Day: November 3, 2021

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Self-assembled nanoparticles of reduction-sensitive poly (lactic-co-glycolic acid)-conjugated chondroitin sulfate A for doxorubicin delivery: preparation, characterization and evaluation published in 2019.0. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Ren, J; Yu, JM (corresponding author), Jiujiang Univ, Sch Pharm & Life Sci, 320 Xunyang East Rd, Jiujiang 332000, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

In this study, reduction-sensitive self-assembled polymer nanoparticles based on poly (lactic-co-glycolic acid) (PLGA) and chondroitin sulfate A (CSA) were developed and characterized. PLGA was conjugated with CSA via a disulfide linkage (PLGA-ss-CSA). The critical micelle concentration (CMC) of PLGA-ss-CSA conjugate is 3.5 mu g/mL. The anticancer drug doxorubicin (DOX) was chosen as a model drug, and was effectively encapsulated into the nanoparticles (PLGA-ss-CSA/DOX) with high loading efficiency of 15.1%. The cumulative release of DOX from reduction-sensitive nanoparticles was only 34.8% over 96h in phosphate buffered saline (PBS, pH 7.4). However, in the presence of 20mM glutathione-containing PBS environment, DOX release was notably accelerated and almost complete from the reduction-sensitive nanoparticles up to 96h. Moreover, efficient intracellular DOX release of PLGA-ss-CSA/DOX nanoparticles was confirmed by CLSM assay in A549 cells. In vitro cytotoxicity study showed that the half inhibitory concentrations of PLGA-ss-CSA/DOX nanoparticles and free DOX against A549 cells were 1.141 and 1.825 mu g/mL, respectively. Therefore, PLGA-ss-CSA/DOX nanoparticles enhanced the cytotoxicity of DOX in vitro. These results suggested that PLGA-ss-CSA nanoparticles could be a promising carrier for drug delivery.

Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, XF; Ren, J; He, HQ; Liang, L; Xie, X; Li, ZX; Zhao, JG; Yu, JM or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Computed Properties of C4H14Cl2N2S2. I found the field of Polymer Science very interesting. Saw the article Redox-Responsive Heparin-Chlorambucil Conjugate Polymeric Prodrug for Improved Anti-Tumor Activity published in 2020.0, Reprint Addresses Tsai, HC (corresponding author), Natl Taiwan Univ Sci & Technol, Grad Inst Appl Sci & Technol, Taipei 106, Taiwan.; Tsai, HC (corresponding author), Natl Taiwan Univ Sci & Technol, Adv Membrane Mat Ctr, Taipei 106, Taiwan.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Polymeric prodrug-based delivery systems have been extensively studied to find a better solution for the limitations of a single drug and to improve the therapeutic and pharmacodynamics properties of chemotherapeutic agents, which can lead to efficient therapy. In this study, redox-responsive disulfide bond-containing amphiphilic heparin-chlorambucil conjugated polymeric prodrugs were designed and synthesized to enhance anti-tumor activities of chlorambucil. The conjugated prodrug could be self-assembled to form spherical vesicles with 61.33% chlorambucil grafting efficiency. The cell viability test results showed that the prodrug was biocompatible with normal cells (HaCaT) and that it selectively killed tumor cells (HeLa cells). The uptake of prodrugs by HeLa cells increased with time. Therefore, the designed prodrugs can be a better alternative as delivery vehicles for the chlorambucil controlled release in cancer cells.

Computed Properties of C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Andrgie, AT; Birhan, YS; Mekonnen, TW; Hanurry, EY; Darge, HF; Lee, RH; Chou, HY; Tsai, HC or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Luo, TT; Han, JT; Zhao, F; Pan, XH; Tian, BC; Ding, XJ; Zhang, J in [Luo, Tingting; Han, Jingtian; Zhao, Feng; Pan, Xiaohong; Tian, Baocheng; Ding, Xiujuan; Zhang, Jing] Binzhou Med Univ, Sch Pharm, 346 Guanhai Rd, Yantai 264003, Peoples R China published Redox-sensitive micelles based on retinoic acid modified chitosan conjugate for intracellular drug delivery and smart drug release in cancer therapy in 2019.0, Cited 44.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Novel chitosan-cystamine-retinoic acid conjugate (CS-SS-RA) was synthesized and could self-assemble into redox-sensitive micelles in aqueous environment with low critical micelle concentration value. CS-SS-RA micelles were characterized with spherical shape, desirable particle size, negative zeta potential, high paclitaxel (PTX) loading and encapsulation efficiency and redox-sensitivity. Hemolysis and cytotoxicity studies proved the safety of CS-SS-RA micelles for intravenous administration. Cytotoxicity study against HepG2 cells and the growth inhibition study on three-dimensional multicellular tumor spheroids (MCTSs) revealed that PTX-loaded CS-SS-RA micelles exhibited higher antitumor activity than free PTX. The in vitro cellular uptake profiles of FITC-labeled CS-SS-RA micelles evaluated via confocal laser scanning microscopy and flow cytometry indicated that CS-SS-RA micelles could enhance cellular uptake efficiency of PTX, and their internalization by HepG2 cells were mediated by clathrin-mediated endocytosis and macropinocytosis. These results demonstrated that CS-SS-RA micelles could be developed as a promising platform for intracellular delivery of hydrophobic antitumor agents.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Luo, TT; Han, JT; Zhao, F; Pan, XH; Tian, BC; Ding, XJ; Zhang, J or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Modular core-shell polymeric nanoparticles mimicking viral structures for vaccination WOS:000454022400005 published article about END GROUP REMOVAL; DENDRITIC CELLS; DELIVERY-SYSTEMS; OVALBUMIN; NANOGELS; ANTIGENS; SIZE; PH; IMMUNOGENICITY; IMMUNOTHERAPY in [Lou, Bo; Boonstra, Eger; Li, Dandan; Mastrobattista, Enrico; Hennink, Wim E.] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3584 CG Utrecht, Netherlands; [De Beuckelaer, Ans; De Koker, Stefaan] Univ Ghent, Dept Biomed Mol Biol, Lab Mol Immunol, B-9052 Zwijnaarde, Belgium; [De Geest, Bruno G.] Univ Ghent, Dept Pharmaceut, B-9000 Ghent, Belgium in 2019.0, Cited 63.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Product Details of 56-17-7

Recent advances in the development of protein-based vaccines have expanded the opportunities for preventing and treating both infectious diseases as well as cancer. However, the development of readily and efficient antigen delivery systems capable of stimulating strong cytotoxic T-lymphocyte (CTL) responses remains a challenge. With the attempt to closely mimic the properties of viruses in terms of their size and molecular organization, we constructed RNA (which is a ligand for Toll-like receptor 7 (TLR7) and TLR8) and antigen-loaded nanoparticles resembling the structural organization of viruses. Cationic polymers containing either azide or bicyclo[6.1.0]nonyne (BCN) groups were synthesized as electrostatic glue that binds negatively charged single stranded RNA (PolyU) to form a self-crosslinked polyplex core. An azide-modified model antigen (ovalbumin, OVA) and a BCN-modified mannosylated or galactosylated polymer were sequentially conjugated to the RNA core via disulfide bonds using copper free click chemistry to form the shell of the polyplexes. The generated reducible virus mimicking particles (VMPs) with a diameter of 200 nm and negatively surface charge (-14 mV) were colloidally stable in physiological conditions. The immunogenicity of these VMP vaccines was evaluated both in vitro and in vivo. The surface mannosylated VMPs (VMP-Man) showed 5 times higher cellular uptake by bone marrow derived DCs (BMDCs) compared to galactosylated VMP (VMP-Gal) counterpart. Moreover, VMP-Man efficiently activated DCs and greatly facilitated MHC I Ag presentation in vitro. Vaccination of mice with VMP-Man elicited strong OVA-specific CTL responses as well as humoral immune responses. These results demonstrate that the modular core-shell polymeric nanoparticles described in this paper are superior in inducing strong and durable immune responses compared to adjuvanted protein subunit vaccines and offer therefore a flexible platform for personalized vaccines.

Product Details of 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Lou, B; De Beuckelaer, A; Boonstra, E; Li, DD; De Geest, BG; De Koker, S; Mastrobattista, E; Hennink, WE or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Siirila, J; Karesoja, M; Pulkkinen, P; Malho, JM; Tenhu, H in [Siirila, Joonas; Karesoja, Mikko; Pulkkinen, Petri; Tenhu, Heikki] Univ Helsinki, Dept Chem, PB 55, FIN-00014 Helsinki, Finland; [Malho, Jani-Markus] Aalto Univ, Dept Appl Phys, FI-00076 Espoo, Finland published Soft poly(N-vinylcaprolactam) nanogels surface-decorated with AuNPs. Response to temperature, light, and RF-field in 2019.0, Cited 64.0. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Soft poly(N-vinylcaprolactam) (PNVCL) based nanogels were prepared and surface-decorated with gold nanoparticles (AuNPs). The applicability of the hybrid nanogels (PNVCL-AuNPs) as carriers for low molar mass substances was of special interest. AuNPs protected with a mixture of 11-azidoundecanothiol and 11-mercaptoundecanoic acid were bound to propargyl functionalized PNVCL based nanogels. Acidic groups on the surfaces of AuNPs and PNVCL based nanogels stabilize the particle dispersions against precipitation above the phase transition temperature of PNVCL. Both the neat PNVCL nanogels and the PVCL-AuNPs shrink upon heating the dispersions. Even though the AuNPs are mainly located in the soft surface layer of the nanogels, the PNVCL-AuNPs respond to visible light as well as to radio-frequency (RF) irradiation by shrinking due to the AuNPs acting as nanoheaters. Interactions of linear PNVCL, PNVCL nanogels and PNVCL-AuNPs with two fluorescent probes were studied as function of increasing temperature. Once bound to the polymer the fluorescent probe may or may not be released from it, depending on its polarity and water solubility. Presence of AuNPs changed the release behavior of the water soluble charged fluorescent probe from the nanogels.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Siirila, J; Karesoja, M; Pulkkinen, P; Malho, JM; Tenhu, H or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Engineering; Materials Science very interesting. Saw the article A comparative study on solubility improvement of tetracycline and dexamethasone by poly(propylene imine) and polyamidoamine dendrimers: An insight into cytotoxicity and cell proliferation published in 2020.0. Category: thiazines, Reprint Addresses Salami-Kalajahi, M; Roghani-Mamaqani, H (corresponding author), Sahand Univ Technol, Fac Polymer Engn, POB 51335-1996, Tabriz, Iran.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Many of new chemical discovered in pharmaceutical industry are hydrophobic compounds. Various techniques have been used to overcome solubility problems of hydrophobic drugs in aqueous media. In the meantime, dendrimers have been considered for sustainability, nanoscale size, high carry capacity, tunable terminal functional groups in terms of drug delivery and solubility. In this work, we have synthesized poly(propylene imine) (PPI) dendrimer up to fifth generation using reduction of nitrile groups after Michael addition and also, polyamidoamine (PAMAM) dendrimer up to fourth generation using Michael addition and amidation reactions. fourth and fifth generations of PPI dendrimer and fourth and third generations of PAMAM dendrimer in different concentrations were used to evaluate the solubility of two hydrophobic drugs (tetracycline and dexamethasone). Furthermore, cytotoxicity of dendrimers and dendrimers/drugs hybrids was studied. The results showed that with increasing concentrations and also the generation of dendrimers, the solubility of these two hydrophobic drugs was increased. Cytotoxicity study through MTT assay against Osteoblast-like cell line (MG-63 cells) showed that dendrimers were relatively cytotoxic where adding dexamethasone caused higher cytotoxicity. However, tetracycline showed no significant effect on cytotoxicity whereas prevented cell proliferation.

Category: thiazines. Welcome to talk about 56-17-7, If you have any questions, you can contact Najafi, F; Salami-Kalajahi, M; Roghani-Mamaqani, H; Kahaie-Khosrowshahi, A or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Zeng, XJ; Yang, KQ; Huang, CY; Yang, K; Xu, SP; Wang, L; Pi, PH; Wen, XF in [Zeng, Xinjuan; Yang, Kangquan; Yang, Kai; Xu, Shouping; Pi, Pihui; Wen, Xiufang] South China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China; [Wang, Li] Minist Environm Protect PRC, South China Inst Environm Sci, Guangzhou 510655, Guangdong, Peoples R China; [Huang, Chaoyun] MEP, Nucl & Radiat Safety Ctr, Beijing 100082, Peoples R China published Novel pH-Responsive Smart Fabric: From Switchable Wettability to Controllable On-Demand Oil/Water Separation in 2019.0, Cited 35.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Stimulus-responsive materials have great potential in advanced controllable oil/water separation applications. Here, a novel, cost-effective, and green approach is developed to produce a pH-responsive smart fabric with switchable wettability. The approach first involves grafting polydopamine (PDA) and cystamine dihydrochloride (cystamine) on a fabric surface to obtain thiol-functionalized fabric (Fabric-SH). Hydrophobic stearyl methacrylate (SMA) and pH-responsive undecylenic acid are then decorated on the Fabric-SH surface through efficient and green photoinduced thiol-ene click coupling chemistry. The obtained fabric exhibits rapidly switchable wettability between superhydrophobicity and superhydrophilicity depending on the contacting liquid pH value and can be applied in controllable separation of various mixtures of water and oil with high efficiency up to 99%. More importantly, the as prepared fabric is able to realize the separation of oil/water/oil ternary mixtures and can self-clean and repel oil fouling during the separation process. Its superhydrophobicity is robust, showing no significant change after a 500 cycle peeling test. This novel and cost-effective smart cotton fabric exhibits significant potential in satisfying different separation purposes under complicated conditions.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Zeng, XJ; Yang, KQ; Huang, CY; Yang, K; Xu, SP; Wang, L; Pi, PH; Wen, XF or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Chen, JJ; Wu, M; Veroniaina, H; Mukhopadhyay, S; Li, JQ; Wu, ZH; Wu, ZH; Qi, XL in [Chen, Jiaojiao; Wu, Ming; Veroniaina, Hanitrarimalala; Mukhopadhyay, Subhankar; Li, Juequan; Wu, Zhenghong; Qi, Xiaole] China Pharmaceut Univ, Key Lab Modern Chinese Med, Nanjing 21000, Jiangsu, Peoples R China; [Chen, Jiaojiao] Yantai Yuhuangding Hosp, Yantai 264000, Peoples R China; [Wu, Ziheng] Monash Univ, Parkville Campus, Parkville, Vic 3052, Australia published Poly(N-isopropylacrylamide) derived nanogels demonstrated thermosensitive self-assembly and GSH-triggered drug release for efficient tumor Therapy in 2019.0, Cited 31.0. SDS of cas: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Recently, interest in stimuli-responsive core-shell nanogels as drug delivery systems for tumor therapy has increased. Here, a temperature-activated drug locking and glutathione-triggered drug unlocking nanogel is designed, which is composed of hyaluronic acid (HA) conjugated with poly(N-isopropylacrylamide) (PNIPAAm) using a disulfide bond as the linker (HA-SS-PNIPAAm, H-SS-P). After injection into the systemic circulation, these synthetic copolymers endure temperature-motivated lock behaviors to form nanogels due to the thermosensitive lipophilic transformation of PNIPAAm, accompanied by doxorubicin (DOX) locking into the cavities of the nanogels. When they reach tumor cells, these nanogels exhibit glutathione (GSH)-triggered opening behavior to unlock the drugs for tumor therapy. The transmission electron microscopy (TEM) results demonstrate that the H-SS-P copolymer solutions are irregular at room temperature, while spherical structures (similar to 30 nm) can be observed below 37 degrees C, but dissociate in the presence of 40 mM GSH. Based on flow cytometry and fluorescence microscopy analyses, observations reveal that H-SS-P@DOX nanogels are intracellularly taken up into human lung cancer cells (A549) via HA-receptor mediated endocytosis. More importantly, these nanogels possess much higher tumor targeting capacity than free DOX and efficiently enhance the antitumor effect with reduced systemic toxicity in 4T1 tumor-bearing mice.

SDS of cas: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Chen, JJ; Wu, M; Veroniaina, H; Mukhopadhyay, S; Li, JQ; Wu, ZH; Wu, ZH; Qi, XL or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about TUMOR MICROENVIRONMENT; FLUORESCENT-PROBE; NANOPARTICLES; ACTIVATION; SOFT, Saw an article supported by the National Funds for Distinguished Young Scientists [51725202]; Key Project of Shanghai Science and Technology CommissionScience & Technology Commission of Shanghai Municipality (STCSM) [19JC1412000]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51872094, 81974274]; National Science Foundation for the Young Scientists of China [51702211, 21805090]; National Key R&D Program of China [2018YFA0107900]; Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong. Recommanded Product: 56-17-7. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Wang, K; Zhang, HL; Shen, AJ; Zhao, PR; Meng, XF; Chen, XY; Liu, Y; Liu, YY; Gong, T; Wu, WL; Fang, XM; Wang, PJ; Bu, WB. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Glutathione (GSH) plays a vital role in maintaining biological redox homeostasis. Accordingly, accurate imaging of glutathione in vivo is of great significance. Herein, we propose a magnetic resonance energy transfer (MRET) strategy based on a distance-dependent magnetic exchange coupling effect (MECE), which can realize GSH detection within tumors in vivo by susceptibility weighted imaging (SWI). Fe3O4 nanoparticles (NPs) and CoFe2O4 NPs linked with cystamine (Fe3O4-S-S-CoFe2O4) have been successfully designed as SWI nanoprobes. After the disulfide bonds are broken by excess GSH in the tumor, the increase in the distance between Fe3O4 NPs and CoFe2O4 NPs will induce a decrease of MECE and magnetic susceptibility. As a result, the changes in the SWI signals are used for tumor GSH detection in vivo. Experimental results in vitro and in vivo demonstrate that the Fe3O4-S-S-CoFe2O4 SWI nanoprobe can sensitively detect concentrations of GSH in tumors. Hence, this strategy not only improves the sensitivity of the GSH response in SWI but also provides a powerful basis for the design of other responsive functional MRI nanoprobes.

Recommanded Product: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, K; Zhang, HL; Shen, AJ; Zhao, PR; Meng, XF; Chen, XY; Liu, Y; Liu, YY; Gong, T; Wu, WL; Fang, XM; Wang, PJ; Bu, WB or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Wang, J; Fei, GX; Pan, YQ; Zhang, KY; Hao, S; Zheng, Z; Xia, HS in [Wang, Jian; Fei, Guoxia; Pan, Yunqi; Zhang, Kaiye; Hao, Shuai; Zheng, Zhuo; Xia, Hesheng] Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat Engn, Chengdu 610065, Sichuan, Peoples R China published Simultaneous reduction and surface functionalization of graphene oxide by cystamine dihydrochloride for rubber composites in 2019.0, Cited 59.0. Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

The simultaneous reduction and functionalization of graphene oxide (GO) was achieved through a chemical grafting reaction with cystamine dihydrochloride (CDHC), a novel functional agent with dynamic disulfide bond. CDHC-reduced GO (CGO) can be uniformly and stably dispersed in the aqueous phase. Furthermore, CGO reinforced styrene-butadiene rubber (SBR) composites with highly filled silica content were prepared by a latex mixing and coagulation process. TEM confirmed both CGO and silica can be uniformly dispersed in the rubber matrix. The dynamic disulfide bonds of the grafted CDHC in the CGO can participate in the subsequent vulcanization of SBR rubber through disulfide exchange reactions, thereby forming a tight interaction between GO and rubber. Compared with normally reduced GO system, the mechanical and thermal properties of CGOcontaining rubber nanocomposites were significantly improved. The results show that CGO is effective to reinforce rubber composites, which has the potential to be used for tire rubber materials.

Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, J; Fei, GX; Pan, YQ; Zhang, KY; Hao, S; Zheng, Z; Xia, HS or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem