Day: November 16, 2021

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Zhang, XQ; Ren, XM; Tang, JY; Wang, JT; Zhang, X; He, P; Yao, C; Bian, WH; Sun, LZ in [Zhang, Xiaoqing; Ren, Xiaomei; Tang, Jiayin; Wang, Jiangtao; He, Peng; Yao, Chang; Bian, Weihe] Nanjing Univ Chinese Med, Jiangsu Prov Hosp TCM, Dept Mastopathy, Affiliated Hosp, Nanjing, Peoples R China; [Zhang, Xiang; Sun, Lizhu] Xuzhou Med Univ, Affiliated Shuyang Hosp, Dept Oncol, Suqian, Peoples R China published Hyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance in 2020.0, Cited 42.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Multidrug resistance (MDR) of cancer cells is a significant challenge in chemotherapy, highlighting the urgent medical need for simple and reproducible strategies to reverse this process. Here, we report the development of an active tumor-targeting and redox-responsive nanoplatform (PA-ss-NP) using hyaluronic acid-g-cystamine dihydrochloride-poly-epsilon-(benzyloxycarbonyl)-L-lysine (HA-ss-PLLZ) to co-deliver paclitaxel (PTX) and apatinib (APA) for effective reversal of MDR. This smart nanoplatform specifically bound to CD44 receptors, leading to selective accumulation at the tumor site and uptake by MCF-7/ADR cells. Under high concentrations of cellular glutathione (GSH), the nanocarrier was degraded rapidly with complete release of its encapsulated drugs. Released APA effectively inhibited the function of the P-glycoprotein (P-gp) drug pump and improved the sensitivity of MDR cells to chemotherapeutic agents, leading to the recovery of PTX chemosensitivity in MDR cells. As expected, this newly developed intelligent drug delivery system could effectively control MDR, both in vitro and in vivo.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Authors Yeh, CM; Lin, CH; Han, TY; Xiao, YT; Chen, YA; Chou, HH in ROYAL SOC CHEMISTRY published article about in [Yeh, Chun-Ming; Lin, Chun-Hsiu; Han, Tzung-You; Xiao, Yu-Ting; Chen, Yi-An; Chou, Ho-Hsiu] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 30013, Taiwan in 2021.0, Cited 62.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

For next-generation electronics, it is crucial to be able to accurately mimic the nature of human skin and develop skin-inspired materials and devices for electronic skin (e-skin) applications. However, it is a great challenge to design such a materials because they require the complex integration of stretchability, skin adhesiveness, transparency, healability, and tactile sensing. Herein, we present the first dual covalently reversible dynamic bond-based polymer that can be integrated with various functional materials and used as a skin-like sensor. A series of polymers was designed using polypropylene glycol (PPG)-based polyurethane (PU) as the polymer backbone, and these polymers could integrate two types of covalent reversible dynamic bonds, Diels-Alder and disulfide bonds, in one polymer for the first time. Based on our design, a polymer was created with the advantages of high stretchability, fast healing abilities (60 degrees C, 5 min), skin adhesion, recyclability, high transparency, and tactile sensing abilities. We provide an alternative strategy for the construction of skin-inspired multifunctional materials for e-skin applications.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Yeh, CM; Lin, CH; Han, TY; Xiao, YT; Chen, YA; Chou, HH or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Peng, N; Ding, X; Wang, ZY; Cheng, Y; Gong, ZW; Xu, XJ; Gao, XF; Cai, Q; Huang, SW; Liu, Y in [Peng, Na; Ding, Xiao; Cheng, Yang; Gong, Zhiwei; Xu, Xiangjiao; Gao, Xiaofang; Cai, Qun; Liu, Yi] Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Coal Convers & New Carbon Mat Hubei Prov, Wuhan 430081, Hubei, Peoples R China; [Wang, Ziyu; Huang, Shiwen; Liu, Yi] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China published Novel dual responsive alginate-based magnetic nanogels for onco-theranostics in 2019.0, Cited 39.0. SDS of cas: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

The aim of this work was to obtain a novel onco-theranostic system for early diagnosis and improved chemotherapeutic outcome. Hybrid nanogels with magnetic and dual responsive properties were fabricated by covalently attaching superparamagnetic iron oxide nanoparticles (SPIONs) with a disulfide-modified alginate derivative, while simultaneously encapsulating the anticancer drug doxorubicin. The resulting nanogels exhibited magnetic-targeted characteristics, high drug loading content, co-triggered release behavior, high toxicity to tumor cells, low side effects to normal cells, and magnetic resonance imaging (MRI) functions. These findings proved that the hybrid nanogels have great potential as novel tumor-targeting nano-theranostic agents for simultaneous MRI imaging and efficient anti-tumor treatment.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Computed Properties of C4H14Cl2N2S2. Recently I am researching about POLY(AMIDOAMINE)-FUNCTIONALIZED GRAPHENE OXIDE; PAMAM DENDRIMERS; DRUG CARRIERS; GENE DELIVERY; IN-VITRO; NANOPARTICLES; NANOCARRIERS; REDUCTION; BIOAVAILABILITY; ENCAPSULATION, Saw an article supported by the Iran National Science FoundationIran National Science Foundation (INSF) [96013146]. Published in WILEY in HOBOKEN ,Authors: Najafi, F; Salami-Kalajahi, M; Roghani-Mamaqani, H; Kahaie-Khosrowshahi, A. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Many of new chemical discovered in pharmaceutical industry are hydrophobic compounds. Various techniques have been used to overcome solubility problems of hydrophobic drugs in aqueous media. In the meantime, dendrimers have been considered for sustainability, nanoscale size, high carry capacity, tunable terminal functional groups in terms of drug delivery and solubility. In this work, we have synthesized poly(propylene imine) (PPI) dendrimer up to fifth generation using reduction of nitrile groups after Michael addition and also, polyamidoamine (PAMAM) dendrimer up to fourth generation using Michael addition and amidation reactions. fourth and fifth generations of PPI dendrimer and fourth and third generations of PAMAM dendrimer in different concentrations were used to evaluate the solubility of two hydrophobic drugs (tetracycline and dexamethasone). Furthermore, cytotoxicity of dendrimers and dendrimers/drugs hybrids was studied. The results showed that with increasing concentrations and also the generation of dendrimers, the solubility of these two hydrophobic drugs was increased. Cytotoxicity study through MTT assay against Osteoblast-like cell line (MG-63 cells) showed that dendrimers were relatively cytotoxic where adding dexamethasone caused higher cytotoxicity. However, tetracycline showed no significant effect on cytotoxicity whereas prevented cell proliferation.

Computed Properties of C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Chemistry very interesting. Saw the article Preparation of functionalized star polymer nanoparticles by RAFT polymerization and their application in positionally assembled enzymes for cascade reactions published in 2019.0. HPLC of Formula: C4H14Cl2N2S2, Reprint Addresses Cao, H; Tan, TW (corresponding author), Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

A well-defined functional star polymer nanoparticle was prepared using an “ arm first” approach via RAFT polymerization. In this work, N-adamantylacrylamide and N-succinimidyl acrylate were copolymerized with N-isopropylacrylamide sucessfully. The obtained diblock copolymer regarded as an “ arm” endowed the star polymer with multiple conjugate functions. By adjusting the amount of crosslinking agent, the size and polydispersity of the star polymer were controlled. With the star polymer as the scaffold, a sequential multi-enzyme system was constructed, where HRP was placed in the inner layer through covalent conjugation, and b-cyclodextrin-modified GOx was assembled in the outer layer through hostguest recognition. More interestingly, the activity of the enzyme modified by b-cyclodextrin was improved. In addition to the enhanced thermal stability, this multienzyme system also exhibited a reduced Km value (from 2.18 mM to 0.39 mM) and an excellent substrate affinity. The specificity constant (Kcat/Km) for GOx in the star polymer@ HRP@ GOx system was 1.7-fold higher than that of the free HRP with free GOx system. This strategy will promote the development of biocatalysis reactions and biosensors as a promising method.

HPLC of Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. I found the field of Biotechnology & Applied Microbiology; Chemistry; Engineering very interesting. Saw the article Catalytic activity of surface-functionalized nanoscale nickel zinc multiferrites: potential vector for water purification published in 2020.0, Reprint Addresses Kar, KK (corresponding author), Indian Inst Technol, Dept Mech Engn, Adv Nanoengn Mat Lab, Kanpur, Uttar Pradesh, India.; Kar, KK (corresponding author), Indian Inst Technol, Mat Sci Program, Kanpur, Uttar Pradesh, India.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

BACKGROUND Decontamination of water by means of photocatalysis is seen as a sustainable solution. However, catalysts with low recovery from liquid suspension remain the main predicament that obstructs their industrial applications. To overcome this shortcoming, a methodology is reported here for the functionalization of nanospinel nickel zinc ferrite by cystamine ligand to develop Ni0.5Zn0.5Fe2O4@cystamine magnetic recyclable catalyst for water decontamination applications. RESULTS The diffraction patterns of bare and functionalized nanoferrites indicated that the cubic inverse spinel structure of the particles was not changed after cystamine functionalization. X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy analyses confirmed the chemical bonding between cystamine and spinel ferrites. The spherical morphology and elemental composition were studied through high-resolution transmission electron spectroscopy (HRTEM) images and energy-dispersive X-ray (EDX) analysis respectively. Deeper understanding of the catalyst’s optical behavior and calculation of the energy band gap were achieved by means of photoluminescence spectroscopy. Magnetic saturation values were calculated from vibrating sample magnetometer (VSM) analysis, and almost negligible change was found. A possible photocatalytic mechanism for the removal of organic dye is proposed. CONCLUSION The present findings imply that the presence of amine groups on the catalyst surface, good dispersibility stability and outstanding catalytic activity make functionalized nanoferrite a suitable candidate for industrial wastewater treatment. Easy synthesis, easy work-up and short reaction times are some of the advantages of the methodology. (c) 2019 Society of Chemical Industry

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Tanwar, R; Kumari, R; Mandal, UK; Kar, KK or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Product Details of 56-17-7. In 2020.0 MACROMOLECULES published article about ELASTIC-MODULI; THIN; FILMS; METROLOGY; WRINKLES; STRESS; CAST in [Thompson, Brittany J.; Logan, Phillip K.; Stafford, Christopher M.] NIST, Mat Sci & Engn Div, Gaithersburg, MD 20899 USA; [Reese, Cassandra M.; Guo, Wei; Thompson, Brittany J.; Logan, Phillip K.; Patton, Derek L.] Univ Southern Mississippi, Sch Polymer Sci & Engn, Hattiesburg, MS 39406 USA in 2020.0, Cited 41.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

A compressive strain applied to bilayer films (e.g., a thin film adhered to a thick substrate) can lead to buckled or wrinkled morphologies, which has many important applications in stretchable electronics, anticounterfeit technology, and high-precision micrometrology and nano-metrology. A number of buckling-based metrology methods have been developed to quantify the residual stress and viscoelastic properties of polymer thin films. However, in some systems (e.g., solvent-induced swelling or thermal strain), the compressive strain is unknown or difficult to measure. We present a quantitative method of measuring the compressive strain of wrinkled polymer films and coatings with knowledge of the skin thickness, wrinkle wavelength, and wrinkle amplitude. The derived analytical expression is validated with a well-studied model system, e.g., a stiff, thin film bonded to a thick, compliant substrate. After validation, we use our expression to quantify the applied swelling strain of previously reported wrinkled poly(styrene-alt-maleic anhydride) brush surfaces. Finally, the applied strain is used to rationalize the observed persistence length of aligned wrinkles created during atomic force microscopy lithography and subsequent solvent exposure.

Welcome to talk about 56-17-7, If you have any questions, you can contact Reese, CM; Guo, W; Thompson, BJ; Logan, PK; Stafford, CM; Patton, DL or send Email.. Product Details of 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2019.0 CARBOHYD POLYM published article about LOW-DENSITY-LIPOPROTEIN; CO-DELIVERY; MIXED MICELLES; POLYMERIC NANOPARTICLES; TARGETED DELIVERY; TUMOR-CELLS; IN-VITRO; PACLITAXEL; REDUCTION; PH in [Luo, Tingting; Han, Jingtian; Zhao, Feng; Pan, Xiaohong; Tian, Baocheng; Ding, Xiujuan; Zhang, Jing] Binzhou Med Univ, Sch Pharm, 346 Guanhai Rd, Yantai 264003, Peoples R China in 2019.0, Cited 44.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Category: thiazines

Novel chitosan-cystamine-retinoic acid conjugate (CS-SS-RA) was synthesized and could self-assemble into redox-sensitive micelles in aqueous environment with low critical micelle concentration value. CS-SS-RA micelles were characterized with spherical shape, desirable particle size, negative zeta potential, high paclitaxel (PTX) loading and encapsulation efficiency and redox-sensitivity. Hemolysis and cytotoxicity studies proved the safety of CS-SS-RA micelles for intravenous administration. Cytotoxicity study against HepG2 cells and the growth inhibition study on three-dimensional multicellular tumor spheroids (MCTSs) revealed that PTX-loaded CS-SS-RA micelles exhibited higher antitumor activity than free PTX. The in vitro cellular uptake profiles of FITC-labeled CS-SS-RA micelles evaluated via confocal laser scanning microscopy and flow cytometry indicated that CS-SS-RA micelles could enhance cellular uptake efficiency of PTX, and their internalization by HepG2 cells were mediated by clathrin-mediated endocytosis and macropinocytosis. These results demonstrated that CS-SS-RA micelles could be developed as a promising platform for intracellular delivery of hydrophobic antitumor agents.

Category: thiazines. Welcome to talk about 56-17-7, If you have any questions, you can contact Luo, TT; Han, JT; Zhao, F; Pan, XH; Tian, BC; Ding, XJ; Zhang, J or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Interfacial Liquid-Liquid Phase Separation-Driven Polymerization-Induced Electrostatic Self-Assembly WOS:000665741600027 published article about VISIBLE-LIGHT; COMPLEX COACERVATION; RAFT POLYMERIZATION; COPOLYMER VESICLES; NANOPARTICLES; MONOMERS; SEQUENCE; WATER in [Wang, Ye; Li, Chao; Ma, Lei; Wang, Xiyu; Wang, Kai; Lu, Xinhua; Cai, Yuanli] Soochow Univ, Coll Chem Chem Engn & Mat Sci, State Local Joint Engn Lab Novel Funct Polymer Ma, Suzhou 215123, Peoples R China in 2021.0, Cited 54.0. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Development of spatially restricted liquid-liquid phase separation (LLPS) systems emulating biomolecular condensates is a major challenge in coacervating materials science, due to lack of approaches for spatially restricted coacervation of sequence-defined zwitterionic segments resembling intrinsically disordered proteins. Herein, we present interfacial LLPS-driven polymerization-induced electrostatic self-assembly, namely, interfacial LLPS-PIESA. The asymmetric charge sequence patterning of zwitterionic growing segments is achieved via spontaneous polymerization of ion-pair monomers within a nanopartide core-shell interface. We show that charge sequence can profoundly affect the self-coacervation, leading to droplet dispersions, dense coacervates, and free-standing hydrogels. Moreover, the interfacial LLPS-PIESA shows a programmed hierarchical condensation self-assembly mechanism involving vesicles-to-lamellae transition, interfacial self-coacervation, lamellae-to-sheets transition, layer-by-layer sheet self-assembly, spatially restricted condensation and agglomeration, and redispersing into fibril network condensates under dynamic evolving surface charge regulation. The spatially restricted asymmetric charge sequence patterning, interfacial self-coacervation, and programmed hierarchical condensation self-assembly, all these elements can serve as the primary principles for the asymmetric charge sequence patterning design of hierarchically nanostructured condensates that emulate cellular biomolecular condensates.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, Y; Li, C; Ma, L; Wang, XY; Wang, K; Lu, XH; Cai, YL or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 56-17-7. In 2020.0 THERANOSTICS published article about CYANINE DYES; IN-VIVO; PHOTODYNAMIC THERAPY; CANCER; NANOPARTICLES; RELEASE; NANOMEDICINE; CHEMOTHERAPY; DOXORUBICIN; METASTASES in [Mo, Shanyan; Zhang, Xiaoting; Hameed, Sadaf; Zhou, Yiming; Dai, Zhifei] Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China; [Mo, Shanyan] Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China in 2020.0, Cited 58.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Near-infrared (NIR) fluorescence imaging has been proved as an effective modality in identifying the tumor border and distinguishing the tumor cells from healthy tissue during the oncological surgery. Developing NIR fluorescent probes with high tumor to background (T/B) signal is essential for the complete debulking of the tumor, which will prolong the survival rate of tumor patients. However, the nonspecific binding and always-on properties of the conventional fluorescent probes leads to high background signals and poor specificity. Method: To address this problem, glutathione (GSH)-responsive, two disulfide-bonded dicyanine dyes (ss-diCy5 and ss-diNH800CW) were synthesized. As synthesized dyes are quenched under normal physiological conditions, however, once reached to the tumor site, these dyes are capable of emitting strong fluorescence signals primarily because of the cleavage of the disulfide bond in the tumor microenvironment with high GSH concentration. Besides, the GSH-responsive behavior of these dyes was monitored using the UV-vis and fluorescence spectroscopy. The diagnostic accuracy of the aforementioned dyes was also tested both in tumor cells and 4T1-bearing mice. Results: The fluorescence signal intensity of disulfide dicyanine dyes was quenched up to 89% compared to the mono cyanine dyes, thus providing a very low fluorescence background. However, when the disulfide dicyanine dye reaches the tumor site, the dicyanine is cleaved by GSH into two mono-dyes with high fluorescence strength, thus producing strong fluorescent signals upon excitation. The fluorescent signal of the dicyanine was enhanced by up to 27-fold after interacting with the GSH solution. In vivo xenografts tumor studies further revealed that the fluorescence signals of aforementioned dyes can be quickly recovered in the solid tumor. Conclusion: In summary, the disulfide dicyanines dyes can provide a promising platform for specific tumor-activatable fluorescence imaging with improved T/B value.

Recommanded Product: 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem