A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 196597-78-1, Name is 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one, molecular formula is C11H10O2. In an article, author is Gomha, Sobhi M.,once mentioned of 196597-78-1, SDS of cas: 196597-78-1.
Synthesis, Characterization, and Molecular Docking of Novel bis-thiazolyl Thienothiophene Derivatives as Promising Cytotoxic Antitumor Drug
A novel, facile reaction for the synthesis of series of bis-thiazole derivatives has been developed from the reaction of the appropriate thiosemicarbazone derivatives and bis-2-bromoacetylthieno[2,3-b]thiophene derivatives in ethanol under reflux. The structures of the newly synthesized products were established on the basis of spectral data (mass, IR, and H-1 and C-13 NMR) and elemental analyses. Fifteen compounds of the synthesized compounds were evaluated for their anticancer activity against human liver hepatocellular carcinoma cell line (HepG2). All compounds showed anticancer activity but differs in potency comparable with the reference drug Cisplatin. Moreover, molecular docking study using MOE software predicted the best binding mode between the most active compound 5o into the active site of human heat-shock protein 90. The computational studies are confirming the results in biological activity.
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem