Month: December 2021

An article Preparation of redox responsive modified xanthan gum nanoparticles and the drug controlled release WOS:000538407700001 published article about ZWITTERIONIC NANOPARTICLES; POLYMERIC MICELLES; PH; DELIVERY; ACID); NANOGELS; POLY(ETHYLENE; COPOLYMER in [Feng, Zhiyun] Yangtze Univ, Coll Chem & Environm Engn, Jingzhou, Peoples R China; [Xu, Jie; Ni, Caihua] Jiangnan Univ, Sch Chem & Mat Engn, Wuxi, Jiangsu, Peoples R China in 2021.0, Cited 35.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Formula: C4H14Cl2N2S2

A new kind of redox responsive nanoparticles was prepared through the modification and crosslinking reaction of xanthan gum. The nanoparticles had regular spherical shapes with diameters ranging from 110 to 180 nm. The nanoparticles showed good redox responsiveness. Doxorubicin (DOX) was loaded in the nanoparticles via ionic interaction with SO3-, for increasing the drug loading rate and avoiding drug leakage. The in vitro drug release could be controlled by pH and reduction conditions simulated to the internal environment of tumor cells. The nanoparticles were biocompatible and could be potentially applied as anti-cancer drug vehicles for targeted release.

Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Category: thiazines. I found the field of Polymer Science very interesting. Saw the article Fabrication of Injectable, Porous Hyaluronic Acid Hydrogel Based on an In-Situ Bubble-Forming Hydrogel Entrapment Process published in 2020.0, Reprint Addresses Yuan, Y (corresponding author), East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China.; Yuan, Y (corresponding author), East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China.; Yuan, Y (corresponding author), East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China.; Yang, ZG; Jiang, W (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Dept Radiat Oncol, Dallas, TX 75390 USA.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Injectable hydrogels have been widely applied in the field of regenerative medicine. However, current techniques for injectable hydrogels are facing a challenge when trying to generate a biomimetic, porous architecture that is well-acknowledged to facilitate cell behaviors. In this study, an injectable, interconnected, porous hyaluronic acid (HA) hydrogel based on an in-situ bubble self-generation and entrapment process was developed. Through an amide reaction between HA and cystamine dihydrochloride activated by EDC/NHS, CO2 bubbles were generated and were subsequently entrapped inside the substrate due to a rapid gelation-induced retention effect. HA hydrogels with different molecular weights and concentrations were prepared and the effects of the hydrogel precursor solution’s concentration and viscosity on the properties of hydrogels were investigated. The results showed that HA10-10 (10 wt.%, MW 100,000 Da) and HA20-2.5 (2.5 wt.%, MW 200,000 Da) exhibited desirable gelation and obvious porous structure. Moreover, HA10-10 represented a high elastic modulus (32 kPa). According to the further in vitro and in vivo studies, all the hydrogels prepared in this study show favorable biocompatibility for desirable cell behaviors and mild host response. Overall, such an in-situ hydrogel with a self-forming bubble and entrapment strategy is believed to provide a robust and versatile platform to engineer injectable hydrogels for a variety of applications in tissue engineering, regenerative medicine, and personalized therapeutics.

Category: thiazines. Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, LX; Dong, SY; Liu, YT; Ma, YF; Zhang, JJ; Yang, ZG; Jiang, W; Yuan, Y or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Formula: C4H14Cl2N2S2. I found the field of Chemistry; Polymer Science very interesting. Saw the article Redox-responsive nanoparticles based on Chondroitin Sulfate and Docetaxel prodrug for tumor targeted delivery of Docetaxel published in 2021.0, Reprint Addresses Li, LB; Zhai, GX (corresponding author), Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Dept Pharmaceut,Minist Educ,Key Lab Chem Biol, 44 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

In this paper, a novel redox-responsive nanoparticles has been designed for targeted delivery of docetaxel (DTX). Chondroitin sulfate (CS) was used to construct the nanoparticles due to the ability of tumor targeting through binding with CD44 receptor that overexpresses on the surfaces of various tumor cells. A redox-responsive small-molecular DTX prodrug was prepared through modifying with cystamine containing disulfide bonds (Cys-DTX). Then the DTX prodrug was grafted to the CS to construct the amphiphilic polymer (CS-ss-DTX). Further, Cys-DTX/CS-ss-DTX nanoparticles were formed by self-assembly of amphiphilic polymer and incorporation of free Cys-DTX prodrug. This category of nanosized DTX delivery system was expected for not only exhibiting high permeability and cytotoxicity of Cys-DTX prodrug, but also targeting transportation of encapsulated redox-responsive Cys-DTX prodrug. According to results of related researches on physicochemical properties and biological evaluation, the novel redox-responsive Cys-DTX/CS-ss-DTX nanoparticles increased amount of DTX released from the nanoparticles in reductive environment, improved permeability in tumor tissues, enhanced cytotoxicity and decreased side effects compared with free DTX. All of these results showed that this kind of Cys-DTX/CS-ss-DTX nanoparticles were worthy of being expectation in tumor chemotherapy in future.

Welcome to talk about 56-17-7, If you have any questions, you can contact Li, YM; Chen, XL; Ji, JB; Li, LB; Zhai, GX or send Email.. Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about FILLER-ELASTOMER INTERACTIONS; EPOXIDIZED NATURAL-RUBBER; COUPLING AGENTS; SURFACE MODIFICATION; NANOCOMPOSITES; NANOPARTICLES; PARTICLES; TIME, Saw an article supported by the . Published in ELSEVIER SCI LTD in OXFORD ,Authors: Wang, XF; Wu, LL; Yu, HW; Xiao, TL; Li, HM; Yang, J. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Modified silica-based isoprene rubber (IR) composite has been designed and prepared by using a multi-functional silane, 2-aminoethyl 2-(3-triethoxysilylpropyl)aminoethyl disulfide (ATD), as coupling agent. Such modification significantly improved the dispersity of silica in the corresponding composites, as verified by SEM observation. And the hardness, tensile strength, stress at definite elongation, tear strength and temperature rise as well as the value of dynamic loss coefficient ranging from 0 degrees C to 80 degrees C of silica/IR vulcanized composites, are significantly improved, especially with low ATD dosage (2-4 phr). This modification of silica-based IR composite by employing ATD as coupling agent provides a facile and effective method to prepare silica-based rubber composites with improved mechanical properties and low hysteresis.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Engineering; Materials Science very interesting. Saw the article Scale-up manufacturing of gelatin-based microcarriers for cell therapy published in 2020.0. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Artzi, N (corresponding author), Harvard Med Sch, Brigham & Womens Hosp, Div Engn Med, Dept Med, Boston, MA 02115 USA.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Microcarriers, including crosslinked porous gelatin beads (Cultispher G) are widely used as cell carriers for cell therapy applications. Microcarriers can support a range of adherent cell types in stirred tank bioreactor culture, which is scalable up to several thousands of liters. Cultispher G in particular is advantageous for cell therapy applications because it can be dissolved enzymatically, and thus cells can be harvested without the need to perform a large-scale cell-bead filtration step. This enzymatic dissolution, however, is challenged by the slow degradation of the carriers in the presence of enzymes as new extracellular matrix is being deposited by the proliferating cells. This extended dissolution timelimits the yield of cell recovery while compromising cellular viability. We report herein the development of crosslinked porous gelatin beads that afford rapid, stimuli-triggered dissolution for facile cell removal using human mesenchymal stem cells (hMSC) as a model system. We successfully fabricated redox-sensitive beads (RS beads) and studied their cell growth, dissolution time and cell yield, compared to regular gelatin-based beads (Reg beads). We have shown that RS beads allow for much faster dissolution compared to Reg beads, supporting better hMSC detachment and recovery following 8 days of culture in spinner flasks, or in 3L bioreactors. These newly synthesized RS beads show promise as cellular microcarriers and can be used for scale-up manufacturing of different cell types while providing on-demand degradation for facile cell retrieval.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Recently I am researching about REDOX-RESPONSIVE MICELLES; MULTIDRUG-RESISTANCE; DELIVERY SYSTEM; CO-DELIVERY; TARGETING DELIVERY; IN-VITRO; PACLITAXEL; NANOPARTICLES; DOCETAXEL, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U1704172]; Key Program for Basic Research of Universities in Henan province [19A350231]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M640686]. Published in ELSEVIER in AMSTERDAM ,Authors: Hou, L; Tian, CY; Chen, DD; Yuan, YJ; Yan, YS; Huang, QX; Zhang, HJ; Zhang, ZZ. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Multidrug resistance (MDR) is a major reason for anticancer chemotherapy failure, and P-glycoprotein (P-gp) over-expressing on tumor cells is considered as the important target to overcome MDR. Emerging reports have showed that vitamin E (VE) can cause significant reversal of MDR due to inhibition of ATPase activity. Accordingly, we synthesized hyaluronic acid (HA) conjugated vitamin E succinate (VES) polymer, which can self-assemble into micelles and thus achieve high drug (paclitaxel (PTX) used as model drug) encapsulation as well as tumor accumulation owing to the enhanced permeability and retention (EPR) effect and HA active targeting ability. In addition, the linker between HA and VES utilized in this work was disulfide bond with reduction-sensitive property, which would respond to high glutathione (GSH) concentration in tumor cytoplasmic environment and trigger HA-CYS-VES polymer disassociation and drug release. In vitro, PTX loaded HA-CYS-VES demonstrated enhanced cytotoxicity, high apoptosis-inducing activities and reversal effects of PTX on MCF-7/Adr cells, compared to PTX. Also, cellular uptake and intracellular PTX accumulation tests displayed that PTX loaded HA-CYS-VES could more efficiently enter tumor cells and selectively release drug in cytosol so as to facilitate its function on microtubule. More importantly, PTX loaded HA-CYS-VES showed better tumor targeting ability, improved antitumor efficacy and low adverse effects on tumor-bearing mice. In conclusion, PTX loaded HA-CYS-VES exhibited a great potential for reversing MDR in anticancer chemotherapeutics.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Hou, L; Tian, CY; Chen, DD; Yuan, YJ; Yan, YS; Huang, QX; Zhang, HJ; Zhang, ZZ or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Kopitzki, S; Thiem, J in ELSEVIER SCI LTD published article about 6-PHOSPHATE in [Kopitzki, Sebastian; Thiem, Joachim] Univ Hamburg, Fac Sci, Dept Chem, Martin Luther King Pl 6, D-201146 Hamburg, Germany; [Kopitzki, Sebastian] KD Pharma Bexbach GmbH, Kraftwerk 6, D-66450 Bexbach, Germany in 2019.0, Cited 22.0. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Direct 6-thiophosphorylation of mannopyranoside gave both the wanted S- as well as the undesired O-phosphates. This required sequential protecting group syntheses to give mannopyranoside6-phosphate and 6-thiophosphate as well as 6-deoxy-6-thio-mannopyranoside6-phosphate, which were transformed into amino-linker compo-nents for affinity chromatography.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about CHEMISTRY; DESIGN; GELS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51973073, 51622303, 51703080]; Natural Science Foundation of Hubei Scientific Committee [2018CFA059]; Applied and Fundamental Frontier Program of Wuhan [2019010701011409]. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Jo, YH; Li, SQ; Zuo, C; Zhang, Y; Gan, HH; Li, SB; Yu, LP; He, D; Xie, XL; Xue, ZG. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Compared with liquid electrolytes, the solid polymer electrolyte (SPE), which possesses improved thermal and mechanical stability, is believed the broadest potential application for satisfying the safety needs of advanced electro-chemical devices. However, some breakable SPEs could lead to catastrophic failure of batteries that triggered by a short circuit. In the present contribution, a new class of SPE containing disulfide bonds and urea groups is reported. The hydrogen bonding between the urea groups and disulfide metathesis reaction endows the SPE with a high level of self-healing without external stimuli at room temperature as well as ultrafast self-healing at elevated temperatures. The completely healed SPE with extreme damage shows a high self-healing efficiency and no changes in the ionic conductivity and cycling performance of the solid-state lithium-metal/LiFePO4 cell compared to the pristine one.

Welcome to talk about 56-17-7, If you have any questions, you can contact Jo, YH; Li, SQ; Zuo, C; Zhang, Y; Gan, HH; Li, SB; Yu, LP; He, D; Xie, XL; Xue, ZG or send Email.. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Magnetic resonance energy transfer for in vivo glutathione susceptibility weighted imaging WOS:000514748200020 published article about TUMOR MICROENVIRONMENT; FLUORESCENT-PROBE; NANOPARTICLES; ACTIVATION; SOFT in [Wang, Kun; Zhang, Huilin; Zhao, Peiran; Meng, Xianfu; Chen, Xiaoyan; Liu, Yang; Liu, Yanyan; Gong, Teng; Bu, Wenbo] East China Normal Univ, Coll Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China; [Wu, Wanlu; Fang, Xiangming] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Med Imaging, Nanjing, Peoples R China; [Shen, Aijun; Wang, Peijun] Tongji Univ, Tongji Hosp, Dept Med Imaging, Shanghai 200065, Peoples R China in 2020.0, Cited 44.0. Product Details of 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Glutathione (GSH) plays a vital role in maintaining biological redox homeostasis. Accordingly, accurate imaging of glutathione in vivo is of great significance. Herein, we propose a magnetic resonance energy transfer (MRET) strategy based on a distance-dependent magnetic exchange coupling effect (MECE), which can realize GSH detection within tumors in vivo by susceptibility weighted imaging (SWI). Fe3O4 nanoparticles (NPs) and CoFe2O4 NPs linked with cystamine (Fe3O4-S-S-CoFe2O4) have been successfully designed as SWI nanoprobes. After the disulfide bonds are broken by excess GSH in the tumor, the increase in the distance between Fe3O4 NPs and CoFe2O4 NPs will induce a decrease of MECE and magnetic susceptibility. As a result, the changes in the SWI signals are used for tumor GSH detection in vivo. Experimental results in vitro and in vivo demonstrate that the Fe3O4-S-S-CoFe2O4 SWI nanoprobe can sensitively detect concentrations of GSH in tumors. Hence, this strategy not only improves the sensitivity of the GSH response in SWI but also provides a powerful basis for the design of other responsive functional MRI nanoprobes.

Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, K; Zhang, HL; Shen, AJ; Zhao, PR; Meng, XF; Chen, XY; Liu, Y; Liu, YY; Gong, T; Wu, WL; Fang, XM; Wang, PJ; Bu, WB or send Email.. Product Details of 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

HPLC of Formula: C4H14Cl2N2S2. In 2021.0 CARBOHYD POLYM published article about PH; POLYMERS; YIELD; FILMS in [Guo, Tianyu; Wang, Wangxia; Song, Junlong; Jin, Yongcan] Nanjing Forestry Univ, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat F, Nanjing 210037, Peoples R China; [Wang, Wangxia] Yancheng Inst Technol, Sch Chem & Chem Engn, Yancheng 224001, Peoples R China; [Guo, Tianyu; Wang, Wangxia; Xiao, Huining] Univ New Brunswick, Dept Chem Engn, Fredericton, NB E3B 5A3, Canada in 2021.0, Cited 46.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

The utilization of agrochemicals in crop production is often inefficient due to lack of appropriate carriers, raising in the significant concerns of ecological environment and public health. To enhance the efficiency of agrochemical delivery, a novel cellulose-based hydrogel was constructed in this work by cross-linking dopamine (DA)-modified carboxymethyl cellulose (CMC) with cystamine (CYS) in the presence of Fe3+ ions. The hydrogels displayed reversible sol-gel transitions upon exposure to stimulation of changes in pH and redox, leading to the controllable release of model agrochemical (6-benzyladenine). Compared with single-triggered condition, the hydrogel doubled the cumulative release when co-triggered by pH and redox. The dynamic metal/catechol complexation and disulfide bonding coexist in the hydrogel networks, enabling occurrence of dynamic reaction under a variety of environmental conditions. The finite element method (FEM) was employed to simulate the hydrogel to provide a theoretical insight into the tested drug delivery. Benefitting from the reversibly cross linked networks and the excellent biodegradability of the hydrogels, we anticipate that this dual-responsive, polysaccharide-based hydrogel will offer diverse applications to reach the full potential in sustainable advancement of crop production.

HPLC of Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Guo, TY; Wang, WX; Song, JL; Jin, YC; Xiao, HN or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem