Heterocyclic Building Blocks-Thiazines

I found the field of Polymer Science very interesting. Saw the article Redox-Responsive Heparin-Chlorambucil Conjugate Polymeric Prodrug for Improved Anti-Tumor Activity published in 2020.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Tsai, HC (corresponding author), Natl Taiwan Univ Sci & Technol, Grad Inst Appl Sci & Technol, Taipei 106, Taiwan.; Tsai, HC (corresponding author), Natl Taiwan Univ Sci & Technol, Adv Membrane Mat Ctr, Taipei 106, Taiwan.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Polymeric prodrug-based delivery systems have been extensively studied to find a better solution for the limitations of a single drug and to improve the therapeutic and pharmacodynamics properties of chemotherapeutic agents, which can lead to efficient therapy. In this study, redox-responsive disulfide bond-containing amphiphilic heparin-chlorambucil conjugated polymeric prodrugs were designed and synthesized to enhance anti-tumor activities of chlorambucil. The conjugated prodrug could be self-assembled to form spherical vesicles with 61.33% chlorambucil grafting efficiency. The cell viability test results showed that the prodrug was biocompatible with normal cells (HaCaT) and that it selectively killed tumor cells (HeLa cells). The uptake of prodrugs by HeLa cells increased with time. Therefore, the designed prodrugs can be a better alternative as delivery vehicles for the chlorambucil controlled release in cancer cells.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Andrgie, AT; Birhan, YS; Mekonnen, TW; Hanurry, EY; Darge, HF; Lee, RH; Chou, HY; Tsai, HC or concate me.. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Computed Properties of C4H14Cl2N2S2. Recently I am researching about CYTOPLASMIC DRUG-DELIVERY; HYALURONIC-ACID; IRGD; GLUTATHIONE; POLYMER; THERAPEUTICS; DOXORUBICIN; CELL; NANOCARRIERS; PENETRATION, Saw an article supported by the Taishan Scholars Program of Shandong Province, China. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Feng, SS; Wu, ZX; Zhao, ZY; Liu, JH; Sun, KX; Guo, CY; Wang, HB; Wu, ZM. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

This study aimed to develop an efficient step-by-step osteosarcoma (OS)-targeting liposome system functionalized with a redox-cleavable, bone- and cluster of differentiation 44 (CD44)-dual-targeting polymer. Furthermore, the effect of coadministration of a tumor-penetrating peptide, internalizing RGD (iRGD), was investigated. First, a bone-targeting moiety, alendronate (ALN), was conjugated with hyaluronic acid (HA), a ligand for CD44. This ALN-HA conjugate was coupled with DSPE PEG(2000)-COOH through a bioreducible disulfide linker (-SS-) to obtain a functionalized lipid, ALN-HA-SS-L, to be postinserted into preformed liposomes loaded with doxorubicin (DOX). The roles of ALN, HA, and the redox sensitivity of the ALN-HA-SS-L liposomes (ALN-HA-SS-L-L) in the anti-OS effect were critically evaluated against various reference liposomal formulations (with only ALN, HA, or redox sensitivity). ALN-HA-SS-L-L displayed a zeta potential of -26.07 +/- 0.32 mV and selectively disassembled in the presence of a reducing agent, 10 mM glutathione, which can be found in cancer cells. cells. Compared to various reference liposomes, ALN-HA-SS-L-L/DOX had significantly higher cytotoxicity to human OS MG-63 cells alongside high and rapid cellular uptake. In the orthotopic OS nude mouse models, ALN-HA-SS-L-L/DOX showed remarkable tumor growth suppression and prolonged survival time. This result was further improved by the coadministration of iRGD. The antitumor effects of various liposomes were ranked in the same order as the degree of tumor biodistribution shown by in vivo/ex vivo imaging: ALN-HA-SS-L-L coadministered with iRGD > ALN-HA-SS-L-L > HA-SS-L-L > HA-L-L > PEG-L> free drug. ALN-HA-SS-L-L/DOX also reduced the cardiotoxicity of DOX and lung metastases. Overall, this study demonstrated that ALN-HA-SS-L-L/DOX, equipped with bone- and CD44-dual-targeting abilities and redox sensitivity, could be a promising OS-targeted therapy. The efficacy could also be augmented by coadministration of iRGD.

Computed Properties of C4H14Cl2N2S2. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Feng, SS; Wu, ZX; Zhao, ZY; Liu, JH; Sun, KX; Guo, CY; Wang, HB; Wu, ZM or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2021.0 MICROCHEM J published article about HYBRID MONOLITHIC COLUMN; ENRICHMENT in [Mompo-Rosello, Oscar; Vergara-Barberan, Maria; Lerma-Garcia, Maria Jesus; Simo-Alfonso, Ernesto F.; Herrero-Martinez, Jose Manuel] Univ Valencia, Dept Analyt Chem, C Dr Moliner 50, Valencia 46100, Spain in 2021.0, Cited 46.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. COA of Formula: C4H14Cl2N2S2

In this work, two novel boronate affinity monolithic materials able to extract glycopeptides within a polypropylene syringe are described and compared. The first material was synthesized from glycidyl methacrylate (GMA)-based monoliths modified with poly-3-mercaptopropyl-methylsiloxane (PMPMS) followed by attachment of 4-vinylphenylboronic acid (VPBA) via thiol-ene click reaction. The second material was prepared by using gold nanoparticle (AuNP)-modified monoliths as substrate followed by subsequent attachment of PMPMS and VPBA. The resulting materials were used as sorbents for solid-phase extraction (SPE) to selectively preconcentrate glycopeptides from horseradish peroxidase (HRP) digests. The material that gave the superior performance was that prepared with AuNPs due to the presence of abundant boronic acid groups, being its practical applicability also examined. The hybrid material exhibited a satisfactory efficiency of glycopeptide enrichment (identifying 24 glycopeptides from a total of 27) in mixture of tryptic digests of HRP and bovine serum albumin (BSA) (1:100, w/w). The sorbent shows low sensitivity (0.5 fmol/?L), good adsorption capacity (25 mg g-1) and suitable reusability (over 10 times). Moreover, the hybrid monolith was successfully applied to the selective enrichment of glycopeptides from human serum digests, without any pretreatment, in which 85 glycopeptides were identified by nano-LC-MS/MS, suggesting a great potential for application in glycoproteome field.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Mompo-Rosello, O; Vergara-Barberan, M; Lerma-Garcia, MJ; Simo-Alfonso, EF; Herrero-Martinez, JM or concate me.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Redox-responsive nanoparticles based on Chondroitin Sulfate and Docetaxel prodrug for tumor targeted delivery of Docetaxel WOS:000608727400001 published article about DRUG-DELIVERY in [Li, Yimu; Chen, Xuling; Ji, Jianbo; Li, Lingbing; Zhai, Guangxi] Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Dept Pharmaceut,Minist Educ,Key Lab Chem Biol, 44 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China; [Li, Yimu] Fudan Univ, Sch Pharm, Dept Med Chem, 826 Zhangheng Rd, Shanghai 201203, Peoples R China in 2021.0, Cited 15.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

In this paper, a novel redox-responsive nanoparticles has been designed for targeted delivery of docetaxel (DTX). Chondroitin sulfate (CS) was used to construct the nanoparticles due to the ability of tumor targeting through binding with CD44 receptor that overexpresses on the surfaces of various tumor cells. A redox-responsive small-molecular DTX prodrug was prepared through modifying with cystamine containing disulfide bonds (Cys-DTX). Then the DTX prodrug was grafted to the CS to construct the amphiphilic polymer (CS-ss-DTX). Further, Cys-DTX/CS-ss-DTX nanoparticles were formed by self-assembly of amphiphilic polymer and incorporation of free Cys-DTX prodrug. This category of nanosized DTX delivery system was expected for not only exhibiting high permeability and cytotoxicity of Cys-DTX prodrug, but also targeting transportation of encapsulated redox-responsive Cys-DTX prodrug. According to results of related researches on physicochemical properties and biological evaluation, the novel redox-responsive Cys-DTX/CS-ss-DTX nanoparticles increased amount of DTX released from the nanoparticles in reductive environment, improved permeability in tumor tissues, enhanced cytotoxicity and decreased side effects compared with free DTX. All of these results showed that this kind of Cys-DTX/CS-ss-DTX nanoparticles were worthy of being expectation in tumor chemotherapy in future.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Li, YM; Chen, XL; Ji, JB; Li, LB; Zhai, GX or concate me.. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Ma, DJ; Chen, ZY; Yi, L; Xi, Z in [Chen, Zhuoyue; Yi, Long] Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China; [Ma, Dejun; Xi, Zhen] Nankai Univ, Natl Pesticide Engn Res Ctr Tianjin, Dept Chem Biol, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China; [Xi, Zhen] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China published Development of improved dual-diazonium reagents for faster crosslinking of tobacco mosaic virus to form hydrogels in 2019.0, Cited 65.0. SDS of cas: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

New bench-stable reagents with two diazonium sites were designed and synthesized for protein crosslinking. Because of the faster diazonium-tyrosine coupling reaction, hydrogels from the crosslinking of tobacco mosaic virus and the reagent DDA-3 could be prepared within 1 min at room temperature. Furthermore, hydrogels with the introduction of disulfide bonds viaDDA-4 could be chemically degraded by dithiothreitol. Our results provided a facile approach for the direct construction of virus-based hydrogels.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Ma, DJ; Chen, ZY; Yi, L; Xi, Z or concate me.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Magnetic resonance energy transfer for in vivo glutathione susceptibility weighted imaging WOS:000514748200020 published article about TUMOR MICROENVIRONMENT; FLUORESCENT-PROBE; NANOPARTICLES; ACTIVATION; SOFT in [Wang, Kun; Zhang, Huilin; Zhao, Peiran; Meng, Xianfu; Chen, Xiaoyan; Liu, Yang; Liu, Yanyan; Gong, Teng; Bu, Wenbo] East China Normal Univ, Coll Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China; [Wu, Wanlu; Fang, Xiangming] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Med Imaging, Nanjing, Peoples R China; [Shen, Aijun; Wang, Peijun] Tongji Univ, Tongji Hosp, Dept Med Imaging, Shanghai 200065, Peoples R China in 2020.0, Cited 44.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Formula: C4H14Cl2N2S2

Glutathione (GSH) plays a vital role in maintaining biological redox homeostasis. Accordingly, accurate imaging of glutathione in vivo is of great significance. Herein, we propose a magnetic resonance energy transfer (MRET) strategy based on a distance-dependent magnetic exchange coupling effect (MECE), which can realize GSH detection within tumors in vivo by susceptibility weighted imaging (SWI). Fe3O4 nanoparticles (NPs) and CoFe2O4 NPs linked with cystamine (Fe3O4-S-S-CoFe2O4) have been successfully designed as SWI nanoprobes. After the disulfide bonds are broken by excess GSH in the tumor, the increase in the distance between Fe3O4 NPs and CoFe2O4 NPs will induce a decrease of MECE and magnetic susceptibility. As a result, the changes in the SWI signals are used for tumor GSH detection in vivo. Experimental results in vitro and in vivo demonstrate that the Fe3O4-S-S-CoFe2O4 SWI nanoprobe can sensitively detect concentrations of GSH in tumors. Hence, this strategy not only improves the sensitivity of the GSH response in SWI but also provides a powerful basis for the design of other responsive functional MRI nanoprobes.

Formula: C4H14Cl2N2S2. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Wang, K; Zhang, HL; Shen, AJ; Zhao, PR; Meng, XF; Chen, XY; Liu, Y; Liu, YY; Gong, T; Wu, WL; Fang, XM; Wang, PJ; Bu, WB or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Category: thiazines. In 2020.0 J PAK MED ASSOC published article about MANAGEMENT in [Hanif, Rida; Afridi, Muhammad Iqbal; Dars, Jawed Akbar; Lqbal, Fariha] Jinnah Postgrad Med Ctr, Dept Psychiat, Karachi, Pakistan in 2020.0, Cited 25.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Objective: To determine the pattern of presentations and characteristics of patients at a psychiatric emergency services facility. Methods: The cross-sectional study was conducted in November 2016 at the Department of Psychiatry and Behavioural Sciences, Jinnah Postgraduate Medical Centre, Karachi, and comprised all patients presenting to the departmental emergency services. Data was documented on a pre-designed semi-structured proforma, and analysed using SPSS 22. Results: Of the 316 cases, 162(51.3%) were males and 154(48.7%) were females. The overall mean age was 30.78+/-13.09 years (range: 8-80 years). Psychiatric emergencies comprised suicidal attempt, excitement, violence, altered sensorium, altered/inappropriate behaviour and extrapyramidal symptoms / acute dystonia together constituting for 123(38.9%) of the total presentations, while there were 20(6.33%) cases of hysterical fits and 6(1.89%) with acute anxiety symptoms. Overall, 56(17.7%) subjects were found to have no psychiatric diagnosis, and 46(81.5%) of these were referred cases. Conclusion: Non-emergency visits constituted high percentage of emergency presentation.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Hanif, R; Afridi, MI; Dars, JA; Lqbal, F or concate me.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about STAR-ASTERISK-D; MENTAL-HEALTH; LARGE-SCALE; DISORDER; EPIDEMIOLOGY; CLINICIAN; QUESTIONNAIRE; VALIDATION; INSTRUMENT; CITALOPRAM, Saw an article supported by the Center for Depression Research and Clinical Care; Rees-Jones Foundation; Meadows Foundation; Hersh Foundation. Published in ANNALS FAMILY MEDICINE in LEAWOOD ,Authors: Jha, MK; Grannemann, BD; Trombello, JM; Clark, EW; Eidelman, SL; Lawson, T; Greer, TL; Rush, AJ; Trivedi, MH. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Formula: C4H14Cl2N2S2

PURPOSE This report describes outcomes of an ongoing quality-improvement project (VitalSign6) in a large US metropolitan area to improve recognition, treatment, and outcomes of depressed patients in 16 primary care clinics (6 charity clinics, 6 federally qualified health care centers, 2 private clinics serving low-income populations, and 2 private clinics serving patients with either Medicare or private insurance). METHODS Inclusion in this retrospective analysis was restricted to the first 25,000 patients (aged >= 12 years) screened with the 2-item Patient Health Questionnaire (PHQ-2) in the aforementioned quality-improvement project. Further evaluations with self-reports and clinician assessments were recorded for those with positive screen (PHQ-2 >2). Data collected from August 2014 though November 2016 were available at 3 levels: (1) initial PHQ-2 (n = 25,000), (2) positive screen (n = 4,325), and (3) clinician-diagnosed depressive disorder with 18 or more weeks of enrollment (n = 2,160). RESULTS Overall, 17.3% (4,325/25,000) of patients screened positive for depression. Of positive screens, 56.1% (2,426/4,325) had clinician-diagnosed depressive disorder. Of those enrolled for 18 or more weeks, 64.8% were started on measurement-based pharmacotherapy and 8.9% referred externally. Of the 1,400 patients started on pharmacotherapy, 45.5%, 30.2%, 12.6%, and 11.6% had 0, 1, 2, and 3 or more follow-up visits, respectively. Remission rates were 20.3% (86/423), 31.6% (56/177), and 41.7% (68/163) for those with 1, 2, and 3 or more follow-up visits, respectively. Baseline characteristics associated with higher attrition were: non-white, positive drug-abuse screen, lower depression/anxiety symptom severity, and younger age. CONCLUSION Although remission rates are high in those with 3 or more followup visits after routine screening and treatment of depression, attrition from care is a significant issue adversely affecting outcomes.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Jha, MK; Grannemann, BD; Trombello, JM; Clark, EW; Eidelman, SL; Lawson, T; Greer, TL; Rush, AJ; Trivedi, MH or concate me.. Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 56-17-7. Huang, YW; Li, YZ; Tang, ZL; Su, QP; Liao, TT; Gu, YX; Lin, XF; Zu, XH; Lin, WJ; Yi, GB in [Huang, Yunwei; Li, Yanzhe; Tang, Zilun; Su, Qiuping; Liao, Tingting; Lin, Xiaofeng; Zu, Xihong; Lin, Wenjing; Yi, Guobin] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China; [Gu, Yuxin] Guangzhou Kinte Ind Co Ltd, Guangdong Prov Key Lab Adv Coatings Res & Dev, Guangzhou 510300, Peoples R China published Dual-Responsive Cross-Linked Micelles from Amphiphilic Four-Arm Star Copolymers with Different Block Ratios for Triggering DOX Release in 2020.0, Cited 33.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

The four-arm star copolymers poly(methacrylic acid)-poly(2-hydroxyethyl methacrylate-disulfide similar to)-poly(poly(ethylene glycol) methyl ether methacrylate) (4AS-PMAA(x)-(PHEMA-SS similar to)(y)-PPEGMA(z)) with four different block ratios were synthesized and could self-assembled into cross-linked polymer micelles for the exploration of the structure-property relationship. The cross-linked polymer micelles in aqueous solution had low critical micelle concentration (CMC) values (1.9-4.6 mg/L), which exhibited better stability than non-cross-linked micelles. The CMC value decreased with the increase of the length of inner PMAA core and hydrophobic PHEMA cross-linked middle layer. The blank and doxorubicin (DOX)-loaded micelles with different block ratios were prepared by dialysis with the particle sizes of 120-240 nm. The longer inner PMAA core and cross-linked middle layer enhanced the drug loading content (DLC) results and led to relatively bigger particle sizes of polymer micelles. The in vitro DOX release data revealed that DOX-loaded micelles had low DOX cumulative release percentages of 18-37% after 110 h at pH 7.4, but up to 83-90% when introducing reductant GSH at pH 5.0. The 4AS-PMAA(21.2)-(PHEMASS approximate to)(13.1)-PPEGMA(5.1) micelles with the longest PMAA core had the largest cumulative release of 90.1%. The DOX release process and mechanism of the micelles at different conditions fitted well with the semi-empirical equation. Overall, the results demonstrated that the block ratios and pH/redox-responsiveness of these four-arm star copolymers could be well-controlled and their self-assembled cross-linked micelles as anticancer drug carrier system could be improved by optimizing the different ratios.

Recommanded Product: 56-17-7. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Huang, YW; Li, YZ; Tang, ZL; Su, QP; Liao, TT; Gu, YX; Lin, XF; Zu, XH; Lin, WJ; Yi, GB or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about METAL-ORGANIC FRAMEWORKS; HOST-GUEST INTERACTIONS; RADICAL POLYMERIZATION; HOLLOW NANOFIBERS; CROSS-LINKING; IMMOBILIZATION; COLOCALIZATION; COPOLYMERS; SCAFFOLDS; EFFICIENT, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21436002]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Chen, ZW; Cao, H; Tan, TW. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. HPLC of Formula: C4H14Cl2N2S2

A well-defined functional star polymer nanoparticle was prepared using an “ arm first” approach via RAFT polymerization. In this work, N-adamantylacrylamide and N-succinimidyl acrylate were copolymerized with N-isopropylacrylamide sucessfully. The obtained diblock copolymer regarded as an “ arm” endowed the star polymer with multiple conjugate functions. By adjusting the amount of crosslinking agent, the size and polydispersity of the star polymer were controlled. With the star polymer as the scaffold, a sequential multi-enzyme system was constructed, where HRP was placed in the inner layer through covalent conjugation, and b-cyclodextrin-modified GOx was assembled in the outer layer through hostguest recognition. More interestingly, the activity of the enzyme modified by b-cyclodextrin was improved. In addition to the enhanced thermal stability, this multienzyme system also exhibited a reduced Km value (from 2.18 mM to 0.39 mM) and an excellent substrate affinity. The specificity constant (Kcat/Km) for GOx in the star polymer@ HRP@ GOx system was 1.7-fold higher than that of the free HRP with free GOx system. This strategy will promote the development of biocatalysis reactions and biosensors as a promising method.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Chen, ZW; Cao, H; Tan, TW or concate me.. HPLC of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem