Category: thiazines

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Hydrazide-integrated carbazoles: synthesis, computational, anticancer and molecular docking studies

A new class of carbazole-based hydrazides 6a-c, synthesized from carbazole by employing a multistep synthetic strategy, has been described. Detailed insight into their structures (6a-c) has been elucidated by UV-Vis, FT-IR and NMR (H-1 and C-13) spectroscopic studies. Theoretical investigation of the molecules 6a-c has been accomplished utilizing DFT and TD-DFT techniques with the B3LYP/6-311++G(d,p) method. Theoretical findings such as optimized structural, vibrational, and electronic properties, and proton and carbon chemical shifts of the targets 6a-c are in harmony with their experimental results and/or structurally related reported ones. Cytotoxicity of the target hydrazides 6a-c has been evaluated using human pancreatic cancer cells (AsPC1 and SW1990). The hydrazides 6a-c displayed a significant in vitro cytotoxic effect against both the pancreatic cancer cells AsPC1 (concentration that inhibits 50% cell viability, IC50: 3.42 +/- 0.41 mu M for 6a) and SW1990 (IC50: 22.42 +/- 1.40 mu M for 6a). The superior binding energy resulting from the in silico molecular docking approach of the hydrazide 6a indicates its greater affinity towards the receptor (binding energy: -8.63 kcal mol(-1) and IC50: 475.05 nM). Thus, the hydrazide 6a could serve as a new lead for the development of anticancer agents.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

New month, new HOT articles! We are pleased to share a selection of our referee-recommended HOT articles in 2021. We hope you enjoy reading these articles. , Formula: https://www.ambeed.com/products/20277-69-4.html, 20277-69-4, Name is Sodium methanesulfinate, molecular formula is CH3NaO2S, belongs to thiazines compound. In a document, author is Ansari, Mohd Danish, introduce the new discover.

Organo-nanocatalysis: An emergent green methodology for construction of bioactive oxazines and thiazines under ultrasonic irradiation

A synergistic catalysts system ZnO NPs and Malic acid was used for the highly efficient and eco-friendly synthesis of oxazines and thiazines derivatives. Aldehyde, urea and alkyne derivatives are used as reactants under ultrasonication, which not only allows clean and rapid alteration but also simplifies experimental setup. High yields, environmentally benigness, simple work-up and shorter reaction times are some remarkable advantages of this strategy. (C) 2019 Elsevier B.V. All rights reserved.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

The flat faces of aromatic rings also have partial negative charges due to the π-electrons. Similar to other non-covalent interactions –including hydrogen bonds, electrostatic interactions and Van der Waals interactions. 20277-69-4, Name is Sodium methanesulfinate, molecular formula is CH3NaO2S, Quality Control of Sodium methanesulfinate.

Crystal structure of (E)-2-benzylidene-4-[(3-phenyl-4,5-dihydroisoxazol-5-yl)-methyl]-2H-benzo[b][1,4] thiazin-3(4H)-one

In the title compound, C25H20N2O2S, the dihydroisoxazole ring exhibits an envelope conformation with the methine atom being the flap, while the 1,4-thiazine ring displays a screw-boat conformation. The six-membered ring fused to the 1,4-thiazine ring makes dihedral angles of 63.04 (2) and 54.7 (2)degrees with the mean planes through the five-membered heterocycle and the attached phenyl ring, respectively. The phenyl group connected to the 1,4-thiazine ring is disordered over two sites [major component = 0.57 (2)]. The most prominent interactions in the crystal structure are C-H center dot center dot center dot O hydrogen bonds that link molecules, forming inversion dimers, and C-H center dot center dot center dot N hydrogen bonds that link the dimers into columns parallel to the b axis.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. , COA of Formula: https://www.ambeed.com/products/110553-27-0.html, 110553-27-0, Name is 2-Methyl-4,6-bis((octylthio)methyl)phenol, molecular formula is C25H44OS2, SMILES CODE is OC1=C(CSCCCCCCCC)C=C(CSCCCCCCCC)C=C1C.

The Roles of Solute-Solute and Solute-Solvent Interactions on the Nonlinearity of Aqueous Solutions of Ionic Dyes

In this paper, the roles of intermolecular interactions and probability of aggregates formation on the nonlinear optical properties of thiazine dyes are investigated. Our results show that saturable and reverse saturable absorption properties of these dyes depend strongly on the molecular surrounding media characteristics and their collective properties that tend to form aggregated species at high concentrations. Depending on molecular surrounding media characteristics, by increasing the concentration of dye solutions and formation of aggregates, the strong solute-solute interactions can modify the nonlinear responses of dye solutions. The experimental results indicate that by increasing the contribution of J aggregates, the third-order nonlinear responses of binary mixtures of water and ethanol are increased at room temperature. Therefore, the intermolecular interactions and the presence of J aggregates can be considered as simple techniques for improving the nonlinear responses of selected ionic dyes.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

As the most studied and widely used chiral ligands, C10H8NNaO7S2 have been rapidly developed in recent decades due to their simple synthesis, easy modification, and the ability to achieve excellent results in multiple reactions. 5460-09-3, Name is Sodium 4-Amino-5-hydroxy-2,7-naphthalenedisulfonate, belongs to thiazines compound, is a common compound. In a pantent, author is Vijay, Murugan, once mentioned the new application about 5460-09-3, Synthetic Route of 5460-09-3.

Regiospecific Bi-Catalysed Domino C-N/C-S Bonds Formation: Synthesis of 1,4-Thiazines/1,4-Thiomorpholines

A domino Bi-catalysed C-N/C-S bond formation of N-sulfonylaziridines is developed with 1,4-dithiane-2,5-diol to give 3,4-dihydro-1,4-thiazines at room temperature. The use of Bi(OTf)(3) as a catalyst, atom economy and regioselectivity are the important practical features.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. In a pantent,Novel Synthesis of 1,3-Thiazine and Pyrimidinethione Derivatives from (1-Aryl ethylidene)hydrazinecarbothioamides and Tetracyanoethylene, once mentioned the new application about 56-17-7, Application of 56-17-7.

Novel Synthesis of 1,3-Thiazine and Pyrimidinethione Derivatives from (1-Aryl ethylidene)hydrazinecarbothioamides and Tetracyanoethylene

1,3-Thiazine-5,6,6-tricarbonitrile and 2-thioxo-2,3-dihydropyrimidine-4,5-dicarbonitriles derivatives were synthesized via interactions between (1-aryl ethylidene) hydrazinecarbothioamides and tetracyanoethylene to give the derivatives of tetracyanoethane and tricyanovinylation intermediates, followed by heterocyclization. The structures of the products have been confirmed by different spectroscopic analyses. A rational for the formation of the products is presented.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. COA of Formula: https://www.ambeed.com/products/154445-78-0.html, 154445-78-0, Name is 2,2,4,6,7-Pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl chloride, molecular formula is C13H17ClO3S, belongs to thiazines compound.

N-alkylphenothiazines – synthesis, structure and application as ligands in metal complexes

Phenothiazines are a large group of heterocyclic, aromatic molecules with nitrogen and sulphur between two benzene rings. Their derivatives, N-alkylphenothiazines have substituent on heterocyclic nitrogen atom which gives them different properties. Also, a series of these molecules have substitution on carbon atom at place 2 of phenothiazine benzene ring. Alkylphenothiazines contain aminoalkyl substituent and their alkyl, acyl and sulphonil derivatives, as well as monocyclic and bicyclic heterocycles attached at thiazine nitrogen atom or directly linked to benzene ring. The N-alkylphenothiazines have been known as antipsychotic drugs, but they also possess antibacterial, antifungal, anticancer activity, and ability to react with macromolecules and to coordinate to the metals. Metal complexes with N-alkylphenothiazines are biological active compounds with different antimicrobial activities and cytotoxic effect against tumor cell lines. The large field of application of N-alkylphenothiazines is very attractive in terms of synthesis of new related derivatives, metal complexes, studying their properties and applications. This article presents a review of the literature and a contemporary view at N-alkylphenothiazines – their synthesis and application, as well as their metal complexes which have promising biological effects.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Modeling chemical reactions helps engineers virtually understand the chemistry, optimal size and design of the system, and how it interacts with other physics that may come into play. In a pantent, An efficient ultrasonic-assisted synthesis of ethyl-5-(aryl)-2-(2-alkokxy-2-oxoethylidene)-7-methyl-3-oxo-3, 5-dihydro-2H-thiazolo [3, 2-a] pyrimidine-6-carboxylate derivatives. .

An efficient ultrasonic-assisted synthesis of ethyl-5-(aryl)-2-(2-alkokxy-2-oxoethylidene)-7-methyl-3-oxo-3, 5-dihydro-2H-thiazolo [3, 2-a] pyrimidine-6-carboxylate derivatives

Dihydropyrimidinone derivatives were prepared by tri-component reaction of ethyl aceto acetate, aldehydes and thiourea in the presence of modified montmorillonite nanostructure as a catalyst and used as key intermediates for the synthesis of ethyl-5-(aryl)-2-(2-alkokxy-2-oxoethylidene)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyri midine-6-carboxylate derivatives with use of diethyl and dimethyl acetylene dicarboxylate by two methods: (a) in methanol as a solvent under ultrasonic irradiation at ambient temperature (b) in methanol as a solvent at ambient temperature (conventional magnetic stirring). Ultrasound-assisted synthesis provides excellent yields in short reaction times (15-25 min) at room temperature. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of King Saud University.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

The flat faces of aromatic rings also have partial negative charges due to the π-electrons. Similar to other non-covalent interactions –including hydrogen bonds, electrostatic interactions and Van der Waals interactions. 139-65-1, Name is 4,4-Thiodianiline, molecular formula is C12H12N2S, Formula: https://www.ambeed.com/products/139-65-1.html.

Antimicrobial Properties of Substituted Quino [3,2-b]benzo[1,4] thiazines

Our previous studies demonstrated that among phenothiazines several derivatives could be found showing strong antiproliferative actions and the property of inhibiting inducible tumor necrosis factor alpha (TNF alpha) production in human blood cultures. The aim of this investigation was to determine potential antimicrobial actions of forty four new phenothiazine derivatives with the quinobenzothiazine structure. The compounds showed differential antibacterial and antifungal activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans depending on the compound structures, concentrations and bacterial strains. More specifically, 6-(1-methyl-2-piperidylethyl) quinobenzothiazine displayed strongest actions against S. aureus and E. coli whereas 6-methanesulfonylaminobutyl-9-methylthioquinobenzothiazine exhibited the most universal antimicrobial properties. The correlation between antimicrobial activity and the chemical structure of quinobenzothiazines was discussed.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. In a pantent, Site-Selective Pd-Catalysed Fujiwara-Moritani type Reaction of N,S-Heterocyclic Systems with Olefins. HPLC of Formula: https://www.ambeed.com/products/110553-27-0.html.

Site-Selective Pd-Catalysed Fujiwara-Moritani type Reaction of N,S-Heterocyclic Systems with Olefins

Dihydro-1,4-thiazine skeletons bearing olefin fragment at their alpha-position were prepared through a Pd(OAc)(2)-catalysed Fujiwara-Moritani type reaction via C-H alkenylation with olefins. This approach is selective, generalizable to a wide range of olefins and requires only 1 eq. of Ag2CO3 without the need of co-oxidant. The C-H bond activation proved to be strongly dependent on the olefin’s substitution while unfused dihydro-1,4-thiazines seemed to be affected by the oxidation state of the sulfur atom. The utility of olefins obtained was demonstrated by their implication in the dipolar cycloaddition reaction with a non-stabilized azomethine ylide.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem