Month: November 2021

I found the field of Chemistry; Science & Technology – Other Topics; Engineering very interesting. Saw the article Novel pH-Responsive Smart Fabric: From Switchable Wettability to Controllable On-Demand Oil/Water Separation published in 2019.0. Computed Properties of C4H14Cl2N2S2, Reprint Addresses Pi, PH; Wen, XF (corresponding author), South China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China.; Wang, L (corresponding author), Minist Environm Protect PRC, South China Inst Environm Sci, Guangzhou 510655, Guangdong, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Stimulus-responsive materials have great potential in advanced controllable oil/water separation applications. Here, a novel, cost-effective, and green approach is developed to produce a pH-responsive smart fabric with switchable wettability. The approach first involves grafting polydopamine (PDA) and cystamine dihydrochloride (cystamine) on a fabric surface to obtain thiol-functionalized fabric (Fabric-SH). Hydrophobic stearyl methacrylate (SMA) and pH-responsive undecylenic acid are then decorated on the Fabric-SH surface through efficient and green photoinduced thiol-ene click coupling chemistry. The obtained fabric exhibits rapidly switchable wettability between superhydrophobicity and superhydrophilicity depending on the contacting liquid pH value and can be applied in controllable separation of various mixtures of water and oil with high efficiency up to 99%. More importantly, the as prepared fabric is able to realize the separation of oil/water/oil ternary mixtures and can self-clean and repel oil fouling during the separation process. Its superhydrophobicity is robust, showing no significant change after a 500 cycle peeling test. This novel and cost-effective smart cotton fabric exhibits significant potential in satisfying different separation purposes under complicated conditions.

Welcome to talk about 56-17-7, If you have any questions, you can contact Zeng, XJ; Yang, KQ; Huang, CY; Yang, K; Xu, SP; Wang, L; Pi, PH; Wen, XF or send Email.. Computed Properties of C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Redox-Sensitive Clustered Ultrasmall Iron Oxide Nanoparticles for Switchable T-2/T-1-Weighted Magnetic Resonance Imaging Applications WOS:000515196200018 published article about ALGINATE NANOGELS; DRUG-DELIVERY; TUMOR; SIZE; GLUTATHIONE; T-1; ACCUMULATION; PENETRATION; ASSEMBLIES; MICELLES in [Ma, Dan; Zhang, Jiulong; Peng, Chen; Shi, Xiangyang] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Canc Ctr, Shanghai 200072, Peoples R China; [Ma, Dan; Shi, Menghan; Li, Xin; Fan, Yu; Jiang, Tingting; Shi, Xiangyang] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China; [Sun, Kai] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA; [Peng, Chen] Ninghai First Hosp, Ningbo 315600, Peoples R China in 2020.0, Cited 44.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Product Details of 56-17-7

Development of novel activable dual-mode T-1/T-2-weighted magnetic resonance (MR) contrast agents with the same composition for dynamic precision imaging of tumors has been a challenging task. Here, we demonstrated a strategy to prepare clustered Fe3O4 nanoparticles (NPs) with redox-responsiveness to tumor microenvironment to achieve switchable T-2/T-1-weighted dual-mode MR imaging applications. In this study, we first synthesized ultrasmall Fe3O4 NPs with an average size of 3.3 nm and an r, relaxivity of 4.3 mM(-1) s(-1), and then cross-linked the single Fe3O4 NPs using cystamine dihydrochloride (Cys) to form clustered Fe3O4/Cys NPs. The Fe3O4 nanoclusters (NCs) possess desirable colloidal stability, cytocompatibility, high r(2) relaxivity (26.4 mM(-1) s(-1)), and improved cellular uptake efficiency. Importantly, with the redox-responsiveness of the disulfide bond of Cys, the Fe3O4 NCs can be dissociated to form single particles under a reducing condition, hence displaying a switchable T-2/T-1-weighted MR imaging property that can be utilized for dynamic precision imaging of cancer cells in vitro and a subcutaneous tumor model in vivo due to the reductive intracellular environment of cancer cells and the tumor microenvironment. With the tumor reductive microenvironment-mediated switching of T-2 to T-1 MR effect and the ultrasmall size of the single particles that can pass through the kidney filter, the developed Fe3O4 NCs may be used as a promising switchable T-2/T-1 dual-mode MR contrast agent for precision imaging of different biosystems.

Product Details of 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Ma, D; Shi, MH; Li, X; Zhang, JL; Fan, Y; Sun, K; Jiang, TT; Peng, C; Shi, XY or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Chemistry very interesting. Saw the article Electrochemical CO2 Reduction – The Effect of Chalcogenide Exchange in Ni-Isocyclam Complexes published in 2020.0. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Ray, K (corresponding author), Humboldt Univ, Dept Chem, D-12489 Berlin, Germany.; Apfel, UP (corresponding author), Ruhr Univ Bochum, Dept Chem & Biochem, D-44801 Bochum, Germany.; Apfel, UP (corresponding author), Fraunhofer UMSICHT, D-46047 Oberhausen, Germany.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Among the numerous homogeneous electrochemical CO2 reduction catalysts, [Ni(cyclam)](2+) is known as one of the most potent catalysts. Likewise, [Ni(isocyclam)](2+) was reported to enable electrochemical CO2 conversion but has received significantly less attention. However, for both catalysts, a purposeful substitution of a single nitrogen donor group by chalcogen atoms was never reported. In this work, we report a series of isocyclam-based Ni complexes with {ON3}, {SN3}, {SeN3}, and {N-4} moieties and investigated the influence of nitrogen/chalcogen substitution on electrochemical CO2 reduction. While [Ni(isocyclam)](2+) showed the highest selectivity toward CO2 reduction within this series with a Faradaic efficiency of 86% for the generation of CO at an overpotential of -1.20 V and acts as a homogeneous catalyst, the O- and S-containing Ni complexes revealed comparable catalytic activities at ca. 0.3 V milder overpotential but tend to form deposits on the electrode, acting as precursors for a heterogeneous catalysis. Moreover, the heterogeneous species generated from the O- and S-containing complexes enable a catalytic hydride transfer to acetonitrile, resulting in the generation of acetaldehyde. The incorporation of selenium, however, resulted in loss of CO2 reduction activity, mainly leading to hydrogen generation that is also catalyzed by a heterogeneous electrodeposit.

Welcome to talk about 56-17-7, If you have any questions, you can contact Gerschel, P; Battistella, B; Siegmund, D; Ray, K; Apfel, UP or send Email.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2020.0 J PORPHYR PHTHALOCYA published article about MESOPOROUS SILICA NANOPARTICLES; MULTIDRUG-RESISTANCE; PHOTODYNAMIC THERAPY; COMBINATION THERAPY; CANCER-THERAPY; DELIVERY; NANOMEDICINE; STRATEGIES in [Lo, Pui-Chi] City Univ Hong Kong, Dept Biomed Sci, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China; City Univ Hong Kong, Shenzhen Res Inst, Shenzhen 518057, Peoples R China in 2020.0, Cited 31.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Category: thiazines

Doxorubicin (DOX) resistance, which results in a reduced accumulation of DOX in the nucleus and hence decreased DNA damage, is a major challenge for chemotherapy against hepatocellular carcinoma. In this paper, we combined chemotherapy with photodynamic therapy (PDT) to combat DOX-resistant human hepatocellular carcinoma cells. We have prepared the polymeric micelles conjugating with DOX and zinc(II) phthalocyanine (ZnPc) through a pH-responsive hydrazone linker and a glutathione (GSH)-responsive disulfide linker, respectively. The polymeric micelles (DOX-ZnPc-micelles) exhibited a spherical shape with a size of about 98 mn diameter and showed excellent stability in aqueous solution. Due to the self-quenching of the ZnPc inside the micelles, DOX-ZnPc-micelles did not emit fluorescence upon red light irradiation. Drug release experiments verified that DOX and ZnPc could be released under acidic conditions and reducing environments, respectively. A higher concentration of DOX was internalized into DOX-resistant R-HepG2 cells through the delivery of polymeric micelles when compared with the free DOX, hence DOX-ZnPc-micelles exhibited a significant enhancement in anticancer activity. The IC50 value of DOX against R-HepG2 cells was found to be 21 mu M when combined with PDT and it was 5-fold less than that of a single treatment of DOX (102 mu M). The DOX-ZnPc-micelles could induce cell apoptosis and necrosis on R-HepG2 cells by combined therapeutic modalities, while these micelles induced only apoptosis on IiepG2 cells. We have demonstrated that utilization of polymeric micelles can significantly enhance the cellular uptake and cytotoxicity of DOX against R-HepG2 cells when compared with free DOX. Moreover, PDT can act as an adjuvant therapeutic modality and combine with chemotherapy to further improve therapeutic efficacy. Overall speaking, DOX-ZnPc-micelles can overcome DOX resistance and induce a synergistic therapeutic effect against DOX-resistant R-HepG2 cells, hence improving the therapeutic efficacy when compared with monotherapy.

Category: thiazines. Welcome to talk about 56-17-7, If you have any questions, you can contact Gao, D; Lo, PC or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Programmable multistage drug delivery to lymph nodes WOS:000539544500002 published article about POLY(PROPYLENE SULFIDE) NANOPARTICLES; DENDRITIC CELLS; ADAPTIVE IMMUNITY; CELLULAR-IMMUNITY; VIVO; TRANSPORT; PEPTIDES; ACTIVATION; MOLECULES; THERAPY in [Schudel, Alex; Francis, David Mark; Manspeaker, Margaret Patricia; Rohner, Nathan Andrew; Finn, M. G.; Thomas, Susan Napier] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA; [Schudel, Alex] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA; [Chapman, Asheley Poole; Yau, Mei-Kwan; Higginson, Cody James; Finn, M. G.] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA; [Francis, David Mark; Manspeaker, Margaret Patricia] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA; [Avecilla, Alexa Regina Chua; Thomas, Susan Napier] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA; [Avecilla, Alexa Regina Chua; Thomas, Susan Napier] Emory Univ, Atlanta, GA 30322 USA; [Rohner, Nathan Andrew; Thomas, Susan Napier] Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USA; [Finn, M. G.; Thomas, Susan Napier] Georgia Inst Technol, Sch Biol Sci, Atlanta, GA 30332 USA; [Thomas, Susan Napier] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA in 2020.0, Cited 50.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. HPLC of Formula: C4H14Cl2N2S2

Therapeutic delivery selectively to lymph nodes has the potential to address a variety of unmet clinical needs. However, owing to the unique structure of the lymphatics and the size-restrictive nature of the lymph node reticular network, delivering cargo to specific cells in the lymph node cortex and paracortex is difficult. Here, we describe a delivery system to overcome lymphatic and intra-lymph node transport barriers by combining nanoparticles that are rapidly conveyed to draining lymph nodes after administration in peripheral tissues with programmable degradable linkers. This platform enables the controlled release of intra-lymph-mobile small-molecular cargo, which can reach vastly more immune cells throughout the lymph node than either the particles or free compounds alone. The release rate can be programmed, allowing access to different lymph node structures and therefore specific lymphocyte subpopulations. We are thus able to alter the subtypes of drugged lymph node cells to improve immunotherapeutic effects. Nanoparticles that access lymphatic vessels and are functionalized with degradable linkers, whose half-lives can be programmed, enable the controlled release of therapeutic cargo in different regions of the lymph nodes, allowing the targeting of otherwise difficult-to-reach lymphocyte subpopulations.

HPLC of Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2021.0 NANOMATERIALS-BASEL published article about DRUG-DELIVERY; DOXORUBICIN; MICELLES; BEHAVIOR; CELL in [Curcio, Manuela; Paoli, Alessandro; Cirillo, Giuseppe; Forestiero, Martina; Giordano, Francesca; Mauro, Loredana; Amantea, Diana; Nicoletta, Fiore Pasquale; Iemma, Francesca] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy; [Di Pietro, Sebastiano; Di Bussolo, Valeria] Univ Pisa, Dept Pharm, Via Bonanno Pisano 33, I-56126 Pisa, Italy in 2021.0, Cited 42.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

Welcome to talk about 56-17-7, If you have any questions, you can contact Curcio, M; Paoli, A; Cirillo, G; Di Pietro, S; Forestiero, M; Giordano, F; Mauro, L; Amantea, D; Di Bussolo, V; Nicoletta, FP; Iemma, F or send Email.. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Jiang, JT; Li, JB; Zhou, BY; Niu, CH; Wang, WD; Wu, WL; Liang, J in [Jiang, Junting; Li, Junbo; Zhou, Biyu; Niu, Chaohuang; Wang, Wendi; Liang, Ju] Henan Univ Sci & Technol, Sch Chem Engn & Pharmaceut, 263 Kaiyuan Rd, Luoyang 471023, Peoples R China; [Wu, Wenlan] Henan Univ Sci & Technol, Sch Med, 263 Kaiyuan Rd, Luoyang 471023, Peoples R China published Fabrication of Polymer Micelles with Zwitterionic Shell and Biodegradable Core for Reductively Responsive Release of Doxorubicin in 2019.0, Cited 44.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

To achieve a high stability in physiological environment and rapid intracellular drug release, a biodegradable zwitterionic triblock copolymer with a disulfide-linked poly-epsilon-caprolactone and polycarboxybetaine methacrylate (PCBMA-SS-PCL-SS-PCBMA) was prepared for micellar carrier to delivery doxorubicin (DOX) into tumor cells. PCBMA-SS-PCL-SS-PCBMA was obtained by following steps: i) introducing disulfide bonds through end-group modification of PCL diol with cystamine dihydrochloride; ii) preparing PCL-RAFT macromolecular chain transfer agent by EDC/NHS chemistry; iii) RAFT polymerization of zwitterionic monomer. Self-assembling from PCBMA-SS-PCL-SS-PCBMA, polymeric micelles had many advantages, such as ultra-low protein absorption in serum and obvious reduction-responsiveness in the presence of DTT. Furthermore, DOX-loaded micelles exhibited high stability upon centrifugation and lyophilization, a fast intracellular drug release and enhanced drug efficacy due to GSH-triggered PCBMA shell shedding and micellar reassembling. Thus, the polymeric micelles integrated several functions and properties could be prospectively utilized as valuable nanocarriers in cancer chemotherapeutics.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Bai, JA; Tian, Y; Liu, FZ; Li, XL; Shao, Y; Lu, XT; Wang, JT; Zhu, GQ; Xue, BY; Liu, M; Hu, P; He, N; Tang, QY in AMER CHEMICAL SOC published article about UNIMOLECULAR MICELLES; THAILANDEPSIN-A; DRUG-DELIVERY; CANCER; TUMORS; RESTRICTION; DOXORUBICIN in [Bai, Jianan; Tian, Ye; Li, Xiaolin; Shao, Yun; Lu, Xintong; Wang, Jintian; Zhu, Guoqin; Xue, Bingyan; Liu, Min; Hu, Ping; He, Na; Tang, Qiyun] Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr Gastroenterol, Nanjing 210029, Jiangsu, Peoples R China; [Liu, Fangzhou] Nanjing Med Univ, Jiangsu Canc Hosp, Dept Head & Neck Surg, Nanjing 210029, Jiangsu, Peoples R China; [Liu, Fangzhou] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Inst Canc Res, Nanjing 210029, Jiangsu, Peoples R China in 2019.0, Cited 37.0. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

The study of multifunctional polymer micelles combined with chemotherapy due to reduced systemic toxicity and enhanced efficacy has attracted intensive attention. Herein, a multifunctional core-cross-linked hybrid micelle system based on mPEG-b-PGu(BA-TPE) and OCT-PEG-b-PGu(DA-TPE) with pH- and redox-triggered drug release and aggregation-induced emission (AIE) active imaging has been developed for active targeting of neuroendocrine neoplasms (NENs), especially neuroendocrine carcinomas (NECs) with poor prognosis. These micelles showed excellent biocompatibility and stability. After the formation of borate ester bonds, core-cross-linked micelles (CCLMs) showed enhanced emission properties. In addition, etoposide (ETO), one of the most important anticancer drugs of NECs, was loaded into the hydrophobic core of micelles by self-assembly with an average diameter of 274.6 nm and spherical morphology. Octreotide (OCT) conjugated onto the micelles enhanced cellular uptake by receptor-mediated endocytosis. ETO-loaded micelles demonstrated the dual-responsive triggered intracellular drug release and great tumor suppression ability in vitro. Compared with free ETO, ETO-loaded CCLMs exhibited a considerable antitumor effect and significantly reduced side effects. Considering the active tumor targeting, dual-responsive drug release and the AIE effect, the polymer micelle system will be a potential candidate for diagnosis and oncotherapy of NENs.

Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Bai, JA; Tian, Y; Liu, FZ; Li, XL; Shao, Y; Lu, XT; Wang, JT; Zhu, GQ; Xue, BY; Liu, M; Hu, P; He, N; Tang, QY or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Facile preparation of pH/reduction dual-stimuli responsive dextran nanogel as environment-sensitive carrier of doxorubicin WOS:000540268800015 published article about INTRACELLULAR DRUG; POLYMER PARTICLES; REDUCTION; DELIVERY; PH; NANOPARTICLES; HYDROGELS; NANOCARRIERS; GLUTATHIONE; MICELLES in [Yu, Kun; He, Lihua; Zheng, Rong; Min, Jie; Su, Hongying; Shan, Shaoyun; Jia, Qingming] Kunming Univ Sci & Technol, Fac Chem Engn, 727 South Jingming Rd, Kunming 650500, Yunnan, Peoples R China; [Yang, Xiyao] Kunming Univ Sci & Technol, Fac Life Sci & Technol, 727 South Jingming Rd, Kunming 650500, Yunnan, Peoples R China in 2020.0, Cited 39.0. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Dual and multi-stimuli responsive polymeric nanoparticles that can respond to two or more signals have been demonstrated as prospective drug carriers with enhanced tumor accumulation and on-demand drug release profiles. In this study, dextran-based (Dex-SS) nanogels were developed via a facile method based on the disulfide containing Schiff base formation between polyaldehyde dextran and cystamine in water-in-oil inverse microemulsion. Acidic and reductive (GSH) environment sensitive degradation behaviors of the resulted nanogels were investigated by morphology analysis of the treated nanogels using SEM imaging. Doxorubicin (DOX) was covalently conjugated into the dextran nanogels via Schiff base linkages, and pH/GSH dual sensitive drug release profiles were demonstrated. Effective cell uptake of the DOX-loaded nanogels was finally identified by human cancer cell line of H1299. Take advantage of the acidic and reductive tumor microenvironment, the dual-stimuli responsive Dex-SS nanogels can serve as micmenvironment-sensitive drug delivery systems for tumor therapy.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Yu, K; Yang, XY; He, LH; Zheng, R; Min, J; Su, HY; Shan, SY; Jia, QM or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2019.0 J CONTROL RELEASE published article about END GROUP REMOVAL; DENDRITIC CELLS; DELIVERY-SYSTEMS; OVALBUMIN; NANOGELS; ANTIGENS; SIZE; PH; IMMUNOGENICITY; IMMUNOTHERAPY in [Lou, Bo; Boonstra, Eger; Li, Dandan; Mastrobattista, Enrico; Hennink, Wim E.] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3584 CG Utrecht, Netherlands; [De Beuckelaer, Ans; De Koker, Stefaan] Univ Ghent, Dept Biomed Mol Biol, Lab Mol Immunol, B-9052 Zwijnaarde, Belgium; [De Geest, Bruno G.] Univ Ghent, Dept Pharmaceut, B-9000 Ghent, Belgium in 2019.0, Cited 63.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Computed Properties of C4H14Cl2N2S2

Recent advances in the development of protein-based vaccines have expanded the opportunities for preventing and treating both infectious diseases as well as cancer. However, the development of readily and efficient antigen delivery systems capable of stimulating strong cytotoxic T-lymphocyte (CTL) responses remains a challenge. With the attempt to closely mimic the properties of viruses in terms of their size and molecular organization, we constructed RNA (which is a ligand for Toll-like receptor 7 (TLR7) and TLR8) and antigen-loaded nanoparticles resembling the structural organization of viruses. Cationic polymers containing either azide or bicyclo[6.1.0]nonyne (BCN) groups were synthesized as electrostatic glue that binds negatively charged single stranded RNA (PolyU) to form a self-crosslinked polyplex core. An azide-modified model antigen (ovalbumin, OVA) and a BCN-modified mannosylated or galactosylated polymer were sequentially conjugated to the RNA core via disulfide bonds using copper free click chemistry to form the shell of the polyplexes. The generated reducible virus mimicking particles (VMPs) with a diameter of 200 nm and negatively surface charge (-14 mV) were colloidally stable in physiological conditions. The immunogenicity of these VMP vaccines was evaluated both in vitro and in vivo. The surface mannosylated VMPs (VMP-Man) showed 5 times higher cellular uptake by bone marrow derived DCs (BMDCs) compared to galactosylated VMP (VMP-Gal) counterpart. Moreover, VMP-Man efficiently activated DCs and greatly facilitated MHC I Ag presentation in vitro. Vaccination of mice with VMP-Man elicited strong OVA-specific CTL responses as well as humoral immune responses. These results demonstrate that the modular core-shell polymeric nanoparticles described in this paper are superior in inducing strong and durable immune responses compared to adjuvanted protein subunit vaccines and offer therefore a flexible platform for personalized vaccines.

Computed Properties of C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Lou, B; De Beuckelaer, A; Boonstra, E; Li, DD; De Geest, BG; De Koker, S; Mastrobattista, E; Hennink, WE or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem