Day: October 13, 2021

Recommanded Product: 56-17-7. Recently I am researching about HEPTAMETHINE CYANINES; TARGETED DELIVERY; IN-VITRO; CANCER; NANOPARTICLES; CHEMOTHERAPY; PRODRUG, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81671758, 32000982]; Guangdong Natural Science Fund [2019A1515110222, 2020B1111540001]; Shenzhen Science and Technology Program [JCYJ20200109114616534]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019M660219]; Chinese Academy of SciencesChinese Academy of Sciences [Y959101001]; UNSW-CAS Collaborative Research Seed Fund Program [172644KYSB20190059]; SIAT Innovation Program for Excellent Young Researchers [201920]; Guangxi Natural Science FoundationNational Natural Science Foundation of Guangxi Province [2017GXNSFGA198005]; Research Program of Shenzhen Institute of Technology [2111015]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Li, Y; Zhou, LH; Zhu, BD; Xiang, JJ; Du, J; He, MW; Fan, XX; Zhang, PF; Zeng, RS; Gong, P. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Triptolide (TP) is one of the most common systemic treatments for inflammatory and immune diseases in China for centuries. However, TP exhibits some disadvantages, such as poor solubility in water, poor bioavailability, liver toxicity, renal toxicity, and other side effects. In order to reduce the adverse effects of TP, researchers have developed numerous strategies to address the adverse properties of triptolide. Nano-carrier-based triptolide delivery systems represent an emerging technology and are one of the strategies of nanomedicine that combines diagnostic and therapeutic applications in a single agent. In this approach, we developed a glutathione-activated carrier-free nanodrug of triptolide (CyssTPN) as a trackable drug delivery system. In this system, CyssTP self-assemble to form a carrier-free nanodrug, which possesses a monodisperse spherical morphology with hydrodynamic average sizes of about 50 nm. In addition, CyssTPN had good stability under different physiological conditions (pH, high salt, etc.). Apart from cellular imaging and cell uptake, CyssTPN can be tracked by the activation of TP ability in real-time and applied for cancer cell treatment efficiently. The result showed that CyssTPN could improve solubility, reduce the side effects, and increase the bioavailability of triptolide. It could also track triptolide activation timely and tumor therapy successfully.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Li, Y; Zhou, LH; Zhu, BD; Xiang, JJ; Du, J; He, MW; Fan, XX; Zhang, PF; Zeng, RS; Gong, P or concate me.. Recommanded Product: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about CARBON-DIOXIDE; ELECTROCATALYTIC REDUCTION; NICKEL(II) COMPLEXES; CRYSTAL-STRUCTURE; CONVERSION; CATALYST; ELECTROREDUCTION; SELECTIVITY; NI(CYCLAM); BEARING, Saw an article supported by the Fonds of the Chemical Industry (Liebig Grant); Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [AP242/2-1, AP242/5-1]; DFG (Cluster of Excellence Unifying Concepts in Catalysis)German Research Foundation (DFG) [ECX 314-2]; DFG (Heisenberg-Program)German Research Foundation (DFG); Fraunhofer Internal Programs [Attract 097-602175]; Fonds of the Chemical Industry (Kekule fellowship). Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Gerschel, P; Battistella, B; Siegmund, D; Ray, K; Apfel, UP. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Among the numerous homogeneous electrochemical CO2 reduction catalysts, [Ni(cyclam)](2+) is known as one of the most potent catalysts. Likewise, [Ni(isocyclam)](2+) was reported to enable electrochemical CO2 conversion but has received significantly less attention. However, for both catalysts, a purposeful substitution of a single nitrogen donor group by chalcogen atoms was never reported. In this work, we report a series of isocyclam-based Ni complexes with {ON3}, {SN3}, {SeN3}, and {N-4} moieties and investigated the influence of nitrogen/chalcogen substitution on electrochemical CO2 reduction. While [Ni(isocyclam)](2+) showed the highest selectivity toward CO2 reduction within this series with a Faradaic efficiency of 86% for the generation of CO at an overpotential of -1.20 V and acts as a homogeneous catalyst, the O- and S-containing Ni complexes revealed comparable catalytic activities at ca. 0.3 V milder overpotential but tend to form deposits on the electrode, acting as precursors for a heterogeneous catalysis. Moreover, the heterogeneous species generated from the O- and S-containing complexes enable a catalytic hydride transfer to acetonitrile, resulting in the generation of acetaldehyde. The incorporation of selenium, however, resulted in loss of CO2 reduction activity, mainly leading to hydrogen generation that is also catalyzed by a heterogeneous electrodeposit.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Gerschel, P; Battistella, B; Siegmund, D; Ray, K; Apfel, UP or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Javorskis, T; Jurys, A; Bagdziunas, G; Orentas, E in [Javorskis, Tomas; Jurys, Arminas; Orentas, Edvinas] Vilnius Univ, Dept Organ Chem, Naugarduko 24, LT-03225 Vilnius, Lithuania; [Javorskis, Tomas; Bagdziunas, Gintautas] Ctr Phys Sci & Technol, Sauletekio Av 3, LT-10257 Vilnius, Lithuania; [Bagdziunas, Gintautas] Vilnius Univ, Life Sci Ctr, Inst Biochem, Sauletekio Av 7, LT-10257 Vilnius, Lithuania published Synthesis of C- and N-Substituted 1,5,2,6-Dithiadiazocanes -Electrophilic-Nucleophilic Thioamination (ENTA) Reagents in 2021.0, Cited 38.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

A synthetic method is presented for S-N bond formation starting from cheap and affordable materials. We show that (un)substituted N-protected cyclic eight-membered C-2-symmetric sulfenamides have been prepared in a few steps using this procedure. The synthetic utility of these ambipolar derivatives was demonstrated in a variety of synthetic transformations affording different S,N-heterocyles of pharmaceutical relevance in one or two steps from simple starting materials.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Javorskis, T; Jurys, A; Bagdziunas, G; Orentas, E or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Chen, JJ; Wu, M; Veroniaina, H; Mukhopadhyay, S; Li, JQ; Wu, ZH; Wu, ZH; Qi, XL in ROYAL SOC CHEMISTRY published article about SIRNA DELIVERY; TEMPERATURE; MICELLES; TARGET; NANOPARTICLE; CD44 in [Chen, Jiaojiao; Wu, Ming; Veroniaina, Hanitrarimalala; Mukhopadhyay, Subhankar; Li, Juequan; Wu, Zhenghong; Qi, Xiaole] China Pharmaceut Univ, Key Lab Modern Chinese Med, Nanjing 21000, Jiangsu, Peoples R China; [Chen, Jiaojiao] Yantai Yuhuangding Hosp, Yantai 264000, Peoples R China; [Wu, Ziheng] Monash Univ, Parkville Campus, Parkville, Vic 3052, Australia in 2019.0, Cited 31.0. Category: thiazines. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Recently, interest in stimuli-responsive core-shell nanogels as drug delivery systems for tumor therapy has increased. Here, a temperature-activated drug locking and glutathione-triggered drug unlocking nanogel is designed, which is composed of hyaluronic acid (HA) conjugated with poly(N-isopropylacrylamide) (PNIPAAm) using a disulfide bond as the linker (HA-SS-PNIPAAm, H-SS-P). After injection into the systemic circulation, these synthetic copolymers endure temperature-motivated lock behaviors to form nanogels due to the thermosensitive lipophilic transformation of PNIPAAm, accompanied by doxorubicin (DOX) locking into the cavities of the nanogels. When they reach tumor cells, these nanogels exhibit glutathione (GSH)-triggered opening behavior to unlock the drugs for tumor therapy. The transmission electron microscopy (TEM) results demonstrate that the H-SS-P copolymer solutions are irregular at room temperature, while spherical structures (similar to 30 nm) can be observed below 37 degrees C, but dissociate in the presence of 40 mM GSH. Based on flow cytometry and fluorescence microscopy analyses, observations reveal that H-SS-P@DOX nanogels are intracellularly taken up into human lung cancer cells (A549) via HA-receptor mediated endocytosis. More importantly, these nanogels possess much higher tumor targeting capacity than free DOX and efficiently enhance the antitumor effect with reduced systemic toxicity in 4T1 tumor-bearing mice.

Category: thiazines. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Chen, JJ; Wu, M; Veroniaina, H; Mukhopadhyay, S; Li, JQ; Wu, ZH; Wu, ZH; Qi, XL or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 56-17-7. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis and evaluation of redox-sensitive gonadotropin-releasing hormone receptor-targeting peptide conjugates published in 2019.0, Reprint Addresses Qian, H (corresponding author), China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Lytic peptides have been demonstrated to exhibit obvious advantages in cancer therapy with binding ability toward tumor cells via electrostatic attractions, which are lack of active targeting and aggregation to tumor tissue. In the present study, five conjugated lytic peptides were redesigned and constructed to target gonadotropin releasing hormone receptors (GnRHr), meanwhile, the disulfide bridge was introduced to achieve redox sensitive delivery based on the experience from the preliminary work of lytic peptides P3 and P7. YX-1, was considered to be the most promising for in-depth study. YX-1 possessed high potency (IC50 = 3.16 +/- 0.3 mu M), low hemolytic effect, and cell membrane permeability in human A2780 ovarian cancer cells. Moreover, YX-1 had prominent pro-apoptotic activity by activating the mitochondria-cytochrome c-caspase apoptotic pathway. The study yielded the conjugate YX-1 with superior properties for antineoplastic activity, which makes it a promising potential candidate for targeting cancer therapy.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Dai, YX; Yue, N; Liu, CX; Cai, XG; Su, X; Bi, XZ; Li, QF; Li, CY; Huang, WL; Qian, H or concate me.. Recommanded Product: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Discovery of a Novel Cabazitaxel Nanoparticle-Drug Conjugate (CRLX522) with Improved Pharmacokinetic Properties and Anticancer Effects Using a beta-Cyclodextrin-PEG Copolymer Based Delivery Platform WOS:000497260700011 published article about POLYMERIC MICELLES; CANCER THERAPEUTICS; ANTITUMOR-ACTIVITY; NANOCARRIERS; RELEASE; NANOTECHNOLOGY; NANOMEDICINE; CHALLENGES; TRANSPORT; CRLX101 in [Metcalf, Chester A., III; Case, Roy I.; Harlfinger, Stephanie; Teng, Chi-Hse] Novartis Inst BioMed Res Inc, 181 Massachusetts Ave, Cambridge, MA 02139 USA; [Svenson, Sonke; Hwang, Jungyeon; Tripathi, Snehlata; Gangal, Geeti; Kabir, Sujan; Lazarus, Douglas; Cole, Roderic; Sweryda-Krawiec, Beata; Shum, Pochi; Brown, Donna; van der Poll, Derek; Rohde, Ellen; Eliasof, Scott] Cerulean Pharma Inc, 35 Gatehouse Dr, Waltham, MA 02451 USA in 2019.0, Cited 68.0. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Novel nanoparticle drug conjugates (NDCs) containing diverse, clinically relevant anticancer drug payloads (docetaxel, cabazitaxel, and gemcitabine) were successfully generated and tested in drug discovery studies. The NDCs utilized structurally varied linkers that attached the drug payloads to a beta-cyclodextrin-PEG copolymer to form self-assembled nanoparticles. In vitro release studies revealed a diversity of release rates driven by linker structure activity relationships (SARs). Improved in vivo pharmacokinetics (PK) for the cabazitaxel (CBTX) NDCs with glycinate-containing (1c) and hexanoate-containing linkers (2c) were demonstrated, along with high and sustained tumor levels (>168 h of released drug in tumor tissues). This led to potent efficacy and survival in both taxane- and docetaxel-resistant in vivo anticancer mouse efficacy models. Overall, the CBTX-hexanoate NDC 2c (CRLX522), demonstrated optimal and improved in vivo PK (plasma and tumor) and efficacy profile versus those of the parent drug, and the results support the potential therapeutic use of CRLX522 as a new anticancer agent.

Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Metcalf, CA; Svenson, S; Hwang, J; Tripathi, S; Gangal, G; Kabir, S; Lazarus, D; Cole, R; Sweryda-Krawiec, B; Shum, P; Brown, D; Case, RI; van der Poll, D; Rohde, E; Harlfinger, S; Teng, CH; Eliasof, S or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Sun, JJ; Wang, Z; Cao, A; Sheng, RL in ROYAL SOC CHEMISTRY published article about BLOCK-COPOLYMER MICELLES; CONTROLLED-RELEASE; POLYMERIC MICELLES; DRUG-DELIVERY; TRIGGERED RELEASE; PH; NANOPARTICLES; CORE; DOXORUBICIN; LOCATION in [Sun, Jingjing; Sheng, Ruilong] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Radiol, Shanghai 200072, Peoples R China; [Sun, Jingjing; Wang, Zhao; Cao, Amin; Sheng, Ruilong] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet & Self Assembly Chem Organ Funct, Lingling Rd 345, Shanghai 200032, Peoples R China; [Wang, Zhao] Jinling Inst Technol, Dept Mat, Nanjing 211169, Jiangsu, Peoples R China; [Sheng, Ruilong] Univ Madeira, CQM Ctr Quim Madeira, Campus Penteada, P-9000390 Funchal, Portugal in 2019.0, Cited 39.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Crosslinked polymer nanomaterials have attracted great attention due to their stability and highly controllable drug delivery; herein, a series of well-defined amphiphilic PDPA-b-P(NMS-co-OEG) diblock terpolymers (P1-P3) were designed and prepared via RAFT polymerization and were self-assembled into non-cross-linked (NCL) nanomicelles, which were further prepared into shell-cross-linked (SCL) micelles via cystamine-based in situ shell cross-linking. Using P3 as an optimized polymer, SCL-P3 micelles were prepared, which demonstrated remarkable pH/redox-dual responsive behaviour. For drug delivery, camptothecin (CPT)-loaded SCL-P3 micelles were prepared and showed much higher CPT-loading capability than their NCL-P3 counterparts. Notably, the SCL-P3 micelles showed good synergistic pH/redox-dual responsive CPT release properties, making them potential smart nanocarriers for drug delivery.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Sun, JJ; Wang, Z; Cao, A; Sheng, RL or concate me.. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. I found the field of Chemistry; Polymer Science very interesting. Saw the article Dual-responsive carboxymethyl cellulose/dopamine/cystamine hydrogels driven by dynamic metal-ligand and redox linkages for controllable release of agrochemical published in 2021.0, Reprint Addresses Jin, YC (corresponding author), Nanjing Forestry Univ, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat F, Nanjing 210037, Peoples R China.; Xiao, HN (corresponding author), Univ New Brunswick, Dept Chem Engn, Fredericton, NB E3B 5A3, Canada.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

The utilization of agrochemicals in crop production is often inefficient due to lack of appropriate carriers, raising in the significant concerns of ecological environment and public health. To enhance the efficiency of agrochemical delivery, a novel cellulose-based hydrogel was constructed in this work by cross-linking dopamine (DA)-modified carboxymethyl cellulose (CMC) with cystamine (CYS) in the presence of Fe3+ ions. The hydrogels displayed reversible sol-gel transitions upon exposure to stimulation of changes in pH and redox, leading to the controllable release of model agrochemical (6-benzyladenine). Compared with single-triggered condition, the hydrogel doubled the cumulative release when co-triggered by pH and redox. The dynamic metal/catechol complexation and disulfide bonding coexist in the hydrogel networks, enabling occurrence of dynamic reaction under a variety of environmental conditions. The finite element method (FEM) was employed to simulate the hydrogel to provide a theoretical insight into the tested drug delivery. Benefitting from the reversibly cross linked networks and the excellent biodegradability of the hydrogels, we anticipate that this dual-responsive, polysaccharide-based hydrogel will offer diverse applications to reach the full potential in sustainable advancement of crop production.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Guo, TY; Wang, WX; Song, JL; Jin, YC; Xiao, HN or concate me.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Guo, C; Gao, JF; Ma, SK; Zhang, HQ in [Guo, Chen; Gao, Jianfeng] North Univ China, Dept Chem, Coll Sci, Taiyuan 030051, Peoples R China; [Guo, Chen; Ma, Shengkui; Zhang, Huiqi] Nankai Univ, State Key Lab Med Chem Biol, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Key Lab Funct Polymer Mat,Minist Educ, Tianjin 300071, Peoples R China; [Guo, Chen; Ma, Shengkui; Zhang, Huiqi] Nankai Univ, Coll Chem, Tianjin 300071, Peoples R China published Efficient preparation of chemically crosslinked recyclable photodeformable azobenzene polymer fibers with high processability and reconstruction ability via a facile post-crosslinking method in 2020.0, Cited 33.0. COA of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Chemically crosslinked recyclable photodeformable azobenzene (azo) polymer actuators with good stability (toward organic solvents and higher temperatures) and high processability and reconstruction ability hold great promise in many applications, but their development remains a challenging task. Herein, we report on for the first time a facile and highly efficient post-crosslinking method for addressing this issue. It involves first the synthesis of side-chain polymers bearing N-hydroxysuccinimide (NHS) carboxylate-substituted azo mesogens, fabrication of uniaxially oriented fibers from these azo polymers by the simple melt spinning method, and their subsequent post-crosslinking with cystamine (a diamine containing a disulfide bond) under mild conditions. The resulting chemically crosslinked fibers not only showed rapid and reversible photoinduced bending and unbending at ambient temperature as well as high mechanical strength and good solvent/heating stability, but also could be easily recycled into processable azo polymers in the presence of a reducing agent that can cleave the disulfide bond into thiol groups (i.e., tributylphosphine). In particular, the occurrence of the post-crosslinking reaction only on the thin surface layers of the azo polymer fibers afforded recycled polymers with large amounts of NHS carboxylate-substituted azo mesogens (together with a small amount of oxygen/heating-sensitive thiolsubstituted ones) in the first several (at least 5) recycling processes, thus allowing highly efficient reconstruction of photodeformable fibers with excellent photomobile properties by applying melt spinning and post-cross-linking (by using cystamine) methods. The strategy presented here opens the new possibility to the facile and efficient development of various advanced chemically crosslinked recyclable photodriven actuators.

COA of Formula: C4H14Cl2N2S2. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Guo, C; Gao, JF; Ma, SK; Zhang, HQ or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Computed Properties of C4H14Cl2N2S2. Recently I am researching about 1 M HCL; CORROSION INHIBITION PERFORMANCE; ECO-FRIENDLY INHIBITOR; X70 STEEL; DERIVATIVES; EXTRACT; MEDIA; EFFICIENCY; COMPOUND, Saw an article supported by the . Published in ELSEVIER in AMSTERDAM ,Authors: Sigircik, G. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Inhibition performance of 2,2′-diaminodiethyl disulfide (DA) was studied against mild steel (MS) corrosion in 0.5 M HCl. Electrochemical impedance spectroscopy (EIS), potentiodynamic (PD) polarization measurements were utilized to investigate the influence of inhibitor concentration and temperature on efficiency, as well as explanation of inhibition mechanism. Scanning electron microscopy (SEM) analysis was utilized to investigate the surface damages due to corrosion, in the absence and presence of inhibitor molecules. PD data revealed that the studied molecule exhibits mixed type inhibitor behavior on steel surface. Moreover, the calculated free adsorption energy (Delta G(ads)(o)) value is 38.45 kJ mol(-1), which indicates to strong adsorptive interaction by both physical and chemical means. UV-Visible study results supported the idea that there is strong interaction between the surface with the molecule, via its -S and -N atoms. As a consequence, 91.7% inhibition efficiency was determined in presence of 1.0 mM DA. (C) 2020 Elsevier B.V. All rights reserved.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Sigircik, G or concate me.. Computed Properties of C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem