When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. , Formula: https://www.ambeed.com/products/151-21-3.html, 151-21-3, Name is Sodium dodecyl sulfate, molecular formula is C12H25NaO4S, belongs to thiazines compound. In a document, author is Dighe, Shashikant U., introduce the new discover.
Reinvestigations into synthesis of allyldithiocarbamates and their intramolecular cyclization: synthesis and antihyperglycemic activity of 2-thioxothiazolidine-4-alkanoates
Reinvestigating the synthesis of allylthiocarbamates from MBH derivatives revealed that they are obtained more efficiently from allylbromides in isopropanol rather than acetates in water. Further unlike reported, the base-mediated intramolecular cyclization of these allyldithiocarbamates give substituted 2-thioxothiazolidine-4-alkanoates instead of substituted 1,3-thiazines and the reaction was restricted to 2- or 4-nitrophenyl carrying substrates. Screening of these products for antihyperglycemic activity revealed that 5bC displays significant activity via partial agonist activity on PPAR gamma at transcriptional level, which was corroborated by molecular docking studies. (C) 2014 Elsevier Ltd. All rights reserved.
By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 151-21-3, Formula: https://www.ambeed.com/products/151-21-3.html.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem