Heterocyclic Building Blocks-Thiazines

Authors Zhou, J; Xue, CC; Hou, YH; Li, MH; Hu, Y; Chen, QF; Li, YA; Li, K; Song, GB; Cai, KY; Luo, Z in ELSEVIER SCI LTD published article about ALBUMIN-MNO2 NANOPARTICLES; FE3O4 NANOPARTICLES; HIGHLY EFFICIENT; IN-SITU; DELIVERY; CELL; THERAPY; RESISTANCE; ENHANCE; MICROENVIRONMENT in [Zhou, Jun; Xue, Chencheng; Li, Menghuan; Luo, Zhong] Chongqing Univ, Sch Life Sci, Chongqing 400044, Peoples R China; [Hu, Yan; Chen, Qiufang; Li, Yanan; Li, Ke; Song, Guanbin; Cai, Kaiyong] Chongqing Univ, Minist Educ, Key Lab Biorheol Sci & Technol, Chongqing 400044, Peoples R China; [Hou, Yanhua] Chongqing Med & Pharmaceut Coll, Chongqing Engn Res Ctr Pharmaceut Sci, Chongqing 401331, Peoples R China in 2019.0, Cited 62.0. Product Details of 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Hypoxia plays vital roles in the development of tumor resistance against typical anticancer therapies and local reoxygenation has proved effective to overcome the hypoxia-induced chemoresistance. Perfluorocarbon (PFC) is an FDA approved oxygen carrier and currently vigorously investigated for oxygen delivery to tumors. This study reports a perfluorocarbon and etoposide (EP) loaded porous hollow Fe3O4-based theranostic nanoplatform capable of delivering oxygen to solid tumors to enhance their susceptibility against EP. Results show that oxygen could be released at a moderate rate from the porous hollow magnetic Fe3O4 nanoparticles (PHMNPs) over an extended period of time, therefore effectively reducing the hypoxia-induced EP resistance of tumor cells. Moreover, the surface of PHMNPs was modified with lactobionic acid (LA)-containing amphiphilic polymers via hydrophobic interaction, which could provide targeting effect against certain types of tumors. The hydrophilic moiety would be subsequently shed by the intratumoral GSH after cellular internalization and result in the agglomeration of nanocarriers inside tumor cells, consequently impeding the nanoparticle exocytosis to enhance their intracellular retention. The enhanced retention could elevate the intracellular EP level and effectively boost the tumor cell killing effect. In addition to the therapeutic benefits, the Fe3O4 nanocage could also be used for the magnetic resonance imaging of the tumor area. The assorted benefits of the composite nanosystem are anticipated to be advantageous for the treatment of drug-resistant hypoxic tumors.

Product Details of 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Zhou, J; Xue, CC; Hou, YH; Li, MH; Hu, Y; Chen, QF; Li, YA; Li, K; Song, GB; Cai, KY; Luo, Z or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Biomimetic glycosaminoglycan-based scaffolds improve skeletal muscle regeneration in a Murine volumetric muscle loss model WOS:000616630300024 published article about TISSUE; CELL; CLUSTERS; SULFATE; FIBERS; LEADS in [Narayanan, Naagarajan; Kuang, Liangju; Lengemann, Paul; Deng, Meng] Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47906 USA; [Narayanan, Naagarajan; Kuang, Liangju; Lengemann, Paul; Deng, Meng] Purdue Univ, Bindley Biosci Ctr, W Lafayette, IN 47906 USA; [Jia, Zhihao; Kim, Kun Ho; Kuang, Shihuan] Purdue Univ, Dept Anim Sci, W Lafayette, IN 47906 USA; [Shafer, Gabrielle; Bernal-Crespo, Victor] Purdue Univ, Ctr Comparat Translat Res, W Lafayette, IN 47906 USA; [Deng, Meng] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47906 USA; [Deng, Meng] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47906 USA in 2021.0, Cited 47.0. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Volumetric muscle loss (VML) injuries characterized by critical loss of skeletal muscle tissues result in severe functional impairment. Current treatments involving use of muscle grafts are limited by tissue availability and donor site morbidity. In this study, we designed and synthesized an implantable glycosaminoglycan-based hydrogel system consisting of thiolated hyaluronic acid (HA) and thiolated chondroitin sulfate (CS) crosslinked with poly(ethylene glycol) diacrylate to promote skeletal muscle regeneration of VML injuries in mice. The HA-CS hydrogels were optimized with suitable biophysical properties by fine-tuning degree of thiol group substitution to support C2C12 myoblast proliferation, myogenic differentiation and expression of myogenic markers MyoD, MyoG and MYH8. Furthermore, in vivo studies using a murine quadriceps VML model demonstrated that the HA-CS hydrogels supported integration of implants with the surrounding host tissue and facilitated migration of Pax7(+) satellite cells, de novo myofiber formation, angiogenesis, and innervation with minimized scar tissue formation during 4-week implantation. The hydrogel-treated and autograft-treated mice showed similar functional improvements in treadmill performance as early as 1-week post-implantation compared to the untreated groups. Taken together, our results demonstrate the promise of HA-CS hydrogels as regenerative engineering matrices to accelerate healing of skeletal muscle injuries.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Narayanan, N; Jia, ZH; Kim, KH; Kuang, LJ; Lengemann, P; Shafer, G; Bernal-Crespo, V; Kuang, SH; Deng, M or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis and evaluation of redox-sensitive gonadotropin-releasing hormone receptor-targeting peptide conjugates published in 2019.0. SDS of cas: 56-17-7, Reprint Addresses Qian, H (corresponding author), China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Lytic peptides have been demonstrated to exhibit obvious advantages in cancer therapy with binding ability toward tumor cells via electrostatic attractions, which are lack of active targeting and aggregation to tumor tissue. In the present study, five conjugated lytic peptides were redesigned and constructed to target gonadotropin releasing hormone receptors (GnRHr), meanwhile, the disulfide bridge was introduced to achieve redox sensitive delivery based on the experience from the preliminary work of lytic peptides P3 and P7. YX-1, was considered to be the most promising for in-depth study. YX-1 possessed high potency (IC50 = 3.16 +/- 0.3 mu M), low hemolytic effect, and cell membrane permeability in human A2780 ovarian cancer cells. Moreover, YX-1 had prominent pro-apoptotic activity by activating the mitochondria-cytochrome c-caspase apoptotic pathway. The study yielded the conjugate YX-1 with superior properties for antineoplastic activity, which makes it a promising potential candidate for targeting cancer therapy.

SDS of cas: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Dai, YX; Yue, N; Liu, CX; Cai, XG; Su, X; Bi, XZ; Li, QF; Li, CY; Huang, WL; Qian, H or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of General & Internal Medicine very interesting. Saw the article A Structured Approach to Detecting and Treating Depression in Primary Care: VitalSign6 Project published in 2019.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Trivedi, MH (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Ctr Depress Res & Clin Care, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

PURPOSE This report describes outcomes of an ongoing quality-improvement project (VitalSign6) in a large US metropolitan area to improve recognition, treatment, and outcomes of depressed patients in 16 primary care clinics (6 charity clinics, 6 federally qualified health care centers, 2 private clinics serving low-income populations, and 2 private clinics serving patients with either Medicare or private insurance). METHODS Inclusion in this retrospective analysis was restricted to the first 25,000 patients (aged >= 12 years) screened with the 2-item Patient Health Questionnaire (PHQ-2) in the aforementioned quality-improvement project. Further evaluations with self-reports and clinician assessments were recorded for those with positive screen (PHQ-2 >2). Data collected from August 2014 though November 2016 were available at 3 levels: (1) initial PHQ-2 (n = 25,000), (2) positive screen (n = 4,325), and (3) clinician-diagnosed depressive disorder with 18 or more weeks of enrollment (n = 2,160). RESULTS Overall, 17.3% (4,325/25,000) of patients screened positive for depression. Of positive screens, 56.1% (2,426/4,325) had clinician-diagnosed depressive disorder. Of those enrolled for 18 or more weeks, 64.8% were started on measurement-based pharmacotherapy and 8.9% referred externally. Of the 1,400 patients started on pharmacotherapy, 45.5%, 30.2%, 12.6%, and 11.6% had 0, 1, 2, and 3 or more follow-up visits, respectively. Remission rates were 20.3% (86/423), 31.6% (56/177), and 41.7% (68/163) for those with 1, 2, and 3 or more follow-up visits, respectively. Baseline characteristics associated with higher attrition were: non-white, positive drug-abuse screen, lower depression/anxiety symptom severity, and younger age. CONCLUSION Although remission rates are high in those with 3 or more followup visits after routine screening and treatment of depression, attrition from care is a significant issue adversely affecting outcomes.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Zeng, XJ; Yang, KQ; Huang, CY; Yang, K; Xu, SP; Wang, L; Pi, PH; Wen, XF in [Zeng, Xinjuan; Yang, Kangquan; Yang, Kai; Xu, Shouping; Pi, Pihui; Wen, Xiufang] South China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China; [Wang, Li] Minist Environm Protect PRC, South China Inst Environm Sci, Guangzhou 510655, Guangdong, Peoples R China; [Huang, Chaoyun] MEP, Nucl & Radiat Safety Ctr, Beijing 100082, Peoples R China published Novel pH-Responsive Smart Fabric: From Switchable Wettability to Controllable On-Demand Oil/Water Separation in 2019.0, Cited 35.0. COA of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Stimulus-responsive materials have great potential in advanced controllable oil/water separation applications. Here, a novel, cost-effective, and green approach is developed to produce a pH-responsive smart fabric with switchable wettability. The approach first involves grafting polydopamine (PDA) and cystamine dihydrochloride (cystamine) on a fabric surface to obtain thiol-functionalized fabric (Fabric-SH). Hydrophobic stearyl methacrylate (SMA) and pH-responsive undecylenic acid are then decorated on the Fabric-SH surface through efficient and green photoinduced thiol-ene click coupling chemistry. The obtained fabric exhibits rapidly switchable wettability between superhydrophobicity and superhydrophilicity depending on the contacting liquid pH value and can be applied in controllable separation of various mixtures of water and oil with high efficiency up to 99%. More importantly, the as prepared fabric is able to realize the separation of oil/water/oil ternary mixtures and can self-clean and repel oil fouling during the separation process. Its superhydrophobicity is robust, showing no significant change after a 500 cycle peeling test. This novel and cost-effective smart cotton fabric exhibits significant potential in satisfying different separation purposes under complicated conditions.

COA of Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Zeng, XJ; Yang, KQ; Huang, CY; Yang, K; Xu, SP; Wang, L; Pi, PH; Wen, XF or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Authors Ang, JJ; Chia, DKA; Chan, DKH in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Ang, Jia Jun; Chia, Daryl Kai Ann; Chan, Dedrick Kok Hong] Natl Univ Hlth Syst, Univ Surg Cluster, Div Colorectal Surg, 1E Kent Ridge Rd, Singapore 119228, Singapore; [Chan, Dedrick Kok Hong] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, Singapore, Singapore in 2021.0, Cited 35.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Background: A preoperative marker for morbidity in patients with colorectal cancer would help to risk stratify patients and allow for timely intervention to avert poor outcomes. We conducted this study to evaluate preoperative lymphocyte-white blood cell ratio (LWR) as a marker of postoperative morbidity. Methods: A prospective cohort of patients who underwent elective surgery for colorectal cancer was reviewed. Three morbidity-related outcomes were described-overall morbidity, multiple morbidities, and severe morbidity, defined as Clavien-Dindo Class >= 3. Univariable and multivariable analyses of presurgical predictors of these three outcomes were performed. Preoperative variables included hemoglobin levels, neoadjuvant therapy, albumin levels, white blood cell count, lymphocyte count, LWR, neutrophil-lymphocyte ratio, and prognostic nutritional index. Results: Of 177 patients, 31.6% (56/177) suffered at least one morbidity, 15.3% (27/177) had multiple morbidities, 7.9% (14/177) suffered severe morbidity. On multivariate analysis, only LWR <0.180 (odds ratio [OR] 2.53, 95% confidence interval [CI] 1.15-5.55) and neoadjuvant therapy (OR 2.49, 95% CI 1.16-5.24) were associated with overall morbidity. For multiple morbidities and severe morbidity, only LWR <0.180 was significantly associated on multivariate analysis with an OR of 2.92 (95% CI 1.19-7.13) and 4.62 (95% CI 1.45-14.73), respectively. Conclusions: LWR is a preoperative marker which can be conveniently applied using standard preoperative blood tests. LWR is an independent risk factor for overall morbidity, multiple morbidities, as well as severe morbidity when used with a cut-off of LWR<1.80. (C) 2020 Elsevier Inc. All rights reserved. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Formula: C4H14Cl2N2S2. Authors Li, XF; Zhang, W; Lin, J; Wu, H; Yao, YC; Zhang, JY; Yang, CR in ROYAL SOC CHEMISTRY published article about in [Li, Xiaofang; Zhang, Wen; Lin, Jing; Wu, Hao; Yao, Yucen; Zhang, Jiayi; Yang, Chunrong] Jiamusi Univ, Coll Pharm, 258 Xuefu St, Jiamusi 154007, Heilongjiang, Peoples R China in 2021.0, Cited 42.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

The application of combination immune-chemotherapy makes up for the limitation of monotherapy and achieves superior antitumor activity against cancer. However, combinational therapy is always restricted by poor tumor targeted drug delivery efficacy. Herein, novel T cell membrane cloaking tumor microenvi-ronment-responsive nanoparticles (PBA modified T cell membrane cloaking hyaluronic acid (HA)-disulfide bond-vitamin E succinate/curcumin, shortened as RCM@T) were developed. T cell membrane cloaking not only serves as a protection shell for sufficient drug delivery but also acts as a programmed cell death-1(PD-1) antibody to selectively bind the PD-Li of tumor cells. When RCM@T is intravenously administrated into the blood stream, it accumulates at tumor sites and responds to an acidic pH to achieve a ‘membrane escape effect and expose the HA residues of RCM for tumor targeted drug delivery. RCM accumulates in the cytoplasm via CD44 receptor mediated endocytosis and intracellularly releases antitumor drug in the intracellular redox microenvironment for tumor chemotherapy. T cell membrane debris targets the PD-Llof tumor cells for tumor immunotherapy, which not only directly kills tumor cells, but also improves the CD8(+) T cell level and facilitates effector cytokine release. Taken together, the as-constructed RCM@T creates a new way for the rational design of a drug delivery system via the combination of stimuli-responsive drug release, chemotherapeutical agent delivery and cell membrane based immune checkpoint blockade immunotherapy.

Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Chemistry very interesting. Saw the article Small-sized copolymeric nanoparticles for tumor penetration and intracellular drug release published in 2020.0. Category: thiazines, Reprint Addresses Zhu, CN (corresponding author), South Cent Univ Nationalities, Coll Biomed Engn, Hubei Key Lab Med Informat Anal & Tumor Diag & Tr, Wuhan 430074, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Poor solid-tumor penetration of nanocarriers limits the drug efficacy. Herein, small-sized copolymeric nanoparticles are prepared for delivering the chemotherapeutic drug DOX into solid tumors deeply and releasing the drug effectively. These small-sized copolymeric nanoparticles represent substantial potential for clinical translation.

Category: thiazines. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Formula: C4H14Cl2N2S2. In 2020.0 ORG BIOMOL CHEM published article about PEGYLATION; BONDS in [Nielsen, Thorbjorn; Marcher, Anders; Gothelf, Kurt, V] Aarhus Univ, Interdisciplinary Nanosci Ctr, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark; [Nielsen, Thorbjorn; Marcher, Anders; Gothelf, Kurt, V] Aarhus Univ, Dept Chem, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark; [Nielsen, Thorbjorn; Wiberg, Charlotte; Nielsen, Per F.; Nielsen, Thomas E.; Clo, Emiliano] Novo Nordisk AS, Novo Nordisk Pk 1, DK-2760 Malov, Denmark; [Drobnakova, Zuzana; Hucko, Michal; Stengl, Milan; Balsanek, Vojtech] APIGENEX Sro, Podebradska 56-186, Prague 918066, Czech Republic in 2020.0, Cited 38.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Methods for chemical modification of native proteins in a controlled fashion are in high demand. Here, a novel protocol that exploits bifunctional reagents for transient targeting of solvent exposed disulphides to direct the introduction of a single exogenous reactive thiol handle at a lysine side chain has been developed. The protocol has successfully been applied to functionalize six different Fabs and human growth hormone.

Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Nielsen, T; Marcher, A; Drobnakova, Z; Hucko, M; Stengl, M; Balsanek, V; Wiberg, C; Nielsen, PF; Nielsen, TE; Gothelf, KV; Clo, E or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Synthesis of crosslinkable diblock terpolymers PDPA-b-P(NMS-co-OEG) and preparation of shell-crosslinked pH/redox-dual responsive micelles as smart nanomaterials WOS:000494684600050 published article about BLOCK-COPOLYMER MICELLES; CONTROLLED-RELEASE; POLYMERIC MICELLES; DRUG-DELIVERY; TRIGGERED RELEASE; PH; NANOPARTICLES; CORE; DOXORUBICIN; LOCATION in [Sun, Jingjing; Sheng, Ruilong] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Radiol, Shanghai 200072, Peoples R China; [Sun, Jingjing; Wang, Zhao; Cao, Amin; Sheng, Ruilong] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet & Self Assembly Chem Organ Funct, Lingling Rd 345, Shanghai 200032, Peoples R China; [Wang, Zhao] Jinling Inst Technol, Dept Mat, Nanjing 211169, Jiangsu, Peoples R China; [Sheng, Ruilong] Univ Madeira, CQM Ctr Quim Madeira, Campus Penteada, P-9000390 Funchal, Portugal in 2019.0, Cited 39.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Category: thiazines

Crosslinked polymer nanomaterials have attracted great attention due to their stability and highly controllable drug delivery; herein, a series of well-defined amphiphilic PDPA-b-P(NMS-co-OEG) diblock terpolymers (P1-P3) were designed and prepared via RAFT polymerization and were self-assembled into non-cross-linked (NCL) nanomicelles, which were further prepared into shell-cross-linked (SCL) micelles via cystamine-based in situ shell cross-linking. Using P3 as an optimized polymer, SCL-P3 micelles were prepared, which demonstrated remarkable pH/redox-dual responsive behaviour. For drug delivery, camptothecin (CPT)-loaded SCL-P3 micelles were prepared and showed much higher CPT-loading capability than their NCL-P3 counterparts. Notably, the SCL-P3 micelles showed good synergistic pH/redox-dual responsive CPT release properties, making them potential smart nanocarriers for drug delivery.

Welcome to talk about 56-17-7, If you have any questions, you can contact Sun, JJ; Wang, Z; Cao, A; Sheng, RL or send Email.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem