Month: November 2021

An article Scale-up manufacturing of gelatin-based microcarriers for cell therapy WOS:000529606400001 published article about MESENCHYMAL STEM-CELLS; OPTIMIZATION; CULTURE; DIFFERENTIATION; EXPANSION; SYSTEM; GROWTH; HMSCS in [Dosta, Pere; Ferber, Shiran; Zhang, Yi; Wang, Kui; Ros, Albert; Artzi, Natalie] MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA; [Dosta, Pere; Ferber, Shiran; Zhang, Yi; Wang, Kui; Ros, Albert; Artzi, Natalie] Harvard Med Sch, Brigham & Womens Hosp, Div Engn Med, Dept Med, Boston, MA 02115 USA; [Uth, Nicholas; Levinson, Yonatan; Abraham, Eytan] Res & Technol, Walkersville, MD USA; [Artzi, Natalie] Broad Inst Harvard & MIT, Cambridge, MA USA in 2020.0, Cited 33.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Microcarriers, including crosslinked porous gelatin beads (Cultispher G) are widely used as cell carriers for cell therapy applications. Microcarriers can support a range of adherent cell types in stirred tank bioreactor culture, which is scalable up to several thousands of liters. Cultispher G in particular is advantageous for cell therapy applications because it can be dissolved enzymatically, and thus cells can be harvested without the need to perform a large-scale cell-bead filtration step. This enzymatic dissolution, however, is challenged by the slow degradation of the carriers in the presence of enzymes as new extracellular matrix is being deposited by the proliferating cells. This extended dissolution timelimits the yield of cell recovery while compromising cellular viability. We report herein the development of crosslinked porous gelatin beads that afford rapid, stimuli-triggered dissolution for facile cell removal using human mesenchymal stem cells (hMSC) as a model system. We successfully fabricated redox-sensitive beads (RS beads) and studied their cell growth, dissolution time and cell yield, compared to regular gelatin-based beads (Reg beads). We have shown that RS beads allow for much faster dissolution compared to Reg beads, supporting better hMSC detachment and recovery following 8 days of culture in spinner flasks, or in 3L bioreactors. These newly synthesized RS beads show promise as cellular microcarriers and can be used for scale-up manufacturing of different cell types while providing on-demand degradation for facile cell retrieval.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Dosta, P; Ferber, S; Zhang, Y; Wang, K; Ros, A; Uth, N; Levinson, Y; Abraham, E; Artzi, N or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry; Polymer Science very interesting. Saw the article Polymer-Upconverting Nanoparticle Hybrid Micelles for Enhanced Synergistic Chemo-Photodynamic Therapy: Effects of Emission- Absorption Spectral Match published in 2019.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Li, YC; Zhu, JT (corresponding author), HUST, Sch Chem & Chem Engn, Minist Educ, Key Lab Mat Chem Energy Convers & Storage, Wuhan 430074, Hubei, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Chemo-photodynamic combined therapy is promising in cancer treatment, although low tissue penetration of visible light for activating photosensitizers (e.g., chlorin e6, Ce6) limited its broad applications. Combination of upcoverting nanoparticles (UCNPs) with the photosensitizers endows us with the possibility to utilize highly tissue penetrable near-infrared light; nevertheless, the mismatch between absorption of common photosensitizers (lambda(abs), mainly red) and emission of UCNPs (lambda(em), mainly green) resulted in low energy utilization and unsatisfied therapeutic efficacy in the current UCNP-PDT (photodymanic therapy) platforms. To resolve this problem, herein, we construct polymer-UCNP hybrid micelles (PUHMs) for codelivery of doxorubicin (DOX) and Ce6, and systemically studied the effects of spectral match between lambda(em) of UCNPs and lambda(abs) of Ce6 on efficiency of synergistic chemo-photodynamic therapy. Compared with spectrally mismatched PUHMs, the spectrally matched PUHMs can significantly enhance the utilization efficiency of upconverted emission energy to activate the photosensitizers and generate more reactive oxygen species (ROS) for enhanced photodynamic therapy. Meanwhile, as the assembled structure of PUHMs can be destroyed by the oxidation of ROS upon 980 nm laser irradiation because of the hydrophobic-hydrophilic transformation of poly(propylene sulfide) (PPS) segment, the spectrally matched PUHMs triggered faster release of DOX, thus resulting in more effective chemotherapy. As a result, the spectrally matched PUHMs induced more prominent cytotoxicity and superior synergistic therapeutic effect for cancer cells in vitro. Our results demonstrated that such spectrally matched PUHMs provide us with an effective strategy for photodynamic-chemo synergistic therapy.

Welcome to talk about 56-17-7, If you have any questions, you can contact Chen, Y; Ren, JL; Tian, D; Li, YC; Jiang, H; Zhu, JT or send Email.. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Zhang, J; Liu, D; Liu, JL; Han, YF; Xu, HY; Leng, XG; Kong, DL; Liu, LX in ROYAL SOC CHEMISTRY published article about CD8 T-CELLS; REGULATORY T; MECHANISMS; ANTI-CTLA-4; INHIBITION; EXPRESSION; RESPONSES in [Zhang, Jing; Liu, Dan; Liu, Jiale; Leng, Xigang; Kong, Deling; Liu, Lanxia] Peking Union Med Coll, Tianjin Key Lab Biomat, Inst Biomed Engn, Tianjin 300192, Peoples R China; [Zhang, Jing; Liu, Dan; Liu, Jiale; Leng, Xigang; Kong, Deling; Liu, Lanxia] Chinese Acad Med Sci, Tianjin 300192, Peoples R China; [Han, Yanfeng] Garvan Inst Med Res, Kinghorn Canc Ctr, Darlinghurst, NSW 2010, Australia; [Xu, Haiyan] Chinese Acad Med Sci, Inst Bas Sci, Sch Basic Med, Peking Union Med Coll, Beijing 100005, Peoples R China; [Kong, Deling] Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China in 2020.0, Cited 25.0. Category: thiazines. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Combined blockades of CTLA-4 and PD-1 can yield better overall complementary clinical outcomes than individual blockades, but the response rates are still relatively low. To investigate the anti-tumor effects of various combined strategies, we designed various spherical nucleotide nanoparticles (SNPs) loaded with CTLA-4 aptamer (cSNPs), PD-1 siRNA (pSNPs) or both (hybrid SNPs, or hSNPs). The results demonstrated that hSNPs could promote significantly stronger anti-tumor immune responses in a nonredundant fashion than the mixture of pSNPs and cSNPs (pSNPs & cSNPs). We reasoned that this is because all individual immune cells could receive both CTLA-4 and PD-1 blockades when they engulfed hSNPs, but it is much less likely that individual immune cells could receive both CTLA-4 and PD-1 blockades as many of them may not take both pSNPs and cSNPS from pSNPs & cSNPs. Further results revealed that the synergistic immune stimulatory effects of CTLA-4 and PD-1 blockades in the form of hSNPs were at least partly through regulating the immune suppressive function of both Tregs and TIM3(+)exhausted-like CD8 T cells and allowing effector T cells to expand. This mechanism is not identical to earlier reported mechanisms of CTLA-4 and PD-1 blockades.

Category: thiazines. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2020.0 J AM HEART ASSOC published article about FIBRILLATION; PREVALENCE in [Weng, Willy; Wiefels, Christiane; Nery, Pablo B.; Celiker-Guler, Emel; Promislow, Steven; Medor, Maria C.; Spence, Stewart; Odabashian, Roupen; Alqarawi, Wael; Juneau, Daniel; de Kemp, Rob; Leung, Eugene; Beanlands, Rob; Birnie, David] Univ Ottawa, Heart Inst, Div Cardiol, 40 Ruskin St, Ottawa, ON K1Y 4W7, Canada; [Chakrabarti, Santabhanu] Univ British Columbia, Div Cardiol, Vancouver, BC, Canada; [Healey, Jeff S.] McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada; [Hruczkowski, Tomasz W.] Univ Alberta, Mazankowski Alberta Heart Inst, Edmonton, AB, Canada; [Quinn, F. Russell] Libin Cardiovasc Inst Alberta, Calgary, AB, Canada; [Juneau, Daniel] Univ Montreal, Ctr Hosp, Dept Nucl Med & Radiol, Montreal, PQ, Canada in 2020.0, Cited 19.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

Background: Recent data have suggested a substantial incidence of atrial arrhythmias (AAs) in cardiac sarcoidosis (CS). Our study aims were to first assess how often AAs are the presenting feature of previously undiagnosed CS. Second, we used prospective follow-up data from implanted devices to investigate AA incidence, burden, predictors, and response to immunosuppression. Methods and Results: This project is a substudy of the CHASM-CS (Cardiac Sarcoidosis Multicenter Prospective Cohort Study; NCT01477359). Inclusion criteria were presentation with clinically manifest cardiac sarcoidosis, treatment-naive status, and implanted with a device that reported accurate AA burden. Data were collected at each device interrogation visit for all patients and all potential episodes of AA were adjudicated. For each intervisit period, the total AA burden was obtained. A total of 33 patients met the inclusion criteria (aged 56.1 +/- 7.7 years, 45.5% women). Only 1 patient had important AAs as a part of the initial CS presentation. During a median follow-up of 49.1 months, 11 of 33 patients (33.3%) had device-detected AAs, and only 2 (6.1%) had a clinically significant AA burden. Both patients had reduced burden after CS was successfully treated and there was no residual fluorodeoxyglucose uptake on positron emission tomography scan. Conclusions: First, we found that AAs are a rare presenting feature of clinically manifest cardiac sarcoidosis. Second, AAs occurred in a minority of patients at follow-up; the burden was very low in most patients. Only 2 patients had clinically significant AA burden, and both had a reduction after CS was treated. REGISTRATION: URL: https://www.clinicaltrials.gov; unique identifier NCT01477359.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Weng, W; Wiefels, C; Chakrabarti, S; Nery, PB; Celiker-Guler, E; Healey, JS; Hruczkowski, TW; Quinn, FR; Promislow, S; Medor, MC; Spence, S; Odabashian, R; Alqarawi, W; Juneau, D; de Kemp, R; Leung, E; Beanlands, R; Birnie, D or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

COA of Formula: C4H14Cl2N2S2. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Redox-Sensitive Clustered Ultrasmall Iron Oxide Nanoparticles for Switchable T-2/T-1-Weighted Magnetic Resonance Imaging Applications published in 2020.0, Reprint Addresses Peng, C; Shi, XY (corresponding author), Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Canc Ctr, Shanghai 200072, Peoples R China.; Shi, XY (corresponding author), Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China.; Peng, C (corresponding author), Ninghai First Hosp, Ningbo 315600, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Development of novel activable dual-mode T-1/T-2-weighted magnetic resonance (MR) contrast agents with the same composition for dynamic precision imaging of tumors has been a challenging task. Here, we demonstrated a strategy to prepare clustered Fe3O4 nanoparticles (NPs) with redox-responsiveness to tumor microenvironment to achieve switchable T-2/T-1-weighted dual-mode MR imaging applications. In this study, we first synthesized ultrasmall Fe3O4 NPs with an average size of 3.3 nm and an r, relaxivity of 4.3 mM(-1) s(-1), and then cross-linked the single Fe3O4 NPs using cystamine dihydrochloride (Cys) to form clustered Fe3O4/Cys NPs. The Fe3O4 nanoclusters (NCs) possess desirable colloidal stability, cytocompatibility, high r(2) relaxivity (26.4 mM(-1) s(-1)), and improved cellular uptake efficiency. Importantly, with the redox-responsiveness of the disulfide bond of Cys, the Fe3O4 NCs can be dissociated to form single particles under a reducing condition, hence displaying a switchable T-2/T-1-weighted MR imaging property that can be utilized for dynamic precision imaging of cancer cells in vitro and a subcutaneous tumor model in vivo due to the reductive intracellular environment of cancer cells and the tumor microenvironment. With the tumor reductive microenvironment-mediated switching of T-2 to T-1 MR effect and the ultrasmall size of the single particles that can pass through the kidney filter, the developed Fe3O4 NCs may be used as a promising switchable T-2/T-1 dual-mode MR contrast agent for precision imaging of different biosystems.

Welcome to talk about 56-17-7, If you have any questions, you can contact Ma, D; Shi, MH; Li, X; Zhang, JL; Fan, Y; Sun, K; Jiang, TT; Peng, C; Shi, XY or send Email.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Authors Yang, X; Cheng, Q; Monnier, V; Charles, L; Karoui, H; Ouari, O; Gigmes, D; Wang, RB; Kermagoret, A; Bardelang, D in WILEY-V C H VERLAG GMBH published article about in [Yang, Xue; Charles, Laurence; Karoui, Hakim; Ouari, Olivier; Gigmes, Didier; Kermagoret, Anthony; Bardelang, David] Aix Marseille Univ, CNRS, ICR, Marseille, France; [Cheng, Qian; Wang, Ruibing] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa, Macau, Peoples R China; [Monnier, Valerie] Aix Marseille Univ, CNRS, Cent Marseille, FSCM,Spectropole, Marseille, France in 2021.0, Cited 87.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Molecular machines are ubiquitous in nature and function away from equilibrium by consuming fuels to produce appropriate work. Chemists have recently excelled at mimicking the fantastic job performed by natural molecular machines with synthetic systems soluble in organic solvents. In efforts toward analogous systems working in water, we show that guest molecules can be exchanged in the synthetic macrocycle cucurbit[7]uril by involving kinetic traps, and in such a way as modulating energy wells and kinetic barriers using pH, light, and redox stimuli. Ditolyl-viologen can also be exchanged using the best kinetic trap and interfaced with alginate, thus affording pH-responsive blue, fluorescent hydrogels. With tunable rate and binding constants toward relevant guests, cucurbiturils may become excellent ring molecules for the construction of advanced molecular machines working in water.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Peng, N; Ding, X; Wang, ZY; Cheng, Y; Gong, ZW; Xu, XJ; Gao, XF; Cai, Q; Huang, SW; Liu, Y in [Peng, Na; Ding, Xiao; Cheng, Yang; Gong, Zhiwei; Xu, Xiangjiao; Gao, Xiaofang; Cai, Qun; Liu, Yi] Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Coal Convers & New Carbon Mat Hubei Prov, Wuhan 430081, Hubei, Peoples R China; [Wang, Ziyu; Huang, Shiwen; Liu, Yi] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China published Novel dual responsive alginate-based magnetic nanogels for onco-theranostics in 2019.0, Cited 39.0. SDS of cas: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

The aim of this work was to obtain a novel onco-theranostic system for early diagnosis and improved chemotherapeutic outcome. Hybrid nanogels with magnetic and dual responsive properties were fabricated by covalently attaching superparamagnetic iron oxide nanoparticles (SPIONs) with a disulfide-modified alginate derivative, while simultaneously encapsulating the anticancer drug doxorubicin. The resulting nanogels exhibited magnetic-targeted characteristics, high drug loading content, co-triggered release behavior, high toxicity to tumor cells, low side effects to normal cells, and magnetic resonance imaging (MRI) functions. These findings proved that the hybrid nanogels have great potential as novel tumor-targeting nano-theranostic agents for simultaneous MRI imaging and efficient anti-tumor treatment.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Atrial Arrhythmias in Clinically Manifest Cardiac Sarcoidosis: Incidence, Burden, Predictors, and Outcomes WOS:000566953100021 published article about FIBRILLATION; PREVALENCE in [Weng, Willy; Wiefels, Christiane; Nery, Pablo B.; Celiker-Guler, Emel; Promislow, Steven; Medor, Maria C.; Spence, Stewart; Odabashian, Roupen; Alqarawi, Wael; Juneau, Daniel; de Kemp, Rob; Leung, Eugene; Beanlands, Rob; Birnie, David] Univ Ottawa, Heart Inst, Div Cardiol, 40 Ruskin St, Ottawa, ON K1Y 4W7, Canada; [Chakrabarti, Santabhanu] Univ British Columbia, Div Cardiol, Vancouver, BC, Canada; [Healey, Jeff S.] McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada; [Hruczkowski, Tomasz W.] Univ Alberta, Mazankowski Alberta Heart Inst, Edmonton, AB, Canada; [Quinn, F. Russell] Libin Cardiovasc Inst Alberta, Calgary, AB, Canada; [Juneau, Daniel] Univ Montreal, Ctr Hosp, Dept Nucl Med & Radiol, Montreal, PQ, Canada in 2020.0, Cited 19.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Product Details of 56-17-7

Background: Recent data have suggested a substantial incidence of atrial arrhythmias (AAs) in cardiac sarcoidosis (CS). Our study aims were to first assess how often AAs are the presenting feature of previously undiagnosed CS. Second, we used prospective follow-up data from implanted devices to investigate AA incidence, burden, predictors, and response to immunosuppression. Methods and Results: This project is a substudy of the CHASM-CS (Cardiac Sarcoidosis Multicenter Prospective Cohort Study; NCT01477359). Inclusion criteria were presentation with clinically manifest cardiac sarcoidosis, treatment-naive status, and implanted with a device that reported accurate AA burden. Data were collected at each device interrogation visit for all patients and all potential episodes of AA were adjudicated. For each intervisit period, the total AA burden was obtained. A total of 33 patients met the inclusion criteria (aged 56.1 +/- 7.7 years, 45.5% women). Only 1 patient had important AAs as a part of the initial CS presentation. During a median follow-up of 49.1 months, 11 of 33 patients (33.3%) had device-detected AAs, and only 2 (6.1%) had a clinically significant AA burden. Both patients had reduced burden after CS was successfully treated and there was no residual fluorodeoxyglucose uptake on positron emission tomography scan. Conclusions: First, we found that AAs are a rare presenting feature of clinically manifest cardiac sarcoidosis. Second, AAs occurred in a minority of patients at follow-up; the burden was very low in most patients. Only 2 patients had clinically significant AA burden, and both had a reduction after CS was treated. REGISTRATION: URL: https://www.clinicaltrials.gov; unique identifier NCT01477359.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Category: thiazines. In 2019.0 ACS MACRO LETT published article about POLYMERS; COVALENT in [Zhang, Shuai; Qin, Bo; Huang, Zehuan; Xu, Jiang-Fei; Zhang, Xi] Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China in 2019.0, Cited 52.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

A new method of supramolecular emulsion interfacial polymerization is developed, which can be used to fabricate supramolecular polymeric nanospheres. We designed a water-soluble monomer containing two maleimide end groups, acting as both building block and surfactant, and an oil-soluble supramonomer bearing two thiol groups connected by quadruple hydrogen bonds. With the assist of ultrasonication, hollow nanospheres can be controllably prepared by thiol-maleimide reaction of two monomers at the emulsion interface, which exhibit good stability and dynamic property. In addition, the encapsulated guest molecules could be controllably released from the supramolecular polymeric nanospheres, owing to their stimuli-responsiveness. It is anticipated that this approach will enrich the methodology of supramolecular polymerization and can be applied to constructing supramolecular materials with controllable structures and functions.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

COA of Formula: C4H14Cl2N2S2. In 2020.0 EUR POLYM J published article about POLY(AMIDOAMINE)-FUNCTIONALIZED GRAPHENE OXIDE; NANOPARTICLES; DESIGN; MULTIVALENT; REDUCTION; RELEASE in [Salami-Kalajahi, Mehdi; Roghani-Mamaqani, Hossein] Sahand Univ Technol, Fac Polymer Engn, POB 51335-1996, Tabriz, Iran; Sahand Univ Technol, Inst Polymer Mat, POB 51335-1996, Tabriz, Iran in 2020.0, Cited 60.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Classic dendrimers are not used in many specific applications such as simultaneous loading of different drugs due to the existence of identical end groups. The possibility of designing the structure in dendrimers paves the way to synthesize more complicated dendrimers. This includes the creation of various types of peripheral groups on the surface of dendrimers to synthesize for example Janus dendrimers. Nowadays, three main methods are proposed for the synthesis of Janus dendrimers in which the high amount of conventional dendrimers is produced. The goal of this work is to develop a new method for synthesis of Janus dendrimers without production of conventional dendrimers. The present method has three main stages for the synthesis of Janus dendrimers including synthesis of 5th generation PPI dendrimer with cystamine core and hydrophobic surface, conversion of disulfide bonds to thiol group using a structure scission approach, and the formation of PAMAM hydrophilic dendrons with amine end groups. Different analyses including FT-IR, NMR, DLS, and GPC are used to prove the success of the synthesis route. Also, due to application of dendrimers in drug delivery including solubility improvement of hydrophobic drugs, Janus dendrimers are used to improve solubility of tetracycline and dexamethasone in presence of different generations of Janus dendrimers. Since the Janus dendrimers have both hydrophilic and hydrophobic ends, as well as having numerous terminal groups and numerous internal cavities, they have resulted in significant improvements in drug solubility. Also, solubility of the two hydrophobic drugs in water was increased by increasing concentration and generation of dendrimer.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem