Tag: M.W=200-250

Recently I am researching about FOREIGN-BODY RESPONSE; GLYCOL) HYDROGELS; MICHAEL ADDITION; CROSS-LINKING; STEM-CELLS; RESISTANCE; COATINGS; RELEASE; CULTURE, Saw an article supported by the Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2018BC026]; Major Program of Shandong Province Natural Science Foundation [ZR2017ZC0529]; Key Research and Development Program of Shandong Province of China [2019GGX102005, 2019GGX102030]. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Zhang, YB; Liu, SY; Li, TY; Zhang, LQ; Azhar, U; Ma, JC; Zhai, CC; Zong, CY; Zhang, SX. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Computed Properties of C4H14Cl2N2S2

In this work, a facile click reaction strategy is employed to form hydrogels in situ with cytocompatibility, biodegradability, self-healing property and resistance to protein. The thiol-functionalized zwitterionic carboxybetaine methacrylate copolymer, which take part as a cross-linker in the thiol-ene click reaction with the methacrylated hyaluronic acid. The hydrogels are obtained under the physiological condition without the presence of any copper catalyst and UV light. The hydrogel consisting of zwitterionic component shows an obvious reduction in protein adsorption and cell adhesion and avoid non-targeted factor interference in the biological experiments. The hydrogels also demonstrate adjustable degradation behavior. Human mesenchymal stem cells (hMSCs) are easily encapsulated into the hydrogels and remains metabolically active, indicating the excellent biocompatibility of the hydrogels. Additionally, the result of the cytokine secretion assays (IL-6 and TNF-alpha) has shown that this clickable hydrogel can serve to suppress inflammatory reactions and is beneficial for in vivo applications. Based on the above results, this clickable hydrogel with excellent performance can be an amenable platform for 3D cell encapsulation.

Computed Properties of C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Zhang, YB; Liu, SY; Li, TY; Zhang, LQ; Azhar, U; Ma, JC; Zhai, CC; Zong, CY; Zhang, SX or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2020.0 DRUG DELIV published article about LOADING CAPACITY; DRUG; DOXORUBICIN; APATINIB; NANOMEDICINE; THERAPEUTICS; CONJUGATE in [Zhang, Xiaoqing; Ren, Xiaomei; Tang, Jiayin; Wang, Jiangtao; He, Peng; Yao, Chang; Bian, Weihe] Nanjing Univ Chinese Med, Jiangsu Prov Hosp TCM, Dept Mastopathy, Affiliated Hosp, Nanjing, Peoples R China; [Zhang, Xiang; Sun, Lizhu] Xuzhou Med Univ, Affiliated Shuyang Hosp, Dept Oncol, Suqian, Peoples R China in 2020.0, Cited 42.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Multidrug resistance (MDR) of cancer cells is a significant challenge in chemotherapy, highlighting the urgent medical need for simple and reproducible strategies to reverse this process. Here, we report the development of an active tumor-targeting and redox-responsive nanoplatform (PA-ss-NP) using hyaluronic acid-g-cystamine dihydrochloride-poly-epsilon-(benzyloxycarbonyl)-L-lysine (HA-ss-PLLZ) to co-deliver paclitaxel (PTX) and apatinib (APA) for effective reversal of MDR. This smart nanoplatform specifically bound to CD44 receptors, leading to selective accumulation at the tumor site and uptake by MCF-7/ADR cells. Under high concentrations of cellular glutathione (GSH), the nanocarrier was degraded rapidly with complete release of its encapsulated drugs. Released APA effectively inhibited the function of the P-glycoprotein (P-gp) drug pump and improved the sensitivity of MDR cells to chemotherapeutic agents, leading to the recovery of PTX chemosensitivity in MDR cells. As expected, this newly developed intelligent drug delivery system could effectively control MDR, both in vitro and in vivo.

Welcome to talk about 56-17-7, If you have any questions, you can contact Zhang, XQ; Ren, XM; Tang, JY; Wang, JT; Zhang, X; He, P; Yao, C; Bian, WH; Sun, LZ or send Email.. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article A novel corona core-shell nanoparticle for enhanced intracellular drug delivery WOS:000523751200029 published article about HYALURONIC-ACID; RELEASE; PERMEABILITY; LIPOSOMES in [Jiang, Jianwei; Zhong, Xiaoming] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China; [Jiang, Jianwei; Zhang, Hongyan; Wang, Chunlei] Zhejiang Canc Hosp, Dept Pharm, 38 Guangji Rd, Hangzhou 310022, Zhejiang, Peoples R China in 2020.0, Cited 26.0. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Drugs, including small molecule anticancer drugs, have to be delivered and released into the cytoplasm or nucleus in order to elicit a therapeutic effect. In the present study, a novel corona core-shell nanoparticle was proposed for enhanced cellular uptake and light-responsive intracellular release. Light-responsive core-shell nanoparticles, i.e., gold nanoparticles-coated liposomes (CS), were prepared and further modified with hyaluronic acid (HA) (CCS). HA modification enhances the endocytosis of the nanoparticles by HA receptor-expressing cells, while the plasmonic properties of gold nanoparticles enable their light-triggered drug release. The results demonstrated that the uptake of CCS in HA receptor-expressing MDA-MB-231R cells was significantly enhanced compared with unmodified CS. Nanosecond pulsed laser irradiation (700 nm; 100 mJ/cm(2); 5 pulses) rapidly triggered the intracellular release of a fluorescent dye, 6-carboxyfluorescein (6-CF), from CCS and CS trapped in endolysosomes. The released 6-CF was evenly distributed throughout the entire cytosol and nucleus. Finally, the cytotoxicity of doxorubicin towards MDA-MB-231 cells was significantly increased by CCS delivery upon pulsed laser irradiation. In conclusion, with enhanced cellular uptake and light-triggered intracellular release, CCS significantly enhanced the therapeutic effects of doxorubicin, and may serve as a promising avenue for intracellular drug delivery.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about ELECTRON-TRANSFER; BISIMIDE DYES; FLUORESCENCE; ASSEMBLIES; DESIGN, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21561162004, N_CityU113/15]; Hong Kong Research Grants CouncilHong Kong Research Grants Council [CityU 11300017, CityU 11300318, CityU T42-103/16-N]; City University of Hong KongCity University of Hong Kong; Hong Kong Research Grants CouncilHong Kong Research Grants Council. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Yip, AMH; Shum, J; Liu, HW; Zhou, HP; Jia, MQ; Niu, N; Li, YX; Yu, C; Lo, KKW. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Formula: C4H14Cl2N2S2

This communication reports novel luminescent rhenium(I)-polypyridine complexes appended with a perylene diimide (PDI) or benzoperylene monoimide (BPMI) moiety through a non-conjugated linker. The photophysical and photochemical properties originating from the interactions of the metal polypyridine and perylene units were exploited to afford new cellular reagents with thiol-sensing capability and excellent photocytotoxic activity.

Welcome to talk about 56-17-7, If you have any questions, you can contact Yip, AMH; Shum, J; Liu, HW; Zhou, HP; Jia, MQ; Niu, N; Li, YX; Yu, C; Lo, KKW or send Email.. Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Triple-Stimuli-Responsive Smart Nanocontainers Enhanced Self-Healing Anticorrosion Coatings for Protection of Aluminum Alloy WOS:000457816900084 published article about CORROSION PROTECTION; CONTROLLED-RELEASE; CARBON-STEEL; MICROCAPSULES; INHIBITOR; BEHAVIOR; HOST; SVET; BENZOTRIAZOLE; CONTAINER in [Wang, Ting; Du, Juan; Ye, Sheng; Fu, JiaJun] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China; [Ye, Sheng; Tan, Linghua] Nanjing Univ Sci & Technol, Natl Special Superfine Powder Engn Res Ctr, Nanjing 210094, Jiangsu, Peoples R China in 2019.0, Cited 45.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Formula: C4H14Cl2N2S2

Novel acid/alkali/corrosion potential triple stimuli -responsive smart nanocontainers (TSR-SNs) were successfully assembled to regulate the release of an encapsulated corrosion inhibitor, benzotriazole (BTA), by installing specially structured bistable pseudorotaxanes as supramolecular nanovalves onto orifices of mesoporous silica nanoparticles. In normal conditions, BTA molecules were sealed in the mesopores. Upon any stimulus of acid, alkali, or corrosion potential, BTA molecules were quickly released because of the open states of the supramolecular nanovalves. TSR-SNs as smart nanocontainers were added into the SiO2 ZrO2 sol gel coating to fabricate a stimuli-feedback, corrosion-compensating self-healing anticorrosion coating (SF-SHAC). Compared with the conventional pH-responsive smart nanocontainers synthesized for the SHAC, TSR-SNs not only respond to the pH changes occurring on corrosive microregions but also, and more importantly, feel the corrosion potential of aluminum alloys and give quick feedback. This design avoids wasting smart nanocontainers because of the local-dependent, gradient pH stimulus intensities and obviously enhances the response sensitivity of the SF-SHAC. Electrochemical impedance spectroscopy and salt spray tests prove the excellent physical barrier of the SF-SHAC. Through scanning vibrating electrode technique measurements, the SF-SHAC doped with TSR-SNs demonstrates inhibiting rates for corrosive microcathodic/anodic current densities that are faster than other control SHACs. The new incorporated corrosion potential-responsive function ensures the efficient working efficiency of TSR-SNs and makes full use of the preloaded corrosion inhibitors as repair factors.

Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, T; Du, J; Ye, S; Tan, LH; Fu, JJ or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about POLYMERIC MICELLES; EFFICIENCY; SYSTEMS, Saw an article supported by the National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21804146]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2018CFC836]; Wuhan Morning Light Plan of Youth Science and Technology [2017050304010322]; Opening Project of Key Laboratory of Analytical Chemistry for Biology and Medicine (Wuhan University), Ministry of Education [ACBM2018007]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Zhu, CN; Zang, LY; Zheng, DY; Cao, HM; Liu, XJ. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. COA of Formula: C4H14Cl2N2S2

Poor solid-tumor penetration of nanocarriers limits the drug efficacy. Herein, small-sized copolymeric nanoparticles are prepared for delivering the chemotherapeutic drug DOX into solid tumors deeply and releasing the drug effectively. These small-sized copolymeric nanoparticles represent substantial potential for clinical translation.

COA of Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Zhu, CN; Zang, LY; Zheng, DY; Cao, HM; Liu, XJ or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Zhou, J; Wu, RN; Chen, YR; Tan, YB in ELSEVIER published article about in [Zhou, Jing; Wu, Ruonan; Chen, Yanru; Tan, Yebang] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China; [Tan, Yebang] Shandong Univ, Key Lab Special Funct Aggregated Mat, Minist Educ, Jinan 250100, Peoples R China in 2021.0, Cited 42.0. COA of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

A triply responsive amphiphilic polymer containing poly (ethylene glycol) (PEG) and pyrene linked by a disulfide bond (PEO-SS-PY) was synthesized. Benefiting from its amphiphilicity, PEO-SS-PY could self-assemble into 126 nm micelles in water. PEO-SS-PY with CB[7] forms a 1:1 pseudorotaxane polymer (PEO-SS-Py@CB[7]) in aqueous solution. After the formation of host-guest complex, the micelles size increased to 136 nm and the fluorescence emission intensity increased. Glutathione would break the disulfide bond, leading to the dissociation of the micelles. Spermine and adamantanamine hydrochloride would dissociate the host-guest complex, leading to change of micelle size and decrease of fluorescence intensity. More interestingly, this self-assembly micelle displayed highly sensitive response to Fe3+. Because the effective absorption of Fe3+ hindered the absorption of PEO-SS-Py@CB[7] at the excitation wavelength of 405 nm, Fe3+ distinctly quenched the fluorescence emission of PEO-SS-Py@CB[7], whereas, a very low changes of intensity was observed for other metal ions. Results of this paper provide a new idea for the combination of metal ion detection and controlled release.

COA of Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Recently I am researching about MESOPOROUS SILICA NANOPARTICLES; MULTIDRUG-RESISTANCE; PHOTODYNAMIC THERAPY; COMBINATION THERAPY; CANCER-THERAPY; DELIVERY; NANOMEDICINE; STRATEGIES, Saw an article supported by the City University of Hong KongCity University of Hong Kong [9610332]; Science Technology and Innovation Committee of Shenzhen Municipality [JCYJ20170818101107167]. Published in WORLD SCI PUBL CO INC in HACKENSACK ,Authors: Gao, D; Lo, PC. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Doxorubicin (DOX) resistance, which results in a reduced accumulation of DOX in the nucleus and hence decreased DNA damage, is a major challenge for chemotherapy against hepatocellular carcinoma. In this paper, we combined chemotherapy with photodynamic therapy (PDT) to combat DOX-resistant human hepatocellular carcinoma cells. We have prepared the polymeric micelles conjugating with DOX and zinc(II) phthalocyanine (ZnPc) through a pH-responsive hydrazone linker and a glutathione (GSH)-responsive disulfide linker, respectively. The polymeric micelles (DOX-ZnPc-micelles) exhibited a spherical shape with a size of about 98 mn diameter and showed excellent stability in aqueous solution. Due to the self-quenching of the ZnPc inside the micelles, DOX-ZnPc-micelles did not emit fluorescence upon red light irradiation. Drug release experiments verified that DOX and ZnPc could be released under acidic conditions and reducing environments, respectively. A higher concentration of DOX was internalized into DOX-resistant R-HepG2 cells through the delivery of polymeric micelles when compared with the free DOX, hence DOX-ZnPc-micelles exhibited a significant enhancement in anticancer activity. The IC50 value of DOX against R-HepG2 cells was found to be 21 mu M when combined with PDT and it was 5-fold less than that of a single treatment of DOX (102 mu M). The DOX-ZnPc-micelles could induce cell apoptosis and necrosis on R-HepG2 cells by combined therapeutic modalities, while these micelles induced only apoptosis on IiepG2 cells. We have demonstrated that utilization of polymeric micelles can significantly enhance the cellular uptake and cytotoxicity of DOX against R-HepG2 cells when compared with free DOX. Moreover, PDT can act as an adjuvant therapeutic modality and combine with chemotherapy to further improve therapeutic efficacy. Overall speaking, DOX-ZnPc-micelles can overcome DOX resistance and induce a synergistic therapeutic effect against DOX-resistant R-HepG2 cells, hence improving the therapeutic efficacy when compared with monotherapy.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article One step synthesis of monodisperse thiol-ene clickable polymer microspheres and application on biological functionalization WOS:000456751000004 published article about BLOCK-COPOLYMER NANOASSEMBLIES; RAFT DISPERSION POLYMERIZATION; NANOPARTICLES; MORPHOLOGY; PROTEINS; DELIVERY; UNIFORM; STYRENE; ACID; DRUG in [Huang, Yongping; Yuan, Jiayu; Tang, Jianhua; Yang, Jianwen; Zeng, Zhaohua] Sun Yat Sen Univ, Sch Mat Sci & Engn, Guangzhou 510275, Guangdong, Peoples R China; [Yang, Jianwen; Zeng, Zhaohua] Sun Yat Sen Univ, Minist Educ, Key Lab Polymer Composite & Funct Mat, Guangzhou 510275, Guangdong, Peoples R China in 2019.0, Cited 53.0. Recommanded Product: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Introducing clickable groups onto polymer microspheres allows the microspheres to be facilely functionalized via a click reaction. In this report, we have synthesized monodisperse PMMA microspheres with clickable double bonds on the surface by one-step RAFT-assisted dispersion photopolymerization using a cyclohexyl-containing macro-RAFT agent as a stabilizer. This macro-RAFT agent, named P(THPAA-b-AA)-TTC, was synthesized by RAFT-mediated block copolymerization of a cyclohexyl-containing monomer (THPAA, obtained by esterification of cis-1,2,3,6-tetrahydrophthalic with 2-hydroxyethyl acrylate) and acrylic acid. The obtained microspheres were analyzed by H-1 NMR and Iodometric method, indicating that the content of carbon double bonds on the microspheres increased with increasing the amount of P(THPAA-b-AA)-TTC in the polymerization feed. We then used a thiolated biotin to perform the photo-click reaction with the cyclohexene double bond on the micro spheres, thereby attaching the biotin unit onto the microspheres. The biotinylated PMMA microspheres were found to be able to effectively immobilize fluorescein isothiocyanate streptavidin (FITC-SAv) via the specific adsorption of biotin to streptavidin, and thus exhibited clear fluorescence under confocal microscope. This study provides a convenient and feasible way to prepare surface-functionalized microspheres, which has great potential in biological applications as well as other fields.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 56-17-7. Authors Saxena, R; Srivastav, S in ELSEVIER published article about in [Saxena, Rahul; Srivastav, Sudha] Jaypee Inst Informat Technol, Dept Biotechnol, Nanobiotechnol Lab, A-10 Sect 62, Noida 201309, UP, India in 2019.0, Cited 10.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

We present a sensitive single step nanobiosensor for thyroid disease diagnosis. Nanoparticles modified screen printed carbon electrode catalyzes the formation of peptide bond between anti-TSH antibody and amino coated gold nanoparticles rendering a covalently coupled antibody. The nanobiosensor detects and quantifies the thyroid stimulating hormone in the sample by sensing the effective resistance offered by electrode. As the TSH concentration increases in serum sample, more is the immunocomplex formed and higher is the resistance offered by electrode. Gold nanoparticles functionalization with cystamine dihydrochloride facilitates a covalent bonding between surface amino group and carboxylic Fc ensuring maximizing available active antibody. This strategy ensures a much lower limit of detection in addition to improved detection range due to increased loading capacity as a result of larger effective surface area offered by gold nanoparticles. These two aspects of immunosensor fabrication resulted in limit of detection as low as 0.001 mu IU/mL and an enhanced detection range of 0.001-150 mu IU/mL. This makes the developed immunosensor suitable for diagnostic purpose covering the clinically relevant range and a simple detection technique makes it potential candidate for fabrication of a Point-of-Care device for detection of Thyroid dysfunctioning. (C) 2019 Elsevier Ltd. All rights reserved.

Recommanded Product: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Saxena, R; Srivastav, S or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem