Day: November 1, 2021

An article Biomimetic glycosaminoglycan-based scaffolds improve skeletal muscle regeneration in a Murine volumetric muscle loss model WOS:000616630300024 published article about TISSUE; CELL; CLUSTERS; SULFATE; FIBERS; LEADS in [Narayanan, Naagarajan; Kuang, Liangju; Lengemann, Paul; Deng, Meng] Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47906 USA; [Narayanan, Naagarajan; Kuang, Liangju; Lengemann, Paul; Deng, Meng] Purdue Univ, Bindley Biosci Ctr, W Lafayette, IN 47906 USA; [Jia, Zhihao; Kim, Kun Ho; Kuang, Shihuan] Purdue Univ, Dept Anim Sci, W Lafayette, IN 47906 USA; [Shafer, Gabrielle; Bernal-Crespo, Victor] Purdue Univ, Ctr Comparat Translat Res, W Lafayette, IN 47906 USA; [Deng, Meng] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47906 USA; [Deng, Meng] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47906 USA in 2021.0, Cited 47.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Category: thiazines

Volumetric muscle loss (VML) injuries characterized by critical loss of skeletal muscle tissues result in severe functional impairment. Current treatments involving use of muscle grafts are limited by tissue availability and donor site morbidity. In this study, we designed and synthesized an implantable glycosaminoglycan-based hydrogel system consisting of thiolated hyaluronic acid (HA) and thiolated chondroitin sulfate (CS) crosslinked with poly(ethylene glycol) diacrylate to promote skeletal muscle regeneration of VML injuries in mice. The HA-CS hydrogels were optimized with suitable biophysical properties by fine-tuning degree of thiol group substitution to support C2C12 myoblast proliferation, myogenic differentiation and expression of myogenic markers MyoD, MyoG and MYH8. Furthermore, in vivo studies using a murine quadriceps VML model demonstrated that the HA-CS hydrogels supported integration of implants with the surrounding host tissue and facilitated migration of Pax7(+) satellite cells, de novo myofiber formation, angiogenesis, and innervation with minimized scar tissue formation during 4-week implantation. The hydrogel-treated and autograft-treated mice showed similar functional improvements in treadmill performance as early as 1-week post-implantation compared to the untreated groups. Taken together, our results demonstrate the promise of HA-CS hydrogels as regenerative engineering matrices to accelerate healing of skeletal muscle injuries.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Narayanan, N; Jia, ZH; Kim, KH; Kuang, LJ; Lengemann, P; Shafer, G; Bernal-Crespo, V; Kuang, SH; Deng, M or concate me.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

HPLC of Formula: C4H14Cl2N2S2. In 2020.0 J IND ENG CHEM published article about IN-VITRO; DELIVERY; MODEL; NANOSTRUCTURES; CELL; NANOPARTICLES; NANOSHELLS; CARCINOMA; HISTORY; LASER in [Choi, Jongseon; Kim, So Yeon] Chungnam Natl Univ, Grad Sch Energy Sci & Technol, Daejeon 34134, South Korea; [Kim, So Yeon] Chungnam Natl Univ, Coll Educ, Dept Chem Engn Educ, Daejeon 34134, South Korea in 2020.0, Cited 66.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Nanocarriers have provided a new platform for the selective delivery of therapeutic agents into targeted cells and tissues using safe, efficient, and tractable routes. In particular, the integration of multiple therapeutic/diagnostic modalities into a single system has the great potential of enhancing theranostic efficiency against serious diseases with reduced side effects. In this study, a new light-triggered theranostic system using photosensitizer-conjugated gold nanorods (AuNR) with glutathione (GSH)-sensitive linkages was developed for cancer imaging and combinational phototherapy of photodynamic therapy (PDT) and photothermal therapy (PTT) to achieve a synergistic cancer treatment. AuNRs with various aspect ratios were prepared as photothermal agents, and then a folic acid (FA)-PEG block copolymer (FAP) and pheophorbide a (Pheo) were chemically conjugated to the surface of AuNRs for active tumor targeting and PDT, respectively. The configuration of Pheo-conjugated AuNR nanocarriers has been precisely controlled through adjusting the feed composition ratio and the relationship between aspect ratio and absorption band of AuNRs. In particular, an AuNR with an aspect ratio of 3.84 and longitudinal plasmon resonance at 873 nm (Pheo-conjugated AuNR100) exhibited superior performance in singlet oxygen generation, photothermal conversion effect, and GSH-mediated selective release of Pheo. Moreover, it also showed tumor targeting activity and a PDT-PTT synergistic effect. These results indicate that this multifunctional AuNR system with tumor targeting ability and GSH-sensitive linkages would be highly efficient for noninvasive cancer treatment by integrating cancer imaging diagnostics and synergistic therapy. (C) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

HPLC of Formula: C4H14Cl2N2S2. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Choi, J; Kim, SY or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Feng, ZY; Xu, J; Ni, CH in [Feng, Zhiyun] Yangtze Univ, Coll Chem & Environm Engn, Jingzhou, Peoples R China; [Xu, Jie; Ni, Caihua] Jiangnan Univ, Sch Chem & Mat Engn, Wuxi, Jiangsu, Peoples R China published Preparation of redox responsive modified xanthan gum nanoparticles and the drug controlled release in 2021.0, Cited 35.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

A new kind of redox responsive nanoparticles was prepared through the modification and crosslinking reaction of xanthan gum. The nanoparticles had regular spherical shapes with diameters ranging from 110 to 180 nm. The nanoparticles showed good redox responsiveness. Doxorubicin (DOX) was loaded in the nanoparticles via ionic interaction with SO3-, for increasing the drug loading rate and avoiding drug leakage. The in vitro drug release could be controlled by pH and reduction conditions simulated to the internal environment of tumor cells. The nanoparticles were biocompatible and could be potentially applied as anti-cancer drug vehicles for targeted release.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Feng, ZY; Xu, J; Ni, CH or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about DRUG-RELEASE; SENSITIVE MICELLES; REDOX; NANOPARTICLES; DOXORUBICIN, Saw an article supported by the . HPLC of Formula: C4H14Cl2N2S2. Published in ELSEVIER in AMSTERDAM ,Authors: Li, J; Wang, JH; Zhang, XT; Xia, X; Zhang, CC. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Melphalan (MEL) is an effective chemotherapeutic agent for treatment of retinoblastoma (Rb) which is the most common childhood malignancy. However, the inherent cardiopulmonary toxicity and hazardous integration limit its therapeutic effect on RB. N-Acetylheparosan (AH), a natural heparin-like polysaccharide in mammals with long circulation effect and good biocompatibility, was linked by d-alpha-tocopherol acid succinate (VES) via and cystamine (CYS) to synthesize reduction-responsive N-acetylheparosan-CYS-Vitamin E succinate (AHV) copolymers. In addition, CYS was replaced by adipic acid dihydrazide (ADH) to obtain a control of non-reduction-responsive polymers N-acetylheparosan-ADH-Vitamin E succinate (ADV). MEL-loaded AHV micelles (MEL/AHV) as well as ADV micelles (MEL/ADV) were prepared with small particle size and high drug loading content. In vitro drug release showed that MEL/AHV micelles presented obvious reduction-triggered release behavior compared with MEL/ADV. In vitro antitumor effects were investigated using WERI-Rb-1 retinoblastoma cells. Cytotoxicity experiments showed that the IC50 of MEL/AHV was significantly lower than that of free MEL and MEL/ADV, suggesting that MEL/AHV enhanced the cytotoxicity against retinoblastoma cells. Furthermore, MEL/AHV micelles were more easily uptaken by multiple pathways compared with MEL/ADV and free MEL. Therefore, MEL/AHV might be a potential delivery system for enhanced delivery of melphalan to Rb cells. (C) 2019 Elsevier B.V. All rights reserved.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Li, J; Wang, JH; Zhang, XT; Xia, X; Zhang, CC or concate me.. HPLC of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Materials Science; Polymer Science very interesting. Saw the article Modified silica-based isoprene rubber composite by a multi -functional silane: Preparation and its mechanical and dynamic mechanical properties published in 2020.0. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Wang, XF (corresponding author), Zhuzhou Times New Mat Technol Co Ltd, Zhuzhou 412007, Hunan, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Modified silica-based isoprene rubber (IR) composite has been designed and prepared by using a multi-functional silane, 2-aminoethyl 2-(3-triethoxysilylpropyl)aminoethyl disulfide (ATD), as coupling agent. Such modification significantly improved the dispersity of silica in the corresponding composites, as verified by SEM observation. And the hardness, tensile strength, stress at definite elongation, tear strength and temperature rise as well as the value of dynamic loss coefficient ranging from 0 degrees C to 80 degrees C of silica/IR vulcanized composites, are significantly improved, especially with low ATD dosage (2-4 phr). This modification of silica-based IR composite by employing ATD as coupling agent provides a facile and effective method to prepare silica-based rubber composites with improved mechanical properties and low hysteresis.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Wang, XF; Wu, LL; Yu, HW; Xiao, TL; Li, HM; Yang, J or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Scale-up manufacturing of gelatin-based microcarriers for cell therapy WOS:000529606400001 published article about MESENCHYMAL STEM-CELLS; OPTIMIZATION; CULTURE; DIFFERENTIATION; EXPANSION; SYSTEM; GROWTH; HMSCS in [Dosta, Pere; Ferber, Shiran; Zhang, Yi; Wang, Kui; Ros, Albert; Artzi, Natalie] MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA; [Dosta, Pere; Ferber, Shiran; Zhang, Yi; Wang, Kui; Ros, Albert; Artzi, Natalie] Harvard Med Sch, Brigham & Womens Hosp, Div Engn Med, Dept Med, Boston, MA 02115 USA; [Uth, Nicholas; Levinson, Yonatan; Abraham, Eytan] Res & Technol, Walkersville, MD USA; [Artzi, Natalie] Broad Inst Harvard & MIT, Cambridge, MA USA in 2020.0, Cited 33.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Microcarriers, including crosslinked porous gelatin beads (Cultispher G) are widely used as cell carriers for cell therapy applications. Microcarriers can support a range of adherent cell types in stirred tank bioreactor culture, which is scalable up to several thousands of liters. Cultispher G in particular is advantageous for cell therapy applications because it can be dissolved enzymatically, and thus cells can be harvested without the need to perform a large-scale cell-bead filtration step. This enzymatic dissolution, however, is challenged by the slow degradation of the carriers in the presence of enzymes as new extracellular matrix is being deposited by the proliferating cells. This extended dissolution timelimits the yield of cell recovery while compromising cellular viability. We report herein the development of crosslinked porous gelatin beads that afford rapid, stimuli-triggered dissolution for facile cell removal using human mesenchymal stem cells (hMSC) as a model system. We successfully fabricated redox-sensitive beads (RS beads) and studied their cell growth, dissolution time and cell yield, compared to regular gelatin-based beads (Reg beads). We have shown that RS beads allow for much faster dissolution compared to Reg beads, supporting better hMSC detachment and recovery following 8 days of culture in spinner flasks, or in 3L bioreactors. These newly synthesized RS beads show promise as cellular microcarriers and can be used for scale-up manufacturing of different cell types while providing on-demand degradation for facile cell retrieval.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Dosta, P; Ferber, S; Zhang, Y; Wang, K; Ros, A; Uth, N; Levinson, Y; Abraham, E; Artzi, N or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Curcio, M; Paoli, A; Cirillo, G; Di Pietro, S; Forestiero, M; Giordano, F; Mauro, L; Amantea, D; Di Bussolo, V; Nicoletta, FP; Iemma, F in [Curcio, Manuela; Paoli, Alessandro; Cirillo, Giuseppe; Forestiero, Martina; Giordano, Francesca; Mauro, Loredana; Amantea, Diana; Nicoletta, Fiore Pasquale; Iemma, Francesca] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy; [Di Pietro, Sebastiano; Di Bussolo, Valeria] Univ Pisa, Dept Pharm, Via Bonanno Pisano 33, I-56126 Pisa, Italy published Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy in 2021.0, Cited 42.0. HPLC of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

HPLC of Formula: C4H14Cl2N2S2. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Curcio, M; Paoli, A; Cirillo, G; Di Pietro, S; Forestiero, M; Giordano, F; Mauro, L; Amantea, D; Di Bussolo, V; Nicoletta, FP; Iemma, F or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

SDS of cas: 56-17-7. I found the field of Oncology; Research & Experimental Medicine very interesting. Saw the article A novel corona core-shell nanoparticle for enhanced intracellular drug delivery published in 2020.0, Reprint Addresses Zhong, XM (corresponding author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China.; Wang, CL (corresponding author), Zhejiang Canc Hosp, Dept Pharm, 38 Guangji Rd, Hangzhou 310022, Zhejiang, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Drugs, including small molecule anticancer drugs, have to be delivered and released into the cytoplasm or nucleus in order to elicit a therapeutic effect. In the present study, a novel corona core-shell nanoparticle was proposed for enhanced cellular uptake and light-responsive intracellular release. Light-responsive core-shell nanoparticles, i.e., gold nanoparticles-coated liposomes (CS), were prepared and further modified with hyaluronic acid (HA) (CCS). HA modification enhances the endocytosis of the nanoparticles by HA receptor-expressing cells, while the plasmonic properties of gold nanoparticles enable their light-triggered drug release. The results demonstrated that the uptake of CCS in HA receptor-expressing MDA-MB-231R cells was significantly enhanced compared with unmodified CS. Nanosecond pulsed laser irradiation (700 nm; 100 mJ/cm(2); 5 pulses) rapidly triggered the intracellular release of a fluorescent dye, 6-carboxyfluorescein (6-CF), from CCS and CS trapped in endolysosomes. The released 6-CF was evenly distributed throughout the entire cytosol and nucleus. Finally, the cytotoxicity of doxorubicin towards MDA-MB-231 cells was significantly increased by CCS delivery upon pulsed laser irradiation. In conclusion, with enhanced cellular uptake and light-triggered intracellular release, CCS significantly enhanced the therapeutic effects of doxorubicin, and may serve as a promising avenue for intracellular drug delivery.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Jiang, JW; Zhong, XM; Zhang, HY; Wang, CL or concate me.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Cyclic telluride reagents with remarkable glutathione peroxidase-like activity for purification-free synthesis of highly pure organodisulfides WOS:000475507500027 published article about AEROBIC OXIDATION; ORGANOSELENIUM COMPOUND; PERMANGANATE OXIDATION; ANTIOXIDANT CAPACITY; SELECTIVE OXIDATION; EFFICIENT SYNTHESIS; THIOLS; DISULFIDES; ISOMERASE; CATALYST in [Arai, Kenta; Osaka, Yuui; Haneda, Masahiro; Sato, Yuumi] Tokai Univ, Dept Chem, Sch Sci, Hiratsuka, Kanagawa 2591292, Japan in 2019.0, Cited 60.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Recommanded Product: 56-17-7

Monoamino cyclic tellurides with a five-or six-membered ring structure and their derivatives were developed as a new class of catalyst for the oxidation of organothiols to organodisulfides in a glutathione peroxidase-like catalytic reaction. Quantitative conversion and high reaction rate were achieved by performing the reaction in an organic-aqueous segmented microflow system. Importantly, the process circumvented product purification, which is a major limitation of current organodisulfide synthetic methods.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Arai, K; Osaka, Y; Haneda, M; Sato, Y or concate me.. Recommanded Product: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2019.0 J COORD CHEM published article about 3,3′-DITHIODIPROPIONIC ACID; DL-HOMOCYSTINE; L-CYSTINE; OXIDATION; PLATINUM(II); KINETICS; REDUCTION; COMPLEXES; GOLD(III); PD(II) in [Petrov, Alexander, I] Krasnoyarsk Sci Ctr SB RAS, Inst Chem & Chem Technol SB RAS, Fed Res Ctr, Krasnoyarsk, Russia; [Novikova, Galina, V; Demina, Anastasia, V; Ivanenko, Timur Y.; Goleva, Elizaveta S.] Siberian Fed Univ, Inst Nonferrous Met & Mat Sci, Krasnoyarsk, Russia in 2019.0, Cited 31.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Product Details of 56-17-7

The interaction of Pt(II) and Au(III) with disulfides (l-cystine, cystamine, dl-homocystine and 3,3?-dithiodipropionic acid) in hydrochloric acid aqueous solutions was studied. In the case of Pt(II), the oxidative addition reaction leads to formation of the Pt(IV) thiol complex. In the case of Au(III) disulfide, binding causes a reduction to Au(0) and oxidation of the disulfide to sulfonic acid. Cyclic voltammetry and different spectroscopic methods were used to study the process. The pattern of influence of the metallic properties for d(8) ions in the direction of the reaction was found.

Product Details of 56-17-7. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Petrov, AI; Novikova, GV; Demina, AV; Ivanenko, TY; Goleva, ES or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem