In an article, author is Cilliers, Cornelius, once mentioned the application of 20277-69-4, Quality Control of Sodium methanesulfinate, Name is Sodium methanesulfinate, molecular formula is CH3NaO2S, molecular weight is 102.0881, MDL number is MFCD00040392, category is thiazines. Now introduce a scientific discovery about this category.
Residualization Rates of Near-Infrared Dyes for the Rational Design of Molecular Imaging Agents
Near-infrared (NIR) fluorescence imaging is widely used for tracking antibodies and biomolecules in vivo. Clinical and preclinical applications include intraoperative imaging, tracking therapeutics, and fluorescent labeling as a surrogate for subsequent radiolabeling. Despite their extensive use, one of the fundamental properties of NIR dyes, the residualization rate within cells following internalization, has not been systematically studied. This rate is required for the rational design of probes and proper interpretation of in vivo results. In this brief report, we measure the cellular residualization rate of eight commonly used dyes encompassing three core structures (cyanine, boron-dipyrromethene (BODIPY), and oxazine/thiazine/carbopyronin). We identify residualizing (half-life > 24 h) and non-residualizing (half-life < 24 h) dyes in both the far-red (similar to 650-680 nm) and near-infrared (similar to 740-800 nm) regions. This data will allow researchers to independently and rationally select the wavelength and residualizing nature of dyes for molecular imaging agent design. If you are interested in 20277-69-4, you can contact me at any time and look forward to more communication. Quality Control of Sodium methanesulfinate.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem