 mu M. Additionally, DPBT was not toxic to normal CCD 841 CoTr and HSF cells at concentrations that induced inhibition of cancer cell proliferation. The nature of the anti-proliferative action of DPBT in the cell cycle progression in colon cancer cells and the expression of proteins involved in this process were examined by flow cytometry and western blotting, respectively. The investigations demonstrated higher sensitivity of LS180 than HT-29 to the DPBT treatment. The anti-proliferative action of DPBT in LS180 was attributed to cell cycle arrest in the G(1) phase via up-regulation of p27(KIP1) and down-regulation of cyclin D1 and CDK4 proteins.

Electric Literature of 6192-52-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 6192-52-5 is helpful to your research.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem