Month: November 2021

An article Interfacial Liquid-Liquid Phase Separation-Driven Polymerization-Induced Electrostatic Self-Assembly WOS:000665741600027 published article about VISIBLE-LIGHT; COMPLEX COACERVATION; RAFT POLYMERIZATION; COPOLYMER VESICLES; NANOPARTICLES; MONOMERS; SEQUENCE; WATER in [Wang, Ye; Li, Chao; Ma, Lei; Wang, Xiyu; Wang, Kai; Lu, Xinhua; Cai, Yuanli] Soochow Univ, Coll Chem Chem Engn & Mat Sci, State Local Joint Engn Lab Novel Funct Polymer Ma, Suzhou 215123, Peoples R China in 2021.0, Cited 54.0. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Development of spatially restricted liquid-liquid phase separation (LLPS) systems emulating biomolecular condensates is a major challenge in coacervating materials science, due to lack of approaches for spatially restricted coacervation of sequence-defined zwitterionic segments resembling intrinsically disordered proteins. Herein, we present interfacial LLPS-driven polymerization-induced electrostatic self-assembly, namely, interfacial LLPS-PIESA. The asymmetric charge sequence patterning of zwitterionic growing segments is achieved via spontaneous polymerization of ion-pair monomers within a nanopartide core-shell interface. We show that charge sequence can profoundly affect the self-coacervation, leading to droplet dispersions, dense coacervates, and free-standing hydrogels. Moreover, the interfacial LLPS-PIESA shows a programmed hierarchical condensation self-assembly mechanism involving vesicles-to-lamellae transition, interfacial self-coacervation, lamellae-to-sheets transition, layer-by-layer sheet self-assembly, spatially restricted condensation and agglomeration, and redispersing into fibril network condensates under dynamic evolving surface charge regulation. The spatially restricted asymmetric charge sequence patterning, interfacial self-coacervation, and programmed hierarchical condensation self-assembly, all these elements can serve as the primary principles for the asymmetric charge sequence patterning design of hierarchically nanostructured condensates that emulate cellular biomolecular condensates.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, Y; Li, C; Ma, L; Wang, XY; Wang, K; Lu, XH; Cai, YL or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 56-17-7. In 2020.0 THERANOSTICS published article about CYANINE DYES; IN-VIVO; PHOTODYNAMIC THERAPY; CANCER; NANOPARTICLES; RELEASE; NANOMEDICINE; CHEMOTHERAPY; DOXORUBICIN; METASTASES in [Mo, Shanyan; Zhang, Xiaoting; Hameed, Sadaf; Zhou, Yiming; Dai, Zhifei] Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China; [Mo, Shanyan] Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China in 2020.0, Cited 58.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Near-infrared (NIR) fluorescence imaging has been proved as an effective modality in identifying the tumor border and distinguishing the tumor cells from healthy tissue during the oncological surgery. Developing NIR fluorescent probes with high tumor to background (T/B) signal is essential for the complete debulking of the tumor, which will prolong the survival rate of tumor patients. However, the nonspecific binding and always-on properties of the conventional fluorescent probes leads to high background signals and poor specificity. Method: To address this problem, glutathione (GSH)-responsive, two disulfide-bonded dicyanine dyes (ss-diCy5 and ss-diNH800CW) were synthesized. As synthesized dyes are quenched under normal physiological conditions, however, once reached to the tumor site, these dyes are capable of emitting strong fluorescence signals primarily because of the cleavage of the disulfide bond in the tumor microenvironment with high GSH concentration. Besides, the GSH-responsive behavior of these dyes was monitored using the UV-vis and fluorescence spectroscopy. The diagnostic accuracy of the aforementioned dyes was also tested both in tumor cells and 4T1-bearing mice. Results: The fluorescence signal intensity of disulfide dicyanine dyes was quenched up to 89% compared to the mono cyanine dyes, thus providing a very low fluorescence background. However, when the disulfide dicyanine dye reaches the tumor site, the dicyanine is cleaved by GSH into two mono-dyes with high fluorescence strength, thus producing strong fluorescent signals upon excitation. The fluorescent signal of the dicyanine was enhanced by up to 27-fold after interacting with the GSH solution. In vivo xenografts tumor studies further revealed that the fluorescence signals of aforementioned dyes can be quickly recovered in the solid tumor. Conclusion: In summary, the disulfide dicyanines dyes can provide a promising platform for specific tumor-activatable fluorescence imaging with improved T/B value.

Recommanded Product: 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about POTENTIAL APPLICATION; ACYLHYDRAZONE; PROPERTY; ADHESIVE, Saw an article supported by the National Key Research and Development Program of China [2016YFA0101102]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51203123]; Major Technological Innovation Program of Hubei Province [2019AAA034]; Project of Wuhan Science and Technology Bureau [2019010702011335]; Testing & Analysis Center, Wuhan Textile University; Australian Research CouncilAustralian Research Council [FT170100301]. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Li, SZ; Pei, MJ; Wan, TT; Yang, HJ; Gu, SJ; Tao, YZ; Liu, X; Zhou, YS; Xu, WL; Xiao, P. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Natural hydrogels are widely investigated for biomedical applications because of their structures similar to extracellular matrix of native tissues, possessing excellent biocompatibility and biodegradability. However, they are often susceptible to mechanical disruption. In this study, self-healing hyaluronic acid (HA) hydrogels are fabricated through a facile dynamic covalent Schiff base reaction. Dialdehyde-modified HA (AHA) precursor was synthesized, and then the AHA/cystamine dihydrochloride (AHA/Cys) hydrogels were formed by blending AHA and Cys at acidic pH levels. By varying Cys to AHA ratio, the hydrogel morphology, swelling and kinetics of gelation could be controlled. Gelation occurred fast, which was predominantly attributed to Schiff base reaction between the dialdehyde groups on AHA and amimo groups on Cys. The hydrogel exhibited improved mechanical properties with increase in Cys content. Furthermore, due to dynamic imine bonds, this hydrogel demonstrated excellent self-healing ability based on the stress after mechanical disruption. Also, it was found to be pH-responsive and injectable. Taken together, this kind of hyaluronic acid hydrogel can provide promising future for various biomedical applications in drug delivery, bioprinting, smart robots and tissue regeneration.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Li, SZ; Pei, MJ; Wan, TT; Yang, HJ; Gu, SJ; Tao, YZ; Liu, X; Zhou, YS; Xu, WL; Xiao, P or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Development of improved dual-diazonium reagents for faster crosslinking of tobacco mosaic virus to form hydrogels WOS:000487104200019 published article about PLANT VIRAL NANOPARTICLES; SUPRAMOLECULAR HYDROGELS; NANOCOMPOSITE HYDROGELS; SURFACE MODIFICATION; SHAPE-MEMORY; CONSTRUCTION; COVALENT; DELIVERY; NANOMATERIALS; PROTEINS in [Chen, Zhuoyue; Yi, Long] Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China; [Ma, Dejun; Xi, Zhen] Nankai Univ, Natl Pesticide Engn Res Ctr Tianjin, Dept Chem Biol, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China; [Xi, Zhen] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China in 2019.0, Cited 65.0. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

New bench-stable reagents with two diazonium sites were designed and synthesized for protein crosslinking. Because of the faster diazonium-tyrosine coupling reaction, hydrogels from the crosslinking of tobacco mosaic virus and the reagent DDA-3 could be prepared within 1 min at room temperature. Furthermore, hydrogels with the introduction of disulfide bonds viaDDA-4 could be chemically degraded by dithiothreitol. Our results provided a facile approach for the direct construction of virus-based hydrogels.

Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Ma, DJ; Chen, ZY; Yi, L; Xi, Z or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Formula: C4H14Cl2N2S2. In 2019.0 INT J BIOL MACROMOL published article about FACILE FABRICATION; DRUG-DELIVERY; PH; NANOPARTICLES in [Wang, Fang; Zhang, Qian; Li, Xinxia; Huang, Kexin; Shao, Wei; Huang, Chaobo] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China; [Yao, Dawei] Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China in 2019.0, Cited 27.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

A simple method to fabricate redox-responsive composite hydrogel films via incorporating chitosan (CS) micro spheres into carboxymethyl cellulose (CMC) hydrogel using a di-sulphide cross-linker cystamine dihydrochloride (CYS) have done in this paper. Dual drugs, an anticancer, 5-Fluorouracil (5-FU) and an antibiotic, Tetracycline Hydrochloride (TH) were used as model drugs. The prepared composite hydrogel films were characterized using FTIR, SEM, rheology measurement, mechanical and swelling tests. Our results showed that the well dispersed spherical CS microspheres endowed hydrogel film increased mechanical properties and swellability. In vitro drug release displayed an accelerated release under weak acidic or reducing media. The in vitro cytotoxicity and cell apoptosis studies showed the drug-loaded composite film caused enhanced inhibition to HepG2 cells in presence of glutathione (GSH). Moreover, the film has exhibited excellent antimicrobial efficacy against E.coli and Staphylococcus aureus. Therefore, our simple and effective dual drug-loaded system has the potential to be used for cancer therapy in the future. (C) 2019 Elsevier B.V. All rights reserved.

Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, F; Zhang, Q; Li, XX; Huang, KX; Shao, W; Yao, DW; Huang, CB or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Discovery of a Novel Cabazitaxel Nanoparticle-Drug Conjugate (CRLX522) with Improved Pharmacokinetic Properties and Anticancer Effects Using a beta-Cyclodextrin-PEG Copolymer Based Delivery Platform published in 2019.0. Recommanded Product: 56-17-7, Reprint Addresses Metcalf, CA (corresponding author), Novartis Inst BioMed Res Inc, 181 Massachusetts Ave, Cambridge, MA 02139 USA.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Novel nanoparticle drug conjugates (NDCs) containing diverse, clinically relevant anticancer drug payloads (docetaxel, cabazitaxel, and gemcitabine) were successfully generated and tested in drug discovery studies. The NDCs utilized structurally varied linkers that attached the drug payloads to a beta-cyclodextrin-PEG copolymer to form self-assembled nanoparticles. In vitro release studies revealed a diversity of release rates driven by linker structure activity relationships (SARs). Improved in vivo pharmacokinetics (PK) for the cabazitaxel (CBTX) NDCs with glycinate-containing (1c) and hexanoate-containing linkers (2c) were demonstrated, along with high and sustained tumor levels (>168 h of released drug in tumor tissues). This led to potent efficacy and survival in both taxane- and docetaxel-resistant in vivo anticancer mouse efficacy models. Overall, the CBTX-hexanoate NDC 2c (CRLX522), demonstrated optimal and improved in vivo PK (plasma and tumor) and efficacy profile versus those of the parent drug, and the results support the potential therapeutic use of CRLX522 as a new anticancer agent.

Recommanded Product: 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Magnetic resonance energy transfer for in vivo glutathione susceptibility weighted imaging WOS:000514748200020 published article about TUMOR MICROENVIRONMENT; FLUORESCENT-PROBE; NANOPARTICLES; ACTIVATION; SOFT in [Wang, Kun; Zhang, Huilin; Zhao, Peiran; Meng, Xianfu; Chen, Xiaoyan; Liu, Yang; Liu, Yanyan; Gong, Teng; Bu, Wenbo] East China Normal Univ, Coll Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China; [Wu, Wanlu; Fang, Xiangming] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Med Imaging, Nanjing, Peoples R China; [Shen, Aijun; Wang, Peijun] Tongji Univ, Tongji Hosp, Dept Med Imaging, Shanghai 200065, Peoples R China in 2020.0, Cited 44.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Glutathione (GSH) plays a vital role in maintaining biological redox homeostasis. Accordingly, accurate imaging of glutathione in vivo is of great significance. Herein, we propose a magnetic resonance energy transfer (MRET) strategy based on a distance-dependent magnetic exchange coupling effect (MECE), which can realize GSH detection within tumors in vivo by susceptibility weighted imaging (SWI). Fe3O4 nanoparticles (NPs) and CoFe2O4 NPs linked with cystamine (Fe3O4-S-S-CoFe2O4) have been successfully designed as SWI nanoprobes. After the disulfide bonds are broken by excess GSH in the tumor, the increase in the distance between Fe3O4 NPs and CoFe2O4 NPs will induce a decrease of MECE and magnetic susceptibility. As a result, the changes in the SWI signals are used for tumor GSH detection in vivo. Experimental results in vitro and in vivo demonstrate that the Fe3O4-S-S-CoFe2O4 SWI nanoprobe can sensitively detect concentrations of GSH in tumors. Hence, this strategy not only improves the sensitivity of the GSH response in SWI but also provides a powerful basis for the design of other responsive functional MRI nanoprobes.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, K; Zhang, HL; Shen, AJ; Zhao, PR; Meng, XF; Chen, XY; Liu, Y; Liu, YY; Gong, T; Wu, WL; Fang, XM; Wang, PJ; Bu, WB or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2021.0 INT J POLYM MATER PO published article about ZWITTERIONIC NANOPARTICLES; POLYMERIC MICELLES; PH; DELIVERY; ACID); NANOGELS; POLY(ETHYLENE; COPOLYMER in [Feng, Zhiyun] Yangtze Univ, Coll Chem & Environm Engn, Jingzhou, Peoples R China; [Xu, Jie; Ni, Caihua] Jiangnan Univ, Sch Chem & Mat Engn, Wuxi, Jiangsu, Peoples R China in 2021.0, Cited 35.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

A new kind of redox responsive nanoparticles was prepared through the modification and crosslinking reaction of xanthan gum. The nanoparticles had regular spherical shapes with diameters ranging from 110 to 180 nm. The nanoparticles showed good redox responsiveness. Doxorubicin (DOX) was loaded in the nanoparticles via ionic interaction with SO3-, for increasing the drug loading rate and avoiding drug leakage. The in vitro drug release could be controlled by pH and reduction conditions simulated to the internal environment of tumor cells. The nanoparticles were biocompatible and could be potentially applied as anti-cancer drug vehicles for targeted release.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. I found the field of Chemistry; Polymer Science very interesting. Saw the article Self-healing hyaluronic acid hydrogels based on dynamic Schiff base linkages as biomaterials published in 2020.0, Reprint Addresses Zhou, YS (corresponding author), Wuhan Text Univ, Coll Mat Sci & Engn, Wuhan 430073, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Natural hydrogels are widely investigated for biomedical applications because of their structures similar to extracellular matrix of native tissues, possessing excellent biocompatibility and biodegradability. However, they are often susceptible to mechanical disruption. In this study, self-healing hyaluronic acid (HA) hydrogels are fabricated through a facile dynamic covalent Schiff base reaction. Dialdehyde-modified HA (AHA) precursor was synthesized, and then the AHA/cystamine dihydrochloride (AHA/Cys) hydrogels were formed by blending AHA and Cys at acidic pH levels. By varying Cys to AHA ratio, the hydrogel morphology, swelling and kinetics of gelation could be controlled. Gelation occurred fast, which was predominantly attributed to Schiff base reaction between the dialdehyde groups on AHA and amimo groups on Cys. The hydrogel exhibited improved mechanical properties with increase in Cys content. Furthermore, due to dynamic imine bonds, this hydrogel demonstrated excellent self-healing ability based on the stress after mechanical disruption. Also, it was found to be pH-responsive and injectable. Taken together, this kind of hyaluronic acid hydrogel can provide promising future for various biomedical applications in drug delivery, bioprinting, smart robots and tissue regeneration.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

COA of Formula: C4H14Cl2N2S2. In 2019.0 BIOORG CHEM published article about CANCER; PRODRUG; RICH; ACTIVATION; MECHANISMS; RESISTANCE; ARGININE; THERAPY; LYSINE in [Dai, Yuxuan; Yue, Na; Liu, Chunxia; Cai, Xingguang; Su, Xin; Bi, Xinzhou; Li, Qifei; Li, Chengye; Huang, Wenlong; Qian, Hai] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China; [Huang, Wenlong; Qian, Hai] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China in 2019.0, Cited 36.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Lytic peptides have been demonstrated to exhibit obvious advantages in cancer therapy with binding ability toward tumor cells via electrostatic attractions, which are lack of active targeting and aggregation to tumor tissue. In the present study, five conjugated lytic peptides were redesigned and constructed to target gonadotropin releasing hormone receptors (GnRHr), meanwhile, the disulfide bridge was introduced to achieve redox sensitive delivery based on the experience from the preliminary work of lytic peptides P3 and P7. YX-1, was considered to be the most promising for in-depth study. YX-1 possessed high potency (IC50 = 3.16 +/- 0.3 mu M), low hemolytic effect, and cell membrane permeability in human A2780 ovarian cancer cells. Moreover, YX-1 had prominent pro-apoptotic activity by activating the mitochondria-cytochrome c-caspase apoptotic pathway. The study yielded the conjugate YX-1 with superior properties for antineoplastic activity, which makes it a promising potential candidate for targeting cancer therapy.

Welcome to talk about 56-17-7, If you have any questions, you can contact Dai, YX; Yue, N; Liu, CX; Cai, XG; Su, X; Bi, XZ; Li, QF; Li, CY; Huang, WL; Qian, H or send Email.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem