Category: thiazines

When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. , Related Products of 103-47-9, 103-47-9, Name is N-Cyclohexyltaurine, molecular formula is C8H17NO3S, belongs to thiazines compound. In a document, author is Ziolkowska, Dorota, introduce the new discover.

Spectral Study on Association of Thiazine Dyes with Anionic Polymers

Feasible method of quantitative determination of anionic polymers in aqueous solutions was described using poly(styrene sulfonate) and poly(acrylate) sodium salts as an example. The method consists in absorbance measurements while titrating with thiazine dye. Volume of dye solution needed to attain specified value of absorbance is linearly dependent on polymer concentration. Optimal wavelengths are 666nm and 640nm for Methylene Blue dye and Toluidine Blue dye, respectively. Calibration plots are straight lines (r(2) > 0.99) ensuring good accuracy of the method developed. Range of measurable concentrations is dependent on chosen value of end-point absorbance.

Related Products of 103-47-9, The π-electrons of these planar compounds are free to cycle around the circular arrangements of atoms found in the aromatic moieties. This stems from the resonance found in planar ring systems, like benzene, and 103-47-9.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemistry built the modern world, from the materials that make up the everyday objects around us, the batteries in our devices and cleaning products that help to maintain sanitation. , Recommanded Product: 92-39-7, 92-39-7, Name is 2-Chloro-10H-phenothiazine, molecular formula is C12H8ClNS, belongs to thiazines compound. In a document, author is Szczesniak-Siega, Berenika M., introduce the new discover.

Synthesis and biological evaluation as well as in silico studies of arylpiperazine-1,2-benzothiazine derivatives as novel anti-inflammatory agents

Novel arylpiperazine-1,2-benzothiazine derivatives have been designed and synthesized as potential antiinflammatory agents. Their structure and properties have been studied using spectroscopic techniques (H-1 NMR, C-13 NMR, FT-IR), MS, elemental analyses, and single-crystal X-ray diffraction (SCXRD, for compound 7b). This study aimed to evaluate the inhibitory activity of new derivatives against both cyclooxygenase isoforms COX-1 and COX-2 due to the similarity of new compounds to oxicams drugs from the NSAIDs group. All new compounds were divided into two series – A and B – with a different linker between thiazine and piperazines nitrogens. Series A included the three-carbon aliphatic linker and series B – two-carbon with a carbonyl group. According to in vitro and molecular docking studies all new compounds exhibited cyclooxygenase inhibitory activity. The series of A compounds included COX-1 inhibitors only. In contrast, the B series showed inhibition of both COX-1 and COX-2, which suggested the importance of the acetoxy linker for COX-2 inhibition. Moreover, the most selective compound 7b, towards COX-2, was non-toxic for the normal human cell line (in concentration of 10 mu M) comparable to reference drug meloxicam. Additionally, investigation of influence on model membranes confirmed the ability of the compound 7b to penetrate lipid bilayers which seemed to be important to the influence with membrane protein-cyclooxygenase.

Recommanded Product: 92-39-7, Therefore, highly desirable that these risks are identified and discharged early on to avoid potential scale-up issues about 92-39-7.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

New month, new HOT articles! We are pleased to share a selection of our referee-recommended HOT articles in 2021. We hope you enjoy reading these articles. , Name: 2,2′-Disulfanediyldiethanamine dihydrochloride, 56-17-7, Name is 2,2′-Disulfanediyldiethanamine dihydrochloride, molecular formula is C4H14Cl2N2S2, belongs to thiazines compound. In a document, author is Thakur, Alok Singh, introduce the new discover.

Synthesis and oral hypoglycemic effect of novel thiazine containing trisubstituted benzenesulfonylurea derivatives

A new series of 3-(4-substituted phenyl)-1-(4-(4,6-dimethyl-6H-1,3-thiazin-2-yl)phenylsulfonyl)-1-substituted urea (5a-o) was synthesized by an effectual route via sulfonylcarbamates and explores the novel site for substitution in sulfonylurea as well as the way of thiazine can be prepared. The molecules were established by elemental analysis and spectroscopic viz. IR, H-1 NMR, C-13 NMR and MS techniques. All the fifteen derivatives were shown very prominent oral hypoglycemic effect at the dose of 40 mg/kg body weight (p.o.) in respect of standard drug glibenclamide and control. The hypoglycemic effect was studied using oral glucose tolerance test in normal and NIDDM in STZ-rat model. The compounds 5a, 5d, 5f, 5i, 5k and 5n were dominant out of fifteen derivatives for blood glucose lowering activity (more than 80%) when comparing with NIDDM control. These derivatives were either containing simply phenyl ring (5a, 5f and 5k) on to the second amine of sulfonylurea (R’ = H) or nitro group at the para position in compound 5d, Si and 5n (R’ = NO2) to produce significant oral hypoglycemic effect. Other structural activity relationship is also observed regarding the heteroaromatic and substituted aromatic group at R and R’ position respectively. (C) 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University.

Name: 2,2′-Disulfanediyldiethanamine dihydrochloride, We very much hope you enjoy reading the articles and that you will join us to present your own research about 56-17-7.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

New month, new HOT articles! We are pleased to share a selection of our referee-recommended HOT articles in 2021. We hope you enjoy reading these articles. , Quality Control of 6-Chloronicotinic acid, 5326-23-8, Name is 6-Chloronicotinic acid, molecular formula is C6H4ClNO2, belongs to thiazines compound. In a document, author is Abu-Hashem, Ameen A., introduce the new discover.

Design, synthesis and identification of novel substituted isothiochromene analogs as potential antiviral and cytotoxic agents

In this study, we present the synthesis of novel isothiochromenes, thiazolidonone, thiazinone, arylidines, triazoles, and pyrimidinone compounds based on the starting material 3-amino- isothiochromene-4-carbonitrile 3. The chemical structures were confirmed using spectroscopic methods and elemental analyses. These compounds were screened for their in vitro antiviral and antitumor activities. Compounds 10a-c and 22a-b showed activity against herpes simplex virus-1 (HSV-1) and human immunodeficiency virus-1 (HIV-1). Compounds 15 and 21a-b exhibited activity against various types of cancer cell lines. [GRAPHICS] .

Quality Control of 6-Chloronicotinic acid, The π-electrons of these planar compounds are free to cycle around the circular arrangements of atoms found in the aromatic moieties. This stems from the resonance found in planar ring systems, like benzene, and 5326-23-8.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemistry built the modern world, from the materials that make up the everyday objects around us, the batteries in our devices and cleaning products that help to maintain sanitation. , Name: 2-(Trifluoromethyl)-10H-phenothiazine, 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, molecular formula is C13H8F3NS, belongs to thiazines compound. In a document, author is Al-Refai, Mahmoud, introduce the new discover.

Synthesis, characterization and antimicrobial activity of new chalcones and their 6-aryl-4-(2,5-dichlorothiophen-3-yl)-6H-1,3-thiazin-2-amine derivatives

Chalcones (5a-h) were prepared in high yields via the condensation of 3-acetyl-2,5-dichlorothiophene (3) with aryl aldehydes (4a-h). The reaction of the resulting chalcones with thiourea in the presence of a catalytic amount of hydrochloric acid provided the 1,3-thiazin-2-amine derivatives (6a-g) in moderate yields. All new compounds were characterized by extensive NMR analysis data, including 1D NMR experiments (H-1 and C-13) and 2D NMR experiments (COSY, HMBC, HSQC), as well as ESIMS and HRESIMS data. The newly synthesized compounds were evaluated for their biological activities, which demonstrate a very good to low bioactivities as antibacterial and antifungal, respectively. [GRAPHICS] .

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 92-30-8, you can contact me at any time and look forward to more communication. Name: 2-(Trifluoromethyl)-10H-phenothiazine.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. In a pantent, Orbicularisine: A Spiro-Indolothiazine Isolated from Gills of the Tropical Bivalve Codakia orbicularis. HPLC of Formula: https://www.ambeed.com/products/154445-78-0.html.

Orbicularisine: A Spiro-Indolothiazine Isolated from Gills of the Tropical Bivalve Codakia orbicularis

A novel spiro-indolofuranone fused to a thiazine skeleton, orbicularisine (1), was isolated from gills of the mollusk Codakia orbicularis. The isolation and structure elucidation using spectroscopic evidence including mass and NMR spectroscopy are described. The final structure of 1 was supported by key HMBC correlation.

HPLC of Formula: https://www.ambeed.com/products/154445-78-0.html, We very much hope you enjoy reading the articles and that you will join us to present your own research about 154445-78-0.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. In a pantent,Isomorphous diethyl 1-(4-chlorobenzyl)-4-(4-chlorophenyl)-2,2-dioxo-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[2,1-c][1,4]thiazine-1,3-dicarboxylate and its 1-(4-methylbenzyl)-4-(4-methylphenyl)-substituted analogue obeying the chloro-methyl exchange rule, once mentioned the new application about 196597-78-1, Electric Literature of 196597-78-1.

Isomorphous diethyl 1-(4-chlorobenzyl)-4-(4-chlorophenyl)-2,2-dioxo-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[2,1-c][1,4]thiazine-1,3-dicarboxylate and its 1-(4-methylbenzyl)-4-(4-methylphenyl)-substituted analogue obeying the chloro-methyl exchange rule

Accurate studies on the effect of substituents on the crystal packing are essential for understanding the intermolecular interactions and thus paving the way to crystal structure prediction. The crystal structures of diethyl 1-(4-chlorobenzyl)4-(4-chlorophenyl)-2,2-dioxo-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[2,1-c][1,4]thiazine-1,3-dicarboxylate, C26H29Cl2NO6S, (I), and its isomorphous pair diethyl 1-(4-methylbenzyl)-4-(4-methylphenyl)-2,2-dioxo-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[2,1-c][1,4]thiazine-1,3-dicarboxylate, C28H35NO6S, (II), are described. The molecular aggregation patterns appear to be strikingly similar despite changes in the substituents, with a Cl atom in (I) being replaced by a methyl group in (II). Inspite of the chemical modifications, the structures of (I) and (I) are isomorphous, isostructural and found to obey the chlorine-methyl exchange rule. Both the structures feature C-H center dot center dot center dot O hydrogen bonding. However, a distinguishing feature between (I) and (II) is observed in the conformation of the pyrrole rings where the twist occurs on different C-N bonds. Hirshfeld analysis of both structures is presented and discussed.

Interested yet? This just the tip of the iceberg, You can reading other blog about 196597-78-1. Electric Literature of 196597-78-1.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. In a pantent, Epinephrine electrochemical sensor based on a carbon paste electrode modified with hydroquinone derivative and graphene oxide nano-sheets: Simultaneous determination of epinephrine, acetaminophen and dopamine. Recommanded Product: Ammonium dodecyl sulfate.

Epinephrine electrochemical sensor based on a carbon paste electrode modified with hydroquinone derivative and graphene oxide nano-sheets: Simultaneous determination of epinephrine, acetaminophen and dopamine

In this paper, an electrochemical sensor was constructed for determination of epinephrine based on carbon paste electrode (CPE) modified with graphene oxide (GO) and 2-(5-Ethyl-2,4-dihydroxyphenyl)-5,7-dimethy1-4H-pyrido[2,3-d][1,3]thiazine-4-one (EDDPT) as modifiers. The modified electrode was applied as an electrochentical sensor for oxidation of epinephrine (EP). Under the optimum conditions, the over potential of EP oxidation decreased about 279 mV at the modified CPE more than a non-modified CPE. Electrochemical behavior of EP was investigated on the fabricated electrode by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods, and some kinetic parameters of EP Were obtained, too. The linear range and the detection limit for EP were found to be 1.5-600.0 WM and 0.65 uM (based on 3 sum), respectively using the EDDPT/GO/CPE sensor and the differential pulse voltammetry (DPV) method. Also, the designed electrochemical sensor was applied to determine EP in the drug sample and simultaneous determination of epinephrine (EP), acetaminophen (AC) and dopamine (DA) in human serum solutions. (C) 2017 Elsevier Ltd. All rights reserved.

Recommanded Product: Ammonium dodecyl sulfate, If you would like any more information about the 2235-54-3, please don’t hesitate to get in touch, you can email us.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

As the most studied and widely used chiral ligands, C20H16N2O4 have been rapidly developed in recent decades due to their simple synthesis, easy modification, and the ability to achieve excellent results in multiple reactions. 7689-03-4, Name is Campathecin, belongs to thiazines compound, is a common compound. In a pantent, author is Haggam, Reda A., once mentioned the new application about 7689-03-4, HPLC of Formula: https://www.ambeed.com/products/7689-03-4.html.

An Efficient Route for Synthesis of a New Class of Quinazolines: Synthesis of Thiazino-, Thiadiazolo-, and Thiazolo- Quinazoline Derivatives

The addition of amino group of anthranilic acid to isothiocyanate 2 provided cinnamoyl thiourea derivative 3. The compound 3 underwent different types of cyclization depending on conditions. The quinazolinthione of type 5 was obtained by treatment with Na2CO3. Quinazolinthione 5 underwent a series of transformation and oxidation reactions to form a new class of quinazoline and thiazoloquinazoline derivatives. All the compounds were tested against antimicrobial and antitumor activity.

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 7689-03-4. HPLC of Formula: https://www.ambeed.com/products/7689-03-4.html.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

A couple of challenges comes to mind: improving temperature dependence of relative stabilities of polymorphs would help in identifying enantiotropic relationships. 5872-08-2, Name is (7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid, belongs to thiazines compound, is a common compound. In a pantent, author is Hamed, Eman O., once mentioned the new application about 5872-08-2, Product Details of 5872-08-2.

Cyclization of N-benzyl cyanoacetamide: Novel synthesis and biological activity of pyrrole, pyrimidine, and pyran derivatives

Heteroannulation of N-Benzyl cyanoacetamide 1 to a new series of heterocycles has been developed. Thus, reaction of 1 with different polarized pi systems afforded pyrrolo 4, pyridone 6, pyridine 8, and diazapene 10 derivatives, respectively. N-Benzyl cyanoacetamide that undergo condensation reaction with salicylaldehyde yielded pyran derivative 11. Nitrosation of 11 furnished condensed pyran 13. Compound 11 reacted with benzaldehyde, carbon disulfide (cyclizing agent), and ammonium thiocyanate to provide pyrane 17, thiazine 18, and thiourea 20 derivatives, respectively. Cinnamoyl isothiocyanate was reacted with compound 11 to produce non-isolable thiourea derivative 21. The newly synthesized compounds have been characterized by infrared (IR), proton nuclear magnetic resonance (H-1 NMR), and carbon nuclear magnetic resonance (C-13 NMR) spectral data. The compounds were then evaluated for antibacterial and anticancer activities.

Product Details of 5872-08-2, We very much hope you enjoy reading the articles and that you will join us to present your own research about 5872-08-2.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem