Tag: M.W=200-250

Computed Properties of C4H14Cl2N2S2. I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article A copper-free click reaction for the synthesis of redox-responsive water-soluble core cross-linked nanoparticles for drug delivery in cancer therapy published in 2019.0, Reprint Addresses Dhara, D (corresponding author), Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Polymer based core cross-linked nanoparticles (CCNPs) have generated a lot of interest as potential stimuli-responsive drug delivery systems. In the present work, we have synthesized smart redox-responsive water soluble polymeric CCNPs by cross-linking water-soluble PEG based copolymers with bis(acryloyl)cystamine via isoxazoline bond formation through a 1,3-dipolar cycloaddition reaction (click reaction) without using a copper catalyst, in a water-THF mixed solvent. The successful synthesis of CCNPs was confirmed by NMR, GPC and FT-IR measurements. Size distribution of the precursor copolymers and the CCNPs was determined by DLS measurement. AFM and FESEM images have confirmed globular morphology of these CCNPs. Their high stability in a physiological environment makes them effective as potent drug carriers with high loading capacity. MTT assays confirmed the biocompatibility of the synthesized CCNPs. Favourable cellular internalization of these DOX loaded CCNPs into cancer cells and redox-responsive release of DOX therefrom make these CCNP potentially smart vehicles to deliver anticancer drugs into cancer cells.

Welcome to talk about 56-17-7, If you have any questions, you can contact Biswas, G; Jena, BC; Sahoo, S; Samanta, P; Mandal, M; Dhara, D or send Email.. Computed Properties of C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

COA of Formula: C4H14Cl2N2S2. In 2020.0 INDIAN J ORTHOP published article about STRESS-FRACTURES; INJURIES in [Pinter, Zachariah W.; Farnell, Chason G.; Huntley, Samuel; Patel, Harshadkumar A.; Peng, Jianguang; McMurtrie, James; Ray, Jessyca L.; Naranje, Sameer; Shah, Ashish B.] Univ Alabama Birmingham, Dept Orthopaed Surg, 1313 13th St South, Birmingham, AL 35205 USA in 2020.0, Cited 20.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Background Turf toe injuries, though most common in athletes, can also occur in non-athletes. No study exists in the current literature investigating operative outcomes in non-athlete patients with chronic turf toe injury. In this study, we present our outcomes on operatively treated turf toe injuries in non-athletes in the only cohort yet studied. Methods Using ICD-10 codes, we assembled a cohort of 12 patients who underwent operative repair of chronic turf toe injury from January 2012 through January 2018 at the investigating institution. These 12 patients were evaluated to determine demographic information, method of injury, length of time from injury to surgery, clinical and radiologic characteristics of the injury, and operative outcomes including mean preoperative and postoperative VAS (Visual Analog Scale) scores, preoperative and postoperative FFI (Foot Function Index) scores, and postoperative complications. Results On initial clinical presentation, all 12 patients had local tenderness with associated painful range of motion. Four patients had restricted range of motion, all patients had a positive Lachman test, two had local edema, and eight had hallux valgus deformity. Mean VAS improved from 4.6 (range 2-9) to 1 (range 0-4). Mean FFI improved from 102.5 (range 56-177) to 61.75 (range 23-144). All patients had a negative Lachman test at final follow-up. No patients developed major complications or required revision surgery. Conclusions Our study is the first to investigate operative outcomes following chronic turf toe injury in non-athlete patients. Based on our study, surgeons and patients can expect significant improvement in overall pain and function following surgery.

COA of Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Pinter, ZW; Farnell, CG; Huntley, S; Patel, HA; Peng, JG; McMurtrie, J; Ray, JL; Naranje, S; Shah, AB or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Polyethylene glycol-modified cystamine for fluorescent sensing WOS:000447384700022 published article about SIDE-CHAIN LENGTH; APPENDED NAPHTHALIMIDE; BLUE PHOTOLUMINESCENCE; HIGHLY FLUORESCENT; POLYMER; DYES; EMISSION; CHEMOSENSORS; SENSOR; IONS in [Shah, Tanveer-Ul-Hassan; Tahir, Mudassir Hussain; Liu, Hewen] Univ Sci & Technol China, Dept Polymer Sci & Engn, CAS Key Lab Soft Matter Chem, 96 Jinzhai Rd, Hefei 230026, Anhui, Peoples R China in 2019.0, Cited 51.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Formula: C4H14Cl2N2S2

Tedious polymeric modifications, laborious syntheses, low water solubility, high cytotoxicity and low quantum yields are still the major concerns related to fluorescent materials used for biosensing applications. Here we report one-pot facile synthesis of polyethylene glycol (PEG)-modified cystamine-based multifunctional fluorescent dyes named as CPEG-168, CPEG-1000 and CPEG-2000, which can be used for biosensing and detection of both cations and anions in pure aqueous medium. Rapid response toward thiols could be achieved due to the presence of disulfide functionality and reversible redox property between thiol and disulfide. A cyclic structure is formed by (NH-H) intramolecular hydrogen bonding to produce electron dense region for strong fluorescence emission. The presence of -NH group made them sensitive toward Cu2+ ions, while excellent sensitivity toward pH and F- ions was provided by intramolecular hydrogen bonding between -NH groups. The increase in chain length of PEGs enhanced the fluorescence emission intensities due to the formation of more rigid structure, and hence, the desired quantum yields can be tuned by changing the chain length of PEG. The aforementioned properties along with high brightness in aqueous solution, at biological pH and temperature range, make these fluorescent dyes potential candidates for biosensing applications and detection of cations and anions.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. I found the field of Materials Science very interesting. Saw the article Fluorinated Redox-Responsive Poly(amidoamine) as a Vaccine Delivery System for Antitumor Immunotherapy published in 2019.0, Reprint Addresses Liu, ZH (corresponding author), Jinan Univ, Key Lab Biomat, Guangdong Higher Educ Inst, Dept Biomed Engn, West Huangpu Rd 601, Guangzhou 510632, Guangdong, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

As a potential method for tumor treatment, tumor vaccine immunization induces a tumor-specific cellular immune response via immunization with tumor antigens. The delivery of exogenous antigen proteins into the cytoplasm of antigen-presenting cells is well known to induce an intensive cellular immune response for tumor treatment. In this work, we fluorinated a redox-responsive hyperbranched poly(amidoamine) (HPAA) with heptafluorobutyric anhydride to prepare a fluorinated HPAA (HPAA-F7) for use as a vaccine delivery system for antitumor therapy. The immunization results show that HPAA-F7 as a vaccine carrier could effectively promote the intracellular uptake and cytoplasmatic delivery of antigen proteins and induce potent antitumor cellular immunity. The novel vaccine carrier HPAA-F7 could be further developed for antitumor immunotherapy.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Zhang, J; Liu, D; Liu, JL; Han, YF; Xu, HY; Leng, XG; Kong, DL; Liu, LX in [Zhang, Jing; Liu, Dan; Liu, Jiale; Leng, Xigang; Kong, Deling; Liu, Lanxia] Peking Union Med Coll, Tianjin Key Lab Biomat, Inst Biomed Engn, Tianjin 300192, Peoples R China; [Zhang, Jing; Liu, Dan; Liu, Jiale; Leng, Xigang; Kong, Deling; Liu, Lanxia] Chinese Acad Med Sci, Tianjin 300192, Peoples R China; [Han, Yanfeng] Garvan Inst Med Res, Kinghorn Canc Ctr, Darlinghurst, NSW 2010, Australia; [Xu, Haiyan] Chinese Acad Med Sci, Inst Bas Sci, Sch Basic Med, Peking Union Med Coll, Beijing 100005, Peoples R China; [Kong, Deling] Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China published Hybrid spherical nucleotide nanoparticles can enhance the synergistic anti-tumor effect of CTLA-4 and PD-1 blockades in 2020.0, Cited 25.0. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Combined blockades of CTLA-4 and PD-1 can yield better overall complementary clinical outcomes than individual blockades, but the response rates are still relatively low. To investigate the anti-tumor effects of various combined strategies, we designed various spherical nucleotide nanoparticles (SNPs) loaded with CTLA-4 aptamer (cSNPs), PD-1 siRNA (pSNPs) or both (hybrid SNPs, or hSNPs). The results demonstrated that hSNPs could promote significantly stronger anti-tumor immune responses in a nonredundant fashion than the mixture of pSNPs and cSNPs (pSNPs & cSNPs). We reasoned that this is because all individual immune cells could receive both CTLA-4 and PD-1 blockades when they engulfed hSNPs, but it is much less likely that individual immune cells could receive both CTLA-4 and PD-1 blockades as many of them may not take both pSNPs and cSNPS from pSNPs & cSNPs. Further results revealed that the synergistic immune stimulatory effects of CTLA-4 and PD-1 blockades in the form of hSNPs were at least partly through regulating the immune suppressive function of both Tregs and TIM3(+)exhausted-like CD8 T cells and allowing effector T cells to expand. This mechanism is not identical to earlier reported mechanisms of CTLA-4 and PD-1 blockades.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Zhang, J; Liu, D; Liu, JL; Han, YF; Xu, HY; Leng, XG; Kong, DL; Liu, LX or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Orthopedics very interesting. Saw the article Outcomes of Chronic Turf Toe Repair in Non-athlete Population: A Retrospective Study published in 2020.0. SDS of cas: 56-17-7, Reprint Addresses Shah, AB (corresponding author), Univ Alabama Birmingham, Dept Orthopaed Surg, 1313 13th St South, Birmingham, AL 35205 USA.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Background Turf toe injuries, though most common in athletes, can also occur in non-athletes. No study exists in the current literature investigating operative outcomes in non-athlete patients with chronic turf toe injury. In this study, we present our outcomes on operatively treated turf toe injuries in non-athletes in the only cohort yet studied. Methods Using ICD-10 codes, we assembled a cohort of 12 patients who underwent operative repair of chronic turf toe injury from January 2012 through January 2018 at the investigating institution. These 12 patients were evaluated to determine demographic information, method of injury, length of time from injury to surgery, clinical and radiologic characteristics of the injury, and operative outcomes including mean preoperative and postoperative VAS (Visual Analog Scale) scores, preoperative and postoperative FFI (Foot Function Index) scores, and postoperative complications. Results On initial clinical presentation, all 12 patients had local tenderness with associated painful range of motion. Four patients had restricted range of motion, all patients had a positive Lachman test, two had local edema, and eight had hallux valgus deformity. Mean VAS improved from 4.6 (range 2-9) to 1 (range 0-4). Mean FFI improved from 102.5 (range 56-177) to 61.75 (range 23-144). All patients had a negative Lachman test at final follow-up. No patients developed major complications or required revision surgery. Conclusions Our study is the first to investigate operative outcomes following chronic turf toe injury in non-athlete patients. Based on our study, surgeons and patients can expect significant improvement in overall pain and function following surgery.

SDS of cas: 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article One step synthesis of monodisperse thiol-ene clickable polymer microspheres and application on biological functionalization WOS:000456751000004 published article about BLOCK-COPOLYMER NANOASSEMBLIES; RAFT DISPERSION POLYMERIZATION; NANOPARTICLES; MORPHOLOGY; PROTEINS; DELIVERY; UNIFORM; STYRENE; ACID; DRUG in [Huang, Yongping; Yuan, Jiayu; Tang, Jianhua; Yang, Jianwen; Zeng, Zhaohua] Sun Yat Sen Univ, Sch Mat Sci & Engn, Guangzhou 510275, Guangdong, Peoples R China; [Yang, Jianwen; Zeng, Zhaohua] Sun Yat Sen Univ, Minist Educ, Key Lab Polymer Composite & Funct Mat, Guangzhou 510275, Guangdong, Peoples R China in 2019.0, Cited 53.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Introducing clickable groups onto polymer microspheres allows the microspheres to be facilely functionalized via a click reaction. In this report, we have synthesized monodisperse PMMA microspheres with clickable double bonds on the surface by one-step RAFT-assisted dispersion photopolymerization using a cyclohexyl-containing macro-RAFT agent as a stabilizer. This macro-RAFT agent, named P(THPAA-b-AA)-TTC, was synthesized by RAFT-mediated block copolymerization of a cyclohexyl-containing monomer (THPAA, obtained by esterification of cis-1,2,3,6-tetrahydrophthalic with 2-hydroxyethyl acrylate) and acrylic acid. The obtained microspheres were analyzed by H-1 NMR and Iodometric method, indicating that the content of carbon double bonds on the microspheres increased with increasing the amount of P(THPAA-b-AA)-TTC in the polymerization feed. We then used a thiolated biotin to perform the photo-click reaction with the cyclohexene double bond on the micro spheres, thereby attaching the biotin unit onto the microspheres. The biotinylated PMMA microspheres were found to be able to effectively immobilize fluorescein isothiocyanate streptavidin (FITC-SAv) via the specific adsorption of biotin to streptavidin, and thus exhibited clear fluorescence under confocal microscope. This study provides a convenient and feasible way to prepare surface-functionalized microspheres, which has great potential in biological applications as well as other fields.

Welcome to talk about 56-17-7, If you have any questions, you can contact Huang, YP; Yuan, JY; Tang, JH; Yang, JW; Zeng, ZH or send Email.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Zhang, XQ; Ren, XM; Tang, JY; Wang, JT; Zhang, X; He, P; Yao, C; Bian, WH; Sun, LZ in TAYLOR & FRANCIS LTD published article about LOADING CAPACITY; DRUG; DOXORUBICIN; APATINIB; NANOMEDICINE; THERAPEUTICS; CONJUGATE in [Zhang, Xiaoqing; Ren, Xiaomei; Tang, Jiayin; Wang, Jiangtao; He, Peng; Yao, Chang; Bian, Weihe] Nanjing Univ Chinese Med, Jiangsu Prov Hosp TCM, Dept Mastopathy, Affiliated Hosp, Nanjing, Peoples R China; [Zhang, Xiang; Sun, Lizhu] Xuzhou Med Univ, Affiliated Shuyang Hosp, Dept Oncol, Suqian, Peoples R China in 2020.0, Cited 42.0. Product Details of 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Multidrug resistance (MDR) of cancer cells is a significant challenge in chemotherapy, highlighting the urgent medical need for simple and reproducible strategies to reverse this process. Here, we report the development of an active tumor-targeting and redox-responsive nanoplatform (PA-ss-NP) using hyaluronic acid-g-cystamine dihydrochloride-poly-epsilon-(benzyloxycarbonyl)-L-lysine (HA-ss-PLLZ) to co-deliver paclitaxel (PTX) and apatinib (APA) for effective reversal of MDR. This smart nanoplatform specifically bound to CD44 receptors, leading to selective accumulation at the tumor site and uptake by MCF-7/ADR cells. Under high concentrations of cellular glutathione (GSH), the nanocarrier was degraded rapidly with complete release of its encapsulated drugs. Released APA effectively inhibited the function of the P-glycoprotein (P-gp) drug pump and improved the sensitivity of MDR cells to chemotherapeutic agents, leading to the recovery of PTX chemosensitivity in MDR cells. As expected, this newly developed intelligent drug delivery system could effectively control MDR, both in vitro and in vivo.

Product Details of 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Simultaneous reduction and surface functionalization of graphene oxide by cystamine dihydrochloride for rubber composites WOS:000470193100003 published article about CROSS-LINKING; INTERFACE; VULCANIZATION; NANOCOMPOSITES; REINFORCEMENT; FABRICATION; NANOSHEETS; HYBRIDS; ROBUST; MODEL in [Wang, Jian; Fei, Guoxia; Pan, Yunqi; Zhang, Kaiye; Hao, Shuai; Zheng, Zhuo; Xia, Hesheng] Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat Engn, Chengdu 610065, Sichuan, Peoples R China in 2019.0, Cited 59.0. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

The simultaneous reduction and functionalization of graphene oxide (GO) was achieved through a chemical grafting reaction with cystamine dihydrochloride (CDHC), a novel functional agent with dynamic disulfide bond. CDHC-reduced GO (CGO) can be uniformly and stably dispersed in the aqueous phase. Furthermore, CGO reinforced styrene-butadiene rubber (SBR) composites with highly filled silica content were prepared by a latex mixing and coagulation process. TEM confirmed both CGO and silica can be uniformly dispersed in the rubber matrix. The dynamic disulfide bonds of the grafted CDHC in the CGO can participate in the subsequent vulcanization of SBR rubber through disulfide exchange reactions, thereby forming a tight interaction between GO and rubber. Compared with normally reduced GO system, the mechanical and thermal properties of CGOcontaining rubber nanocomposites were significantly improved. The results show that CGO is effective to reinforce rubber composites, which has the potential to be used for tire rubber materials.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Formula: C4H14Cl2N2S2. Biswas, G; Jena, BC; Sahoo, S; Samanta, P; Mandal, M; Dhara, D in [Biswas, Gargi; Sahoo, Satyagopal; Samanta, Pousati; Dhara, Dibakar] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India; [Jena, Bikash Chandra; Mandal, Mahitosh] Indian Inst Technol, Sch Med Sci & Technol, Kharagpur 721302, W Bengal, India published A copper-free click reaction for the synthesis of redox-responsive water-soluble core cross-linked nanoparticles for drug delivery in cancer therapy in 2019.0, Cited 51.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Polymer based core cross-linked nanoparticles (CCNPs) have generated a lot of interest as potential stimuli-responsive drug delivery systems. In the present work, we have synthesized smart redox-responsive water soluble polymeric CCNPs by cross-linking water-soluble PEG based copolymers with bis(acryloyl)cystamine via isoxazoline bond formation through a 1,3-dipolar cycloaddition reaction (click reaction) without using a copper catalyst, in a water-THF mixed solvent. The successful synthesis of CCNPs was confirmed by NMR, GPC and FT-IR measurements. Size distribution of the precursor copolymers and the CCNPs was determined by DLS measurement. AFM and FESEM images have confirmed globular morphology of these CCNPs. Their high stability in a physiological environment makes them effective as potent drug carriers with high loading capacity. MTT assays confirmed the biocompatibility of the synthesized CCNPs. Favourable cellular internalization of these DOX loaded CCNPs into cancer cells and redox-responsive release of DOX therefrom make these CCNP potentially smart vehicles to deliver anticancer drugs into cancer cells.

Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Biswas, G; Jena, BC; Sahoo, S; Samanta, P; Mandal, M; Dhara, D or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem