Recently I am researching about SIRNA DELIVERY; TEMPERATURE; MICELLES; TARGET; NANOPARTICLE; CD44, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51472115]; Top-notch Academic Programs Project of Jiangsu Higher Education Institutions [PPZY2015B164]; Administration of Traditional Chinese Medicine of Zhejiang Province [2017ZA075]; Double first-class innovation team of China Pharmaceutical University [CPU2018GY40]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Chen, JJ; Wu, M; Veroniaina, H; Mukhopadhyay, S; Li, JQ; Wu, ZH; Wu, ZH; Qi, XL. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride
Recently, interest in stimuli-responsive core-shell nanogels as drug delivery systems for tumor therapy has increased. Here, a temperature-activated drug locking and glutathione-triggered drug unlocking nanogel is designed, which is composed of hyaluronic acid (HA) conjugated with poly(N-isopropylacrylamide) (PNIPAAm) using a disulfide bond as the linker (HA-SS-PNIPAAm, H-SS-P). After injection into the systemic circulation, these synthetic copolymers endure temperature-motivated lock behaviors to form nanogels due to the thermosensitive lipophilic transformation of PNIPAAm, accompanied by doxorubicin (DOX) locking into the cavities of the nanogels. When they reach tumor cells, these nanogels exhibit glutathione (GSH)-triggered opening behavior to unlock the drugs for tumor therapy. The transmission electron microscopy (TEM) results demonstrate that the H-SS-P copolymer solutions are irregular at room temperature, while spherical structures (similar to 30 nm) can be observed below 37 degrees C, but dissociate in the presence of 40 mM GSH. Based on flow cytometry and fluorescence microscopy analyses, observations reveal that H-SS-P@DOX nanogels are intracellularly taken up into human lung cancer cells (A549) via HA-receptor mediated endocytosis. More importantly, these nanogels possess much higher tumor targeting capacity than free DOX and efficiently enhance the antitumor effect with reduced systemic toxicity in 4T1 tumor-bearing mice.
Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Chen, JJ; Wu, M; Veroniaina, H; Mukhopadhyay, S; Li, JQ; Wu, ZH; Wu, ZH; Qi, XL or concate me.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem