Month: November 2021

Recommanded Product: 56-17-7. In 2019.0 BIOMATERIALS published article about ORGANIC NANOPARTICLES; ENDOTHELIAL-CELLS; DRUG; PRODRUG; OXALIPLATIN; CISPLATIN; DESIGN; TUMOR; NANOMEDICINE; DELIVERY in [Sun, Tao; Guo, Zhongyuan; Chen, Qinjun; Chen, Xinli; Lu, Yifei; Zhang, Yu; Zhang, Yujie; Guo, Qin; Jiang, Chen] Fudan Univ, Sch Pharm, Dept Pharmaceut, Key Lab Smart Drug Delivery,Minist Educ,State Key, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; [Zhang, Guangping] Shandong Normal Univ, Sch Phys Elect, Shandong Prov Key Lab Med Phys & Image Proc Techn, 1 Univ Rd, Jinan 250358, Shandong, Peoples R China; [Zhang, Guangping] Shandong Normal Univ, Sch Phys Elect, Inst Mat & Clean Energy, 1 Univ Rd, Jinan 250358, Shandong, Peoples R China; [Wang, Qingbing] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Intervent Radiol, 197 Ruijin Er Rd, Shanghai 200025, Peoples R China; [Gao, Xiang; Cheng, Yongzhong] Sichuan Univ, West China Med Sch, West China Hosp, Dept Neurosurg, 24 Renmin Nan Rd, Chengdu 610041, Sichuan, Peoples R China; [Gao, Xiang; Cheng, Yongzhong] Sichuan Univ, West China Med Sch, West China Hosp, Inst Neurosurg,State Key Lab Biotherapy, 24 Renmin Nan Rd, Chengdu 610041, Sichuan, Peoples R China in 2019.0, Cited 60.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Real-time monitor of drug-release from drug formulations in a noninvasive way can provide spatio-temporal information for drug activation and guide further clinical rational administration. In this work, a molecular shuttle, as a typical nanosized artificial molecular machine, was managed to act as a conceptually-new nanotheranostics for oxaliplatin. A post-recognition strategy was utilized, where a default supramolecular-dye couple was pre-blocked. The rational design, synthesis, characterization and proof-of-concept of this strategy were described in detail. The drug-release upon reducing environment can be translated into near-infrared (NIR) fluorescence signal (OFF-to-ON), allowing to track the drug-release procedure by multi-modal images including IVIS, FLECT and photoacoustic imaging. The versatile nanotheranostics system can target to triple negative breast tumor via conjugated F3 peptide, and show an improved anti-tumor efficacy with much lower side effect. The intelligent nanotheranostics system based on molecular shuttle provides new reference for precision medicine in preclinical trial and postclinical evaluation.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2019.0 ACS MACRO LETT published article about POLYMERS; COVALENT in [Zhang, Shuai; Qin, Bo; Huang, Zehuan; Xu, Jiang-Fei; Zhang, Xi] Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China in 2019.0, Cited 52.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. COA of Formula: C4H14Cl2N2S2

A new method of supramolecular emulsion interfacial polymerization is developed, which can be used to fabricate supramolecular polymeric nanospheres. We designed a water-soluble monomer containing two maleimide end groups, acting as both building block and surfactant, and an oil-soluble supramonomer bearing two thiol groups connected by quadruple hydrogen bonds. With the assist of ultrasonication, hollow nanospheres can be controllably prepared by thiol-maleimide reaction of two monomers at the emulsion interface, which exhibit good stability and dynamic property. In addition, the encapsulated guest molecules could be controllably released from the supramolecular polymeric nanospheres, owing to their stimuli-responsiveness. It is anticipated that this approach will enrich the methodology of supramolecular polymerization and can be applied to constructing supramolecular materials with controllable structures and functions.

COA of Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Zhang, S; Qin, B; Huang, ZH; Xu, JF; Zhang, X or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Fu, Y; Jang, MS; Wang, NN; Li, Y; Wu, T; Lee, JH; Lee, DS; Yang, HY in ELSEVIER published article about IRON-OXIDE NANOPARTICLES; MAGNETIC-RESONANCE; POLYMERIC MICELLES; ENHANCED PERMEABILITY; CONTRAST AGENTS; NANOPLATFORM; CHITOSAN; DESIGN in [Fu, Yan; Yang, Hong Yu] Jilin Inst Chem Technol, Coll Mat Sci & Engn, Jilin 132022, Jilin, Peoples R China; [Wang, Nannan] Jilin Inst Chem Technol, Coll Biol & Food Engn, Jilin 132022, Jilin, Peoples R China; [Li, Yi] Jiaxing Univ, Coll Mat & Text Engn, Jiaxing 314001, Zhejiang, Peoples R China; [Wu, Te Peng; Lee, Doo Sung] Sungkyunkwan Univ, Theranost Macromol Res Ctr, Suwon 16419, Gyeonggi Do, South Korea; [Wu, Te Peng; Lee, Doo Sung] Sungkyunkwan Univ, Sch Chem Engn, Suwon 16419, Gyeonggi Do, South Korea; [Jang, Moon-Sun; Lee, Jung Hee] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Radiol, Seoul 06351, South Korea; [Jang, Moon-Sun; Lee, Jung Hee] Samsung Biomed Res Inst, Ctr Mol & Cellular Imaging, Seoul 06351, South Korea in 2020.0, Cited 53.0. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Multifunctional nanosystems that can transport therapeutic and diagnostic agents into tumor sites and activate their respective functions via tumor-microenvironment recognition are highly desirable for clinical applications. We fabricated pH and redox dual-activatable self-assembled nanotheranostics (named as DA-SNs) via coordination-driven self-assembly of chlorin e6 (Ce6) disulfide-linked pH sensitive polymer ligand, poly (isobutylene-alt-maleic anhydride-graft-methoxy-poly (ethyleneglycol)-graft-imidazole-graft-Cystamine-Ce6) [PIMA-mPEG-API-SS-Ce6], and gadolinium ions (Gd3+). DA-SNs exhibited uniform particle size of similar to 48 nm, excellent stability, and inherent biosafety. Negatively charged DA-SNs could prolong blood circulation time (t(1/2) = 2.91 h) and improve tumor accumulation. Moreover, DA-SNs could undergo surface charge switch from negative charge to positive one in a slightly acidic tumor extracellular environment (pH 6.8), thus enhancing cellular uptake. After entering tumor cells, fluorescence, photodynamic therapeutic activity, and T1MR contrast from DA-SNs could be activated within this intracellular environment with lowered pH and high level of GSH. Importantly, human tumors implanted in mice could be successfully visualized via distinct pH and redox dual-sensitive T1MR contrast and fluorescence imaging, indicating that DA-SNs could serve as a dual-modal MR/fluorescence imaging probe for tumor-targeting diagnosis. In addition, DA-SNs exhibited superior photodynamic therapeutic efficiency with negligible side effects. Therefore, this DA-SN shows great promise for synergistic photodynamic therapy and diagnostic imaging.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

SDS of cas: 56-17-7. Zhang, YB; Liu, SY; Li, TY; Zhang, LQ; Azhar, U; Ma, JC; Zhai, CC; Zong, CY; Zhang, SX in [Zhang, Yabin; Liu, Shuyan; Li, Tianyu; Zhang, Luqing; Azhar, Umair; Ma, Jiachen; Zhai, Congcong; Zong, Chuanyong; Zhang, Shuxiang] Univ Jinan, Sch Chem & Chem Engn, Shandong Prov Key Lab Fluorine Chem & Chem Mat, Jinan 250022, Peoples R China published Cytocompatible and non-fouling zwitterionic hyaluronic acid-based hydrogels using thiol-ene click chemistry for cell encapsulation in 2020.0, Cited 49.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

In this work, a facile click reaction strategy is employed to form hydrogels in situ with cytocompatibility, biodegradability, self-healing property and resistance to protein. The thiol-functionalized zwitterionic carboxybetaine methacrylate copolymer, which take part as a cross-linker in the thiol-ene click reaction with the methacrylated hyaluronic acid. The hydrogels are obtained under the physiological condition without the presence of any copper catalyst and UV light. The hydrogel consisting of zwitterionic component shows an obvious reduction in protein adsorption and cell adhesion and avoid non-targeted factor interference in the biological experiments. The hydrogels also demonstrate adjustable degradation behavior. Human mesenchymal stem cells (hMSCs) are easily encapsulated into the hydrogels and remains metabolically active, indicating the excellent biocompatibility of the hydrogels. Additionally, the result of the cytokine secretion assays (IL-6 and TNF-alpha) has shown that this clickable hydrogel can serve to suppress inflammatory reactions and is beneficial for in vivo applications. Based on the above results, this clickable hydrogel with excellent performance can be an amenable platform for 3D cell encapsulation.

Welcome to talk about 56-17-7, If you have any questions, you can contact Zhang, YB; Liu, SY; Li, TY; Zhang, LQ; Azhar, U; Ma, JC; Zhai, CC; Zong, CY; Zhang, SX or send Email.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2020.0 BIOMACROMOLECULES published article about PERIODATE-OXIDATION; SERUM GALECTIN-3; CANCER; PECTIN; EXPRESSION; METASTASIS; INHIBITION; THERAPY; TUMORS; CELLS in [Subramanian, Suresh; Mallia, Madhava B.; Dash, Ashutosh] BARC, Radiopharmaceut Div, Mumbai 400085, Maharashtra, India; [Subramanian, Suresh; Mallia, Madhava B.; Dash, Ashutosh] Homi Bhabha Natl Inst, Mumbai 400094, Maharashtra, India; [Repaka, Krishnamohan] Board Radiat & Isotope Technol, Navi Mumbai 400703, India; [Balakrishnan, Biji; Kaur, Shahdeep; Chandan, Rajeet; Bhardwaj, Prateek; Banerjee, Rinti] Indian Inst Technol, Nanomed Lab, Dept Biosci & Bioengn, Mumbai 400076, Maharashtra, India in 2020.0, Cited 44.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. HPLC of Formula: C4H14Cl2N2S2

Galectin-3 (gal-3) plays a crucial role in various cellular events associated to tumor metastasis and progression. In this direction, gal-3 binding core-shell glyconanoparticles based on citrus pectin (CP) have been designed for targeted, trigger-responsive combination drug delivery. Depolymerization via periodate oxidation in heterogeneous medium yielded low-molecular weight dialdehyde oligomers (CPDA) of CP with a gal-3 binding property (K-d = 160.90 mu M). CPDA-based core-shell nanoparticles prepared to enhance the gal-3 binding specificity via a multivalent ligand presentation have shown to reduce homotypic cellular aggregation, tumor cell binding with endothelial cells, and endothelial tube formation, the major steps involved in the progression of cancer. Immune-fluorescence and flow cytometric analysis confirmed significant reduction in gal-3 expression on MDA-MB 231 cancer cells upon incubation with nanoparticles. An on-demand tumor microenvironment-responsive release of drugs at low pH and high concentrations of glucose and glutathione prevailing in tumor milieu was achieved by introducing a cleavable Schiff’s base, a boronate ester, and disulfide linkages within the shell of the nanoparticles. Nanoparticles with encapsulated sulindac in the core and doxorubicin (DOX) in the shell demonstrated target specificity and enhanced internalization with synergistic cytotoxic effects with a 30-fold reduction in IC50 in DOX-resistant, triple-negative MDA-MB 231 breast cancer cells. Nanoparticles were radiolabeled with 131I radioisotopes with >= 80% efficiency while retaining its gal-3 binding property. Biodistribution studies of radiolabeled placebo nanoparticles and drug-loaded CPDA nanoparticles demonstrated proof of concept of gal-3 targeting seen as preferential accumulation in the gal-3-expressing tissues of the gastric tract. The CPDA core-shell nanoparticles are thus promising platforms for gal-3 targeting and inhibition of gal-3-mediated processes involved in cancer progression with a potential of radiolabeling for in vivo monitoring or delivering therapeutic doses of radiation and on-demand triggered, target-specific drug release.

HPLC of Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Balakrishnan, B; Subramanian, S; Mallia, MB; Repaka, K; Kaur, S; Chandan, R; Bhardwaj, P; Dash, A; Banerjee, R or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 56-17-7. In 2020.0 NANO LETT published article about ULTRASENSITIVE DETECTION; TUMOR MICROENVIRONMENT; PROTEIN-DETECTION; RATIONAL DESIGN; NANOPARTICLES; NANOMATERIALS; CELLS; STRATEGY; SIGNALS; PROBES in [Tang, Xiaoxue; Gong, Xuanqing; Li, Ao; Lin, Hongyu; Gao, Jinhao] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, MOE Lab Spectrochem Anal & Instrumentat, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China; [Tang, Xiaoxue; Gong, Xuanqing; Li, Ao; Lin, Hongyu; Gao, Jinhao] Xiamen Univ, Dept Biol Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China; [Peng, Chenyu; Zhang, Xianzhong] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361005, Peoples R China; [Chen, Xiaoyuan] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA in 2020.0, Cited 54.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Molecular probes featuring promising capabilities including specific targeting, high signal-to-noise ratio, and in situ visualization of deep tissues are in great demand for tumor diagnosis and therapy. F-19 magnetic resonance imaging (MRI) techniques incorporating stimuli-responsive probes are anticipated to be highly beneficial for specific detection and imaging of tumors because of negligible background and deep tissue penetration. Herein, we report a cascaded multi-responsive self-assembled nanoprobe, which enables sequential redox-triggered and near-infrared (NIR) irradiation-induced F-19 MR signal activation/amplification for sensing and imaging. Specifically, we designed and synthesized a cascaded multiresponsive F-19-bearing nanoprobe based on the self-assembly of amphiphilic redox-responsive F-19-containing polymers and NIR-absorbing indocyanine green (ICG) molecules. It could realize the activation of F-19 signals in the reducing tumor microenvironment and subsequent signal amplification via the photothermal process. This stepwise two-stage activation/amplification of F-19 signals was validated by F-19 NMR and MRI both in vitro and in vivo. The multiresponsive F-19 nanoprobes capable of cascaded F-19 signal activation/amplification and photothermal effect exertion can provide accurate sensing and imaging of tumors.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Arai, K; Sato, Y; Nakajima, I; Saito, M; Sasaki, M; Kanamori, A; Iwaoka, M in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Arai, Kenta; Sato, Yuumi; Nakajima, Ikumi; Saito, Manami; Sasaki, Moeka; Iwaoka, Michio] Tokai Univ, Sch Sci, Dept Chem, Hiratsuka, Kanagawa 2591292, Japan; [Kanamori, Akiko] Tokai Univ, Dept Appl Biochem, Hiratsuka, Kanagawa 2591292, Japan; [Kanamori, Akiko] Tokai Univ, Inst Adv Biosci, Hiratsuka, Kanagawa 2591292, Japan in 2021.0, Cited 55.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Amphiphilic derivatives of (+/-)-trans-1,2-diselenane-4,5-diol (DSTox) decorated with long alkyl chains or aromatic substituents via ester linkages were applied as glutathione peroxidase (GPx)-like catalysts. The reduction of H2O2 with the diselenide catalysts was accelerated through a GPx-like catalytic cycle, in which the diselenide (Se-Se) bond was reduced to the diselenolate form ([Se-,Se-]) by coexisting dithiothreitol, and the generated highly active [Se-,Se-] subsequently reduced H2O2 to H2O retrieving the original Se-Se form. In the lipid peroxidation of lecithin/cholesterol liposomes induced by 2,2′-azobis(2-amidinopmpane) dihydrochloride (AAPH), on the other hand, the Se-Se form directly reduced lipid peroxide (LOOH) to the corresponding alcohol (LOH), inhibiting the radical chain reaction, to exert the antioxidative effect. Thus, the two GPx-like catalytic cycles can be switched depending on the peroxide substrates. Furthermore, hydrophilic compounds with no or short alkyl groups (C3) showed high antioxidative activities for the catalytic reduction of H2O2, while lipophilic compounds with long alkyl chains (C6-C14) or aromatic substituents were more effective antioxidants against lipid peroxidation. In addition, these compounds showed low cytotoxicity in cultured HeLa cells and exhibited sufficient anti-lipid peroxidative activities, suggesting their potentials as selenium-based antioxidative drugs.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Canovas, C; Moreau, M; Vrigneaud, JM; Bellaye, PS; Collin, B; Denat, F; Goncalves, V in AMER CHEMICAL SOC published article about PROSTATE-CANCER; IN-VITRO; CYCLOADDITIONS; FLUORESCENT; TETRAZINES; ANTIBODIES; CHELATORS in [Canovas, Coline; Moreau, Mathieu; Collin, Bertrand; Denat, Franck; Goncalves, Victor] Univ Bourgogne Franche Comte, Univ Bourgogne, CNRS, Inst Chim Mol,UMR6302, 9 Ave Alain Savary, F-21000 Dijon, France; [Vrigneaud, Jean-Marc; Bellaye, Pierre-Simon; Collin, Bertrand] Georges Francois LECLERC Canc Ctr, UNICANCER, 1 Rue Pr Marion, F-21079 Dijon, France in 2019.0, Cited 39.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

The combination of two imaging probes on the same biomolecule gives access to targeted bimodal imaging agents that can provide more accurate diagnosis, complementary information, or that may be used in different applications, such as nuclear imaging and fluorescence guided surgery. In this study, we demonstrate that dichlorotetrazine, a small, commercially available compound, can be used as a modular platform to easily assemble various imaging probes. Doubly labeled tetrazines can then be conjugated to a protein through a biorthogonal IEDDA reaction. A series of difunctionalized tetrazine compounds containing various chelating agents and fluorescent dyes was synthesized. As a proof of concept, one of these bimodal probes was conjugated to trastuzumab, previously modified with a constrained alkyne group, and the resulting dual-labeled antibody was evaluated in a mouse model, bearing a HER2-positive tumor. A significant uptake into tumor tissues was observed in vivo, by both SPECT-CT and fluorescence imaging, and confirmed ex vivo in biodistribution studies.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

HPLC of Formula: C4H14Cl2N2S2. I found the field of Oncology; Research & Experimental Medicine very interesting. Saw the article A novel corona core-shell nanoparticle for enhanced intracellular drug delivery published in 2020.0, Reprint Addresses Zhong, XM (corresponding author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China.; Wang, CL (corresponding author), Zhejiang Canc Hosp, Dept Pharm, 38 Guangji Rd, Hangzhou 310022, Zhejiang, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Drugs, including small molecule anticancer drugs, have to be delivered and released into the cytoplasm or nucleus in order to elicit a therapeutic effect. In the present study, a novel corona core-shell nanoparticle was proposed for enhanced cellular uptake and light-responsive intracellular release. Light-responsive core-shell nanoparticles, i.e., gold nanoparticles-coated liposomes (CS), were prepared and further modified with hyaluronic acid (HA) (CCS). HA modification enhances the endocytosis of the nanoparticles by HA receptor-expressing cells, while the plasmonic properties of gold nanoparticles enable their light-triggered drug release. The results demonstrated that the uptake of CCS in HA receptor-expressing MDA-MB-231R cells was significantly enhanced compared with unmodified CS. Nanosecond pulsed laser irradiation (700 nm; 100 mJ/cm(2); 5 pulses) rapidly triggered the intracellular release of a fluorescent dye, 6-carboxyfluorescein (6-CF), from CCS and CS trapped in endolysosomes. The released 6-CF was evenly distributed throughout the entire cytosol and nucleus. Finally, the cytotoxicity of doxorubicin towards MDA-MB-231 cells was significantly increased by CCS delivery upon pulsed laser irradiation. In conclusion, with enhanced cellular uptake and light-triggered intracellular release, CCS significantly enhanced the therapeutic effects of doxorubicin, and may serve as a promising avenue for intracellular drug delivery.

Welcome to talk about 56-17-7, If you have any questions, you can contact Jiang, JW; Zhong, XM; Zhang, HY; Wang, CL or send Email.. HPLC of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article A copper-free click reaction for the synthesis of redox-responsive water-soluble core cross-linked nanoparticles for drug delivery in cancer therapy published in 2019.0. SDS of cas: 56-17-7, Reprint Addresses Dhara, D (corresponding author), Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Polymer based core cross-linked nanoparticles (CCNPs) have generated a lot of interest as potential stimuli-responsive drug delivery systems. In the present work, we have synthesized smart redox-responsive water soluble polymeric CCNPs by cross-linking water-soluble PEG based copolymers with bis(acryloyl)cystamine via isoxazoline bond formation through a 1,3-dipolar cycloaddition reaction (click reaction) without using a copper catalyst, in a water-THF mixed solvent. The successful synthesis of CCNPs was confirmed by NMR, GPC and FT-IR measurements. Size distribution of the precursor copolymers and the CCNPs was determined by DLS measurement. AFM and FESEM images have confirmed globular morphology of these CCNPs. Their high stability in a physiological environment makes them effective as potent drug carriers with high loading capacity. MTT assays confirmed the biocompatibility of the synthesized CCNPs. Favourable cellular internalization of these DOX loaded CCNPs into cancer cells and redox-responsive release of DOX therefrom make these CCNP potentially smart vehicles to deliver anticancer drugs into cancer cells.

SDS of cas: 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem