Month: November 2021

Product Details of 56-17-7. Dai, YX; Yue, N; Liu, CX; Cai, XG; Su, X; Bi, XZ; Li, QF; Li, CY; Huang, WL; Qian, H in [Dai, Yuxuan; Yue, Na; Liu, Chunxia; Cai, Xingguang; Su, Xin; Bi, Xinzhou; Li, Qifei; Li, Chengye; Huang, Wenlong; Qian, Hai] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China; [Huang, Wenlong; Qian, Hai] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China published Synthesis and evaluation of redox-sensitive gonadotropin-releasing hormone receptor-targeting peptide conjugates in 2019.0, Cited 36.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Lytic peptides have been demonstrated to exhibit obvious advantages in cancer therapy with binding ability toward tumor cells via electrostatic attractions, which are lack of active targeting and aggregation to tumor tissue. In the present study, five conjugated lytic peptides were redesigned and constructed to target gonadotropin releasing hormone receptors (GnRHr), meanwhile, the disulfide bridge was introduced to achieve redox sensitive delivery based on the experience from the preliminary work of lytic peptides P3 and P7. YX-1, was considered to be the most promising for in-depth study. YX-1 possessed high potency (IC50 = 3.16 +/- 0.3 mu M), low hemolytic effect, and cell membrane permeability in human A2780 ovarian cancer cells. Moreover, YX-1 had prominent pro-apoptotic activity by activating the mitochondria-cytochrome c-caspase apoptotic pathway. The study yielded the conjugate YX-1 with superior properties for antineoplastic activity, which makes it a promising potential candidate for targeting cancer therapy.

Product Details of 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Zhang, XQ; Ren, XM; Tang, JY; Wang, JT; Zhang, X; He, P; Yao, C; Bian, WH; Sun, LZ in TAYLOR & FRANCIS LTD published article about LOADING CAPACITY; DRUG; DOXORUBICIN; APATINIB; NANOMEDICINE; THERAPEUTICS; CONJUGATE in [Zhang, Xiaoqing; Ren, Xiaomei; Tang, Jiayin; Wang, Jiangtao; He, Peng; Yao, Chang; Bian, Weihe] Nanjing Univ Chinese Med, Jiangsu Prov Hosp TCM, Dept Mastopathy, Affiliated Hosp, Nanjing, Peoples R China; [Zhang, Xiang; Sun, Lizhu] Xuzhou Med Univ, Affiliated Shuyang Hosp, Dept Oncol, Suqian, Peoples R China in 2020.0, Cited 42.0. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Multidrug resistance (MDR) of cancer cells is a significant challenge in chemotherapy, highlighting the urgent medical need for simple and reproducible strategies to reverse this process. Here, we report the development of an active tumor-targeting and redox-responsive nanoplatform (PA-ss-NP) using hyaluronic acid-g-cystamine dihydrochloride-poly-epsilon-(benzyloxycarbonyl)-L-lysine (HA-ss-PLLZ) to co-deliver paclitaxel (PTX) and apatinib (APA) for effective reversal of MDR. This smart nanoplatform specifically bound to CD44 receptors, leading to selective accumulation at the tumor site and uptake by MCF-7/ADR cells. Under high concentrations of cellular glutathione (GSH), the nanocarrier was degraded rapidly with complete release of its encapsulated drugs. Released APA effectively inhibited the function of the P-glycoprotein (P-gp) drug pump and improved the sensitivity of MDR cells to chemotherapeutic agents, leading to the recovery of PTX chemosensitivity in MDR cells. As expected, this newly developed intelligent drug delivery system could effectively control MDR, both in vitro and in vivo.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Synthesis of C- and N-Substituted 1,5,2,6-Dithiadiazocanes -Electrophilic-Nucleophilic Thioamination (ENTA) Reagents WOS:000651351800001 published article about S BOND FORMATION; H SULFENYLATION; SULFONAMIDES; SULFENOAMINATION; THIOMORPHOLINE; DERIVATIVES; SULFIDES; ACCESS; ION in [Javorskis, Tomas; Jurys, Arminas; Orentas, Edvinas] Vilnius Univ, Dept Organ Chem, Naugarduko 24, LT-03225 Vilnius, Lithuania; [Javorskis, Tomas; Bagdziunas, Gintautas] Ctr Phys Sci & Technol, Sauletekio Av 3, LT-10257 Vilnius, Lithuania; [Bagdziunas, Gintautas] Vilnius Univ, Life Sci Ctr, Inst Biochem, Sauletekio Av 7, LT-10257 Vilnius, Lithuania in 2021.0, Cited 38.0. Product Details of 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

A synthetic method is presented for S-N bond formation starting from cheap and affordable materials. We show that (un)substituted N-protected cyclic eight-membered C-2-symmetric sulfenamides have been prepared in a few steps using this procedure. The synthetic utility of these ambipolar derivatives was demonstrated in a variety of synthetic transformations affording different S,N-heterocyles of pharmaceutical relevance in one or two steps from simple starting materials.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2020.0 J CONTROL RELEASE published article about IRON-OXIDE NANOPARTICLES; MAGNETIC-RESONANCE; POLYMERIC MICELLES; ENHANCED PERMEABILITY; CONTRAST AGENTS; NANOPLATFORM; CHITOSAN; DESIGN in [Fu, Yan; Yang, Hong Yu] Jilin Inst Chem Technol, Coll Mat Sci & Engn, Jilin 132022, Jilin, Peoples R China; [Wang, Nannan] Jilin Inst Chem Technol, Coll Biol & Food Engn, Jilin 132022, Jilin, Peoples R China; [Li, Yi] Jiaxing Univ, Coll Mat & Text Engn, Jiaxing 314001, Zhejiang, Peoples R China; [Wu, Te Peng; Lee, Doo Sung] Sungkyunkwan Univ, Theranost Macromol Res Ctr, Suwon 16419, Gyeonggi Do, South Korea; [Wu, Te Peng; Lee, Doo Sung] Sungkyunkwan Univ, Sch Chem Engn, Suwon 16419, Gyeonggi Do, South Korea; [Jang, Moon-Sun; Lee, Jung Hee] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Radiol, Seoul 06351, South Korea; [Jang, Moon-Sun; Lee, Jung Hee] Samsung Biomed Res Inst, Ctr Mol & Cellular Imaging, Seoul 06351, South Korea in 2020.0, Cited 53.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Multifunctional nanosystems that can transport therapeutic and diagnostic agents into tumor sites and activate their respective functions via tumor-microenvironment recognition are highly desirable for clinical applications. We fabricated pH and redox dual-activatable self-assembled nanotheranostics (named as DA-SNs) via coordination-driven self-assembly of chlorin e6 (Ce6) disulfide-linked pH sensitive polymer ligand, poly (isobutylene-alt-maleic anhydride-graft-methoxy-poly (ethyleneglycol)-graft-imidazole-graft-Cystamine-Ce6) [PIMA-mPEG-API-SS-Ce6], and gadolinium ions (Gd3+). DA-SNs exhibited uniform particle size of similar to 48 nm, excellent stability, and inherent biosafety. Negatively charged DA-SNs could prolong blood circulation time (t(1/2) = 2.91 h) and improve tumor accumulation. Moreover, DA-SNs could undergo surface charge switch from negative charge to positive one in a slightly acidic tumor extracellular environment (pH 6.8), thus enhancing cellular uptake. After entering tumor cells, fluorescence, photodynamic therapeutic activity, and T1MR contrast from DA-SNs could be activated within this intracellular environment with lowered pH and high level of GSH. Importantly, human tumors implanted in mice could be successfully visualized via distinct pH and redox dual-sensitive T1MR contrast and fluorescence imaging, indicating that DA-SNs could serve as a dual-modal MR/fluorescence imaging probe for tumor-targeting diagnosis. In addition, DA-SNs exhibited superior photodynamic therapeutic efficiency with negligible side effects. Therefore, this DA-SN shows great promise for synergistic photodynamic therapy and diagnostic imaging.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Fu, Y; Jang, MS; Wang, NN; Li, Y; Wu, T; Lee, JH; Lee, DS; Yang, HY or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Controlled Synthesis of Shell Cross-Linked Helical Poly(phenylborate isocyanide) Nanoparticles with H2O2/Redox Dual Responsiveness and Their Application in Antitumor Drug Delivery WOS:000604600600010 published article about MESOPOROUS SILICA NANOPARTICLES; SENSITIVE VESICLES; RELEASE; OXIDATION; HYPOXIA; PATCHES in [Liu, Wen-Bin; Kang, Shu-Ming; Xu, Xun-Hui; Zhou, Li; Liu, Na; Wu, Zong-Quan] Hefei Univ Technol, Sch Chem & Chem Engn, Dept Polymer Sci & Engn, Hefei 230009, Anhui, Peoples R China; [Liu, Wen-Bin; Kang, Shu-Ming; Xu, Xun-Hui; Zhou, Li; Liu, Na; Wu, Zong-Quan] Hefei Univ Technol, Anhui Key Lab Adv Catalyt Mat & React Engn, Hefei 230009, Anhui, Peoples R China in 2020.0, Cited 36.0. HPLC of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

To mimic the helical structure and function of biopolymers, shell cross-linked nanoparticle (P4) composed of left-handed helical poly(phenylborate isocyanide) in core and hydrophilic polyisocyanide in shell was prepared. The phenylborate in the core and the disulfide bonds in the cross-linkage render the nanoparticle with excellent dual stimuli-responsiveness to glutathione (GSH) and H2O2. Nevertheless, it has good stability in normal physiological conditions. Because of the helicity and borate pendants of the core, such nanoparticle has high capacity for anticancer drug loading, for example, the loading capacity of doxorubicin (DOX) was up to 68%. Moreover, the DOX-loaded DOX@P4 showed excellent tumor cell penetration potency and fast drug release. More than 78% of murine breast cancer cell (4T1) can be killed within 48 h, supporting this material with great potential in antitumor drug nanocarriers.

HPLC of Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Liu, WB; Kang, SM; Xu, XH; Zhou, L; Liu, N; Wu, ZQ or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Recently I am researching about PERIODATE-OXIDATION; SERUM GALECTIN-3; CANCER; PECTIN; EXPRESSION; METASTASIS; INHIBITION; THERAPY; TUMORS; CELLS, Saw an article supported by the Science and Engineering Research Board Department of Science & Technology, MHRD, India [SB/FTP/ETA-202/2013]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Balakrishnan, B; Subramanian, S; Mallia, MB; Repaka, K; Kaur, S; Chandan, R; Bhardwaj, P; Dash, A; Banerjee, R. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Galectin-3 (gal-3) plays a crucial role in various cellular events associated to tumor metastasis and progression. In this direction, gal-3 binding core-shell glyconanoparticles based on citrus pectin (CP) have been designed for targeted, trigger-responsive combination drug delivery. Depolymerization via periodate oxidation in heterogeneous medium yielded low-molecular weight dialdehyde oligomers (CPDA) of CP with a gal-3 binding property (K-d = 160.90 mu M). CPDA-based core-shell nanoparticles prepared to enhance the gal-3 binding specificity via a multivalent ligand presentation have shown to reduce homotypic cellular aggregation, tumor cell binding with endothelial cells, and endothelial tube formation, the major steps involved in the progression of cancer. Immune-fluorescence and flow cytometric analysis confirmed significant reduction in gal-3 expression on MDA-MB 231 cancer cells upon incubation with nanoparticles. An on-demand tumor microenvironment-responsive release of drugs at low pH and high concentrations of glucose and glutathione prevailing in tumor milieu was achieved by introducing a cleavable Schiff’s base, a boronate ester, and disulfide linkages within the shell of the nanoparticles. Nanoparticles with encapsulated sulindac in the core and doxorubicin (DOX) in the shell demonstrated target specificity and enhanced internalization with synergistic cytotoxic effects with a 30-fold reduction in IC50 in DOX-resistant, triple-negative MDA-MB 231 breast cancer cells. Nanoparticles were radiolabeled with 131I radioisotopes with >= 80% efficiency while retaining its gal-3 binding property. Biodistribution studies of radiolabeled placebo nanoparticles and drug-loaded CPDA nanoparticles demonstrated proof of concept of gal-3 targeting seen as preferential accumulation in the gal-3-expressing tissues of the gastric tract. The CPDA core-shell nanoparticles are thus promising platforms for gal-3 targeting and inhibition of gal-3-mediated processes involved in cancer progression with a potential of radiolabeling for in vivo monitoring or delivering therapeutic doses of radiation and on-demand triggered, target-specific drug release.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Balakrishnan, B; Subramanian, S; Mallia, MB; Repaka, K; Kaur, S; Chandan, R; Bhardwaj, P; Dash, A; Banerjee, R or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2019.0 BIOCONJUGATE CHEM published article about PROSTATE-CANCER; IN-VITRO; CYCLOADDITIONS; FLUORESCENT; TETRAZINES; ANTIBODIES; CHELATORS in [Canovas, Coline; Moreau, Mathieu; Collin, Bertrand; Denat, Franck; Goncalves, Victor] Univ Bourgogne Franche Comte, Univ Bourgogne, CNRS, Inst Chim Mol,UMR6302, 9 Ave Alain Savary, F-21000 Dijon, France; [Vrigneaud, Jean-Marc; Bellaye, Pierre-Simon; Collin, Bertrand] Georges Francois LECLERC Canc Ctr, UNICANCER, 1 Rue Pr Marion, F-21079 Dijon, France in 2019.0, Cited 39.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

The combination of two imaging probes on the same biomolecule gives access to targeted bimodal imaging agents that can provide more accurate diagnosis, complementary information, or that may be used in different applications, such as nuclear imaging and fluorescence guided surgery. In this study, we demonstrate that dichlorotetrazine, a small, commercially available compound, can be used as a modular platform to easily assemble various imaging probes. Doubly labeled tetrazines can then be conjugated to a protein through a biorthogonal IEDDA reaction. A series of difunctionalized tetrazine compounds containing various chelating agents and fluorescent dyes was synthesized. As a proof of concept, one of these bimodal probes was conjugated to trastuzumab, previously modified with a constrained alkyne group, and the resulting dual-labeled antibody was evaluated in a mouse model, bearing a HER2-positive tumor. A significant uptake into tumor tissues was observed in vivo, by both SPECT-CT and fluorescence imaging, and confirmed ex vivo in biodistribution studies.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Canovas, C; Moreau, M; Vrigneaud, JM; Bellaye, PS; Collin, B; Denat, F; Goncalves, V or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Effect of grafting ratio of poly(propylene imine) dendrimer onto gold nanoparticles on the properties of colloidal hybrids, their DOX loading and release behavior and cytotoxicity WOS:000471084400059 published article about POLY(AMIDOAMINE)-FUNCTIONALIZED GRAPHENE OXIDE; JANUS NANOPARTICLES; PARTICLE-SIZE; SURFACE; REDUCTION; POLYMERIZATION; METHACRYLATE; GENERATION; MECHANISM in [Najafi, Faezeh; Salami-Kalajahi, Mehdi; Roghani-Mamaqani, Hossein] Sahand Univ Technol, Dept Polymer Engn, POB 51335-1996, Tabriz, Iran; [Najafi, Faezeh; Salami-Kalajahi, Mehdi; Roghani-Mamaqani, Hossein] Sahand Univ Technol, Inst Polymer Mat, POB 51335-1996, Tabriz, Iran; [Kahaie-Khosrowshahi, Amir] Sahand Univ Technol, Dept Chem Engn, POB 51335-1996, Tabriz, Iran in 2019.0, Cited 60.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

A facile method via grafting to approach was used to synthesize hybrid gold-dendrimer nanoparticles. To this end, gold nanoparticles (GNPs) were synthesized via Turkevich method and 5th-generation cystamine-cored poly (propylene imine) (PPI) dendrimer was synthesized by iterative Michael addition and hydrogenation reactions. To prepare hybrid nanoparticles, aqueous solution of dendrimer was poured into colloidal solution of GNPs to form gold-S interactions which resulted in hybrid gold-dendrimer nanoparticles. UV-VIS-NIR and Raman spectroscopies, dynamic light scattering (DLS), thermogravimetric analysis (TGA) and field-emission scanning electron microscopy (FE-SEM) were utilized to confirm the surface modification of GNPs by PPI dendrimer. Cytotoxicity study through MIT assay against human fibroblast (FBS) cells showed appropriate proliferation of cells in presence of hybrid nanoparticles whereas higher grafting ratio of dendrimers induced more toxicity due to existence of peripheral amine groups. Also, hybrid gold-dendrimer nanoparticles were used as DOX nano-carriers. Results showed that carriers did not release the drug at pH = 7.4 significantly while up to 92.8% of drug release was measured at pH = 5.3. Also, higher grafting ratio limited the drug release due to shielding effect of grafted dendrimers.

Welcome to talk about 56-17-7, If you have any questions, you can contact Najafi, F; Salami-Kalajahi, M; Roghani-Mamaqani, H; Kahaie-Khosrowshahi, A or send Email.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Authors Yang, X; Cheng, Q; Monnier, V; Charles, L; Karoui, H; Ouari, O; Gigmes, D; Wang, RB; Kermagoret, A; Bardelang, D in WILEY-V C H VERLAG GMBH published article about in [Yang, Xue; Charles, Laurence; Karoui, Hakim; Ouari, Olivier; Gigmes, Didier; Kermagoret, Anthony; Bardelang, David] Aix Marseille Univ, CNRS, ICR, Marseille, France; [Cheng, Qian; Wang, Ruibing] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa, Macau, Peoples R China; [Monnier, Valerie] Aix Marseille Univ, CNRS, Cent Marseille, FSCM,Spectropole, Marseille, France in 2021.0, Cited 87.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Molecular machines are ubiquitous in nature and function away from equilibrium by consuming fuels to produce appropriate work. Chemists have recently excelled at mimicking the fantastic job performed by natural molecular machines with synthetic systems soluble in organic solvents. In efforts toward analogous systems working in water, we show that guest molecules can be exchanged in the synthetic macrocycle cucurbit[7]uril by involving kinetic traps, and in such a way as modulating energy wells and kinetic barriers using pH, light, and redox stimuli. Ditolyl-viologen can also be exchanged using the best kinetic trap and interfaced with alginate, thus affording pH-responsive blue, fluorescent hydrogels. With tunable rate and binding constants toward relevant guests, cucurbiturils may become excellent ring molecules for the construction of advanced molecular machines working in water.

Welcome to talk about 56-17-7, If you have any questions, you can contact Yang, X; Cheng, Q; Monnier, V; Charles, L; Karoui, H; Ouari, O; Gigmes, D; Wang, RB; Kermagoret, A; Bardelang, D or send Email.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Ma, D; Shi, MH; Li, X; Zhang, JL; Fan, Y; Sun, K; Jiang, TT; Peng, C; Shi, XY in [Ma, Dan; Zhang, Jiulong; Peng, Chen; Shi, Xiangyang] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Canc Ctr, Shanghai 200072, Peoples R China; [Ma, Dan; Shi, Menghan; Li, Xin; Fan, Yu; Jiang, Tingting; Shi, Xiangyang] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China; [Sun, Kai] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA; [Peng, Chen] Ninghai First Hosp, Ningbo 315600, Peoples R China published Redox-Sensitive Clustered Ultrasmall Iron Oxide Nanoparticles for Switchable T-2/T-1-Weighted Magnetic Resonance Imaging Applications in 2020.0, Cited 44.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Development of novel activable dual-mode T-1/T-2-weighted magnetic resonance (MR) contrast agents with the same composition for dynamic precision imaging of tumors has been a challenging task. Here, we demonstrated a strategy to prepare clustered Fe3O4 nanoparticles (NPs) with redox-responsiveness to tumor microenvironment to achieve switchable T-2/T-1-weighted dual-mode MR imaging applications. In this study, we first synthesized ultrasmall Fe3O4 NPs with an average size of 3.3 nm and an r, relaxivity of 4.3 mM(-1) s(-1), and then cross-linked the single Fe3O4 NPs using cystamine dihydrochloride (Cys) to form clustered Fe3O4/Cys NPs. The Fe3O4 nanoclusters (NCs) possess desirable colloidal stability, cytocompatibility, high r(2) relaxivity (26.4 mM(-1) s(-1)), and improved cellular uptake efficiency. Importantly, with the redox-responsiveness of the disulfide bond of Cys, the Fe3O4 NCs can be dissociated to form single particles under a reducing condition, hence displaying a switchable T-2/T-1-weighted MR imaging property that can be utilized for dynamic precision imaging of cancer cells in vitro and a subcutaneous tumor model in vivo due to the reductive intracellular environment of cancer cells and the tumor microenvironment. With the tumor reductive microenvironment-mediated switching of T-2 to T-1 MR effect and the ultrasmall size of the single particles that can pass through the kidney filter, the developed Fe3O4 NCs may be used as a promising switchable T-2/T-1 dual-mode MR contrast agent for precision imaging of different biosystems.

Welcome to talk about 56-17-7, If you have any questions, you can contact Ma, D; Shi, MH; Li, X; Zhang, JL; Fan, Y; Sun, K; Jiang, TT; Peng, C; Shi, XY or send Email.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem