Category: thiazines

I found the field of Engineering; Materials Science very interesting. Saw the article Biomimetic glycosaminoglycan-based scaffolds improve skeletal muscle regeneration in a Murine volumetric muscle loss model published in 2021.0. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Deng, M (corresponding author), Purdue Univ, Dept Agr & Biol Engn, Sch Mat Engn, Weldon Sch Biomed Engn,Bindley Biosci Ctr, W Lafayette, IN 47907 USA.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Volumetric muscle loss (VML) injuries characterized by critical loss of skeletal muscle tissues result in severe functional impairment. Current treatments involving use of muscle grafts are limited by tissue availability and donor site morbidity. In this study, we designed and synthesized an implantable glycosaminoglycan-based hydrogel system consisting of thiolated hyaluronic acid (HA) and thiolated chondroitin sulfate (CS) crosslinked with poly(ethylene glycol) diacrylate to promote skeletal muscle regeneration of VML injuries in mice. The HA-CS hydrogels were optimized with suitable biophysical properties by fine-tuning degree of thiol group substitution to support C2C12 myoblast proliferation, myogenic differentiation and expression of myogenic markers MyoD, MyoG and MYH8. Furthermore, in vivo studies using a murine quadriceps VML model demonstrated that the HA-CS hydrogels supported integration of implants with the surrounding host tissue and facilitated migration of Pax7(+) satellite cells, de novo myofiber formation, angiogenesis, and innervation with minimized scar tissue formation during 4-week implantation. The hydrogel-treated and autograft-treated mice showed similar functional improvements in treadmill performance as early as 1-week post-implantation compared to the untreated groups. Taken together, our results demonstrate the promise of HA-CS hydrogels as regenerative engineering matrices to accelerate healing of skeletal muscle injuries.

Welcome to talk about 56-17-7, If you have any questions, you can contact Narayanan, N; Jia, ZH; Kim, KH; Kuang, LJ; Lengemann, P; Shafer, G; Bernal-Crespo, V; Kuang, SH; Deng, M or send Email.. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Small-sized copolymeric nanoparticles for tumor penetration and intracellular drug release WOS:000514651200015 published article about POLYMERIC MICELLES; EFFICIENCY; SYSTEMS in [Zhu, Chun-Nan] South Cent Univ Nationalities, Coll Biomed Engn, Hubei Key Lab Med Informat Anal & Tumor Diag & Tr, Wuhan 430074, Peoples R China; South Cent Univ Nationalities, Key Lab Cognit Sci, State Ethn Affairs Commiss, Wuhan 430074, Peoples R China in 2020.0, Cited 26.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Computed Properties of C4H14Cl2N2S2

Poor solid-tumor penetration of nanocarriers limits the drug efficacy. Herein, small-sized copolymeric nanoparticles are prepared for delivering the chemotherapeutic drug DOX into solid tumors deeply and releasing the drug effectively. These small-sized copolymeric nanoparticles represent substantial potential for clinical translation.

Welcome to talk about 56-17-7, If you have any questions, you can contact Zhu, CN; Zang, LY; Zheng, DY; Cao, HM; Liu, XJ or send Email.. Computed Properties of C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 56-17-7. In 2020.0 ACS APPL MATER INTER published article about ASSEMBLED NANOPARTICLES; INTRACELLULAR DELIVERY; DRUG-RELEASE; MICELLES; MICROENVIRONMENT; COMBINATION; DOXORUBICIN; NANOSYSTEM; CONJUGATE; LIPOSOMES in [Yin, Shaoping; Gao, Yi; Zhang, Yu; Xu, Jianan; Zhu, Jianping; Li, Juan] China Pharmaceut Univ, Dept Pharmaceut, State Key Lab Nat Med, Nanjing 210009, Peoples R China; [Zhou, Fang; Wang, Guangji] China Pharmaceut Univ, Ctr New Drug Safety Evaluat & Res, Nanjing 210009, Peoples R China; [Gu, Xiaochen] Univ Manitoba, Fac Pharm, Winnipeg, MB R3E 0T5, Canada in 2020.0, Cited 53.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Deep tumor penetration, long blood circulation, rapid drug release, and sufficient stability are the most concerning dilemmas of nano-drug-delivery systems for efficient chemotherapy. Herein, we develop reduction/oxidation-responsive hierarchical nanoparticles co-encapsulating paclitaxel (PTX) and pH-stimulated hyaluronidase (pSH) to surmount the sequential biological barriers for precise cancer therapy. Poly(ethylene glycol) diamine (PEG-dia) is applied to collaboratively cross-link the shell of nanoparticles self-assembled by a hyaluronic acid-stearic acid conjugate linked via a disulfide bond (HA-SS-SA, HSS) to fabricate the hierarchical nanoparticles (PHSS). The PTX and pSH coloaded hierarchical nanoparticles (PTX/pSH-PHSS) enhance the stability in normal physiological conditions and accelerate drug release at tumorous pH, and highly reductive or oxidative environments. Functionalized with PEG and HA, the hierarchical nanoparticles preferentially prolong the circulation time, accumulate at the tumor site, and enter MDA-MB-231 cells via CD44-mediated endocytosis. Within the acidic tumor micro-environment, pSH would be partially reactivated to decompose the dense tumor extracellular matrix for deep tumor penetration. Interestingly, PTX/pSH-PHSS could be degraded apace by the completely activated pSH within endo/lysosomes and the intracellular redox micro-environment to facilitate drug release to produce the highest tumor inhibition (93.71%) in breast cancer models.

Recommanded Product: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Yin, SP; Gao, Y; Zhang, Y; Xu, JN; Zhu, JP; Zhou, F; Gu, XC; Wang, GJ; Li, J or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Dual-Responsive Cross-Linked Micelles from Amphiphilic Four-Arm Star Copolymers with Different Block Ratios for Triggering DOX Release WOS:000522581600001 published article about PH-SENSITIVE MICELLES; POLYMERIC MICELLES; ANTICANCER DRUG; DELIVERY-SYSTEMS; NANOCARRIERS; SHELL in [Huang, Yunwei; Li, Yanzhe; Tang, Zilun; Su, Qiuping; Liao, Tingting; Lin, Xiaofeng; Zu, Xihong; Lin, Wenjing; Yi, Guobin] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China; [Gu, Yuxin] Guangzhou Kinte Ind Co Ltd, Guangdong Prov Key Lab Adv Coatings Res & Dev, Guangzhou 510300, Peoples R China in 2020.0, Cited 33.0. Product Details of 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

The four-arm star copolymers poly(methacrylic acid)-poly(2-hydroxyethyl methacrylate-disulfide similar to)-poly(poly(ethylene glycol) methyl ether methacrylate) (4AS-PMAA(x)-(PHEMA-SS similar to)(y)-PPEGMA(z)) with four different block ratios were synthesized and could self-assembled into cross-linked polymer micelles for the exploration of the structure-property relationship. The cross-linked polymer micelles in aqueous solution had low critical micelle concentration (CMC) values (1.9-4.6 mg/L), which exhibited better stability than non-cross-linked micelles. The CMC value decreased with the increase of the length of inner PMAA core and hydrophobic PHEMA cross-linked middle layer. The blank and doxorubicin (DOX)-loaded micelles with different block ratios were prepared by dialysis with the particle sizes of 120-240 nm. The longer inner PMAA core and cross-linked middle layer enhanced the drug loading content (DLC) results and led to relatively bigger particle sizes of polymer micelles. The in vitro DOX release data revealed that DOX-loaded micelles had low DOX cumulative release percentages of 18-37% after 110 h at pH 7.4, but up to 83-90% when introducing reductant GSH at pH 5.0. The 4AS-PMAA(21.2)-(PHEMASS approximate to)(13.1)-PPEGMA(5.1) micelles with the longest PMAA core had the largest cumulative release of 90.1%. The DOX release process and mechanism of the micelles at different conditions fitted well with the semi-empirical equation. Overall, the results demonstrated that the block ratios and pH/redox-responsiveness of these four-arm star copolymers could be well-controlled and their self-assembled cross-linked micelles as anticancer drug carrier system could be improved by optimizing the different ratios.

Welcome to talk about 56-17-7, If you have any questions, you can contact Huang, YW; Li, YZ; Tang, ZL; Su, QP; Liao, TT; Gu, YX; Lin, XF; Zu, XH; Lin, WJ; Yi, GB or send Email.. Product Details of 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Bioorthogonal click chemistries enable simultaneous spatial patterning of multiple proteins to probe synergistic protein effects on fibroblast function WOS:000555693800041 published article about INTERSTITIAL CELL PHENOTYPE; GROWTH-FACTORS; HYDROGELS; FIBROSIS; CALCIFICATION; ELASTICITY; ACTIVATION; CULTURE; SYSTEMS in [Ma, Hao; Caldwell, Alexander S.; Azagarsamy, Malar A.; Rodriguez, Andrea Gonzalez; Anseth, Kristi S.] Univ Colorado Boulder, Dept Chem & Biol Engn, Boulder, CO 80303 USA; [Ma, Hao; Caldwell, Alexander S.; Azagarsamy, Malar A.; Rodriguez, Andrea Gonzalez; Anseth, Kristi S.] Univ Colorado Boulder, BioFrontiers Inst, Boulder, CO 80303 USA in 2020.0, Cited 40.0. Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Three biorthogonal click reactions, a photoinitiated thiol-yne reaction, an azide-alkyne cycloaddition, and a methyltetrazine-transcyclooctene Diels Alder, were used to independently control the presentation of several bioactive proteins to valvular interstitial cells (VICs) in hydrogel scaffolds. Tethered fibroblast growth factor (FGF-2) was found to suppress myofibroblast activation (from 48 +/- 7% to 17 +/- 6%) and promote proliferation (from 10 +/- 2% to 54 +/- 3%) at a concentration of 10 ng/mL. In the presence of the pro-fibrotic cytokine transforming growth factor-beta (TGF-beta 1), FGF-2 could protect the VIC fibroblast phenotype, even at much higher concentrations of TGF-beta 1 than that of FGF-2. With respect to the fibrocalcific VIC phenotype, TGF-beta 1 and bone-morphogenic protein-2 (BMP-2) were found to synergistically promote calcific nodule formation (a five-fold increase in nodules compared to TGF-beta 1 or BMP-2 alone). Exploiting the orthogonal click reactions, FGF-2, TGF-beta 1 and BMP-2 combinations were patterned into distinct regions on a hydrogel to control VIC activation and nodule formation. Cellular crosstalk between separate regions of the same scaffold was affected by the size of each region as well as the interfacial area between different regions. Collectively, these results demonstrate the versatility and robustness of a photoinitiated thiol-yne reaction to template pendant functionalities that allow for the bioconjugation of multiple proteins. This approach maintains protein bioactivity, providing an in vitro platform capable of achieving a better understanding of the complex mechanisms involved in tissue fibrosis.

Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Ma, H; Caldwell, AS; Azagarsamy, MA; Rodriguez, AG; Anseth, KS or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about SELF-HEALING ABILITY; SOYBEAN-OIL; CYCLIC CARBONATES; FREE ROUTES; ELASTOMERS; CHEMISTRY; POLYMERS; RECOVERY; DELIVERY; DIAMINES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51873055, 51373046]; Natural Science Foundation of Hebei ProvinceNatural Science Foundation of Hebei Province [B2018202112]; Basic Science Research Program through the National Research Foundation of Korea [2018R1D1A1A09081809]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Dong, JC; Liu, BY; Ding, HN; Shi, JB; Liu, N; Dai, B; Kim, I. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Category: thiazines

A series of isocyanate-free polyurethanes (NIPUs), showing an intrinsic thermo-healing performance, have been synthesized from sustainable vegetable oil-based cyclic carbonates and bio-based amines. The bio-based contents of the NIPUs are higher than 78%. Their thermo-mechanical and self-healing performances are tailored simply by varying the feed ratios of the amines employed. The biomass linoleic acid dimer-based diamine plays a positive role in maintaining the higher thermal stability and good elasticity of the prepared NIPUs, the cycloaliphatic isophorone diamine contributes to high tensile strength, and cysteine-derived disulfide-containing cystamine (CA) enhances the self-healing efficiency. The combination of intrinsic hydrogen bonds existed in the NIPU matrix with the dynamic exchange reactions of disulfide bonds and the enhanced flexibility of NIPU networks results in 98.1% self-healing efficiency at 25 degrees C. The contributions of disulfide bonds and hydrogen bonds to the healing efficiency were estimated by adjusting the composition of NIPUs, showing that the contribution of disulfide bonds to the healing ability is about 45.3% even at a low amount of CA (6.0 wt%).

Category: thiazines. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Orthopedics very interesting. Saw the article Outcomes of Chronic Turf Toe Repair in Non-athlete Population: A Retrospective Study published in 2020.0. SDS of cas: 56-17-7, Reprint Addresses Shah, AB (corresponding author), Univ Alabama Birmingham, Dept Orthopaed Surg, 1313 13th St South, Birmingham, AL 35205 USA.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Background Turf toe injuries, though most common in athletes, can also occur in non-athletes. No study exists in the current literature investigating operative outcomes in non-athlete patients with chronic turf toe injury. In this study, we present our outcomes on operatively treated turf toe injuries in non-athletes in the only cohort yet studied. Methods Using ICD-10 codes, we assembled a cohort of 12 patients who underwent operative repair of chronic turf toe injury from January 2012 through January 2018 at the investigating institution. These 12 patients were evaluated to determine demographic information, method of injury, length of time from injury to surgery, clinical and radiologic characteristics of the injury, and operative outcomes including mean preoperative and postoperative VAS (Visual Analog Scale) scores, preoperative and postoperative FFI (Foot Function Index) scores, and postoperative complications. Results On initial clinical presentation, all 12 patients had local tenderness with associated painful range of motion. Four patients had restricted range of motion, all patients had a positive Lachman test, two had local edema, and eight had hallux valgus deformity. Mean VAS improved from 4.6 (range 2-9) to 1 (range 0-4). Mean FFI improved from 102.5 (range 56-177) to 61.75 (range 23-144). All patients had a negative Lachman test at final follow-up. No patients developed major complications or required revision surgery. Conclusions Our study is the first to investigate operative outcomes following chronic turf toe injury in non-athlete patients. Based on our study, surgeons and patients can expect significant improvement in overall pain and function following surgery.

SDS of cas: 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about BONDS; FILMS, Saw an article supported by the National Research Foundation of Korea (NRF) – Korea government (MSIP) [NRF-2017R1A2A1A05000752]. Computed Properties of C4H14Cl2N2S2. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Lee, JP; Hwang, H; Chae, S; Kim, JM. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

A reversibly mechanochromic conjugated polymer has been developed. The polymer, polydiacetylene (PDA), obtained by thermal polymerization of a diphenyldisulfide-containing bisdiacetylene undergoes a blue-to-green color change upon grinding. The original blue color of the PDA is regenerated via a metastable red-color state by utilizing a thermochromic (heating-cooling) process.

Welcome to talk about 56-17-7, If you have any questions, you can contact Lee, JP; Hwang, H; Chae, S; Kim, JM or send Email.. Computed Properties of C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Najafi, F; Salami-Kalajahi, M; Roghani-Mamaqani, H; Kahaie-Khosrowshahi, A in [Najafi, Faezeh; Salami-Kalajahi, Mehdi; Roghani-Mamaqani, Hossein] Sahand Univ Technol, Dept Polymer Engn, POB 51335-1996, Tabriz, Iran; [Najafi, Faezeh; Salami-Kalajahi, Mehdi; Roghani-Mamaqani, Hossein] Sahand Univ Technol, Inst Polymer Mat, POB 51335-1996, Tabriz, Iran; [Kahaie-Khosrowshahi, Amir] Sahand Univ Technol, Dept Chem Engn, POB 51335-1996, Tabriz, Iran published Effect of grafting ratio of poly(propylene imine) dendrimer onto gold nanoparticles on the properties of colloidal hybrids, their DOX loading and release behavior and cytotoxicity in 2019.0, Cited 60.0. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

A facile method via grafting to approach was used to synthesize hybrid gold-dendrimer nanoparticles. To this end, gold nanoparticles (GNPs) were synthesized via Turkevich method and 5th-generation cystamine-cored poly (propylene imine) (PPI) dendrimer was synthesized by iterative Michael addition and hydrogenation reactions. To prepare hybrid nanoparticles, aqueous solution of dendrimer was poured into colloidal solution of GNPs to form gold-S interactions which resulted in hybrid gold-dendrimer nanoparticles. UV-VIS-NIR and Raman spectroscopies, dynamic light scattering (DLS), thermogravimetric analysis (TGA) and field-emission scanning electron microscopy (FE-SEM) were utilized to confirm the surface modification of GNPs by PPI dendrimer. Cytotoxicity study through MIT assay against human fibroblast (FBS) cells showed appropriate proliferation of cells in presence of hybrid nanoparticles whereas higher grafting ratio of dendrimers induced more toxicity due to existence of peripheral amine groups. Also, hybrid gold-dendrimer nanoparticles were used as DOX nano-carriers. Results showed that carriers did not release the drug at pH = 7.4 significantly while up to 92.8% of drug release was measured at pH = 5.3. Also, higher grafting ratio limited the drug release due to shielding effect of grafted dendrimers.

Welcome to talk about 56-17-7, If you have any questions, you can contact Najafi, F; Salami-Kalajahi, M; Roghani-Mamaqani, H; Kahaie-Khosrowshahi, A or send Email.. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Polymer Science very interesting. Saw the article Bioinspired glycosaminoglycan hydrogels via click chemistry for 3D dynamic cell encapsulation published in 2019.0. COA of Formula: C4H14Cl2N2S2, Reprint Addresses Deng, M (corresponding author), Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47907 USA.; Deng, M (corresponding author), Purdue Univ, Bindley Biosci Ctr, W Lafayette, IN 47907 USA.; Deng, M (corresponding author), Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA.; Deng, M (corresponding author), Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Cell encapsulation within 3D hydrogels is an attractive approach to develop effective cell-based therapies. However, little is known about how cells respond to the dynamic microenvironment resulting from hydrogel gelation-based cell encapsulation. Here, a tunable biomimetic hydrogel system that possesses alterable gelation kinetics and biologically relevant matrix stiffness is developed to study 3D dynamic cellular responses during encapsulation. Hydrogels are synthesized by crosslinking thiolated hyaluronic acid and thiolated chondroitin sulfate with poly(ethylene glycol) diacrylate under cell-compatible conditions. Hydrogel properties are tailored by altering thiol substitution degrees of glycosaminoglycans or molecular weights of crosslinkers. Encapsulation of human mesenchymal stem cells through hydrogel gelation reveals high cell viability as well as a three-stage gelation-dependent cellular response in real-time focal adhesion kinase (FAK) phosphorylation in live single cells. Furthermore, stiffer hydrogels result in higher equilibrium FAK activity and enhanced actin protrusions. Our results demonstrate the promise of hydrogel-mediated cellular responses during cell encapsulation. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47212.

Welcome to talk about 56-17-7, If you have any questions, you can contact Kuang, LJ; Damayanti, NP; Jiang, CH; Fei, X; Liu, WJ; Narayanan, N; Irudayaraj, J; Campanella, O; Deng, M or send Email.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem