Category: thiazines

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Authors Zheng, M; Yang, ZP; Chen, SZ; Wu, HG; Liu, Y; Wright, A; Lu, JW; Xia, X; Lee, A; Zhang, JC; Yin, HJ; Wang, YZ; Ruan, WM; Liang, XJ in AMER CHEMICAL SOC published article about in [Zheng, Meng; Yang, Zhipeng; Wu, Haigang; Liu, Yang; Xia, Xue; Ruan, Weimin] Henan Univ, Henan & Macquarie Univ Joint Ctr Biomed Innovat, Sch Life Sci, Kaifeng 475004, Henan, Peoples R China; [Chen, Shizhu; Liang, Xing-Jie] Chinese Acad Sci, Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China; [Chen, Shizhu; Liang, Xing-Jie] Chinese Acad Sci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China; [Chen, Shizhu; Zhang, Jinchao] Hebei Univ, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag, Coll Chem & Environm Sci,Minist Educ, Baoding 071002, Hebei, Peoples R China; [Chen, Shizhu; Yin, Huijun] Natl Inst Pharmaceut R&D Co Ltd, China Resources Pharmaceut Grp Ltd, Beijing 102206, Peoples R China; [Wright, Amanda; Lee, Albert] Macquarie Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Sydney, NSW 2109, Australia; [Lu, Jeng-Wei] Natl Univ Singapore, Dept Biol Sci, Singapore, Singapore; [Yin, Huijun] Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China; [Wang, Yingze] Hebei Univ Sci & Technol, Coll Biol Sci & Engn, Shijiazhuang 050018, Hebei, Peoples R China in 2019.0, Cited 38.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

RNA interference (RNAi) is an emerging therapeutic modality for tumors. However, lack of a safe and efficient small interfering RNA (siRNA) delivery system limits its clinical application. Here, we report a bioreducible and less-cationic siRNA delivery carrier by conjugating Zn(II)-dipicolylamine complexes (Zn-DPA) onto hyaluronic acid (HA) via a redox-sensitive disulfide (-SS-) linker. Such polymer conjugates can formulate stable siRNA nanomedicines via coordination between zinc ions of DPA and the anionic phosphate of siRNA. After the conjugates are taken up by cells, intracellular reduction stimulus subsequently triggers the release of siRNAs and elucidates the desired RNAi effect. Our studies showed the formulated siRNA nanomedicines can be efficiently delivered into tumor cells/tissues and mediates less cytotoxicities both in vitro and in vivo. More importantly, when applied in a xenograft glioblastoma tumor model, this siRNA nanomedicine demonstrated significantly enhanced antitumor ability comparing to naked siRNA. This work demonstrates that such bioreducible Zn-DPA-functionalized HA conjugates without using cationic material as a siRNA carrier represents a promising direction for RNAi-based cancer therapy.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Zheng, M; Yang, ZP; Chen, SZ; Wu, HG; Liu, Y; Wright, A; Lu, JW; Xia, X; Lee, A; Zhang, JC; Yin, HJ; Wang, YZ; Ruan, WM; Liang, XJ or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2020.0 INDIAN J ORTHOP published article about STRESS-FRACTURES; INJURIES in [Pinter, Zachariah W.; Farnell, Chason G.; Huntley, Samuel; Patel, Harshadkumar A.; Peng, Jianguang; McMurtrie, James; Ray, Jessyca L.; Naranje, Sameer; Shah, Ashish B.] Univ Alabama Birmingham, Dept Orthopaed Surg, 1313 13th St South, Birmingham, AL 35205 USA in 2020.0, Cited 20.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. COA of Formula: C4H14Cl2N2S2

Background Turf toe injuries, though most common in athletes, can also occur in non-athletes. No study exists in the current literature investigating operative outcomes in non-athlete patients with chronic turf toe injury. In this study, we present our outcomes on operatively treated turf toe injuries in non-athletes in the only cohort yet studied. Methods Using ICD-10 codes, we assembled a cohort of 12 patients who underwent operative repair of chronic turf toe injury from January 2012 through January 2018 at the investigating institution. These 12 patients were evaluated to determine demographic information, method of injury, length of time from injury to surgery, clinical and radiologic characteristics of the injury, and operative outcomes including mean preoperative and postoperative VAS (Visual Analog Scale) scores, preoperative and postoperative FFI (Foot Function Index) scores, and postoperative complications. Results On initial clinical presentation, all 12 patients had local tenderness with associated painful range of motion. Four patients had restricted range of motion, all patients had a positive Lachman test, two had local edema, and eight had hallux valgus deformity. Mean VAS improved from 4.6 (range 2-9) to 1 (range 0-4). Mean FFI improved from 102.5 (range 56-177) to 61.75 (range 23-144). All patients had a negative Lachman test at final follow-up. No patients developed major complications or required revision surgery. Conclusions Our study is the first to investigate operative outcomes following chronic turf toe injury in non-athlete patients. Based on our study, surgeons and patients can expect significant improvement in overall pain and function following surgery.

COA of Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

HPLC of Formula: C4H14Cl2N2S2. In 2020.0 J MOL STRUCT published article about 1 M HCL; CORROSION INHIBITION PERFORMANCE; ECO-FRIENDLY INHIBITOR; X70 STEEL; DERIVATIVES; EXTRACT; MEDIA; EFFICIENCY; COMPOUND in [Sigircik, Gokmen] Cukurova Univ, Fac Sci & Letters, Dept Chem, TR-01330 Adana, Turkey in 2020.0, Cited 43.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Inhibition performance of 2,2′-diaminodiethyl disulfide (DA) was studied against mild steel (MS) corrosion in 0.5 M HCl. Electrochemical impedance spectroscopy (EIS), potentiodynamic (PD) polarization measurements were utilized to investigate the influence of inhibitor concentration and temperature on efficiency, as well as explanation of inhibition mechanism. Scanning electron microscopy (SEM) analysis was utilized to investigate the surface damages due to corrosion, in the absence and presence of inhibitor molecules. PD data revealed that the studied molecule exhibits mixed type inhibitor behavior on steel surface. Moreover, the calculated free adsorption energy (Delta G(ads)(o)) value is 38.45 kJ mol(-1), which indicates to strong adsorptive interaction by both physical and chemical means. UV-Visible study results supported the idea that there is strong interaction between the surface with the molecule, via its -S and -N atoms. As a consequence, 91.7% inhibition efficiency was determined in presence of 1.0 mM DA. (C) 2020 Elsevier B.V. All rights reserved.

Welcome to talk about 56-17-7, If you have any questions, you can contact Sigircik, G or send Email.. HPLC of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2020.0 MAT SCI ENG C-MATER published article about PHOTOLUMINESCENCE SENSING PLATFORM; CYTOCHROME-C; INNER FILTER; ONE-POT; GRAPHENE; HEMOGLOBIN; CYTOTOXICITY; STABILITY; EVOLUTION; MYOGLOBIN in [Wu, Feng-Yi; Wei, Xian-Wen] Anhui Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Mol Solids, Anhui Lab Mol Based Mat,Minist Educ,Anhui Key Lab, Wuhu 241000, Peoples R China; [Wu, Feng-Yi; Wang, Dong-Mei; Li, Ming-Ling; Lu, Wen-Sheng; Xu, Xiao-Yong] Chaohu Univ, Sch Chem & Mat Engn, Inst Novel Funct Mat, Hefei 238000, Peoples R China; [Cheng, Yuan-Sheng] Anhui Univ Technol, Sch Chem & Chem Engn, Inst Mat Sci & Engn, Anhui Prov Key Lab Coal Clean Convers & High Valu, Maanshan 243002, Peoples R China; [Zhou, Xiu-Hong] Anhui Agr Univ, Biotechnol Ctr, Hefei 230036, Peoples R China in 2020.0, Cited 51.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Category: thiazines

Nitrogen-doped MoS2 quantum dots (N-MoS2 QDs) were synthesized via a facile hydrothermal approach, and exhibited high fluorescence quantum yield (QY, 14.9%), excellent photostability, biocompatibility and water solubility. A novel method with good selectivity and sensitivity was established to assay hematin using N-MoS2 QDs as a fluorescent probe based on inner filter effect (IFE). Fluorescent quenching of N-MoS2 QDs has a fine linear dependence with the concentration of hematin in the range of 0.5-15 mu mol/L and a limit of detection of 0.32 mu mol/L (S/N = 3). By the detection method, average concentration of hematin in real health human erythrocytes was measured as 22.5 +/- 3.9 mu mol/L. And, recoveries range varied from 94 to 108% through standard recovery experiment. The N-MoS2 QDs probe shows excellent photostability, low cytotoxicity and anti-interference ability for hematin assay, which may become a promising method for the test of hematin in human blood.

Category: thiazines. Welcome to talk about 56-17-7, If you have any questions, you can contact Wu, FY; Cheng, YS; Wang, DM; Li, ML; Lu, WS; Xu, XY; Zhou, XH; Wei, XW or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Today I’d like to introduce a new chemical compound, CAS is 1953146-81-0, Name is 36-(((2R,3R,4R,5R,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-21,21-bis((3-((3-(5-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)pentanamido)propyl)amino)-3-oxopropoxy)methyl)-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontan-1-oic acid, Formula is C75H134N10O35, Molecular Weight is 1735.91g/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.. Reference of 1953146-81-0

The general reactant of this compound is 1-(Phenylmethyl) dodecanedioate;4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate (1:1), Reagents is Diisopropylethylamine, 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxide, Catalyst(), Solvent is Dimethylformamide, Products 1646203-74-8, Yield: 74%, Synthetic Methods procedure :1. Add HBTU ( 3.28 g, 8.64 mmol ) and DIEA ( 4.10 mL, 23.58 mmol ) to a solution of dodecanoic acid monobenzyl ester ( 2.51 g, 7.86 mmol ) in DMF ( 80 mL ) and stir the resulting mixture for few minutes., 2. Add a solution of reactant ( 15 g, 5.24 mmol ) in DMF ( 20 mL ) and continue stirring at room temperature overnight., 3. Remove the solvents and volatiles under reduced pressure., 4. Dissolve the residue in DCM ( 200 mL ) , wash with saturated NaHCO3 ( 100 mL ) and water ( 100 mL ) ., 5. Dry over anhydrous Na2SO4, evaporate the solvent under reduced pressure., 6. Purify the residue by silica gel chromatography ( eluent: 3-15% MeOH in DCM ) ., Transfornation (Acylation of Nitrogen Nucleophiles by Carboxylic Acids. Characterization Data include ‘s Proton NMR Spectrum : ( 400 MHz, DMSO-d 6 ) : δ 7.86–7.77 ( m, 6H, NH ) ; 7.72 ( t, J = 5.7 Hz, 3H, NH ) ; 7.39-7.28 ( m, 5H ) ; 6.97 ( s, 1H, NH ) ; 5.20 ( d, J = 3.4 Hz, 3H, sugar H4 ) ; 5.07 ( s, 2H ) ; 4.95 ( dd, J = 3.4, 11.2 Hz, 3H, sugar H3 ) ; 4.47 ( d, J = 8.5 Hz, 3H, sugar H1 ) ; 4.07–3.96 ( m, 9H, sugar H5, H6, H6′ ) ; 3.86 ( dt, J = 8.9, 11.2 Hz, 3H, sugar H 2 ) ; 3.69 ( dt, J = 5.9, 9.9 Hz, 3H ) ; 3.60-3.45 ( m, 12H ) ; 3.39 ( dt, J = 6.3, 9.9 Hz, 3H ) ; 3.08-2.95 ( m, 12H ) ; 2.32 ( t, J = 7.4 Hz, 2H ) ; 2.26 ( t, J = 6.3 Hz, 6H ) ; 2.09 ( s, 9H ) , 2.03 ( t, J = 7.0 Hz, 8H ) ; 1.98 ( s, 9H ) ; 1.88 ( s, 9H ) , 1.76 ( s, 9H ) ; 1.56–1.36 ( m, 22H ) ; 1.28–1.14 ( m, 12H ) ., Carbon-13 NMR : ( 126 MHz, DMSO-d 6 ) : δ 172.8, 172.5, 171.9, 170.1, 170.0, 169.9, 169.6, 169.4, 136.3, 128.4, 128.0, 127.9, 101.0, 70.5, 69.8, 68.7, 68.3, 67.3, 66.7, 65.3, 61.4, 59.5, 49.4, 36.4, 36.3, 36.0, 35.9, 35.1, 33.5, 29.5, 28.9, 28.9, 28.8, 28.7, 28.6, 28.6, 28.4, 25.3, 24.5, 22.8, 21.9, 20.5, 20.5, 20.4., Mass Spectrum: MS calc. for C98H154N10O39: 2095.03; found: 2118.05 ( M+Na+, MALDI-TOF, matrix: HABA ) ., State is offwhite solid

I’m so glad you had the patience to read the whole article, if you want know more about 1953146-81-0, you can browse my other blog.. Reference of 1953146-81-0

Reference:
CAS Reaction Number: 31-355-CAS-9994399,
,CAS Method Number: 3-614-CAS-3165786

An article Syntheses of mannopyranoside 6-thiophosphate and 6-deoxy-6-thio-mannopyranoside phosphate as ligands for affinity chromatography WOS:000471601300002 published article about 6-PHOSPHATE in [Kopitzki, Sebastian; Thiem, Joachim] Univ Hamburg, Fac Sci, Dept Chem, Martin Luther King Pl 6, D-201146 Hamburg, Germany; [Kopitzki, Sebastian] KD Pharma Bexbach GmbH, Kraftwerk 6, D-66450 Bexbach, Germany in 2019.0, Cited 22.0. SDS of cas: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Direct 6-thiophosphorylation of mannopyranoside gave both the wanted S- as well as the undesired O-phosphates. This required sequential protecting group syntheses to give mannopyranoside6-phosphate and 6-thiophosphate as well as 6-deoxy-6-thio-mannopyranoside6-phosphate, which were transformed into amino-linker compo-nents for affinity chromatography.

SDS of cas: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Kopitzki, S; Thiem, J or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Formula: C4H14Cl2N2S2. Bai, JA; Tian, Y; Liu, FZ; Li, XL; Shao, Y; Lu, XT; Wang, JT; Zhu, GQ; Xue, BY; Liu, M; Hu, P; He, N; Tang, QY in [Bai, Jianan; Tian, Ye; Li, Xiaolin; Shao, Yun; Lu, Xintong; Wang, Jintian; Zhu, Guoqin; Xue, Bingyan; Liu, Min; Hu, Ping; He, Na; Tang, Qiyun] Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr Gastroenterol, Nanjing 210029, Jiangsu, Peoples R China; [Liu, Fangzhou] Nanjing Med Univ, Jiangsu Canc Hosp, Dept Head & Neck Surg, Nanjing 210029, Jiangsu, Peoples R China; [Liu, Fangzhou] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Inst Canc Res, Nanjing 210029, Jiangsu, Peoples R China published Octreotide-Conjugated Core-Cross-Linked Micelles with pH/Redox Responsivity Loaded with Etoposide for Neuroendocrine Neoplasms Therapy and Bioimaging with Photoquenching Resistance in 2019.0, Cited 37.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

The study of multifunctional polymer micelles combined with chemotherapy due to reduced systemic toxicity and enhanced efficacy has attracted intensive attention. Herein, a multifunctional core-cross-linked hybrid micelle system based on mPEG-b-PGu(BA-TPE) and OCT-PEG-b-PGu(DA-TPE) with pH- and redox-triggered drug release and aggregation-induced emission (AIE) active imaging has been developed for active targeting of neuroendocrine neoplasms (NENs), especially neuroendocrine carcinomas (NECs) with poor prognosis. These micelles showed excellent biocompatibility and stability. After the formation of borate ester bonds, core-cross-linked micelles (CCLMs) showed enhanced emission properties. In addition, etoposide (ETO), one of the most important anticancer drugs of NECs, was loaded into the hydrophobic core of micelles by self-assembly with an average diameter of 274.6 nm and spherical morphology. Octreotide (OCT) conjugated onto the micelles enhanced cellular uptake by receptor-mediated endocytosis. ETO-loaded micelles demonstrated the dual-responsive triggered intracellular drug release and great tumor suppression ability in vitro. Compared with free ETO, ETO-loaded CCLMs exhibited a considerable antitumor effect and significantly reduced side effects. Considering the active tumor targeting, dual-responsive drug release and the AIE effect, the polymer micelle system will be a potential candidate for diagnosis and oncotherapy of NENs.

Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2020.0 CIRC-HEART FAIL published article about CLINICAL CHARACTERISTICS; SODIUM; STRATEGIES; OUTCOMES; BLACKS; THIRST; SYSTEM; WHITES; TRIAL in [Morris, Alanna A.; Nayak, Aditi; D’Souza, Melroy] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA; [Ko, Yi-An] Emory Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA USA; [Felker, G. Michael] Duke Univ, Div Cardiol, Durham, NC USA; [Redfield, Margaret M.] Mayo Clin, Div Cardiol, Rochester, MN USA; [Tang, W. H. Wilson] Cleveland Clin, Div Cardiol, Cleveland, OH 44106 USA; [Testani, Jeffrey M.] Yale Univ, Sch Med, Div Cardiol, New Haven, CT USA; [Butler, Javed] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA in 2020.0, Cited 39.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Background: Black patients have higher rates of hospitalization for acute heart failure than other race/ethnic groups. We sought to determine whether diuretic efficiency is associated with racial differences in risk for rehospitalization after acute heart failure. Methods: A post hoc analysis was performed on 721 subjects (age, 68 +/- 13 years; 22% black) enrolled in 3 acute heart failure clinical trials: ROSE-AHF (Renal Optimization Strategies Evaluation in Acute Heart Failure), DOSE-AHF (Diuretic Optimization Strategy Evaluation in Acute Decompensated Heart Failure), and CARRESS-HF (Cardiorenal Rescue Study in Acute Decompensated Heart Failure). Repeated-measures ANOVA was used to test for a racextime effect on measures of decongestion. Diuretic efficiency was calculated as net fluid balance per total furosemide equivalents. In a subset of subjects, Cox regression was used to examine the association between race and rehospitalization according to plasma renin activity (PRA). Results: Compared with nonblack patients, black patients were younger and more likely to have nonischemic heart failure. During the first 72 to 96 hours, there was greater fluid loss (P=0.001), decrease in NT-proBNP (N-terminal pro-B-type natriuretic peptide;P=0.002), and lower levels of PRA (P<0.0001) in black patients. Diuretic efficiency was higher in black than in nonblack patients (403 [interquartile range, 221-795] versus 325 [interquartile range, 154-698];P=0.014). However, adjustment for baseline PRA attenuated the association between black race and diuretic efficiency. Over a median follow-up of 68 (interquartile range, 56-177) days, there was an increased risk of all-cause and heart failure-specific rehospitalization in nonblack patients with increasing levels of PRA, while the risk of rehospitalization was relatively constant across levels of PRA in black patients. Conclusions: Higher diuretic efficiency in black patients with acute heart failure may be related to racial differences in activity of the renin-angiotensin-aldosterone system. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Morris, AA; Nayak, A; Ko, YA; D’Souza, M; Felker, GM; Redfield, MM; Tang, WHW; Testani, JM; Butler, J or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Pre-blocked molecular shuttle as an in-situ real-time theranostics WOS:000464298400005 published article about ORGANIC NANOPARTICLES; ENDOTHELIAL-CELLS; DRUG; PRODRUG; OXALIPLATIN; CISPLATIN; DESIGN; TUMOR; NANOMEDICINE; DELIVERY in [Sun, Tao; Guo, Zhongyuan; Chen, Qinjun; Chen, Xinli; Lu, Yifei; Zhang, Yu; Zhang, Yujie; Guo, Qin; Jiang, Chen] Fudan Univ, Sch Pharm, Dept Pharmaceut, Key Lab Smart Drug Delivery,Minist Educ,State Key, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; [Zhang, Guangping] Shandong Normal Univ, Sch Phys Elect, Shandong Prov Key Lab Med Phys & Image Proc Techn, 1 Univ Rd, Jinan 250358, Shandong, Peoples R China; [Zhang, Guangping] Shandong Normal Univ, Sch Phys Elect, Inst Mat & Clean Energy, 1 Univ Rd, Jinan 250358, Shandong, Peoples R China; [Wang, Qingbing] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Intervent Radiol, 197 Ruijin Er Rd, Shanghai 200025, Peoples R China; [Gao, Xiang; Cheng, Yongzhong] Sichuan Univ, West China Med Sch, West China Hosp, Dept Neurosurg, 24 Renmin Nan Rd, Chengdu 610041, Sichuan, Peoples R China; [Gao, Xiang; Cheng, Yongzhong] Sichuan Univ, West China Med Sch, West China Hosp, Inst Neurosurg,State Key Lab Biotherapy, 24 Renmin Nan Rd, Chengdu 610041, Sichuan, Peoples R China in 2019.0, Cited 60.0. SDS of cas: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Real-time monitor of drug-release from drug formulations in a noninvasive way can provide spatio-temporal information for drug activation and guide further clinical rational administration. In this work, a molecular shuttle, as a typical nanosized artificial molecular machine, was managed to act as a conceptually-new nanotheranostics for oxaliplatin. A post-recognition strategy was utilized, where a default supramolecular-dye couple was pre-blocked. The rational design, synthesis, characterization and proof-of-concept of this strategy were described in detail. The drug-release upon reducing environment can be translated into near-infrared (NIR) fluorescence signal (OFF-to-ON), allowing to track the drug-release procedure by multi-modal images including IVIS, FLECT and photoacoustic imaging. The versatile nanotheranostics system can target to triple negative breast tumor via conjugated F3 peptide, and show an improved anti-tumor efficacy with much lower side effect. The intelligent nanotheranostics system based on molecular shuttle provides new reference for precision medicine in preclinical trial and postclinical evaluation.

SDS of cas: 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Polymer Science very interesting. Saw the article Fabrication of Polymer Micelles with Zwitterionic Shell and Biodegradable Core for Reductively Responsive Release of Doxorubicin published in 2019.0. HPLC of Formula: C4H14Cl2N2S2, Reprint Addresses Li, JB (corresponding author), Henan Univ Sci & Technol, Sch Chem Engn & Pharmaceut, 263 Kaiyuan Rd, Luoyang 471023, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

To achieve a high stability in physiological environment and rapid intracellular drug release, a biodegradable zwitterionic triblock copolymer with a disulfide-linked poly-epsilon-caprolactone and polycarboxybetaine methacrylate (PCBMA-SS-PCL-SS-PCBMA) was prepared for micellar carrier to delivery doxorubicin (DOX) into tumor cells. PCBMA-SS-PCL-SS-PCBMA was obtained by following steps: i) introducing disulfide bonds through end-group modification of PCL diol with cystamine dihydrochloride; ii) preparing PCL-RAFT macromolecular chain transfer agent by EDC/NHS chemistry; iii) RAFT polymerization of zwitterionic monomer. Self-assembling from PCBMA-SS-PCL-SS-PCBMA, polymeric micelles had many advantages, such as ultra-low protein absorption in serum and obvious reduction-responsiveness in the presence of DTT. Furthermore, DOX-loaded micelles exhibited high stability upon centrifugation and lyophilization, a fast intracellular drug release and enhanced drug efficacy due to GSH-triggered PCBMA shell shedding and micellar reassembling. Thus, the polymeric micelles integrated several functions and properties could be prospectively utilized as valuable nanocarriers in cancer chemotherapeutics.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem