Category: 56-17-7

An article Disulphide-mediated site-directed modification of proteins WOS:000544474600004 published article about PEGYLATION; BONDS in [Nielsen, Thorbjorn; Marcher, Anders; Gothelf, Kurt, V] Aarhus Univ, Interdisciplinary Nanosci Ctr, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark; [Nielsen, Thorbjorn; Marcher, Anders; Gothelf, Kurt, V] Aarhus Univ, Dept Chem, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark; [Nielsen, Thorbjorn; Wiberg, Charlotte; Nielsen, Per F.; Nielsen, Thomas E.; Clo, Emiliano] Novo Nordisk AS, Novo Nordisk Pk 1, DK-2760 Malov, Denmark; [Drobnakova, Zuzana; Hucko, Michal; Stengl, Milan; Balsanek, Vojtech] APIGENEX Sro, Podebradska 56-186, Prague 918066, Czech Republic in 2020.0, Cited 38.0. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Methods for chemical modification of native proteins in a controlled fashion are in high demand. Here, a novel protocol that exploits bifunctional reagents for transient targeting of solvent exposed disulphides to direct the introduction of a single exogenous reactive thiol handle at a lysine side chain has been developed. The protocol has successfully been applied to functionalize six different Fabs and human growth hormone.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Nielsen, T; Marcher, A; Drobnakova, Z; Hucko, M; Stengl, M; Balsanek, V; Wiberg, C; Nielsen, PF; Nielsen, TE; Gothelf, KV; Clo, E or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Formula: C4H14Cl2N2S2. Recently I am researching about POLY(AMIDOAMINE)-FUNCTIONALIZED GRAPHENE OXIDE; PAMAM DENDRIMERS; DRUG CARRIERS; GENE DELIVERY; IN-VITRO; NANOPARTICLES; NANOCARRIERS; REDUCTION; BIOAVAILABILITY; ENCAPSULATION, Saw an article supported by the Iran National Science FoundationIran National Science Foundation (INSF) [96013146]. Published in WILEY in HOBOKEN ,Authors: Najafi, F; Salami-Kalajahi, M; Roghani-Mamaqani, H; Kahaie-Khosrowshahi, A. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Many of new chemical discovered in pharmaceutical industry are hydrophobic compounds. Various techniques have been used to overcome solubility problems of hydrophobic drugs in aqueous media. In the meantime, dendrimers have been considered for sustainability, nanoscale size, high carry capacity, tunable terminal functional groups in terms of drug delivery and solubility. In this work, we have synthesized poly(propylene imine) (PPI) dendrimer up to fifth generation using reduction of nitrile groups after Michael addition and also, polyamidoamine (PAMAM) dendrimer up to fourth generation using Michael addition and amidation reactions. fourth and fifth generations of PPI dendrimer and fourth and third generations of PAMAM dendrimer in different concentrations were used to evaluate the solubility of two hydrophobic drugs (tetracycline and dexamethasone). Furthermore, cytotoxicity of dendrimers and dendrimers/drugs hybrids was studied. The results showed that with increasing concentrations and also the generation of dendrimers, the solubility of these two hydrophobic drugs was increased. Cytotoxicity study through MTT assay against Osteoblast-like cell line (MG-63 cells) showed that dendrimers were relatively cytotoxic where adding dexamethasone caused higher cytotoxicity. However, tetracycline showed no significant effect on cytotoxicity whereas prevented cell proliferation.

Formula: C4H14Cl2N2S2. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Najafi, F; Salami-Kalajahi, M; Roghani-Mamaqani, H; Kahaie-Khosrowshahi, A or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2020.0 J IND ENG CHEM published article about NANOPARTICLES; MICELLE; RELEASE in [Jeong, Chanuk; Kim, Juhwan; Kim, Yeu-Chun] Korea Adv Inst Sci & Technol KAIST, Dept Chem & Biomol Engn, Daejeon, South Korea; [Kim, Yeu-Chun] Korea Adv Inst Sci & Technol KAIST, KAIST Inst Hlth Sci & Technol, Daejeon, South Korea in 2020.0, Cited 20.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. HPLC of Formula: C4H14Cl2N2S2

A multifunctional drug delivery system (MDDS) based on near-infrared (NIR) imaging was developed in various conformations for the accurate diagnosis and therapy of cancer. However, it remains challenging to develop an ideal structure for an MDDS with both exact and variable functionality. Herein, we report a fluorescence color-changeable branched-form heptamethine cyanine dye (PEG-4-CyP) that has both a simple structure and various functionality. The PEG-4-CyP was not only able to construct the nanoparticle (NP) structure by encapsulating DOX (PEG-4-CyP/DOX), but also showed change in the NIR fluorescence color by reacting with glutathione (GSH). The PEG-4-CyP/DOX was broken down in the redox microenvironment inside cancers because of the reduction reaction of PEG-4-CyP to GSH. As a result, the NP disruption, DOX release, and reactivity of PEG-4-CyP to GSH were visualized by NIR fluorescence color-change. Moreover, PEG-4-CyP/DOX showed an excellent chemophototherapeutic effect in cancer cells. This NIR fluorescence color-change strategy demonstrates the applicability of PEG-4-CyP as a novel MDDS able to provide a variety of information with a simple NP structure. (C) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Jeong, C; Kim, J; Kim, YC or concate me.. HPLC of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry; Polymer Science very interesting. Saw the article Biodegradable reduction-responsive polymeric micelles for enhanced delivery of melphalan to retinoblastoma cells published in 2019.0. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Li, J (corresponding author), Jiangnan Univ, Dept Ophthalmol, Affiliated Hosp, Wuxi 214062, Jiangsu, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Melphalan (MEL) is an effective chemotherapeutic agent for treatment of retinoblastoma (Rb) which is the most common childhood malignancy. However, the inherent cardiopulmonary toxicity and hazardous integration limit its therapeutic effect on RB. N-Acetylheparosan (AH), a natural heparin-like polysaccharide in mammals with long circulation effect and good biocompatibility, was linked by d-alpha-tocopherol acid succinate (VES) via and cystamine (CYS) to synthesize reduction-responsive N-acetylheparosan-CYS-Vitamin E succinate (AHV) copolymers. In addition, CYS was replaced by adipic acid dihydrazide (ADH) to obtain a control of non-reduction-responsive polymers N-acetylheparosan-ADH-Vitamin E succinate (ADV). MEL-loaded AHV micelles (MEL/AHV) as well as ADV micelles (MEL/ADV) were prepared with small particle size and high drug loading content. In vitro drug release showed that MEL/AHV micelles presented obvious reduction-triggered release behavior compared with MEL/ADV. In vitro antitumor effects were investigated using WERI-Rb-1 retinoblastoma cells. Cytotoxicity experiments showed that the IC50 of MEL/AHV was significantly lower than that of free MEL and MEL/ADV, suggesting that MEL/AHV enhanced the cytotoxicity against retinoblastoma cells. Furthermore, MEL/AHV micelles were more easily uptaken by multiple pathways compared with MEL/ADV and free MEL. Therefore, MEL/AHV might be a potential delivery system for enhanced delivery of melphalan to Rb cells. (C) 2019 Elsevier B.V. All rights reserved.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Li, J; Wang, JH; Zhang, XT; Xia, X; Zhang, CC or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. I found the field of General & Internal Medicine; Research & Experimental Medicine very interesting. Saw the article Pattern of presentations at psychiatric emergency services of a public sector tertiary care hospital, Pakistan published in 2020.0, Reprint Addresses Hanif, R (corresponding author), Jinnah Postgrad Med Ctr, Dept Psychiat, Karachi, Pakistan.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Objective: To determine the pattern of presentations and characteristics of patients at a psychiatric emergency services facility. Methods: The cross-sectional study was conducted in November 2016 at the Department of Psychiatry and Behavioural Sciences, Jinnah Postgraduate Medical Centre, Karachi, and comprised all patients presenting to the departmental emergency services. Data was documented on a pre-designed semi-structured proforma, and analysed using SPSS 22. Results: Of the 316 cases, 162(51.3%) were males and 154(48.7%) were females. The overall mean age was 30.78+/-13.09 years (range: 8-80 years). Psychiatric emergencies comprised suicidal attempt, excitement, violence, altered sensorium, altered/inappropriate behaviour and extrapyramidal symptoms / acute dystonia together constituting for 123(38.9%) of the total presentations, while there were 20(6.33%) cases of hysterical fits and 6(1.89%) with acute anxiety symptoms. Overall, 56(17.7%) subjects were found to have no psychiatric diagnosis, and 46(81.5%) of these were referred cases. Conclusion: Non-emergency visits constituted high percentage of emergency presentation.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Hanif, R; Afridi, MI; Dars, JA; Lqbal, F or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Hara, M; Kitahata, S; Nishimori, K; Miyahara, K; Morita, K; Tokuda, K; Nishino, T; Maruyama, T in NATURE PUBLISHING GROUP published article about AMINO-GROUPS; POLYMER; ADHESION; IMMOBILIZATION; MEMBRANES; SEGREGATION; MICROARRAYS; POLYOLEFIN; MOLECULES in [Hara, Manami; Kitahata, Shigeru; Nishimori, Keisuke; Miyahara, Koki; Tokuda, Kaya; Nishino, Takashi; Maruyama, Tatsuo] Kobe Univ, Grad Sch Engn, Dept Chem Sci & Engn, Nada Ku, 1-1 Rokkodai, Kobe, Hyogo 6578501, Japan; [Morita, Kenta] Kobe Univ, Res Facil Ctr Sci & Technol, Instrumental Anal Div, Nada Ku, 1-1 Rokkodai, Kobe, Hyogo 6578501, Japan in 2019.0, Cited 48.0. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Isotactic polypropylene (PP) is one of the most popular plastics. However, the remarkably low surface energy of PP prevents the surface functionalization of PP. We studied the surface functionalization of PP by dip-coating with a maleic anhydride-grafted chlorinated polypropylene (MPO)/methacrylate-based terpolymer mixture. A methacrylate-based terpolymer (PMFP) was synthesized, which contained perfluoroalkyl (R-f)-conjugated monomers and poly(ethylene glycol)-conjugated monomers. Tape-peeling tests revealed that MPO successfully immobilized PMFP on a PP surface, although PMFP was less adhesive to PP. X-ray photoelectron spectroscopy (XPS), contact angle, and protein adsorption measurements revealed that the R-f groups and PEG chains in PMFP were segregated to the outermost surface of the dip-coated layer. The surface segregation of these moieties produced a low-fouling surface on the PP substrate. In addition, we synthesized a terpolymer that contained R-f groups and PEG chains with carboxy groups at their termini (PMFB) and used it to dip-coat a PP substrate. The surface segregation of side chains in PMFB induced the presentation of carboxy groups at the outermost surface, which were used as reactive sites for enzyme immobilization.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Hara, M; Kitahata, S; Nishimori, K; Miyahara, K; Morita, K; Tokuda, K; Nishino, T; Maruyama, T or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Douat, C; Bornerie, M; Antunes, S; Guichard, G; Kichler, A in AMER CHEMICAL SOC published article about HOST-DEFENSE PEPTIDES; MOLECULAR TRANSPORTERS; ARGININE; GENE; DNA; SURFACE; DESIGN; CHARGE; HELIX; INTERNALIZATION in [Douat, Celine; Bornerie, Megane; Antunes, Stephanie; Guichard, Gilles] Univ Bordeaux, CNRS, CBMN, UMR 5248,Inst Europeen Chim & Biol, 2 Rue Robert Escarpit, F-33607 Pessac, France; [Douat, Celine] Ludwig Maximilians Univ Munchen, Dept Pharm, Butenandtstr 5-13, D-81377 Munich, Germany; [Kichler, Antoine] Univ Strasbourg, CNRS, Fac Pharm, Equipe 3Bio,CAMB 7199, 74 Route Rhin, F-67401 Illkirch Graffenstaden, France in 2019.0, Cited 54.0. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Sequence specific molecules with high folding ability (i.e., foldamers) can be used to precisely control the distribution and projection of side chains in space and have recently been introduced as tailored systems for delivering nucleic acids into cells. Designed oligourea sequences with an amphipathic distribution of Arg- and His-type residues were shown to form tight complexes with plasmid DNA, and to effectively promote the release of DNA from the endosomes. Herein, we report the synthesis of new cell-penetrating foldamer sequences in which the foldamer segment is conjugated via a reducible disulfide bond to a ligand that binds cell-surface expressed nucleoproteins with the idea that this system could facilitate both assemblies with nucleic acids and cell entry. This new system was evaluated for delivery of DNA in several cell lines and was found to compare favorably with all comparators tested (DOTAP and b-PEI as well as a number of known cell penetrating peptides) in various cell lines and particularly in culture medium containing up to 50% of serum. These results suggest that this dual molecular platform which is long lasting and noncytotoxic could be of practical use for in vivo applications.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Douat, C; Bornerie, M; Antunes, S; Guichard, G; Kichler, A or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2019.0 INT J BIOL MACROMOL published article about FACILE FABRICATION; DRUG-DELIVERY; PH; NANOPARTICLES in [Wang, Fang; Zhang, Qian; Li, Xinxia; Huang, Kexin; Shao, Wei; Huang, Chaobo] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China; [Yao, Dawei] Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China in 2019.0, Cited 27.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

A simple method to fabricate redox-responsive composite hydrogel films via incorporating chitosan (CS) micro spheres into carboxymethyl cellulose (CMC) hydrogel using a di-sulphide cross-linker cystamine dihydrochloride (CYS) have done in this paper. Dual drugs, an anticancer, 5-Fluorouracil (5-FU) and an antibiotic, Tetracycline Hydrochloride (TH) were used as model drugs. The prepared composite hydrogel films were characterized using FTIR, SEM, rheology measurement, mechanical and swelling tests. Our results showed that the well dispersed spherical CS microspheres endowed hydrogel film increased mechanical properties and swellability. In vitro drug release displayed an accelerated release under weak acidic or reducing media. The in vitro cytotoxicity and cell apoptosis studies showed the drug-loaded composite film caused enhanced inhibition to HepG2 cells in presence of glutathione (GSH). Moreover, the film has exhibited excellent antimicrobial efficacy against E.coli and Staphylococcus aureus. Therefore, our simple and effective dual drug-loaded system has the potential to be used for cancer therapy in the future. (C) 2019 Elsevier B.V. All rights reserved.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Wang, F; Zhang, Q; Li, XX; Huang, KX; Shao, W; Yao, DW; Huang, CB or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Controlled Synthesis of Shell Cross-Linked Helical Poly(phenylborate isocyanide) Nanoparticles with H2O2/Redox Dual Responsiveness and Their Application in Antitumor Drug Delivery WOS:000604600600010 published article about MESOPOROUS SILICA NANOPARTICLES; SENSITIVE VESICLES; RELEASE; OXIDATION; HYPOXIA; PATCHES in [Liu, Wen-Bin; Kang, Shu-Ming; Xu, Xun-Hui; Zhou, Li; Liu, Na; Wu, Zong-Quan] Hefei Univ Technol, Sch Chem & Chem Engn, Dept Polymer Sci & Engn, Hefei 230009, Anhui, Peoples R China; [Liu, Wen-Bin; Kang, Shu-Ming; Xu, Xun-Hui; Zhou, Li; Liu, Na; Wu, Zong-Quan] Hefei Univ Technol, Anhui Key Lab Adv Catalyt Mat & React Engn, Hefei 230009, Anhui, Peoples R China in 2020.0, Cited 36.0. Computed Properties of C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

To mimic the helical structure and function of biopolymers, shell cross-linked nanoparticle (P4) composed of left-handed helical poly(phenylborate isocyanide) in core and hydrophilic polyisocyanide in shell was prepared. The phenylborate in the core and the disulfide bonds in the cross-linkage render the nanoparticle with excellent dual stimuli-responsiveness to glutathione (GSH) and H2O2. Nevertheless, it has good stability in normal physiological conditions. Because of the helicity and borate pendants of the core, such nanoparticle has high capacity for anticancer drug loading, for example, the loading capacity of doxorubicin (DOX) was up to 68%. Moreover, the DOX-loaded DOX@P4 showed excellent tumor cell penetration potency and fast drug release. More than 78% of murine breast cancer cell (4T1) can be killed within 48 h, supporting this material with great potential in antitumor drug nanocarriers.

Computed Properties of C4H14Cl2N2S2. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Liu, WB; Kang, SM; Xu, XH; Zhou, L; Liu, N; Wu, ZQ or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Li, SZ; Pei, MJ; Wan, TT; Yang, HJ; Gu, SJ; Tao, YZ; Liu, X; Zhou, YS; Xu, WL; Xiao, P in ELSEVIER SCI LTD published article about POTENTIAL APPLICATION; ACYLHYDRAZONE; PROPERTY; ADHESIVE in [Li, Shangzhi; Pei, Minjie; Wan, Tingting; Yang, Hongjun; Gu, Shaojin; Tao, Yongzhen; Liu, Xin; Zhou, Yingshan] Wuhan Text Univ, Coll Mat Sci & Engn, Wuhan 430073, Peoples R China; [Zhou, Yingshan; Xu, Weilin] Wuhan Text Univ, Key Lab Green Proc & Funct Text New Text Mat, Minist Educ, Wuhan 430073, Peoples R China; [Xiao, Pu] Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia in 2020.0, Cited 47.0. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Natural hydrogels are widely investigated for biomedical applications because of their structures similar to extracellular matrix of native tissues, possessing excellent biocompatibility and biodegradability. However, they are often susceptible to mechanical disruption. In this study, self-healing hyaluronic acid (HA) hydrogels are fabricated through a facile dynamic covalent Schiff base reaction. Dialdehyde-modified HA (AHA) precursor was synthesized, and then the AHA/cystamine dihydrochloride (AHA/Cys) hydrogels were formed by blending AHA and Cys at acidic pH levels. By varying Cys to AHA ratio, the hydrogel morphology, swelling and kinetics of gelation could be controlled. Gelation occurred fast, which was predominantly attributed to Schiff base reaction between the dialdehyde groups on AHA and amimo groups on Cys. The hydrogel exhibited improved mechanical properties with increase in Cys content. Furthermore, due to dynamic imine bonds, this hydrogel demonstrated excellent self-healing ability based on the stress after mechanical disruption. Also, it was found to be pH-responsive and injectable. Taken together, this kind of hyaluronic acid hydrogel can provide promising future for various biomedical applications in drug delivery, bioprinting, smart robots and tissue regeneration.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Li, SZ; Pei, MJ; Wan, TT; Yang, HJ; Gu, SJ; Tao, YZ; Liu, X; Zhou, YS; Xu, WL; Xiao, P or concate me.. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem