Category: thiazines

An article A comparative study on solubility improvement of tetracycline and dexamethasone by poly(propylene imine) and polyamidoamine dendrimers: An insight into cytotoxicity and cell proliferation WOS:000496338500001 published article about POLY(AMIDOAMINE)-FUNCTIONALIZED GRAPHENE OXIDE; PAMAM DENDRIMERS; DRUG CARRIERS; GENE DELIVERY; IN-VITRO; NANOPARTICLES; NANOCARRIERS; REDUCTION; BIOAVAILABILITY; ENCAPSULATION in [Najafi, Faezeh; Salami-Kalajahi, Mehdi; Roghani-Mamaqani, Hossein] Sahand Univ Technol, Fac Polymer Engn, POB 51335-1996, Tabriz, Iran; [Najafi, Faezeh; Salami-Kalajahi, Mehdi; Roghani-Mamaqani, Hossein] Sahand Univ Technol, Inst Polymer Mat, Tabriz, Iran; [Kahaie-Khosrowshahi, Amir] Sahand Univ Technol, Fac Chem Engn, Tabriz, Iran; [Kahaie-Khosrowshahi, Amir] Sahand Univ Technol, Tissue Engn & Stem Cells Res Ctr, Tabriz, Iran; [Kahaie-Khosrowshahi, Amir] Azarbaijan Shahid Madani Univ, Fac Engn, Tissue Engn & Stem Cells Res Ctr, Tabriz, Iran in 2020.0, Cited 74.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Many of new chemical discovered in pharmaceutical industry are hydrophobic compounds. Various techniques have been used to overcome solubility problems of hydrophobic drugs in aqueous media. In the meantime, dendrimers have been considered for sustainability, nanoscale size, high carry capacity, tunable terminal functional groups in terms of drug delivery and solubility. In this work, we have synthesized poly(propylene imine) (PPI) dendrimer up to fifth generation using reduction of nitrile groups after Michael addition and also, polyamidoamine (PAMAM) dendrimer up to fourth generation using Michael addition and amidation reactions. fourth and fifth generations of PPI dendrimer and fourth and third generations of PAMAM dendrimer in different concentrations were used to evaluate the solubility of two hydrophobic drugs (tetracycline and dexamethasone). Furthermore, cytotoxicity of dendrimers and dendrimers/drugs hybrids was studied. The results showed that with increasing concentrations and also the generation of dendrimers, the solubility of these two hydrophobic drugs was increased. Cytotoxicity study through MTT assay against Osteoblast-like cell line (MG-63 cells) showed that dendrimers were relatively cytotoxic where adding dexamethasone caused higher cytotoxicity. However, tetracycline showed no significant effect on cytotoxicity whereas prevented cell proliferation.

Welcome to talk about 56-17-7, If you have any questions, you can contact Najafi, F; Salami-Kalajahi, M; Roghani-Mamaqani, H; Kahaie-Khosrowshahi, A or send Email.. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Synthesis and characterization of a new MeCAT reagent containing a photocleavable linker for labeling of proteins and peptides in mass spectrometric analyses WOS:000449443900027 published article about QUANTITATIVE-PROTEOMICS; RELATIVE QUANTIFICATION; SULFENIC ACID; DERIVATIVES; RELEASE in [Benda, David; Beck, Sebastian; Linscheid, Michael W.] Humboldt Univ, Dept Chem, Brook Taylor Str 2, D-12489 Berlin, Germany in 2019.0, Cited 28.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Recommanded Product: 56-17-7

The quantification of proteins and peptides becomes more important besides mere identification in modern life sciences. Therefore, we have developed a new reagent that adds to the known metall-coded affinity tagging strategy employed in molecular and elemental mass spectrometry containing a photocleavable linker. A synthesis route was developed that provides the new reagent in good yields. The stability of the synthesized reagents was assessed under different temperature and illumination conditions. Labeling reactions were carried out at peptide and protein level, while also the fragmentation behavior of labeled peptides was assessed. In additional experiments, the photocleavability of the new reagent was examined. Upon irradiation with ultraviolet light, the photoproducts were liberated and could be used for quantification of labeled peptides.

Welcome to talk about 56-17-7, If you have any questions, you can contact Benda, D; Beck, S; Linscheid, MW or send Email.. Recommanded Product: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Category: thiazines. In 2020.0 POLYMERS-BASEL published article about DRUG-DELIVERY; NANOPARTICLES; COMBINATION; MICELLES; CELLS in [Andrgie, Abegaz Tizazu; Birhan, Yihenew Simegniew; Mekonnen, Tefera Worku; Hanurry, Endiries Yibru; Darge, Haile Fentahun; Chou, Hsiao-Ying; Tsai, Hsieh-Chih] Natl Taiwan Univ Sci & Technol, Grad Inst Appl Sci & Technol, Taipei 106, Taiwan; [Lee, Rong-Ho] Natl Chung Hsing Univ, Dept Chem Engn, Taichung 402, Taiwan; [Tsai, Hsieh-Chih] Natl Taiwan Univ Sci & Technol, Adv Membrane Mat Ctr, Taipei 106, Taiwan in 2020.0, Cited 47.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Polymeric prodrug-based delivery systems have been extensively studied to find a better solution for the limitations of a single drug and to improve the therapeutic and pharmacodynamics properties of chemotherapeutic agents, which can lead to efficient therapy. In this study, redox-responsive disulfide bond-containing amphiphilic heparin-chlorambucil conjugated polymeric prodrugs were designed and synthesized to enhance anti-tumor activities of chlorambucil. The conjugated prodrug could be self-assembled to form spherical vesicles with 61.33% chlorambucil grafting efficiency. The cell viability test results showed that the prodrug was biocompatible with normal cells (HaCaT) and that it selectively killed tumor cells (HeLa cells). The uptake of prodrugs by HeLa cells increased with time. Therefore, the designed prodrugs can be a better alternative as delivery vehicles for the chlorambucil controlled release in cancer cells.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about COVALENT ORGANIC FRAMEWORKS; INTRINSIC MICROPOROSITY; SELECTIVE ADSORPTION; HYDROGEN STORAGE; METAL-IONS; POLYMER; MEMBRANE; HG(II); ADSORBENTS; EFFICIENT, Saw an article supported by the National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21575141, 21974137]; CAS-Weigao Research & Development Program [[2017]-009]. Computed Properties of C4H14Cl2N2S2. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Xu, JW; Ma, SJ; Li, Y; Li, XW; Ou, JJ; Ye, ML. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Polymers of intrinsic microporosity (PIMs) are a class of microporous polymers with rigid and contorted molecular structures. The special structures lead to incomplete space occupation, and the pores of PIMs originate from the formed void. In this work, we made attempts to expand the applications of PIMs to the aspect of heavy metal removal. First, PIM-1 was synthesized using tetrafluoroterephthalonitrile (TFTPN) and 5,5′,6,6′-tetrahydroxy-3,3,3′,3′-tetramethyl-1,1′-spirobisindane (TTSBI) as precursors. The primary PIM-1 was quite hydrophobic, and thus could not be evenly dispersed in water, resulting in low adsorption capacity for mercury ions (Hg2+). A conversion of nitrile group in PIM-1 to thiol group was then carried out by two steps, namely carboxylation and introduction of thiol groups. The carboxylation made the polymers more active, and the final thiol-functionalization provided the polymers with hydrophilicity and affinity for Hg2+. The thiolethyl modified PIM-1 (assigned as PIM-G) and thiophenyl modified (assigned as PIM-B) possessed maximum Hg2+ adsorption capacity of 136 mg g(-1) and 127 mg g(-1) at pH 5, respectively. Besides, the thiol-functionalized PIMs had fluorescence property and showed potential in sensing for Hg2+.

Welcome to talk about 56-17-7, If you have any questions, you can contact Xu, JW; Ma, SJ; Li, Y; Li, XW; Ou, JJ; Ye, ML or send Email.. Computed Properties of C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Li, Y; Zhou, LH; Zhu, BD; Xiang, JJ; Du, J; He, MW; Fan, XX; Zhang, PF; Zeng, RS; Gong, P in ROYAL SOC CHEMISTRY published article about HEPTAMETHINE CYANINES; TARGETED DELIVERY; IN-VITRO; CANCER; NANOPARTICLES; CHEMOTHERAPY; PRODRUG in [Li, Ying; Zeng, Ruosheng] Guilin Univ Elect Technol, Sch Mat Sci & Engn, Sch Life & Environm Sci, Guilin 541004, Peoples R China; [Li, Ying; Zhou, Lihua; Xiang, Jingjing; Zhang, Pengfei; Gong, Ping] Chinese Acad Sci, Guangdong Key Lab Nanomed,Shenzhen Inst Adv Techn, Shenzhen Engn Lab Nanomed & Nanoformulat,Inst Bio, CAS Key Lab Hlth Informat,CAS HK Joint Lab Biomat, Shenzhen 518055, Peoples R China; [Zhou, Lihua; He, Manwen] Shenzhen Inst Technol, Sch Appl Biol, 1 Jiangjunmao, Shenzhen 518116, Peoples R China; [Zhu, Baode] Xiangnan Univ, Coll Chem Biol & Environm Engn, Chenzhou 423043, Peoples R China; [Du, Jian] Shandong First Med Univ, Dept Urol, Affiliated Hosp 1, 16766 Jingshi Rd, Jinan 250000, Peoples R China; [Fan, Xingxing] Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Macau, Peoples R China; [Zeng, Ruosheng] Guangxi Univ, Sch Phys Sci & Technol, Nanning 530004, Peoples R China in 2021.0, Cited 50.0. Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Triptolide (TP) is one of the most common systemic treatments for inflammatory and immune diseases in China for centuries. However, TP exhibits some disadvantages, such as poor solubility in water, poor bioavailability, liver toxicity, renal toxicity, and other side effects. In order to reduce the adverse effects of TP, researchers have developed numerous strategies to address the adverse properties of triptolide. Nano-carrier-based triptolide delivery systems represent an emerging technology and are one of the strategies of nanomedicine that combines diagnostic and therapeutic applications in a single agent. In this approach, we developed a glutathione-activated carrier-free nanodrug of triptolide (CyssTPN) as a trackable drug delivery system. In this system, CyssTP self-assemble to form a carrier-free nanodrug, which possesses a monodisperse spherical morphology with hydrodynamic average sizes of about 50 nm. In addition, CyssTPN had good stability under different physiological conditions (pH, high salt, etc.). Apart from cellular imaging and cell uptake, CyssTPN can be tracked by the activation of TP ability in real-time and applied for cancer cell treatment efficiently. The result showed that CyssTPN could improve solubility, reduce the side effects, and increase the bioavailability of triptolide. It could also track triptolide activation timely and tumor therapy successfully.

Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2019.0 ACS BIOMATER SCI ENG published article about ANTIGEN; SIRNA; NANOPARTICLES; LIPOSOMES; NANOGELS; ADJUVANT; IMMUNITY; AMINE)S in [Yuan, Hongyuan; Yang, Yong; Xue, Wei; Liu, Zonghua] Jinan Univ, Key Lab Biomat, Guangdong Higher Educ Inst, Dept Biomed Engn, West Huangpu Rd 601, Guangzhou 510632, Guangdong, Peoples R China in 2019.0, Cited 23.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Recommanded Product: 56-17-7

As a potential method for tumor treatment, tumor vaccine immunization induces a tumor-specific cellular immune response via immunization with tumor antigens. The delivery of exogenous antigen proteins into the cytoplasm of antigen-presenting cells is well known to induce an intensive cellular immune response for tumor treatment. In this work, we fluorinated a redox-responsive hyperbranched poly(amidoamine) (HPAA) with heptafluorobutyric anhydride to prepare a fluorinated HPAA (HPAA-F7) for use as a vaccine delivery system for antitumor therapy. The immunization results show that HPAA-F7 as a vaccine carrier could effectively promote the intracellular uptake and cytoplasmatic delivery of antigen proteins and induce potent antitumor cellular immunity. The novel vaccine carrier HPAA-F7 could be further developed for antitumor immunotherapy.

Recommanded Product: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Yuan, HY; Yang, Y; Xue, W; Liu, ZH or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Recently I am researching about METAL-ORGANIC FRAMEWORKS; HOST-GUEST INTERACTIONS; RADICAL POLYMERIZATION; HOLLOW NANOFIBERS; CROSS-LINKING; IMMOBILIZATION; COLOCALIZATION; COPOLYMERS; SCAFFOLDS; EFFICIENT, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21436002]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Chen, ZW; Cao, H; Tan, TW. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

A well-defined functional star polymer nanoparticle was prepared using an “ arm first” approach via RAFT polymerization. In this work, N-adamantylacrylamide and N-succinimidyl acrylate were copolymerized with N-isopropylacrylamide sucessfully. The obtained diblock copolymer regarded as an “ arm” endowed the star polymer with multiple conjugate functions. By adjusting the amount of crosslinking agent, the size and polydispersity of the star polymer were controlled. With the star polymer as the scaffold, a sequential multi-enzyme system was constructed, where HRP was placed in the inner layer through covalent conjugation, and b-cyclodextrin-modified GOx was assembled in the outer layer through hostguest recognition. More interestingly, the activity of the enzyme modified by b-cyclodextrin was improved. In addition to the enhanced thermal stability, this multienzyme system also exhibited a reduced Km value (from 2.18 mM to 0.39 mM) and an excellent substrate affinity. The specificity constant (Kcat/Km) for GOx in the star polymer@ HRP@ GOx system was 1.7-fold higher than that of the free HRP with free GOx system. This strategy will promote the development of biocatalysis reactions and biosensors as a promising method.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Fluorinated Redox-Responsive Poly(amidoamine) as a Vaccine Delivery System for Antitumor Immunotherapy WOS:000458937900026 published article about ANTIGEN; SIRNA; NANOPARTICLES; LIPOSOMES; NANOGELS; ADJUVANT; IMMUNITY; AMINE)S in [Yuan, Hongyuan; Yang, Yong; Xue, Wei; Liu, Zonghua] Jinan Univ, Key Lab Biomat, Guangdong Higher Educ Inst, Dept Biomed Engn, West Huangpu Rd 601, Guangzhou 510632, Guangdong, Peoples R China in 2019.0, Cited 23.0. COA of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

As a potential method for tumor treatment, tumor vaccine immunization induces a tumor-specific cellular immune response via immunization with tumor antigens. The delivery of exogenous antigen proteins into the cytoplasm of antigen-presenting cells is well known to induce an intensive cellular immune response for tumor treatment. In this work, we fluorinated a redox-responsive hyperbranched poly(amidoamine) (HPAA) with heptafluorobutyric anhydride to prepare a fluorinated HPAA (HPAA-F7) for use as a vaccine delivery system for antitumor therapy. The immunization results show that HPAA-F7 as a vaccine carrier could effectively promote the intracellular uptake and cytoplasmatic delivery of antigen proteins and induce potent antitumor cellular immunity. The novel vaccine carrier HPAA-F7 could be further developed for antitumor immunotherapy.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Product Details of 56-17-7. Authors Chen, CH; Chiang, CY; Wu, CW; Wang, CT; Chau, LK in MDPI published article about in [Chen, Chien-Hsing] Natl Pingtung Univ Sci & Technol, Dept Biomechatron Engn, Pingtung 91201, Taiwan; [Chiang, Chang-Yue] Natl Yunlin Univ Sci & Technol, Grad Sch Engn Sci & Technol, Touliu 64002, Yunlin, Taiwan; [Chiang, Chang-Yue; Wu, Chin-Wei] Natl Yunlin Univ Sci & Technol, Bachelor Program Interdisciplinary Studies, Touliu 64002, Yunlin, Taiwan; [Wang, Chien-Tsung] Natl Yunlin Univ Sci & Technol, Dept Chem & Mat Engn, Touliu 64002, Yunlin, Taiwan; [Chau, Lai-Kwan] Natl Chung Cheng Univ, Dept Chem & Biochem, Chiayi 62102, Taiwan; [Chau, Lai-Kwan] Natl Chung Cheng Univ, Ctr Nano Biodetect, Chiayi 62102, Taiwan in 2021.0, Cited 47.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

In this research, a direct, simple and ultrasensitive fiber optic particle plasmon resonance (FOPPR) biosensing platform for immunoglobulin G (IgG) detection was developed using a gold nanoparticle/graphene oxide (AuNP/GO) composite as signal amplification element. To obtain the best analytical performance of the sensor, experimental parameters including the surface concentration of GO on the AuNPs, formation time of the GO, the concentration of the anti-IgG and incubation time of anti-IgG were optimized. The calibration plots displayed a good linear relationship between the sensor response (Delta I/I-0) and the logarithm of the analyte concentrations over a linear range from 1.0 x 10(-10) to 1.0 x 10(-6) g/mL of IgG under the optimum conditions. A limit of detection (LOD) of 0.038 ng/mL for IgG was calculated from the standard calibration curve. The plot has a linear relationship (correlation coefficient, R = 0.9990). The analytical performance of present work’s biosensor was better than that of our previously reported mixed self-assembled monolayer of 11-mercaptoundecanoic acid/6-mercapto-1-hexanol (MUA/MCH = 1:4) method by about three orders of magnitude. The achieved good sensitivity may be attributed to the synergistic effect between GO and AuNPs in this study. In addition, GO could immobilize more antibodies due to the abundant carboxylic groups on its surface. Furthermore, we also demonstrated that the results from this sensor have good reproducibility, with coefficients of variation (CVs) < 8% for IgG. Therefore, the present strategy provides a novel and convenient method for chemical and biochemical quantification and determination. Product Details of 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Glutathione-responsive disassembly of disulfide dicyanine for tumor imaging with reduction in background signal intensity WOS:000508008300009 published article about CYANINE DYES; IN-VIVO; PHOTODYNAMIC THERAPY; CANCER; NANOPARTICLES; RELEASE; NANOMEDICINE; CHEMOTHERAPY; DOXORUBICIN; METASTASES in [Mo, Shanyan; Zhang, Xiaoting; Hameed, Sadaf; Zhou, Yiming; Dai, Zhifei] Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China; [Mo, Shanyan] Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China in 2020.0, Cited 58.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Category: thiazines

Near-infrared (NIR) fluorescence imaging has been proved as an effective modality in identifying the tumor border and distinguishing the tumor cells from healthy tissue during the oncological surgery. Developing NIR fluorescent probes with high tumor to background (T/B) signal is essential for the complete debulking of the tumor, which will prolong the survival rate of tumor patients. However, the nonspecific binding and always-on properties of the conventional fluorescent probes leads to high background signals and poor specificity. Method: To address this problem, glutathione (GSH)-responsive, two disulfide-bonded dicyanine dyes (ss-diCy5 and ss-diNH800CW) were synthesized. As synthesized dyes are quenched under normal physiological conditions, however, once reached to the tumor site, these dyes are capable of emitting strong fluorescence signals primarily because of the cleavage of the disulfide bond in the tumor microenvironment with high GSH concentration. Besides, the GSH-responsive behavior of these dyes was monitored using the UV-vis and fluorescence spectroscopy. The diagnostic accuracy of the aforementioned dyes was also tested both in tumor cells and 4T1-bearing mice. Results: The fluorescence signal intensity of disulfide dicyanine dyes was quenched up to 89% compared to the mono cyanine dyes, thus providing a very low fluorescence background. However, when the disulfide dicyanine dye reaches the tumor site, the dicyanine is cleaved by GSH into two mono-dyes with high fluorescence strength, thus producing strong fluorescent signals upon excitation. The fluorescent signal of the dicyanine was enhanced by up to 27-fold after interacting with the GSH solution. In vivo xenografts tumor studies further revealed that the fluorescence signals of aforementioned dyes can be quickly recovered in the solid tumor. Conclusion: In summary, the disulfide dicyanines dyes can provide a promising platform for specific tumor-activatable fluorescence imaging with improved T/B value.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem