Month: January 2022

In 2020.0 ANAL CHEM published article about BISULFITE-FREE; TET PROTEINS; 5-FORMYLCYTOSINE; 5-HYDROXYMETHYLCYTOSINE; 5-METHYLCYTOSINE; DMTMM; THYMINE; AMINES in [Xie, Yalun; Wang, Yafen; He, Zhiyong; Yang, Wei; Fu, Boshi; Zou, Guangrong; Zhang, Xiong; Huang, Jinguo; Zhou, Xiang] Wuhan Univ, Coll Chem & Mol Sci, Inst Adv Studies, Key Lab Biomed Polymers,Minist Educ,Hubei Prov Ke, Wuhan 430072, Hubei, Peoples R China in 2020.0, Cited 34.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Recommanded Product: 56-17-7

5-Carboxylcytosine (5caC) plays a vital role in the dynamics of DNA demethylation, and sequencing of its sites will help us dig out more biological functions of 5caC. Herein, we present a novel chemical method to efficiently label 5caC distinguished from other bases in DNA. Combined with bisulfite sequencing, 5caC sites can be located at single-base resolution, and the efficiency of 5caC labeling is 92% based on the Sanger sequencing data. Furthermore, dot blot assays have confirmed that 5caC-containing DNA isolated from HeLa cells was successfully labeled using our method. We expect that our strategy can be further applied to selectively tagging other carboxyl-modified bases and mapping their sites in RNA.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2020.0 MAT SCI ENG C-MATER published article about PHOTOLUMINESCENCE SENSING PLATFORM; CYTOCHROME-C; INNER FILTER; ONE-POT; GRAPHENE; HEMOGLOBIN; CYTOTOXICITY; STABILITY; EVOLUTION; MYOGLOBIN in [Wu, Feng-Yi; Wei, Xian-Wen] Anhui Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Mol Solids, Anhui Lab Mol Based Mat,Minist Educ,Anhui Key Lab, Wuhu 241000, Peoples R China; [Wu, Feng-Yi; Wang, Dong-Mei; Li, Ming-Ling; Lu, Wen-Sheng; Xu, Xiao-Yong] Chaohu Univ, Sch Chem & Mat Engn, Inst Novel Funct Mat, Hefei 238000, Peoples R China; [Cheng, Yuan-Sheng] Anhui Univ Technol, Sch Chem & Chem Engn, Inst Mat Sci & Engn, Anhui Prov Key Lab Coal Clean Convers & High Valu, Maanshan 243002, Peoples R China; [Zhou, Xiu-Hong] Anhui Agr Univ, Biotechnol Ctr, Hefei 230036, Peoples R China in 2020.0, Cited 51.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Nitrogen-doped MoS2 quantum dots (N-MoS2 QDs) were synthesized via a facile hydrothermal approach, and exhibited high fluorescence quantum yield (QY, 14.9%), excellent photostability, biocompatibility and water solubility. A novel method with good selectivity and sensitivity was established to assay hematin using N-MoS2 QDs as a fluorescent probe based on inner filter effect (IFE). Fluorescent quenching of N-MoS2 QDs has a fine linear dependence with the concentration of hematin in the range of 0.5-15 mu mol/L and a limit of detection of 0.32 mu mol/L (S/N = 3). By the detection method, average concentration of hematin in real health human erythrocytes was measured as 22.5 +/- 3.9 mu mol/L. And, recoveries range varied from 94 to 108% through standard recovery experiment. The N-MoS2 QDs probe shows excellent photostability, low cytotoxicity and anti-interference ability for hematin assay, which may become a promising method for the test of hematin in human blood.

Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

HPLC of Formula: C4H14Cl2N2S2. Jiang, JT; Li, JB; Zhou, BY; Niu, CH; Wang, WD; Wu, WL; Liang, J in [Jiang, Junting; Li, Junbo; Zhou, Biyu; Niu, Chaohuang; Wang, Wendi; Liang, Ju] Henan Univ Sci & Technol, Sch Chem Engn & Pharmaceut, 263 Kaiyuan Rd, Luoyang 471023, Peoples R China; [Wu, Wenlan] Henan Univ Sci & Technol, Sch Med, 263 Kaiyuan Rd, Luoyang 471023, Peoples R China published Fabrication of Polymer Micelles with Zwitterionic Shell and Biodegradable Core for Reductively Responsive Release of Doxorubicin in 2019.0, Cited 44.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

To achieve a high stability in physiological environment and rapid intracellular drug release, a biodegradable zwitterionic triblock copolymer with a disulfide-linked poly-epsilon-caprolactone and polycarboxybetaine methacrylate (PCBMA-SS-PCL-SS-PCBMA) was prepared for micellar carrier to delivery doxorubicin (DOX) into tumor cells. PCBMA-SS-PCL-SS-PCBMA was obtained by following steps: i) introducing disulfide bonds through end-group modification of PCL diol with cystamine dihydrochloride; ii) preparing PCL-RAFT macromolecular chain transfer agent by EDC/NHS chemistry; iii) RAFT polymerization of zwitterionic monomer. Self-assembling from PCBMA-SS-PCL-SS-PCBMA, polymeric micelles had many advantages, such as ultra-low protein absorption in serum and obvious reduction-responsiveness in the presence of DTT. Furthermore, DOX-loaded micelles exhibited high stability upon centrifugation and lyophilization, a fast intracellular drug release and enhanced drug efficacy due to GSH-triggered PCBMA shell shedding and micellar reassembling. Thus, the polymeric micelles integrated several functions and properties could be prospectively utilized as valuable nanocarriers in cancer chemotherapeutics.

Welcome to talk about 56-17-7, If you have any questions, you can contact Jiang, JT; Li, JB; Zhou, BY; Niu, CH; Wang, WD; Wu, WL; Liang, J or send Email.. HPLC of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Hydrophilic domains compose of interlocking cation-? blocks for constructing hard actuator with robustness and rapid humidity responsiveness WOS:000641316100002 published article about PI INTERACTIONS; FLOW-CONTROL; TRANSPORT; MEMBRANES; HYDROGELS; DRIVEN; FIELD in [Li, Yicheng; Du, Mengqi; Yang, Li; Bao, Yunjia; Xu, Yewei; Chang, Guanjun] Southwest Univ Sci & Technol, State Key Lab Environm Friendly Energy Mat, Mianyang 621010, Sichuan, Peoples R China; [Li, Yicheng; Du, Mengqi; Yang, Li; Bao, Yunjia; Xu, Yewei; Chang, Guanjun] Southwest Univ Sci & Technol, Sch Mat Sci & Engn, Mianyang 621010, Sichuan, Peoples R China; [Li, Yicheng; Yin, Qiang] China Acad Engn Phys, Res Ctr Laser Fus, Mianyang 621900, Sichuan, Peoples R China; [Yang, Li; Chang, Guanjun] Univ Penn, Dept Chem & Biomol Engn, Philadelphia, PA 19104 USA; [Lan, Yang] UCL, Dept Chem Engn, Torrington Pl, London WC1E 7JE, England in 2021.0, Cited 55.0. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Biomimetic actuators have seemingly infinite potential for use in previously unexplored areas. However, large stresses and a rapid water response are difficult to realize in soft actuators, owing to which their practical applicability is currently limited. In this paper, a new method for designing and fabricating humidity-responsive sturdy hard actuator. By combining a rigid matrix and hydrophilic water domains consisting of dynamic interlocking cation-? blocks, high-performance polymer actuator was synthesized that swell rapidly in response to a water gradient in their environment, resulting in unprecedentedly large stresses. More critically, the strong interlocking cation-? blocks reform and the intermolecular distance is reduced when the water is removed, allowing the deformed actuator to revert its original shape. The proposed design principle can potentially be extended to produce different types of sturdy actuators with rapid water responsiveness.

Welcome to talk about 56-17-7, If you have any questions, you can contact Li, YC; Du, MQ; Yang, L; Bao, YJ; Xu, YW; Yin, Q; Lan, Y; Chang, GJ or send Email.. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Jha, MK; Grannemann, BD; Trombello, JM; Clark, EW; Eidelman, SL; Lawson, T; Greer, TL; Rush, AJ; Trivedi, MH in [Jha, Manish K.; Grannemann, Bruce D.; Trombello, Joseph M.; Clark, E. Will; Eidelman, Sara Levinson; Greer, Tracy L.; Trivedi, Madhukar H.] Univ Texas Southwestern Med Ctr Dallas, Ctr Depress Res & Clin Care, 5323 Harry Hines Blvd, Dallas, TX 75390 USA; [Jha, Manish K.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA; [Jha, Manish K.] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA; [Rush, A. John] Duke Natl Univ Singapore, Singapore, Singapore; [Rush, A. John] Duke Med Sch, Dept Psychiat, Durham, NC USA; [Rush, A. John] Texas Tech Univ, Hlth Sci Ctr, Permian Basin, TX USA published A Structured Approach to Detecting and Treating Depression in Primary Care: VitalSign6 Project in 2019.0, Cited 43.0. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

PURPOSE This report describes outcomes of an ongoing quality-improvement project (VitalSign6) in a large US metropolitan area to improve recognition, treatment, and outcomes of depressed patients in 16 primary care clinics (6 charity clinics, 6 federally qualified health care centers, 2 private clinics serving low-income populations, and 2 private clinics serving patients with either Medicare or private insurance). METHODS Inclusion in this retrospective analysis was restricted to the first 25,000 patients (aged >= 12 years) screened with the 2-item Patient Health Questionnaire (PHQ-2) in the aforementioned quality-improvement project. Further evaluations with self-reports and clinician assessments were recorded for those with positive screen (PHQ-2 >2). Data collected from August 2014 though November 2016 were available at 3 levels: (1) initial PHQ-2 (n = 25,000), (2) positive screen (n = 4,325), and (3) clinician-diagnosed depressive disorder with 18 or more weeks of enrollment (n = 2,160). RESULTS Overall, 17.3% (4,325/25,000) of patients screened positive for depression. Of positive screens, 56.1% (2,426/4,325) had clinician-diagnosed depressive disorder. Of those enrolled for 18 or more weeks, 64.8% were started on measurement-based pharmacotherapy and 8.9% referred externally. Of the 1,400 patients started on pharmacotherapy, 45.5%, 30.2%, 12.6%, and 11.6% had 0, 1, 2, and 3 or more follow-up visits, respectively. Remission rates were 20.3% (86/423), 31.6% (56/177), and 41.7% (68/163) for those with 1, 2, and 3 or more follow-up visits, respectively. Baseline characteristics associated with higher attrition were: non-white, positive drug-abuse screen, lower depression/anxiety symptom severity, and younger age. CONCLUSION Although remission rates are high in those with 3 or more followup visits after routine screening and treatment of depression, attrition from care is a significant issue adversely affecting outcomes.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Jha, MK; Grannemann, BD; Trombello, JM; Clark, EW; Eidelman, SL; Lawson, T; Greer, TL; Rush, AJ; Trivedi, MH or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2020.0 J CONTROL RELEASE published article about IRON-OXIDE NANOPARTICLES; MAGNETIC-RESONANCE; POLYMERIC MICELLES; ENHANCED PERMEABILITY; CONTRAST AGENTS; NANOPLATFORM; CHITOSAN; DESIGN in [Fu, Yan; Yang, Hong Yu] Jilin Inst Chem Technol, Coll Mat Sci & Engn, Jilin 132022, Jilin, Peoples R China; [Wang, Nannan] Jilin Inst Chem Technol, Coll Biol & Food Engn, Jilin 132022, Jilin, Peoples R China; [Li, Yi] Jiaxing Univ, Coll Mat & Text Engn, Jiaxing 314001, Zhejiang, Peoples R China; [Wu, Te Peng; Lee, Doo Sung] Sungkyunkwan Univ, Theranost Macromol Res Ctr, Suwon 16419, Gyeonggi Do, South Korea; [Wu, Te Peng; Lee, Doo Sung] Sungkyunkwan Univ, Sch Chem Engn, Suwon 16419, Gyeonggi Do, South Korea; [Jang, Moon-Sun; Lee, Jung Hee] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Radiol, Seoul 06351, South Korea; [Jang, Moon-Sun; Lee, Jung Hee] Samsung Biomed Res Inst, Ctr Mol & Cellular Imaging, Seoul 06351, South Korea in 2020.0, Cited 53.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Multifunctional nanosystems that can transport therapeutic and diagnostic agents into tumor sites and activate their respective functions via tumor-microenvironment recognition are highly desirable for clinical applications. We fabricated pH and redox dual-activatable self-assembled nanotheranostics (named as DA-SNs) via coordination-driven self-assembly of chlorin e6 (Ce6) disulfide-linked pH sensitive polymer ligand, poly (isobutylene-alt-maleic anhydride-graft-methoxy-poly (ethyleneglycol)-graft-imidazole-graft-Cystamine-Ce6) [PIMA-mPEG-API-SS-Ce6], and gadolinium ions (Gd3+). DA-SNs exhibited uniform particle size of similar to 48 nm, excellent stability, and inherent biosafety. Negatively charged DA-SNs could prolong blood circulation time (t(1/2) = 2.91 h) and improve tumor accumulation. Moreover, DA-SNs could undergo surface charge switch from negative charge to positive one in a slightly acidic tumor extracellular environment (pH 6.8), thus enhancing cellular uptake. After entering tumor cells, fluorescence, photodynamic therapeutic activity, and T1MR contrast from DA-SNs could be activated within this intracellular environment with lowered pH and high level of GSH. Importantly, human tumors implanted in mice could be successfully visualized via distinct pH and redox dual-sensitive T1MR contrast and fluorescence imaging, indicating that DA-SNs could serve as a dual-modal MR/fluorescence imaging probe for tumor-targeting diagnosis. In addition, DA-SNs exhibited superior photodynamic therapeutic efficiency with negligible side effects. Therefore, this DA-SN shows great promise for synergistic photodynamic therapy and diagnostic imaging.

Welcome to talk about 56-17-7, If you have any questions, you can contact Fu, Y; Jang, MS; Wang, NN; Li, Y; Wu, T; Lee, JH; Lee, DS; Yang, HY or send Email.. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Dual-responsive carboxymethyl cellulose/dopamine/cystamine hydrogels driven by dynamic metal-ligand and redox linkages for controllable release of agrochemical WOS:000596863400008 published article about PH; POLYMERS; YIELD; FILMS in [Guo, Tianyu; Wang, Wangxia; Song, Junlong; Jin, Yongcan] Nanjing Forestry Univ, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat F, Nanjing 210037, Peoples R China; [Wang, Wangxia] Yancheng Inst Technol, Sch Chem & Chem Engn, Yancheng 224001, Peoples R China; [Guo, Tianyu; Wang, Wangxia; Xiao, Huining] Univ New Brunswick, Dept Chem Engn, Fredericton, NB E3B 5A3, Canada in 2021.0, Cited 46.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Recommanded Product: 56-17-7

The utilization of agrochemicals in crop production is often inefficient due to lack of appropriate carriers, raising in the significant concerns of ecological environment and public health. To enhance the efficiency of agrochemical delivery, a novel cellulose-based hydrogel was constructed in this work by cross-linking dopamine (DA)-modified carboxymethyl cellulose (CMC) with cystamine (CYS) in the presence of Fe3+ ions. The hydrogels displayed reversible sol-gel transitions upon exposure to stimulation of changes in pH and redox, leading to the controllable release of model agrochemical (6-benzyladenine). Compared with single-triggered condition, the hydrogel doubled the cumulative release when co-triggered by pH and redox. The dynamic metal/catechol complexation and disulfide bonding coexist in the hydrogel networks, enabling occurrence of dynamic reaction under a variety of environmental conditions. The finite element method (FEM) was employed to simulate the hydrogel to provide a theoretical insight into the tested drug delivery. Benefitting from the reversibly cross linked networks and the excellent biodegradability of the hydrogels, we anticipate that this dual-responsive, polysaccharide-based hydrogel will offer diverse applications to reach the full potential in sustainable advancement of crop production.

Welcome to talk about 56-17-7, If you have any questions, you can contact Guo, TY; Wang, WX; Song, JL; Jin, YC; Xiao, HN or send Email.. Recommanded Product: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Supramolecular Valves Functionalized Rattle-Structured UCNPs@hm-SiO2 Nanoparticles with Controlled Drug Release Triggered by Quintuple Stimuli and Dual-Modality Imaging Functions: A Potential Theranostic Nanomedicine WOS:000496344800048 published article about MESOPOROUS SILICA NANOPARTICLES; UP-CONVERSION NANOPARTICLES; SYNERGISTIC THERAPY; DELIVERY; PLATFORM; CANCER; NANOPLATFORM; SYSTEMS; PH in [Zhou, Shuai; Ding, Chendi; Wang, Yang; Fu, Jiajun] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China; [Jiang, Wei] Nanjing Univ Sci & Technol, Natl Special Superfine Powder Engn Res Ctr, Nanjing 210094, Jiangsu, Peoples R China; [Fu, Jiajun] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China in 2019.0, Cited 52.0. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Integrating multimodality bioimaging and multiple stimuli-responsive controlled drug release properties into one single nanosystem for therapeutic application is highly desirable but still remains a challenge. Herein, we coated a hollow mesoporous silica shell on to upconversion nanoparticles (UCNPs) and conjugated pillarene-based supramolecular valves on to surface of UCNPs@hm-SiO2 using amine-coumarin phototriggers to obtain the multifunctional nanoparticles, UCNPs@hm-SiO2-Cou-Cys-DOX/WP[5]. Benefiting from the core shell structured UCNPs, the UCNPs@hm-SiO2-Cou-Cys-DOX/WP[5] can serve as efficient contrast agents for upconversion luminescence and T-1-weighted magnetic resonance imaging in vitro/in vivo. More importantly, depending on exquisitely designed supramolecular valves, UCNPs@hm-SiO2-Cou-Cys-DOX/WP[5] can realize zero-premature release under normal physiological conditions (pH 7.4), which produces minimal damage to normal tissue, whereas this nanosystem can respond to several disease-related signals, including acid (most cancers), alkali (metabolic alkalosis), and Zn2+ (Alzheimer’s disease), along with two external stimuli, including near-infrared (NIR) light and reductive electrical potential, via altering the spatial structure of pseudorotaxanes, disassembling the molecular stalks, or undergoing photochemical reactions, ultimately resulting in opening of the gatekeepers and release of encapsulated drugs. The multifunctional UCNP-based nanoparticles were endowed with such quintuple stimuli-responsive controlled release characteristics. Specifically, in anticancer application, the rational utilization of the two of them, acid and NIR light, could regulate the release amount and rate of DOX from UCNPs@hm-SiO2-Cou-Cys-DOX/WP[S], accelerate the accumulation of DOX in cell nuclei, and thereby promote the cancer cell apoptosis, indicating that the nanomaterials have promising application in cancer treatment. This study provides a novel design strategy for constructing multifunctional UCNP-based nanoparticles with multiple stimuli-responsive drug release features, which have great potential in diagnosis and therapy of relevant diseases as theranostic nanomedicines.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2020.0 BIOCONJUGATE CHEM published article about ALGINATE NANOGELS; DRUG-DELIVERY; TUMOR; SIZE; GLUTATHIONE; T-1; ACCUMULATION; PENETRATION; ASSEMBLIES; MICELLES in [Ma, Dan; Zhang, Jiulong; Peng, Chen; Shi, Xiangyang] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Canc Ctr, Shanghai 200072, Peoples R China; [Ma, Dan; Shi, Menghan; Li, Xin; Fan, Yu; Jiang, Tingting; Shi, Xiangyang] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China; [Sun, Kai] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA; [Peng, Chen] Ninghai First Hosp, Ningbo 315600, Peoples R China in 2020.0, Cited 44.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Computed Properties of C4H14Cl2N2S2

Development of novel activable dual-mode T-1/T-2-weighted magnetic resonance (MR) contrast agents with the same composition for dynamic precision imaging of tumors has been a challenging task. Here, we demonstrated a strategy to prepare clustered Fe3O4 nanoparticles (NPs) with redox-responsiveness to tumor microenvironment to achieve switchable T-2/T-1-weighted dual-mode MR imaging applications. In this study, we first synthesized ultrasmall Fe3O4 NPs with an average size of 3.3 nm and an r, relaxivity of 4.3 mM(-1) s(-1), and then cross-linked the single Fe3O4 NPs using cystamine dihydrochloride (Cys) to form clustered Fe3O4/Cys NPs. The Fe3O4 nanoclusters (NCs) possess desirable colloidal stability, cytocompatibility, high r(2) relaxivity (26.4 mM(-1) s(-1)), and improved cellular uptake efficiency. Importantly, with the redox-responsiveness of the disulfide bond of Cys, the Fe3O4 NCs can be dissociated to form single particles under a reducing condition, hence displaying a switchable T-2/T-1-weighted MR imaging property that can be utilized for dynamic precision imaging of cancer cells in vitro and a subcutaneous tumor model in vivo due to the reductive intracellular environment of cancer cells and the tumor microenvironment. With the tumor reductive microenvironment-mediated switching of T-2 to T-1 MR effect and the ultrasmall size of the single particles that can pass through the kidney filter, the developed Fe3O4 NCs may be used as a promising switchable T-2/T-1 dual-mode MR contrast agent for precision imaging of different biosystems.

Welcome to talk about 56-17-7, If you have any questions, you can contact Ma, D; Shi, MH; Li, X; Zhang, JL; Fan, Y; Sun, K; Jiang, TT; Peng, C; Shi, XY or send Email.. Computed Properties of C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2019.0 EUR J PHARM SCI published article about REDOX-RESPONSIVE MICELLES; MULTIDRUG-RESISTANCE; DELIVERY SYSTEM; CO-DELIVERY; TARGETING DELIVERY; IN-VITRO; PACLITAXEL; NANOPARTICLES; DOCETAXEL in [Hou, Lin; Tian, Chunyu; Chen, Dandan; Yuan, Yujie; Yan, Yingshan; Huang, Qianxiao; Zhang, Huijuan; Zhang, Zhenzhong] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou, Henan, Peoples R China; [Hou, Lin; Huang, Qianxiao; Zhang, Huijuan; Zhang, Zhenzhong] Key Lab Targeting Therapy & Diag Crit Dis, Zhengzhou, Henan, Peoples R China; [Hou, Lin; Huang, Qianxiao; Zhang, Huijuan; Zhang, Zhenzhong] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou, Henan, Peoples R China; [Tian, Chunyu; Chen, Dandan; Yuan, Yujie; Yan, Yingshan; Huang, Qianxiao] Zhengzhou Univ, Modern Anal & Comp Ctr, Zhengzhou, Henan, Peoples R China in 2019.0, Cited 29.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Multidrug resistance (MDR) is a major reason for anticancer chemotherapy failure, and P-glycoprotein (P-gp) over-expressing on tumor cells is considered as the important target to overcome MDR. Emerging reports have showed that vitamin E (VE) can cause significant reversal of MDR due to inhibition of ATPase activity. Accordingly, we synthesized hyaluronic acid (HA) conjugated vitamin E succinate (VES) polymer, which can self-assemble into micelles and thus achieve high drug (paclitaxel (PTX) used as model drug) encapsulation as well as tumor accumulation owing to the enhanced permeability and retention (EPR) effect and HA active targeting ability. In addition, the linker between HA and VES utilized in this work was disulfide bond with reduction-sensitive property, which would respond to high glutathione (GSH) concentration in tumor cytoplasmic environment and trigger HA-CYS-VES polymer disassociation and drug release. In vitro, PTX loaded HA-CYS-VES demonstrated enhanced cytotoxicity, high apoptosis-inducing activities and reversal effects of PTX on MCF-7/Adr cells, compared to PTX. Also, cellular uptake and intracellular PTX accumulation tests displayed that PTX loaded HA-CYS-VES could more efficiently enter tumor cells and selectively release drug in cytosol so as to facilitate its function on microtubule. More importantly, PTX loaded HA-CYS-VES showed better tumor targeting ability, improved antitumor efficacy and low adverse effects on tumor-bearing mice. In conclusion, PTX loaded HA-CYS-VES exhibited a great potential for reversing MDR in anticancer chemotherapeutics.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem